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Collaborative Vascular Research in Europe to Improve Care for Patients With Vascular Diseases: What Is Out There, and How to Participate? 欧洲合作开展血管研究,改善对血管疾病患者的护理:有哪些研究,如何参与?
IF 0.6 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.05.009
Fabien Lareyre, Matthias Trenner
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引用次数: 0
Systematic Review of Femoral Artery Stent Fractures 股动脉支架骨折的系统回顾
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.08.001
Arielle Bellissard , Salomé Kuntz , Anne Lejay , Nabil Chakfé

Objective

Primary stenting for long femoropopliteal (FP) lesions remains controversial because of the high risk of stent fracture (SF). This study aimed to summarise current knowledge on SF from randomised control trials about FP stenting.

Methods

A systematic review of the Medline database was performed by a combined strategy of MeSH terms: femoral artery, popliteal artery, stenting, and stent fracture. SF was classified according to a standard classification: 1 = single strut fracture; 2 = ≥ two struts fracture; 3 = type 2 with deformation; 4 = multiple struts fracture with acquired transection; 5, type 4 with gap in the stent body.

Results

The literature search identified 25 publications including covered stents (CSs; n = 3), drug eluting stents (DESs; n = 8), bare metal stents (BMS; n = 17), and bioabsorbable stents (n = 1). Data were extracted from 4 047 patients; mean age ± standard deviation was 68.9 ± 3.0 years and 69% were male. The median lesion length was 87.6 mm (interquartile range [IQR] 70.0, 149) with a median chronic total occlusion proportion of 36.8% (IQR 29.0, 56.5). In 208 patients treated with CS, SF rates ranged from none to 2.6% at 36 months with no clinical correlation. In 1 106 patients treated with DES, SF rates were relatively low in large cohorts, ranging from 0% at 12 months to 1.9% at 60 months. In smaller cohorts (under 100 patients per group), they ranged from 12.5% at six months to 46.7% at 12 months, with no clinical repercussion. In 1 610 patients treated with BMS, SF rates ranged from 2% to 32.7% at 12 months and from 2.9% to 48.9% at 24 months, with no clinical repercussion.

Conclusion

SF rates in large cohorts were low in CF and DES, and quite common in BMS, although none of them had clinical consequences. However, longer follow up and detailed, accurate reports are needed to assess eventual real clinical outcomes.

目的由于支架断裂(SF)的高风险,对股骨腘动脉(FP)长病变进行初级支架植入术仍存在争议。本研究旨在总结有关股腘动脉支架置入术的随机对照试验中有关 SF 的现有知识。方法采用 MeSH 术语:股动脉、腘动脉、支架置入术和支架骨折,对 Medline 数据库进行了系统性回顾。SF 按照标准分类法进行分类:结果文献检索发现了25篇文献,包括覆盖支架(CS;n = 3)、药物洗脱支架(DES;n = 8)、裸金属支架(BMS;n = 17)和生物可吸收支架(n = 1)。从 4 047 名患者中提取了数据;平均年龄(标准差)为 68.9 ± 3.0 岁,69% 为男性。病变长度中位数为 87.6 毫米(四分位数间距 [IQR] 70.0,149),慢性全闭塞比例中位数为 36.8%(IQR 29.0,56.5)。在208名接受CS治疗的患者中,36个月时的SF率从无到2.6%不等,且无临床相关性。在1 106例接受DES治疗的患者中,大样本队列的SF率相对较低,从12个月时的0%到60个月时的1.9%不等。在较小的队列中(每组不足100人),SF率从6个月时的12.5%到12个月时的46.7%不等,没有临床反响。在1610名接受BMS治疗的患者中,12个月时的SF率从2%到32.7%不等,24个月时的SF率从2.9%到48.9%不等,没有临床反响。然而,要评估最终的实际临床结果,还需要更长时间的随访和详细准确的报告。
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引用次数: 0
Outcomes Following Vascular and Endovascular Procedures Performed During the First COVID-19 Pandemic Wave 第一次 COVID-19 大流行期间进行的血管和血管内手术的结果
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.08.002
Panagiota Birmpili , Ruth A. Benson , Brenig Gwilym , Sandip Nandhra , Nina Al-Saadi , Graeme K. Ambler , Robert Blair , David Bosanquet , Nikesh Dattani , Louise Hitchman , Katherine Hurndall , Matthew Machin , Sarah Onida , Athanasios Saratzis , Joseph Shalhoub , Lauren Shelmerdine , Aminder A. Singh

Objective

The first COVID-19 pandemic wave was a period of reduced surgical activity and redistribution of resources to only those with late stage or critical presentations. This Vascular and Endovascular Research Network COVID-19 Vascular Service (COVER) study aimed to describe the six-month outcomes of patients who underwent open surgery and or endovascular interventions for major vascular conditions during this period.

Methods

In this international, multicentre, prospective, observational study, centres recruited consecutive patients undergoing vascular procedures over a 12-week period. The study opened in March 2020 and closed to recruitment in August 2020. Patient demographics, procedure details, and post-operative outcomes were collected on a secure online database. The reported outcomes at 30 days and six months were post-operative complications, re-interventions, and all cause in-hospital mortality rate. Multivariable logistic regression was used to assess factors associated with six-month mortality rate.

Results

Data were collected on 3 150 vascular procedures, including 1 380 lower limb revascularisations, 609 amputations, 403 aortic, 289 carotid, and 469 other vascular interventions. The median age was 68 years (interquartile range 59, 76), 73.5% were men, and 1.7% had confirmed COVID-19 disease. The cumulative all cause in-hospital, 30-day, and six-month mortality rates were 9.1%, 10.4%, and 12.8%, respectively. The six-month mortality rate was 32.1% (95% CI 24.2–40.8%) in patients with confirmed COVID-19 compared with 12.0% (95% CI 10.8–13.2%) in those without. After adjustment, confirmed COVID-19 was associated with a three times higher odds of six-month death (adjusted OR 3.25, 95% CI 2.18–4.83). Increasing ASA grade (3–5 vs. 1–2), frailty scores 4–9, diabetes mellitus, and urgent and or immediate procedures were also independently associated with increased odds of death by six months, while statin use had a protective effect.

Conclusion

During the first wave of the pandemic, the six-month mortality rate after vascular and endovascular procedures was higher compared with historic pre-pandemic studies and associated with COVID-19 disease.
目的COVID-19大流行的第一波期间,外科手术活动减少,资源仅重新分配给晚期或危重病人。这项血管和血管内研究网络COVID-19血管服务(COVER)研究旨在描述在此期间接受开放手术和血管内介入治疗的主要血管疾病患者的6个月预后。研究于 2020 年 3 月开始,2020 年 8 月结束招募。患者的人口统计学资料、手术细节和术后结果都收集在一个安全的在线数据库中。报告的 30 天和 6 个月的结果包括术后并发症、再次介入治疗和所有原因的院内死亡率。结果 收集到了 3 150 例血管手术的数据,包括 1 380 例下肢血管再通手术、609 例截肢手术、403 例主动脉手术、289 例颈动脉手术和 469 例其他血管介入手术。中位年龄为68岁(四分位数范围为59-76岁),73.5%为男性,1.7%确诊患有COVID-19疾病。所有病因的累计住院死亡率、30天死亡率和6个月死亡率分别为9.1%、10.4%和12.8%。确诊COVID-19患者的6个月死亡率为32.1%(95% CI 24.2-40.8%),而未确诊COVID-19患者的6个月死亡率为12.0%(95% CI 10.8-13.2%)。经调整后,确诊的 COVID-19 与六个月内死亡几率增加三倍有关(调整后 OR 3.25,95% CI 2.18-4.83)。ASA等级的提高(3-5级与1-2级)、虚弱评分4-9分、糖尿病以及紧急或立即手术也与6个月内死亡几率的增加独立相关,而他汀类药物的使用则具有保护作用。
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引用次数: 0
Integrating Intravascular Lithotripsy to Overcome Severe Aorto-Iliac Atherosclerosis in Standard Endovascular Aortic Repair: A Case Report 在标准血管内主动脉修复术中结合血管内碎石术克服严重的主动脉-髂动脉粥样硬化:病例报告
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.09.005
Giuseppe Mastropaolo, Andrea Cumino, Fabiana Zandrino, Sara Pomatto, Vittorio Pasta, Ilaria Ambrogio, Alberto Pecchio

Introduction

Endovascular aneurysm repair (EVAR) is a safe and widespread treatment option for abdominal aortic aneurysm (AAA). Unfavourable anatomy, such as hostile neck and aorto-iliac atherosclerosis, can lead to many complications and compromise the long term reliability of the endograft, resulting in a high rate of EVAR failure. Intravascular lithotripsy (IVL) has emerged as an alternative treatment to address severe iliofemoral atherosclerosis, aiding trackability of devices in EVAR. However, the use of IVL to address severe calcification in hostile necks has not yet been described.

Report

A 74 year old man with multiple comorbidities was referred for definitive treatment of an asymptomatic infrarenal AAA with severe aorto-iliac atherosclerosis. Kissing lithotripsy was firstly performed to treat the calcified stenosis of the aortic bifurcation and iliac axes. To prevent infolding and type Ia endoleak (ELIa), IVL was also performed through simultaneous inflation of two IVL balloon catheters and a compliant aortic balloon on a conical shape neck with an eccentric calcified plaque. The procedure was completed with standard EVAR. The three month follow up computed tomography angiography confirmed a successful outcome with shrinkage of the excluded aneurysmal sac, patent iliac axes, and complete disruption of the severe eccentric calcification of the aortic neck with no signs of infolding or endoleak.

Discussion

This case report highlights the potential of IVL to improve the proximal sealing zone, prevent infolding and ELIa, enhance trackability of devices, reduce major complications, and extend the application of standard EVAR in patients with challenging anatomy. However, further studies and long term follow up are needed to define the efficacy and safety of integrating IVL in standard EVAR.
导言血管内动脉瘤修补术(EVAR)是治疗腹主动脉瘤(AAA)的一种安全而广泛的方法。不利的解剖结构,如敌对的颈部和主动脉-髂动脉粥样硬化,可导致许多并发症,并损害血管内移植物的长期可靠性,导致 EVAR 失败率很高。血管内碎石术(IVL)已成为解决严重髂股动脉粥样硬化的替代治疗方法,有助于EVAR中设备的可追踪性。报告称,一名 74 岁的男性患者患有多种并发症,因无症状的肾下 AAA 和严重的主动脉-髂动脉粥样硬化而转诊接受最终治疗。首先进行了吻合碎石术,治疗主动脉分叉和髂轴的钙化狭窄。为了防止内折和Ia型内漏(ELIa),还通过在有偏心钙化斑块的锥形颈部同时充气两个IVL球囊导管和一个顺应性主动脉球囊来进行IVL。手术以标准的 EVAR 完成。随访三个月的计算机断层扫描血管造影证实了手术的成功,排除的动脉瘤囊缩小,髂轴通畅,主动脉颈部严重偏心钙化完全被破坏,没有任何折叠或内漏的迹象。 讨论该病例报告强调了 IVL 在改善近端密封区、防止折叠和 ELIa、提高设备的可追踪性、减少主要并发症以及扩大标准 EVAR 在具有挑战性解剖的患者中的应用范围方面的潜力。不过,还需要进一步研究和长期随访,以确定将 IVL 纳入标准 EVAR 的有效性和安全性。
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引用次数: 0
Antegrade In Situ Fenestration During Thoracic Endovascular Aortic Repair for Preserving Isolated Left Vertebral Artery 胸腔内血管主动脉修复术中的逆行原位穿孔术,以保留孤立的左侧椎动脉
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.10.001
Xu-xian Qiu , Qing-long Zeng , Pei-er Shen , Dong-lin Li

Introduction

An isolated left vertebral artery (ILVA) on the aortic arch with aortic arch pathologies is common, but how to preserve the ILVA blood flow during endovascular repair remains challenging. Several strategies have been reported but there is still no consensus on the best treatment. This case report presents a novel totally endovascular technique for ILVA revascularisation using antegrade in situ needle assisted fenestration without neck surgical procedures.

Report

A 72 year old man with an ILVA and an incomplete circle of Willis underwent endovascular repair of an aortic arch dissection aneurysm. A 30–26 x 160 mm polytetrafluoroethylene aortic stent graft (Ankura; Lifetech, Shenzhen, China) was deployed proximally in zone 2 of the aortic arch covering the primary tear together with the ILVA and left subclavian artery (LSA). A 6F steerable sheath was placed in the LSA through brachial access, and another 6F long sheath with an adjustable puncture needle was introduced through the right femoral access and placed against the ILVA ostium with the guidance of LSA angiography. Antegrade ILVA fenestration was successfully performed using a needle, and a 0.018 inch guidewire was introduced through the puncture hole, followed by balloon dilation and implantation of a 4.5 × 12 mm balloon expandable bare stent (Dynamic; Biotronik, Bulach, Switzerland). The LSA was reconstructed using a retrograde in situ needle fenestration technique through the steerable sheath from left brachial access, and a 9 × 50 mm Viabahn stent graft was deployed. Post-operatively, the patient recovered uneventfully without neurological deficit. One year follow up imaging confirmed patent ILVA and LSA, and favourable aortic remodelling without any leakage.

Conclusion

This case suggests that the totally endovascular technique of antegrade in situ fenestration is feasible and effective for preserving an ILVA.
导言:主动脉弓上孤立的左椎动脉(ILVA)伴有主动脉弓病变很常见,但如何在血管内修复过程中保留ILVA的血流仍具有挑战性。已有多种策略被报道,但对于最佳治疗方法仍未达成共识。本病例报告介绍了一种新颖的完全血管内技术,即使用前向原位针辅助栅栏术进行 ILVA 血管再通,而无需颈部外科手术。报告一名患有 ILVA 和不完全威利斯圈的 72 岁男性接受了主动脉弓夹层动脉瘤的血管内修复术。在主动脉弓 2 区近端植入 30-26 x 160 毫米的聚四氟乙烯主动脉支架移植物(Ankura;中国深圳 Lifetech 公司),覆盖原发性撕裂以及 ILVA 和左锁骨下动脉 (LSA)。在 LSA 血管造影的引导下,通过肱动脉入路在 LSA 中置入一根 6F 可转向鞘,并通过右股动脉入路导入另一根带可调节穿刺针的 6F 长鞘,将其置于 ILVA 骨膜上。使用穿刺针成功进行了ILVA前向穿刺,并通过穿刺孔引入了一根0.018英寸的导丝,随后进行了球囊扩张并植入了4.5 × 12 mm的球囊扩张裸支架(Dynamic;Biotronik,瑞士布拉赫)。使用逆行原位针穿刺技术从左肱入路通过可转向鞘重建 LSA,并植入 9 × 50 毫米的 Viabahn 支架移植物。术后,患者恢复顺利,无神经功能障碍。一年的随访成像证实,ILVA 和 LSA 通畅,主动脉重塑良好,无任何渗漏。
{"title":"Antegrade In Situ Fenestration During Thoracic Endovascular Aortic Repair for Preserving Isolated Left Vertebral Artery","authors":"Xu-xian Qiu ,&nbsp;Qing-long Zeng ,&nbsp;Pei-er Shen ,&nbsp;Dong-lin Li","doi":"10.1016/j.ejvsvf.2024.10.001","DOIUrl":"10.1016/j.ejvsvf.2024.10.001","url":null,"abstract":"<div><h3>Introduction</h3><div>An isolated left vertebral artery (ILVA) on the aortic arch with aortic arch pathologies is common, but how to preserve the ILVA blood flow during endovascular repair remains challenging. Several strategies have been reported but there is still no consensus on the best treatment. This case report presents a novel totally endovascular technique for ILVA revascularisation using antegrade <em>in situ</em> needle assisted fenestration without neck surgical procedures.</div></div><div><h3>Report</h3><div>A 72 year old man with an ILVA and an incomplete circle of Willis underwent endovascular repair of an aortic arch dissection aneurysm. A 30–26 x 160 mm polytetrafluoroethylene aortic stent graft (Ankura; Lifetech, Shenzhen, China) was deployed proximally in zone 2 of the aortic arch covering the primary tear together with the ILVA and left subclavian artery (LSA). A 6F steerable sheath was placed in the LSA through brachial access, and another 6F long sheath with an adjustable puncture needle was introduced through the right femoral access and placed against the ILVA ostium with the guidance of LSA angiography. Antegrade ILVA fenestration was successfully performed using a needle, and a 0.018 inch guidewire was introduced through the puncture hole, followed by balloon dilation and implantation of a 4.5 × 12 mm balloon expandable bare stent (Dynamic; Biotronik, Bulach, Switzerland). The LSA was reconstructed using a retrograde <em>in situ</em> needle fenestration technique through the steerable sheath from left brachial access, and a 9 × 50 mm Viabahn stent graft was deployed. Post-operatively, the patient recovered uneventfully without neurological deficit. One year follow up imaging confirmed patent ILVA and LSA, and favourable aortic remodelling without any leakage.</div></div><div><h3>Conclusion</h3><div>This case suggests that the totally endovascular technique of antegrade <em>in situ</em> fenestration is feasible and effective for preserving an ILVA.</div></div>","PeriodicalId":36502,"journal":{"name":"EJVES Vascular Forum","volume":"62 ","pages":"Pages 93-96"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Low Cost Emergency Laparotomy Task Trainer for Major Abdominal Bleeding: An Option for Surgical Residents to Learn Lifesaving Basic Surgical Skills 针对腹部大出血的低成本紧急腹腔手术任务训练器:外科住院医师学习救生基本外科技能的一种选择
IF 0.6 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.04.002
Tiia Kukkonen , Eerika Rosqvist , Marika Ylönen , Annika Mäkeläinen , Juha Paloneva , Teuvo Antikainen

Objective

To instantly stop life threatening abdominal bleeding (e.g., a ruptured abdominal aneurysm), every surgeon should be familiar with the principles of emergency laparotomy (EL) and aortic clamping. Simulation training in a safe environment can be used to rehearse these situations like other medical emergencies. Owing to the lack of a suitable commercial simulator, a homemade task trainer was constructed. This study aimed to evaluate the feasibility of an EL simulation training course among surgical residents using this low cost task trainer.

Methods

To enable simulation training for massive abdominal bleeding with subsequent EL and aortic clamping, a multiprofessional team developed an EL task trainer. A structured evaluation of the trainer and its applicability was performed by external consultants, who tested the trainer themselves. Instructions for constructing the trainer were created and costs were calculated. During the EL simulation course targeted for surgical trainees early in their careers, 34 participants familiarised themselves with EL. Their experiences of the feasibility of the course and increase in self assessed clinical competence in managing the situation were studied using a questionnaire. In a subgroup of trainees, the simulation was compared with a real life EL subsequent to the course.

Results

Participants found that the trainer was fit for its purpose (mean score, 4.7 out of 5). Their self assessed clinical competence increased in several domains: EL as a procedure (p < 0.01), handling of intra-abdominal tissues and organs during EL (p = 0.008), and emergency procedures in intra-abdominal haemorrhage (p < 0.001). The cost for the body of the trainer was €108 and there was an additional €42 for the disposables for one training scenario.

Conclusion

A low cost task trainer with pulsatile flow enabling surgical residents to rehearse EL with aortic clamping can be constructed from commonly available materials. Preliminary experience of its feasibility and effects on learning in a simulation training course have been positive.

目的为了立即止住危及生命的腹腔出血(如腹部动脉瘤破裂),每位外科医生都应熟悉紧急开腹手术(EL)和主动脉夹闭的原理。可以在安全的环境中进行模拟训练,像演练其他医疗紧急情况一样演练这些情况。由于缺乏合适的商业模拟器,我们自制了一个任务训练器。本研究旨在评估使用这种低成本任务训练器在外科住院医师中开展 EL 模拟培训课程的可行性。方法为了能够对大量腹腔出血及随后的 EL 和主动脉夹闭进行模拟培训,一个多专业团队开发了 EL 任务训练器。外部顾问对训练器及其适用性进行了结构化评估,并亲自对训练器进行了测试。此外,还制作了培训器械的构造说明,并计算了成本。在针对初入职场的外科学员开设的 EL 模拟课程中,34 名学员熟悉了 EL。通过问卷调查,研究了他们对课程可行性的体验以及自我评估的临床处理能力的提高情况。结果学员们认为培训师符合其目的(平均分 4.7 分,满分 5 分)。他们自我评估的临床能力在多个领域都有所提高:EL作为一种程序(p < 0.01)、EL过程中腹腔内组织和器官的处理(p = 0.008)以及腹腔内出血的急救程序(p < 0.001)。训练器主体的成本为 108 欧元,一个训练场景的一次性耗材成本为 42 欧元。其在模拟培训课程中的可行性和学习效果的初步经验是积极的。
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引用次数: 0
Thoracic Aneurysm Rupture Due to Thoracic Endovascular Aneurysm Repair Stent Graft Disintegration 胸腔血管内动脉瘤修复支架移植物解体导致胸腔动脉瘤破裂
IF 0.6 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.04.001
Jeffrey M.A. van der Krogt, Johanna H. Nederhoed
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引用次数: 0
Merging Geometrical, Biomechanical, and Clinical Data To Assess the Rupture Risk of Abdominal Aortic Aneurysms 综合几何、生物力学和临床数据评估腹主动脉瘤破裂风险
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.07.034
M. Alloisio , A. Siika , J. Roy , S. Zerwes , A. Hyhlik-duerr , T.C. Gasser ∗
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引用次数: 0
Xenopericardial Self Made Tube Grafts in Infectious Vascular Reconstructions: Technical Details 感染性血管重建中的心外膜自制管移植物:技术细节
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.07.024
A. Verrengia ∗ , A. Mellonia , P. Baggi , M. Cambiaghi , A. Grandi , P. Dioni , S. Bonardelli , L. Bertoglio
{"title":"Xenopericardial Self Made Tube Grafts in Infectious Vascular Reconstructions: Technical Details","authors":"A. Verrengia ∗ ,&nbsp;A. Mellonia ,&nbsp;P. Baggi ,&nbsp;M. Cambiaghi ,&nbsp;A. Grandi ,&nbsp;P. Dioni ,&nbsp;S. Bonardelli ,&nbsp;L. Bertoglio","doi":"10.1016/j.ejvsvf.2024.07.024","DOIUrl":"10.1016/j.ejvsvf.2024.07.024","url":null,"abstract":"","PeriodicalId":36502,"journal":{"name":"EJVES Vascular Forum","volume":"62 ","pages":"Page S16"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Artery Blood Flow and Surface Parenchymal Perfusion During Renal Artery Endoshunting in a Porcine Model 猪模型肾动脉内窥过程中的肾动脉血流和表面实质灌注
IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-01-01 DOI: 10.1016/j.ejvsvf.2024.10.003
Johan Millinger , Marcus Langenskiöld , Andreas Nygren , Klas Österberg , Joakim Nordanstig

Objective

Ischaemia and reperfusion can result in permanent tissue damage. During complex open abdominal aortic surgery, transient clamping of the renovisceral arteries may be required to successfully complete the vascular repair. Endovascular shunting (endoshunting) presents an alternative technique for managing such temporary renovisceral ischaemia. This study aimed to investigate the performance of endoshunting to the renal circulation in a porcine model.

Methods

This study of five domestic pigs investigated arterial volume flow rates during endoshunting of a single renal artery and the associated impact on renal perfusion parameters (laser Doppler renal parenchymal perfusion, renal oxygen extraction, and selective urinary output). The study was performed in three steps: baseline registrations (30 minutes), endoshunting (120 minutes), and restoration (60 minutes). The right kidney was used as the experimental side and the left kidney as control.

Results

The median arterial flow rate in the left control kidney remained constant throughout the experiment. On the right (endoshunted) side, the baseline median arterial flow rate was 267 (range, 160–404) mL/min. Following activation of the endoshunt, the median arterial volume flow dropped by 59%–110 (range, 45–150) mL/min (p = .018). During endoshunting, the median kidney surface perfusion decreased to 42% of the baseline value. On the control side, a rise in the median parenchymal perfusion was observed after endoshunt activation, which was again normalised following restoration of native right renal artery flow. During endoshunting, the median regional urine production was 0.32 (range, 0.12–0.50) mL/hour but resumed after renal artery flow restoration.

Conclusion

On average, the endoshunted kidneys showed a rapid restoration of blood flow, parenchymal perfusion, and urine production after 120 minutes of endoshunting. This suggests that endoshunting to the kidney using an endoshunt system might be a promising strategy to preserve renal function when temporary interruption of native renal artery blood flow is needed during complex vascular surgical repairs involving the renal arteries.
目的缺血和再灌注可导致永久性组织损伤。在复杂的开放式腹主动脉手术中,可能需要短暂夹闭内脏动脉才能成功完成血管修复。血管内分流术(endoshunting)是处理这种暂时性胰内动脉缺血的另一种技术。本研究旨在调查在猪模型中对肾循环进行血管内分流的性能。这项对五头家猪进行的研究调查了单个肾动脉血管内分流时的动脉容积流速以及对肾灌注参数(激光多普勒肾实质灌注、肾氧萃取和选择性尿量)的相关影响。研究分三步进行:基线注册(30 分钟)、肾内分流(120 分钟)和恢复(60 分钟)。右肾作为实验侧,左肾作为对照组。结果左肾对照组的中位动脉流速在整个实验过程中保持不变。右侧(内分流)的基线中位动脉流速为 267(160-404)毫升/分钟。启动内分流后,中位动脉体积流量下降了 59%-110(范围:45-150)毫升/分钟(p = .018)。内分流期间,中位肾表面灌注量下降至基线值的 42%。在对照组一侧,内分流激活后观察到中位肾实质灌注量上升,恢复原生右肾动脉血流后,中位肾实质灌注量再次恢复正常。结论:平均而言,内分流肾脏在内侧分流 120 分钟后,血流、实质灌注和尿量均迅速恢复。这表明,在涉及肾动脉的复杂血管手术修复过程中,如果需要暂时中断原生肾动脉血流,使用内分流系统对肾脏进行内分流可能是一种很有前途的保护肾功能的策略。
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引用次数: 0
期刊
EJVES Vascular Forum
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