Pub Date : 2023-07-14DOI: 10.26442/20795696.2023.2.201838
N. Tyuvina, Angelina O. Nikolayevskaya, V. Balabanova, Kaleriia N. Ilchenko
Background. Issues of the relationship and interaction of menstrual and reproductive function and the mental state of women are not sufficiently studied and need additional research. Aim. To conduct a comparative assessment of individual indicators of reproductive function in mentally healthy and mentally ill women with infertility. Materials and methods. Of the 348 women with primary and secondary infertility aged 21 to 40 included in the study, 120 had been treated for a psychiatric disorder in a psychiatric hospital before this study. Patients were clinically evaluated using a specially designed questionnaire card and subsequent statistical processing of the results obtained. Results. The menstrual-generative function of patients in the study groups significantly differed in several indicators. Mentally ill women with primary infertility were characterized by a later age of menarche, menstruation irregularity or absence during the disease exacerbation, scanty menstruations or heavy menstrual bleeding, inadequate emotional response to menarche, and irregularity and dissatisfaction with sexual life. Spontaneous miscarriages and stillbirths were more common in mentally ill women, especially those with endogenous diseases (schizophrenia, affective disorders), and abortions and gynecological operations were more common in mentally healthy women. Predictors of infertility related to mental health were early onset and chronic course of mental disorder, severity and duration of the disease exacerbations, short and incomplete remissions, and personality changes or a defect (schizophrenic) due to mental illness. Conclusion. Menstrual and reproductive functions of women depend on their mental state. In women with mental conditions, menstrual function disorders, along with psychopathological symptoms of diseases (a decrease in sexual vigor, communication, anesthesia of feelings), and decreased social and family adaptation, lead to reproductive function disorders. Improving a woman's mental state can contribute to the recovery of her reproductive function.
{"title":"Comparative characteristics of reproductive function in mentally healthy and mentally ill women with infertility","authors":"N. Tyuvina, Angelina O. Nikolayevskaya, V. Balabanova, Kaleriia N. Ilchenko","doi":"10.26442/20795696.2023.2.201838","DOIUrl":"https://doi.org/10.26442/20795696.2023.2.201838","url":null,"abstract":"Background. Issues of the relationship and interaction of menstrual and reproductive function and the mental state of women are not sufficiently studied and need additional research. \u0000Aim. To conduct a comparative assessment of individual indicators of reproductive function in mentally healthy and mentally ill women with infertility. \u0000Materials and methods. Of the 348 women with primary and secondary infertility aged 21 to 40 included in the study, 120 had been treated for a psychiatric disorder in a psychiatric hospital before this study. Patients were clinically evaluated using a specially designed questionnaire card and subsequent statistical processing of the results obtained. \u0000Results. The menstrual-generative function of patients in the study groups significantly differed in several indicators. Mentally ill women with primary infertility were characterized by a later age of menarche, menstruation irregularity or absence during the disease exacerbation, scanty menstruations or heavy menstrual bleeding, inadequate emotional response to menarche, and irregularity and dissatisfaction with sexual life. Spontaneous miscarriages and stillbirths were more common in mentally ill women, especially those with endogenous diseases (schizophrenia, affective disorders), and abortions and gynecological operations were more common in mentally healthy women. Predictors of infertility related to mental health were early onset and chronic course of mental disorder, severity and duration of the disease exacerbations, short and incomplete remissions, and personality changes or a defect (schizophrenic) due to mental illness. \u0000Conclusion. Menstrual and reproductive functions of women depend on their mental state. In women with mental conditions, menstrual function disorders, along with psychopathological symptoms of diseases (a decrease in sexual vigor, communication, anesthesia of feelings), and decreased social and family adaptation, lead to reproductive function disorders. Improving a woman's mental state can contribute to the recovery of her reproductive function.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88502702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-14DOI: 10.26442/20795696.2023.2.202235
S. V. Rybnikov, N. Artymuk
Aim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility. Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the comparison group (group 2) included 58 women with tuboperitoneal infertility due to distal occlusion of the fallopian tubes. In group 1 patients, at the final stage of endoscopic reconstructive plastic surgery on the surface of the fallopian tubes, anti-adhesion barrier Anti-adhesion was applied (5 mL per each operated fallopian tube). Primary outcomes (patency of the fallopian tubes after 3 months) and secondary outcomes (onset of uterine pregnancy during the first year) were assessed. Statistical results were processed using the IBM SPSS Statistics version 25.0 software package. Results. Within 3 months after surgical treatment, the patency of the fallopian tubes was reported in 32 (59.3%) group 1 patients and 24 (41.4%) group 2 patients (2=3.445; p=0.064). The rate of uterine pregnancy in group 1 during the first year after surgical treatment was significantly higher than in group 2: 21 (38.9%) and 12 (20.7%) women, respectively (2=4.447; p=0.035). Conclusion. Endoscopic reconstructive plastic surgeries using hyaluronic acid-based anti-adhesion gel in patients with distal tubal occlusion slightly reduces the frequency of postoperative reocclusions of the fallopian tubes within 3 months after surgical treatment and significantly increase the rate of uterine pregnancy during the year after surgery mainly due to patients with grade IIIIV of adhesive process in the pelvis.
{"title":"Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study","authors":"S. V. Rybnikov, N. Artymuk","doi":"10.26442/20795696.2023.2.202235","DOIUrl":"https://doi.org/10.26442/20795696.2023.2.202235","url":null,"abstract":"Aim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility. \u0000Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the comparison group (group 2) included 58 women with tuboperitoneal infertility due to distal occlusion of the fallopian tubes. In group 1 patients, at the final stage of endoscopic reconstructive plastic surgery on the surface of the fallopian tubes, anti-adhesion barrier Anti-adhesion was applied (5 mL per each operated fallopian tube). Primary outcomes (patency of the fallopian tubes after 3 months) and secondary outcomes (onset of uterine pregnancy during the first year) were assessed. Statistical results were processed using the IBM SPSS Statistics version 25.0 software package. \u0000Results. Within 3 months after surgical treatment, the patency of the fallopian tubes was reported in 32 (59.3%) group 1 patients and 24 (41.4%) group 2 patients (2=3.445; p=0.064). The rate of uterine pregnancy in group 1 during the first year after surgical treatment was significantly higher than in group 2: 21 (38.9%) and 12 (20.7%) women, respectively (2=4.447; p=0.035). \u0000Conclusion. Endoscopic reconstructive plastic surgeries using hyaluronic acid-based anti-adhesion gel in patients with distal tubal occlusion slightly reduces the frequency of postoperative reocclusions of the fallopian tubes within 3 months after surgical treatment and significantly increase the rate of uterine pregnancy during the year after surgery mainly due to patients with grade IIIIV of adhesive process in the pelvis.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86735241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202037
F. R. Kutueva, R. Glushakov, N. Tapilskaya, A. Nikolaeva, Artem A. Poromov, O. Pustotina
Design. A prospective, multicenter, open-label, randomized, comparative clinical study. Objective. To compare the efficacy and safety of Flucovag (sertaconazole) vaginal suppositories, 300 mg (OTCPharm JSC, Russia; manufactured by Altpharm LLC, Russia) and the brand-name drug Zalain (sertaconazole), 300 mg (Egis Pharmaceuticals PLC, Hungary) in the treatment of vulvovaginal candidiasis. Materials and methods. The study included female patients (1855 years old) with uncomplicated vulvovaginal candidiasis treated in outpatient settings. In total, 220 patients were randomized into two groups: group 1 (n=110) received a single dose of Flucovag vaginal suppositories, and group 2 (n=110) received a single dose of Zalain vaginal suppositories. Seven days after the treatment, its clinical efficacy was evaluated. In case of incomplete clinical improvement after 7 days, patients received an additional dose of Flucovag (n=4) or Zalain (n=5) suppositories, respectively. Results. At the end of therapy in the study groups, the clinical cure rates (99.1% vs. 96.3%, p0.05), microscopic, and culture results were comparable. No serious adverse events were reported in both groups throughout the study. Conclusion. The study results demonstrate a favorable safety profile and high antifungal activity of sertaconazole.
{"title":"Flucovag: efficacy and safety in patients with vulvovaginal candidiasis: a prospective, multicenter, open-label, randomized, comparative clinical study","authors":"F. R. Kutueva, R. Glushakov, N. Tapilskaya, A. Nikolaeva, Artem A. Poromov, O. Pustotina","doi":"10.26442/20795696.2023.1.202037","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202037","url":null,"abstract":"Design. A prospective, multicenter, open-label, randomized, comparative clinical study. \u0000Objective. To compare the efficacy and safety of Flucovag (sertaconazole) vaginal suppositories, 300 mg (OTCPharm JSC, Russia; manufactured by Altpharm LLC, Russia) and the brand-name drug Zalain (sertaconazole), 300 mg (Egis Pharmaceuticals PLC, Hungary) in the treatment of vulvovaginal candidiasis. \u0000Materials and methods. The study included female patients (1855 years old) with uncomplicated vulvovaginal candidiasis treated in outpatient settings. In total, 220 patients were randomized into two groups: group 1 (n=110) received a single dose of Flucovag vaginal suppositories, and group 2 (n=110) received a single dose of Zalain vaginal suppositories. Seven days after the treatment, its clinical efficacy was evaluated. In case of incomplete clinical improvement after 7 days, patients received an additional dose of Flucovag (n=4) or Zalain (n=5) suppositories, respectively. \u0000Results. At the end of therapy in the study groups, the clinical cure rates (99.1% vs. 96.3%, p0.05), microscopic, and culture results were comparable. No serious adverse events were reported in both groups throughout the study. \u0000Conclusion. The study results demonstrate a favorable safety profile and high antifungal activity of sertaconazole.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73924809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201761
E. Kravchenko, E. Khomutova, Elmira N. Engurazova, M. Vorontsova
Currently, the diagnostic criteria for polycystic ovary syndrome (PCOS) are focused on the stratification of subtypes by metabolic features. Depending on the identified subtype, treatment options are revised following the management goal: improvement of the hyperandrogenism symptoms, menstruation regulation, and fertility recovery. The PCOS diagnostic features, including ultrasound pattern, are essential for the diagnosis. Future studies should focus on the health effects of postmenopausal women with PCOS.
{"title":"Diagnostic features of polycystic ovary syndrome: A review","authors":"E. Kravchenko, E. Khomutova, Elmira N. Engurazova, M. Vorontsova","doi":"10.26442/20795696.2023.1.201761","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201761","url":null,"abstract":"Currently, the diagnostic criteria for polycystic ovary syndrome (PCOS) are focused on the stratification of subtypes by metabolic features. Depending on the identified subtype, treatment options are revised following the management goal: improvement of the hyperandrogenism symptoms, menstruation regulation, and fertility recovery. The PCOS diagnostic features, including ultrasound pattern, are essential for the diagnosis. Future studies should focus on the health effects of postmenopausal women with PCOS.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73313383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202119
V. Sturov, Nikolay I. Melchenko, Anastasya S. Balysheva
Iron deficiency anemia (IDA) and latent iron deficiency are common. The article describes the mechanisms of development, diagnostic criteria, the clinical presentation of the IDA. The current options for treating anemia with oral iron supplements and their indications, effectiveness and safety criteria. Aim. To analyze and prove the effectiveness of iron fumarate combined with folate for treating and preventing iron deficiency in women of reproductive age. Materials and methods. Sixty women aged 1847 with mild to moderate iron deficiency were examined. All patients received of iron fumarate (equivalent to 150 mg of elemental iron) combined with 1500 mcg of folic acid for 2142 days. Hemoglobin, ferritin, serum iron, and erythrocyte indices were measured. Results. In most patients, recovery from anemia was observed: an increase in hemoglobin by 2732% and ferritin by a mean of 35%, i.e., 1.67 times compared with alternative iron therapy (iron sulfate and gluconate). The rate of side effects was less than 4%. Conclusion. Co-administration of iron fumarate with folic acid has been shown to increase the therapeutic efficacy and has a high safety profile in patients with IDA (especially in pregnant women requiring additional folate supplements).
{"title":"Anemia in women of reproductive age in current clinical practice and effectiveness of iron fumarate combined with folate","authors":"V. Sturov, Nikolay I. Melchenko, Anastasya S. Balysheva","doi":"10.26442/20795696.2023.1.202119","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202119","url":null,"abstract":"Iron deficiency anemia (IDA) and latent iron deficiency are common. The article describes the mechanisms of development, diagnostic criteria, the clinical presentation of the IDA. The current options for treating anemia with oral iron supplements and their indications, effectiveness and safety criteria. \u0000Aim. To analyze and prove the effectiveness of iron fumarate combined with folate for treating and preventing iron deficiency in women of reproductive age. \u0000Materials and methods. Sixty women aged 1847 with mild to moderate iron deficiency were examined. All patients received of iron fumarate (equivalent to 150 mg of elemental iron) combined with 1500 mcg of folic acid for 2142 days. Hemoglobin, ferritin, serum iron, and erythrocyte indices were measured. \u0000Results. In most patients, recovery from anemia was observed: an increase in hemoglobin by 2732% and ferritin by a mean of 35%, i.e., 1.67 times compared with alternative iron therapy (iron sulfate and gluconate). The rate of side effects was less than 4%. \u0000Conclusion. Co-administration of iron fumarate with folic acid has been shown to increase the therapeutic efficacy and has a high safety profile in patients with IDA (especially in pregnant women requiring additional folate supplements).","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"55 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83553973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201877
Elena A. Baklygina, Vadim V. Pchelintsev, Eugenia M. Pristupa, A. V. Markin
Endometriosis is the presence of tissue with morphological and functional features similar to endometrium outside the uterine cavity. Endometriosis affects approximately 10% of women worldwide, mostly of reproductive age. The rate of extragenital endometriosis is 0.33.5%. Diagnosis of endometriosis of the anterior abdominal wall is complex and includes analysis of clinical and medical history data, ultrasound, magnetic resonance imaging, and histological examination of the removed tissues. The article presents a clinical case of a large lesion of extragenital endometriosis localized in the subcutaneous fat of the anterior abdominal wall in a patient with a history of cesarean section. The main clinical manifestations of this disorder were cyclic pain during menstruation and an enlargement of the existing mass in the subcutaneous fat.
{"title":"Endometriosis of the surgical scar of the anterior abdominal wall. Case report","authors":"Elena A. Baklygina, Vadim V. Pchelintsev, Eugenia M. Pristupa, A. V. Markin","doi":"10.26442/20795696.2023.1.201877","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201877","url":null,"abstract":"Endometriosis is the presence of tissue with morphological and functional features similar to endometrium outside the uterine cavity. Endometriosis affects approximately 10% of women worldwide, mostly of reproductive age. The rate of extragenital endometriosis is 0.33.5%. Diagnosis of endometriosis of the anterior abdominal wall is complex and includes analysis of clinical and medical history data, ultrasound, magnetic resonance imaging, and histological examination of the removed tissues. The article presents a clinical case of a large lesion of extragenital endometriosis localized in the subcutaneous fat of the anterior abdominal wall in a patient with a history of cesarean section. The main clinical manifestations of this disorder were cyclic pain during menstruation and an enlargement of the existing mass in the subcutaneous fat.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76854461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201923
N. Artymuk, Anastasia V. Breus, D. Artymuk
Aim. Toassess the prevalence of various types of human papillomavirus (HPV) of high carcinogenic risk (HCR) and the rate of abnormal findings of cytological examination in HPV-positive and HPV-negative women of the Kemerovo region. Materials and methods. A continuous cross-sectional study was conducted. The study included 675 women aged 21 to 65 (mean age 40.510.6 years) residing in the Kemerovo region. Patients were sampled from the cervical canal for semi-quantitative HPV-typing and cytological examination with Papanicolaou staining (PAP-test) using a liquid-based cytology method. For HPV-positive patients, an HPV typing with the quantification of 14 HCR HPV types was performed by polymerase chain reaction with real-time detection. Statistical data processing was performed using the StatSoft Statistica 6.1 software bundle. Results. The mean rate of HCR HPV detection in women of the Kemerovo region in the age group of 2165 years is 17.8% and decreases with age. HPV type 16 prevailed and was detected in 31.6% of women. In 19.2% of women, the HPV subtype 31 was diagnosed; in 18.3%, the subtype 35; in 16.7%, the subtype 33. The HPV subtypes 39, 56, and 66 were the rarest. One subtype of HCR HPV was detected in 26.7% of women, two subtypes in 6.7%, and three or more subtypes in 66.6% of women. According to the cytological examination, CIN 1, 2, and 3 rates were 3.3, 0.8, and 0.7%, respectively. HSIL (CIN 23) was detected in 1.5% of cases, LSIL (CIN 1) in 3.3%. The rate of CIN 1 in HPV(+) women was higher: 13.3% vs 1.0% in HPV(-) (2=43.197; p0.001). CIN 2 and CIN 3 were reported in HPV(+) patients only. HSIL+ was diagnosed in 7.9% of HPV(+) females (2=39.778; p0.001). Conclusion. Thus, the study results showed that the mean infection rate of HCR HPV in women of the Kemerovo region at the age of 2165 years is 17.8% and decreases with age. HPV subtype 16 is predominant; subtypes 31, 35, and 33 were less common. In HPV-positive women, abnormal findings of cytological examination were significantly more common.
{"title":"The incidence of HPV infection of high carcinogenic risk in women of the Kemerovo region","authors":"N. Artymuk, Anastasia V. Breus, D. Artymuk","doi":"10.26442/20795696.2023.1.201923","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201923","url":null,"abstract":"Aim. Toassess the prevalence of various types of human papillomavirus (HPV) of high carcinogenic risk (HCR) and the rate of abnormal findings of cytological examination in HPV-positive and HPV-negative women of the Kemerovo region. \u0000Materials and methods. A continuous cross-sectional study was conducted. The study included 675 women aged 21 to 65 (mean age 40.510.6 years) residing in the Kemerovo region. Patients were sampled from the cervical canal for semi-quantitative HPV-typing and cytological examination with Papanicolaou staining (PAP-test) using a liquid-based cytology method. For HPV-positive patients, an HPV typing with the quantification of 14 HCR HPV types was performed by polymerase chain reaction with real-time detection. Statistical data processing was performed using the StatSoft Statistica 6.1 software bundle. \u0000Results. The mean rate of HCR HPV detection in women of the Kemerovo region in the age group of 2165 years is 17.8% and decreases with age. HPV type 16 prevailed and was detected in 31.6% of women. In 19.2% of women, the HPV subtype 31 was diagnosed; in 18.3%, the subtype 35; in 16.7%, the subtype 33. The HPV subtypes 39, 56, and 66 were the rarest. One subtype of HCR HPV was detected in 26.7% of women, two subtypes in 6.7%, and three or more subtypes in 66.6% of women. According to the cytological examination, CIN 1, 2, and 3 rates were 3.3, 0.8, and 0.7%, respectively. HSIL (CIN 23) was detected in 1.5% of cases, LSIL (CIN 1) in 3.3%. The rate of CIN 1 in HPV(+) women was higher: 13.3% vs 1.0% in HPV(-) (2=43.197; p0.001). CIN 2 and CIN 3 were reported in HPV(+) patients only. HSIL+ was diagnosed in 7.9% of HPV(+) females (2=39.778; p0.001). \u0000Conclusion. Thus, the study results showed that the mean infection rate of HCR HPV in women of the Kemerovo region at the age of 2165 years is 17.8% and decreases with age. HPV subtype 16 is predominant; subtypes 31, 35, and 33 were less common. In HPV-positive women, abnormal findings of cytological examination were significantly more common.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83063064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202033
M. R. Orazov, V. V. Ermakov, Dmitrii S. Novginov
The use of hormonal contraception is widespread worldwide. Over the years of use, it has been possible to study its contraceptive effectiveness and its effect on carbohydrate metabolism, blood coagulation, lipid profile, liver function tests, and other systems and organs. However, the effect on sexual function has not been sufficiently studied. For a long time, ethinylestradiol remained the main estrogen in combined oral contraceptives; however, the desire to improve safety led to the development of a new drug containing natural, highly selective estrogen estetrol and the well-known progestogen drospirenone. Therefore, it is relevant to study the effect of the new combined oral contraceptive on sexual function.
{"title":"Effect of an estetrol/drospirenone contraceptive on sexual function in women of reproductive age","authors":"M. R. Orazov, V. V. Ermakov, Dmitrii S. Novginov","doi":"10.26442/20795696.2023.1.202033","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202033","url":null,"abstract":"The use of hormonal contraception is widespread worldwide. Over the years of use, it has been possible to study its contraceptive effectiveness and its effect on carbohydrate metabolism, blood coagulation, lipid profile, liver function tests, and other systems and organs. However, the effect on sexual function has not been sufficiently studied. For a long time, ethinylestradiol remained the main estrogen in combined oral contraceptives; however, the desire to improve safety led to the development of a new drug containing natural, highly selective estrogen estetrol and the well-known progestogen drospirenone. Therefore, it is relevant to study the effect of the new combined oral contraceptive on sexual function.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91240428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202109
M. R. Orazov, V. Radzinsky, E. Dolgov, Yu. G. Abramashvili
Endometriosis is still one of the most mysterious and urgent gynecological diseases. The prevalence of endometriosis is steadily increasing, despite the development of innovative methods of diagnosis and treatment. Endometriosis is the presence of a heterotopic endometrium outside the uterine cavity and most often affects the pelvic organs. However, more and more often, the world medical community actualizes the study of extrapelvic endometriosis as a unique clinical entity with specific pathogenetic patterns, approaches to verification, and therapeutic concepts. The article summarizes and systematizes the current scientific data on pathogenesis, clinical phenotypes, and therapy of extrapelvic endometriosis.
{"title":"Extrapelvic endometriosis: the mystery of the \"black square\" or \"quintessential classics\"?","authors":"M. R. Orazov, V. Radzinsky, E. Dolgov, Yu. G. Abramashvili","doi":"10.26442/20795696.2023.1.202109","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202109","url":null,"abstract":"Endometriosis is still one of the most mysterious and urgent gynecological diseases. The prevalence of endometriosis is steadily increasing, despite the development of innovative methods of diagnosis and treatment. Endometriosis is the presence of a heterotopic endometrium outside the uterine cavity and most often affects the pelvic organs. However, more and more often, the world medical community actualizes the study of extrapelvic endometriosis as a unique clinical entity with specific pathogenetic patterns, approaches to verification, and therapeutic concepts. The article summarizes and systematizes the current scientific data on pathogenesis, clinical phenotypes, and therapy of extrapelvic endometriosis.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74977988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201486
S. P. Sinchikhin, E. Kostenko, L. Stepanyan, Ekaterina S. Sinchikhina
A historical perspective on the issue of device-based endometrial destruction is presented. The article describes in detail various current methods of thermal coagulation of the uterine mucosa for its destruction. A comparative analysis of hysteroscopic and non-hysteroscopic methods of endometrial destruction in terms of treatment effectiveness, complications, and recurrence prevention is presented. The ways of technological development of instrumental treatment methods of intrauterine disorders are highlighted.
{"title":"Historical aspects and current view for device-based endometrial destruction","authors":"S. P. Sinchikhin, E. Kostenko, L. Stepanyan, Ekaterina S. Sinchikhina","doi":"10.26442/20795696.2023.1.201486","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201486","url":null,"abstract":"A historical perspective on the issue of device-based endometrial destruction is presented. The article describes in detail various current methods of thermal coagulation of the uterine mucosa for its destruction. A comparative analysis of hysteroscopic and non-hysteroscopic methods of endometrial destruction in terms of treatment effectiveness, complications, and recurrence prevention is presented. The ways of technological development of instrumental treatment methods of intrauterine disorders are highlighted.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"23 58","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72396134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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