Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202032
Tatiana I. Gorbacheva, Maria G. Nikolaeva, Alexander E. Stroganov, Olga V. Orlova, Larisa A. Khoreva, Yulia M. Uvarova, Ekaterina A. Denisyuk, Yury S. Оловянников
Aim. To assess the impact of new coronavirus infection (NCI) and COVID-19 vaccination on menstrual function in comparison with the frequency of depressive disorders during the COVID-19 pandemic among female students of a medical university.
Materials and methods. Data for a continuous transverse (cross-sectional) study were obtained using an online survey. The questions included demographics, characteristics of menstrual function, the history of COVID-19 and vaccinations against it, and the standard CES-D (Center for Epidemiologic Studies Depression Scale) questionnaire. The survey included 1.879 female medical students. The exclusion criteria were age under 18 and over 25 years, hormonal contraceptives, pregnancy, childbirth during the last year, and vaccination after COVID-19. After applying the exclusion criteria, three study groups were formed. Group 1 included female students with a history of NCI (n=140), group 2 included students with no history of NCI, who were initially vaccinated against COVID-19 (n=647), group 3 (control group) included unvaccinated students with no history of NCI (n=55).
Results. There were no differences in the prevalence of changes in menstrual function in female students after the NCI (49.3%) and after COVID-19 vaccination (39.6%) compared to the control group (43.6%); p=0.477. The rate of depression in the overall study cohort was 43.3%, without any significant differences between the study groups. Significant predictors of changes in menstrual function during the pandemic were marriage (odds ratio OR 2.33 [1.513.61]), depression (OR 1.72 [1.282.3]), a history of menstrual dysfunction (OR 1.5 [0.121.99]), and later menarche (OR 1.76 [1.023.04]). Multivariate analysis did not show the significance of the history of NCI and vaccination as factors of menstrual dysfunction (OR 1.61 [0.892.90] and OR 0.91 [0.591.41], respectively).
Conclusion. During the COVID-19 pandemic, female medical students reported frequent changes in menstrual function and depressive disorders. During the pandemic, the most significant predictors of menstrual disorders in female students were depression, a history of menstrual dysfunction, and marriage. A multicenter prospective study is necessary to clarify the mechanisms of the pandemic's impact on menstrual function.
{"title":"Menstrual function and mental health of medical students during the COVID-19 pandemic: a continuous cross-sectional study","authors":"Tatiana I. Gorbacheva, Maria G. Nikolaeva, Alexander E. Stroganov, Olga V. Orlova, Larisa A. Khoreva, Yulia M. Uvarova, Ekaterina A. Denisyuk, Yury S. Оловянников","doi":"10.26442/20795696.2023.3.202032","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202032","url":null,"abstract":"Aim. To assess the impact of new coronavirus infection (NCI) and COVID-19 vaccination on menstrual function in comparison with the frequency of depressive disorders during the COVID-19 pandemic among female students of a medical university.
 Materials and methods. Data for a continuous transverse (cross-sectional) study were obtained using an online survey. The questions included demographics, characteristics of menstrual function, the history of COVID-19 and vaccinations against it, and the standard CES-D (Center for Epidemiologic Studies Depression Scale) questionnaire. The survey included 1.879 female medical students. The exclusion criteria were age under 18 and over 25 years, hormonal contraceptives, pregnancy, childbirth during the last year, and vaccination after COVID-19. After applying the exclusion criteria, three study groups were formed. Group 1 included female students with a history of NCI (n=140), group 2 included students with no history of NCI, who were initially vaccinated against COVID-19 (n=647), group 3 (control group) included unvaccinated students with no history of NCI (n=55).
 Results. There were no differences in the prevalence of changes in menstrual function in female students after the NCI (49.3%) and after COVID-19 vaccination (39.6%) compared to the control group (43.6%); p=0.477. The rate of depression in the overall study cohort was 43.3%, without any significant differences between the study groups. Significant predictors of changes in menstrual function during the pandemic were marriage (odds ratio OR 2.33 [1.513.61]), depression (OR 1.72 [1.282.3]), a history of menstrual dysfunction (OR 1.5 [0.121.99]), and later menarche (OR 1.76 [1.023.04]). Multivariate analysis did not show the significance of the history of NCI and vaccination as factors of menstrual dysfunction (OR 1.61 [0.892.90] and OR 0.91 [0.591.41], respectively).
 Conclusion. During the COVID-19 pandemic, female medical students reported frequent changes in menstrual function and depressive disorders. During the pandemic, the most significant predictors of menstrual disorders in female students were depression, a history of menstrual dysfunction, and marriage. A multicenter prospective study is necessary to clarify the mechanisms of the pandemic's impact on menstrual function.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135644105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202341
Olga Ya. Leschenko
Mastodynia is a common clinical symptom in general medical and gynecological practice. The objectives of this literature review are to analyze scientific information on the epidemiology of mastodynia/mastalgia, the impact on quality of life, inconsistencies in the etiology determination, to formulate a diagnostic concept, classification, and treatment, and to assess the therapeutic effects of Vitex Agnus-Castus. Scientific publications over the past 30 years were searched in the main research databases, CochraneLibrary, PubMed, Science Direct, Google Scholar, and ELibrary, using the terms "mastalgia," "mastodynia," "Vitex Agnus-Castus," "chest pain," "chest pain, breast pain." The pathophysiology of mastodynia is multifaceted, with various etiology factors and independent ways of pain occurrence. Most studies have emphasized the importance of correctly classifying breast pain for accurate diagnosis and effective therapy to reduce the frequency and severity of pain episodes and improve quality of life while minimizing side effects. Vitex Agnus-Castus is safe and effective in the treatment of mastodynia.
乳突痛是普通医学和妇科实践中常见的临床症状。本文献综述的目的是分析有关乳突痛/乳痛的流行病学、对生活质量的影响、病因确定的不一致，制定诊断概念、分类和治疗方法，并评估牡荆的治疗效果。在主要的研究数据库，CochraneLibrary, PubMed, Science Direct, Google Scholar和ELibrary中检索了过去30年的科学出版物，使用术语“mastalgia”，“mastodynia”，“Vitex Agnus-Castus”，“胸痛”，“胸痛，乳房痛”。乳突痛的病理生理是多方面的，有多种病因和独立的疼痛发生方式。大多数研究都强调正确分类乳房疼痛对于准确诊断和有效治疗的重要性，以减少疼痛发作的频率和严重程度，提高生活质量，同时最大限度地减少副作用。白荆治疗乳突痛安全有效。
{"title":"Mastodynia: Current data on the causes, course, diagnosis, and treatment approaches. A review","authors":"Olga Ya. Leschenko","doi":"10.26442/20795696.2023.3.202341","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202341","url":null,"abstract":"Mastodynia is a common clinical symptom in general medical and gynecological practice. The objectives of this literature review are to analyze scientific information on the epidemiology of mastodynia/mastalgia, the impact on quality of life, inconsistencies in the etiology determination, to formulate a diagnostic concept, classification, and treatment, and to assess the therapeutic effects of Vitex Agnus-Castus. Scientific publications over the past 30 years were searched in the main research databases, CochraneLibrary, PubMed, Science Direct, Google Scholar, and ELibrary, using the terms \"mastalgia,\" \"mastodynia,\" \"Vitex Agnus-Castus,\" \"chest pain,\" \"chest pain, breast pain.\" The pathophysiology of mastodynia is multifaceted, with various etiology factors and independent ways of pain occurrence. Most studies have emphasized the importance of correctly classifying breast pain for accurate diagnosis and effective therapy to reduce the frequency and severity of pain episodes and improve quality of life while minimizing side effects. Vitex Agnus-Castus is safe and effective in the treatment of mastodynia.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135644373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202360
Mekan R. Orazov, Viktor E. Radzinskiy, Evgeny D. Dolgov
Breast diseases (BD) are among the most urgent issues of modern reproductive medicine. This organ is an integral part of the female reproductive system and undergoes cyclic changes during the menstrual cycle. The modern "nosological trio" of BD is mastodynia, benign dysplasia, and breast cancer. These diseases have an extremely high prevalence, and breast cancer, in turn, ranks 1st in the structure of mortality from malignant neoplasms of the female reproductive system. All these aspects warrant the research of the key pathogenetic mechanisms of these conditions. However, one of the most relevant topics in modern gynecology is the counseling on the selection of contraceptive methods in these patients. Therefore, it is necessary to address the safety of hormonal contraceptive methods and to analyze innovations in hormonal contraceptives, which may have several protective and risk-reducing properties for BD.
{"title":"Prospects for hormonal contraception in patients with breast diseases: the Mona Lisa smile effect. A review","authors":"Mekan R. Orazov, Viktor E. Radzinskiy, Evgeny D. Dolgov","doi":"10.26442/20795696.2023.3.202360","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202360","url":null,"abstract":"Breast diseases (BD) are among the most urgent issues of modern reproductive medicine. This organ is an integral part of the female reproductive system and undergoes cyclic changes during the menstrual cycle. The modern \"nosological trio\" of BD is mastodynia, benign dysplasia, and breast cancer. These diseases have an extremely high prevalence, and breast cancer, in turn, ranks 1st in the structure of mortality from malignant neoplasms of the female reproductive system. All these aspects warrant the research of the key pathogenetic mechanisms of these conditions. However, one of the most relevant topics in modern gynecology is the counseling on the selection of contraceptive methods in these patients. Therefore, it is necessary to address the safety of hormonal contraceptive methods and to analyze innovations in hormonal contraceptives, which may have several protective and risk-reducing properties for BD.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135552984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202332
Natalya A. Chekeneva, Natalya A. Buralkina, Aleksandra V. Asaturova, Vladimir D. Chuprynin
Aim. To analyze the profile of anti-Mllerian hormone (AMH) and the expression level of the transmembrane AMH receptor type II (AMHRII) in the eutopic and ectopic endometrium of patients with deep infiltrative endometriosis (DIE).
Materials and methods. A comparative analysis of AMHRII expression in epithelial and stromal cells of eutopic and ectopic endometrial samples and the level of serum AMH in patients of reproductive age with DIE (n=50) and tuboperitoneal infertility (n=9) was performed.
Results. AMHRII expression in eutopic endometrial stromal cells of DIE patients was significantly higher compared to glandular cells in all study groups (p0.5). AMHRII expression was found to be significantly higher in glandular cells of the eutopic endometrium compared to the ectopic endometrium of pelvic peritoneal foci in DIE patients: 1.600.77 and 1.090.68 points, respectively (p=0.001).
Conclusion. The inhibitory effect of AMH on cell proliferation and the proven expression of AMHRII by eutopic and ectopic endometrioid cells may indicate the role of AMH in the pathogenesis of endometriosis and endometriosis-associated infertility.
{"title":"The role of the anti-Müllerian hormone/anti-Müllerian hormone receptor type II signaling pathway in the eutopic and ectopic endometrium in patients with deep endometriosis: A cross-sectional study","authors":"Natalya A. Chekeneva, Natalya A. Buralkina, Aleksandra V. Asaturova, Vladimir D. Chuprynin","doi":"10.26442/20795696.2023.3.202332","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202332","url":null,"abstract":"Aim. To analyze the profile of anti-Mllerian hormone (AMH) and the expression level of the transmembrane AMH receptor type II (AMHRII) in the eutopic and ectopic endometrium of patients with deep infiltrative endometriosis (DIE).
 Materials and methods. A comparative analysis of AMHRII expression in epithelial and stromal cells of eutopic and ectopic endometrial samples and the level of serum AMH in patients of reproductive age with DIE (n=50) and tuboperitoneal infertility (n=9) was performed.
 Results. AMHRII expression in eutopic endometrial stromal cells of DIE patients was significantly higher compared to glandular cells in all study groups (p0.5). AMHRII expression was found to be significantly higher in glandular cells of the eutopic endometrium compared to the ectopic endometrium of pelvic peritoneal foci in DIE patients: 1.600.77 and 1.090.68 points, respectively (p=0.001).
 Conclusion. The inhibitory effect of AMH on cell proliferation and the proven expression of AMHRII by eutopic and ectopic endometrioid cells may indicate the role of AMH in the pathogenesis of endometriosis and endometriosis-associated infertility.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202290
Mekan R. Orazov, Viktor E. Radzinski, Evgeny D. Dolgov
Currently, endometriosis is one of the most common and relevant gynecological conditions. It is characterized by a wide range of symptoms, with highly heterogeneous pain being one of the most typical. The unifying concept of the algological patterns of endometriosis is chronic pelvic pain, which contributes to a pronounced decrease in patients' quality of life. Therefore, it is necessary to analyze the key pathogenetic mechanisms of pelvic pain associated with endometriosis and to determine a personalized therapeutic approach based on them.
{"title":"Chronic pelvic pain in endometriosis: from therapeutic Abstraction to clinical definition: A review","authors":"Mekan R. Orazov, Viktor E. Radzinski, Evgeny D. Dolgov","doi":"10.26442/20795696.2023.3.202290","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202290","url":null,"abstract":"Currently, endometriosis is one of the most common and relevant gynecological conditions. It is characterized by a wide range of symptoms, with highly heterogeneous pain being one of the most typical. The unifying concept of the algological patterns of endometriosis is chronic pelvic pain, which contributes to a pronounced decrease in patients' quality of life. Therefore, it is necessary to analyze the key pathogenetic mechanisms of pelvic pain associated with endometriosis and to determine a personalized therapeutic approach based on them.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202339
Niso M. Nazarova, Vera N. Prilepskaya, Anna N. Mgeryan, Elmira R. Dovletkhanova, Patimat R. Abakarova, Elena A. Mezhevitinova
The data on managing patients with vulvovaginal atrophy and abnormal cytological results are provided for obstetrician-gynecologists.
处理外阴阴道萎缩和异常细胞学结果的患者的数据提供给妇产科医生。
{"title":"Management of patients with vulvovaginal atrophy and cytological abnormalities","authors":"Niso M. Nazarova, Vera N. Prilepskaya, Anna N. Mgeryan, Elmira R. Dovletkhanova, Patimat R. Abakarova, Elena A. Mezhevitinova","doi":"10.26442/20795696.2023.3.202339","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202339","url":null,"abstract":"The data on managing patients with vulvovaginal atrophy and abnormal cytological results are provided for obstetrician-gynecologists.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135644371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202333
Tatiana E. Belokrinitskaya, Nataly I. Frolova, Viktor A. Mudrov, Kristina A. Kargina, Evgeniya A. Shametova, Chimita Tch. Zhamyanova, Shakhnozakhon R. Osmonova
Aim. To assess the incidence and severity of new persistent symptoms in somatically healthy young women with and without a history of COVID-19.
Materials and methods. The main study group included patients who had PCR-confirmed COVID-19 in JulyOctober 2021 (n=181); the comparison group included women without COVID-19 during this period (n=71). Inclusion criteria: female sex, age 1835 years, no pregnancy, overweight/obesity, diabetes mellitus, chronic hypertension, premenstrual syndrome, and other somatic and/or chronic infectious diseases. Post-COVID syndrome (PCS) was diagnosed based on symptoms absent before COVID-19, appeared 4 weeks from the disease onset, and lasted at least 2 months, which could not be explained by alternative diagnoses. We used primary medical records and interviewed patients using a special questionnaire to develop a statistical database. The severity of symptoms was assessed using a 10-point scale.
Results. New persistent symptoms during the pandemic in young, initially somatically healthy women with and without COVID-19 were reported with similar frequency: 96.1 and 93.0%, respectively (odds ratio OR 1.88, 95% confidence interval CI 0.586.14; p2=0.327). Only patients with COVID-19 reported cough (43.6%), shortness of breath (26.5%), chest pain (18.2%), weight loss (18.8%), hair loss (60.8%); in the comparison group, these symptoms were not reported; p20.001. Patients with PCS were more likely to experience memory impairment 49.2% vs 12.7% (OR 6.66, 95% CI 3.1314.21; p20.001); headache 43.1% vs 11.3% (OR 5.96, 95% CI 2.713.17; p20.001); depression 19.9% vs 8.5% (OR 2.69, 95% CI 1.086.7; p2=0.029); myalgia 31.5% vs 8.5% (OR 4.98, 95% CI 2.0412.17; p20.001). Patients of both groups showed similar frequency of fatigue (69.0% vs 71.8%; p2=0.66), drowsiness (54.9% vs 43.6%; p2=0.11), palpitations (19.7% vs 29.8%; p2=0.1), menstrual cycle changes (22.5% vs 21.0%; p2=0.865), and skin manifestations (2.8% vs 6.6%; p2=0.24). COVID-19 survivors had a more pronounced memory impairment (4.0 vs 1.0 points; p0.001), headache (5.0 vs 3.0 points; p=0.001), myalgia (5.0 vs 1.0 points; p0.001) and less severe insomnia (3.0 vs 5.0 points; p=0.004).
Conclusion. The PCS symptoms are common in initially somatically healthy women of early reproductive age. Similar symptoms in women with no history of COVID-19 may be due to post-traumatic stress anxiety disorder. Further interdisciplinary research is needed to identify the pathophysiological mechanisms for the occurrence of new persistent symptoms in different age and social groups during the COVID-19 pandemic.
的目标。评估有和无COVID-19病史的身体健康年轻女性新发持续性症状的发生率和严重程度。
材料和方法。主要研究组包括2021年7月- 10月pcr确诊的COVID-19患者(n=181);对照组包括在此期间未感染COVID-19的妇女(n=71)。纳入标准:女性，年龄1835岁，未怀孕，超重/肥胖，糖尿病，慢性高血压，经前综合征，以及其他躯体和/或慢性传染病。后冠状病毒综合征(PCS)是基于发病前未出现的症状，出现于发病后4周，持续时间至少2个月，无法用其他诊断来解释。我们使用原始医疗记录，并使用特殊问卷对患者进行访谈，以建立统计数据库。使用10分制评估症状的严重程度。
结果。在感染和未感染COVID-19的年轻、最初身体健康的女性中，报告的新持续症状的频率相似:分别为96.1%和93.0%(优势比OR 1.88, 95%可信区间CI 0.586.14;p = 0.327)。只有COVID-19患者报告咳嗽(43.6%)、呼吸短促(26.5%)、胸痛(18.2%)、体重减轻(18.8%)、脱发(60.8%);在对照组中，没有报告这些症状;p20.001。PCS患者更容易出现记忆障碍(49.2% vs 12.7%) (OR 6.66, 95% CI 3.1314.21;p20.001);头痛43.1% vs 11.3% (OR 5.96, 95% CI 2.713.17;p20.001);抑郁症19.9% vs 8.5% (OR 2.69, 95% CI 1.086.7;p = 0.029);肌痛31.5% vs 8.5% (OR 4.98, 95% CI 2.0412.17;p20.001)。两组患者出现疲劳的频率相似(69.0% vs 71.8%;P2 =0.66)，嗜睡(54.9% vs 43.6%;P2 =0.11)，心悸(19.7% vs 29.8%;P2 =0.1)，月经周期变化(22.5% vs 21.0%;P2 =0.865)，皮肤表现(2.8% vs 6.6%;p = 0.24)。COVID-19幸存者有更明显的记忆障碍(4.0比1.0分;P0.001)，头痛(5.0分vs 3.0分;P =0.001)，肌痛(5.0 vs 1.0分;P0.001)和较轻的失眠症(3.0 vs 5.0分;p = 0.004)强生# x0D;结论。PCS症状在最初身体健康的早期育龄妇女中很常见。没有COVID-19病史的女性出现类似症状可能是由于创伤后应激性焦虑症。需要进一步开展跨学科研究，以确定新冠肺炎大流行期间不同年龄和社会群体出现新的持续症状的病理生理机制。
{"title":"POST-COVID-19-syndrome in young healthy women: myth or reality?","authors":"Tatiana E. Belokrinitskaya, Nataly I. Frolova, Viktor A. Mudrov, Kristina A. Kargina, Evgeniya A. Shametova, Chimita Tch. Zhamyanova, Shakhnozakhon R. Osmonova","doi":"10.26442/20795696.2023.3.202333","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202333","url":null,"abstract":"Aim. To assess the incidence and severity of new persistent symptoms in somatically healthy young women with and without a history of COVID-19.
 Materials and methods. The main study group included patients who had PCR-confirmed COVID-19 in JulyOctober 2021 (n=181); the comparison group included women without COVID-19 during this period (n=71). Inclusion criteria: female sex, age 1835 years, no pregnancy, overweight/obesity, diabetes mellitus, chronic hypertension, premenstrual syndrome, and other somatic and/or chronic infectious diseases. Post-COVID syndrome (PCS) was diagnosed based on symptoms absent before COVID-19, appeared 4 weeks from the disease onset, and lasted at least 2 months, which could not be explained by alternative diagnoses. We used primary medical records and interviewed patients using a special questionnaire to develop a statistical database. The severity of symptoms was assessed using a 10-point scale.
 Results. New persistent symptoms during the pandemic in young, initially somatically healthy women with and without COVID-19 were reported with similar frequency: 96.1 and 93.0%, respectively (odds ratio OR 1.88, 95% confidence interval CI 0.586.14; p2=0.327). Only patients with COVID-19 reported cough (43.6%), shortness of breath (26.5%), chest pain (18.2%), weight loss (18.8%), hair loss (60.8%); in the comparison group, these symptoms were not reported; p20.001. Patients with PCS were more likely to experience memory impairment 49.2% vs 12.7% (OR 6.66, 95% CI 3.1314.21; p20.001); headache 43.1% vs 11.3% (OR 5.96, 95% CI 2.713.17; p20.001); depression 19.9% vs 8.5% (OR 2.69, 95% CI 1.086.7; p2=0.029); myalgia 31.5% vs 8.5% (OR 4.98, 95% CI 2.0412.17; p20.001). Patients of both groups showed similar frequency of fatigue (69.0% vs 71.8%; p2=0.66), drowsiness (54.9% vs 43.6%; p2=0.11), palpitations (19.7% vs 29.8%; p2=0.1), menstrual cycle changes (22.5% vs 21.0%; p2=0.865), and skin manifestations (2.8% vs 6.6%; p2=0.24). COVID-19 survivors had a more pronounced memory impairment (4.0 vs 1.0 points; p0.001), headache (5.0 vs 3.0 points; p=0.001), myalgia (5.0 vs 1.0 points; p0.001) and less severe insomnia (3.0 vs 5.0 points; p=0.004).
 Conclusion. The PCS symptoms are common in initially somatically healthy women of early reproductive age. Similar symptoms in women with no history of COVID-19 may be due to post-traumatic stress anxiety disorder. Further interdisciplinary research is needed to identify the pathophysiological mechanisms for the occurrence of new persistent symptoms in different age and social groups during the COVID-19 pandemic.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"308 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135644377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202288
Dmitry I. Trukhan, Evgeny N. Degovtsov, Elena А. Degovtsova, Vladimir E. Karasev
In obstetric and gynecological practice, after operations on the abdominal cavity, the development of dynamic intestinal obstruction, which is referred to as postoperative ileus, is possible. The frequency of POI after gynecological surgery averages 1015% (range 525%). Chewing gum has been used in abdominal surgery and obstetric and gynecological practice to reduce postoperative intestinal obstruction since the beginning of the 21st century. The present review considers the main randomized clinical trials, reviews and meta-analyses devoted to the study of the effect of chewing gum after surgical interventions in obstetric and gynecological practice for the prevention of postoperative ileus. The data presented in the review indicate the effectiveness and safety of the use of chewing gum in the postoperative period for the prevention of postoperative ileus in obstetric and gynecological practice.
{"title":"Postoperative ileus in obstetric and gynecological practice: a prospective solution to the problem: A review","authors":"Dmitry I. Trukhan, Evgeny N. Degovtsov, Elena А. Degovtsova, Vladimir E. Karasev","doi":"10.26442/20795696.2023.3.202288","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202288","url":null,"abstract":"In obstetric and gynecological practice, after operations on the abdominal cavity, the development of dynamic intestinal obstruction, which is referred to as postoperative ileus, is possible. The frequency of POI after gynecological surgery averages 1015% (range 525%). Chewing gum has been used in abdominal surgery and obstetric and gynecological practice to reduce postoperative intestinal obstruction since the beginning of the 21st century. The present review considers the main randomized clinical trials, reviews and meta-analyses devoted to the study of the effect of chewing gum after surgical interventions in obstetric and gynecological practice for the prevention of postoperative ileus. The data presented in the review indicate the effectiveness and safety of the use of chewing gum in the postoperative period for the prevention of postoperative ileus in obstetric and gynecological practice.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135590421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202296
Anna N. Mheryan, Niso M. Nazarova, Vera N. Prilepskaya
The analytical review presents data from the world literature, which discusses the relevance of vulvar intraepithelial neoplasia associated with human papillomavirus (uVIN). The incidence of uVIN is steadily increasing, especially in young women, and 1011.2% of cases can progress to vulvar carcinoma. More than 50% of uVIN cases are associated with anogenital diseases associated with the human papillomavirus, which determines the need for a comprehensive assessment and proper treatment of uVIN patients.
{"title":"Vulvar intraepithelial neoplasia associated with HPV infection: clinical, diagnostic, therapeutic and prophylactic aspects: A review","authors":"Anna N. Mheryan, Niso M. Nazarova, Vera N. Prilepskaya","doi":"10.26442/20795696.2023.3.202296","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202296","url":null,"abstract":"The analytical review presents data from the world literature, which discusses the relevance of vulvar intraepithelial neoplasia associated with human papillomavirus (uVIN). The incidence of uVIN is steadily increasing, especially in young women, and 1011.2% of cases can progress to vulvar carcinoma. More than 50% of uVIN cases are associated with anogenital diseases associated with the human papillomavirus, which determines the need for a comprehensive assessment and proper treatment of uVIN patients.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135590427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.26442/20795696.2023.3.202323
Yulia E. Dobrokhotova, Irina A. Lapina, Anastasiya A. Malakhova, Tatiana G. Chirvon, Vladislav V. Taranov, Yury А. Sorokin, Maria А. Tverdikova, Valeriia M. Gomzikova, Anastasia A. Zateeva, Olesya V. Kaikova
According to the World Health Organization, the number of patients of reproductive age with cancer steadily increases. Therefore, improving their quality of life is one of the priority tasks of the medical community. It is known that more than 30% of women with cancer at the time of diagnosis have not yet given birth. Therefore, one of the relevant issues is developing and improving methods for preserving reproductive function. In vitro oocyte maturation is a promising technique of oncofertility, which is used as an alternative to traditional cycles of ovulation stimulation followed by the production of mature oocytes. This review aims to study the in vitro maturation procedure and analyze the literature data regarding its effectiveness and safety when used as a part of programs for preserving reproductive material in patients with cancer.
{"title":"In vitro maturation for fertility preservation in patients with cancer: A review","authors":"Yulia E. Dobrokhotova, Irina A. Lapina, Anastasiya A. Malakhova, Tatiana G. Chirvon, Vladislav V. Taranov, Yury А. Sorokin, Maria А. Tverdikova, Valeriia M. Gomzikova, Anastasia A. Zateeva, Olesya V. Kaikova","doi":"10.26442/20795696.2023.3.202323","DOIUrl":"https://doi.org/10.26442/20795696.2023.3.202323","url":null,"abstract":"According to the World Health Organization, the number of patients of reproductive age with cancer steadily increases. Therefore, improving their quality of life is one of the priority tasks of the medical community. It is known that more than 30% of women with cancer at the time of diagnosis have not yet given birth. Therefore, one of the relevant issues is developing and improving methods for preserving reproductive function. In vitro oocyte maturation is a promising technique of oncofertility, which is used as an alternative to traditional cycles of ovulation stimulation followed by the production of mature oocytes. This review aims to study the in vitro maturation procedure and analyze the literature data regarding its effectiveness and safety when used as a part of programs for preserving reproductive material in patients with cancer.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135643950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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