Epilepsy and Behavior Reports最新文献_第4页

Mapping change in self narrative after prolonged exposure therapy: An exploration in recovery from functional dissociative seizures 长期暴露治疗后自我叙述的映射改变：功能性分离性癫痫恢复的探索

IF 1.5 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-28 DOI: 10.1016/j.ebr.2025.100812

Jon D. Perkins , Sam Meekings

This study explored self-narrative transformations in a participant with functional dissociative seizures (FDS) following prolonged exposure therapy. The study aimed to establish emergent themes that indicated psychological challenges and the subsequent psychological shifts that accompany FDS resolution. Two interviews were held one month apart. An open-ended questionnaire was employed in the first interview, followed by a structured questionnaire based on previous findings in the second. Thematic analysis was used to explore the narrative of the transcribed interviews and extract themes. Themes constituted four or more references to the same topic during the interviews. Six main themes were identified. These were, in order of the most prevalent, Emotional and Cognitive Insights (29 %), Understanding and Negotiating Fear (24 %), Detachment and Attachment (21 %), Self-Management and Resolution (18 %), Physiological Insights (13 %) and Shifting Relationships and Social Interactions (11 %). Narratology reveals key features of an individual’s story and offers insight into their psychological experience. In FDS patients, where psychological disturbance may be a causal factor for symptoms, the formation of a coherent self-narrative can be mapped from pathology through to symptom resolution. In doing so, this process identifies important possible narrative markers underlying the psychological processes involved in FDS.

本研究探讨了长期暴露治疗后功能性分离性癫痫（FDS）患者的自我叙述转变。该研究旨在建立突发性主题，表明心理挑战和伴随FDS解决的后续心理转变。两次面试相隔一个月。第一次访谈采用开放式问卷，第二次访谈采用基于先前调查结果的结构化问卷。采用主题分析的方法探讨访谈记录的叙事，提取主题。主题是在访谈中对同一主题的四次或四次以上提及。确定了六个主题。依次为：情感和认知洞察力（29%）、理解和协商恐惧（24%）、超然和依恋（21%）、自我管理和解决（18%）、生理洞察力（13%）和转变关系和社会互动（11%）。叙事学揭示了个人故事的关键特征，并提供了对他们心理体验的洞察。在FDS患者中，心理障碍可能是症状的一个原因，连贯的自我叙述的形成可以从病理到症状消退。在这样做的过程中，这个过程确定了FDS中涉及的心理过程的重要可能的叙事标记。

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引用次数: 0

Prospective assessment of depression and suicidality in patients with epilepsy having baseline NDDI-E Scores > 13: Associations with seizure frequency and psychiatric treatment 基线NDDI-E评分bbbb13的癫痫患者抑郁和自杀的前瞻性评估：与癫痫发作频率和精神治疗的关系

IF 1.5 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-24 DOI: 10.1016/j.ebr.2025.100810

Satoshi Saito , Go Taniguchi , Hideo Kato , Chihiro Nakata , Izumi Kuramochi

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is commonly used to screen for major depressive disorder (MDD) in patients with epilepsy, yet little is known about longitudinal changes in NDDI-E scores in relation to seizure control and psychiatric care. This study evaluated temporal changes in NDDI-E total and Item 4 scores (ΔNDDI-E, ΔItem 4) over ≥6 months in 34 adults (≥18 years) with baseline NDDI-E scores >13. Patients were seen in a specialized outpatient psychiatry clinic within an epilepsy center. Data included Clinical Global Impression–Improvement (CGI-I) ratings by psychiatrists specialized in epilepsy care, seizure frequency, DSM-5-based psychiatric diagnoses, and treatment interventions (e.g., medication adjustments, psychotherapy, and psychosocial support). Patients also completed a self-report questionnaire. No significant difference in MDD diagnoses was found between those with baseline NDDI-E scores of 14–16 and ≥17 (6.7 % vs. 21.1 %, p = 0.36). Comorbidities included autism spectrum disorder, dissociative disorder, and other mental health conditions. Changes in seizure frequency did not correlate with ΔNDDI-E or CGI-I scores, while ΔNDDI-E and ΔItem 4 showed moderate correlations with CGI-I (ρ = 0.51 and 0.56). All patients with improved Item 4 scores had better CGI-I ratings (p < 0.001). Qualitative analysis indicated that emotional fluctuations and psychosocial stressors influenced NDDI-E scores. These results suggest that longitudinal improvement in NDDI-E Item 4 may serve as a marker for psychiatric benefit. Effective use of the NDDI-E requires considering the psychiatric and psychosocial dimensions beyond seizure control. To validate these findings, studies with larger sample sizes and longer follow-up are necessary.

癫痫神经障碍抑郁量表（NDDI-E）通常用于筛查癫痫患者的重度抑郁障碍（MDD），但NDDI-E评分与癫痫发作控制和精神护理之间的纵向变化知之甚少。本研究评估了34名具有基线NDDI-E评分的成人（≥18岁）在≥6个月内NDDI-E总量和第4项评分（ΔNDDI-E， ΔItem 4）的时间变化[gt；13]。患者在癫痫中心的专门门诊精神病学诊所就诊。数据包括临床总体印象改善（CGI-I）由专门从事癫痫治疗的精神病学家评分，癫痫发作频率，基于dsm -5的精神病诊断和治疗干预（例如，药物调整，心理治疗和社会心理支持）。患者还完成了一份自我报告问卷。基线NDDI-E评分为14-16分和≥17分的患者在MDD诊断方面无显著差异（6.7% vs. 21.1%, p = 0.36）。合并症包括自闭症谱系障碍、分离性障碍和其他精神健康状况。发作频率的变化与ΔNDDI-E或CGI-I评分无相关性，而ΔNDDI-E和ΔItem 4与CGI-I有中度相关性（ρ = 0.51和0.56）。所有第4项评分提高的患者CGI-I评分均提高(p <；0.001)。定性分析表明情绪波动和心理社会压力因素影响NDDI-E评分。这些结果表明NDDI-E第4项的纵向改善可以作为精神病学获益的标志。有效使用NDDI-E需要考虑癫痫控制之外的精神病学和社会心理层面。为了验证这些发现，需要更大样本量和更长时间的随访研究。

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引用次数: 0

Changes in brain network dynamics during functional/dissociative seizures: An exploratory pilot study on EEG microstates 功能性/解离性癫痫发作期间脑网络动力学的变化：脑电图微观状态的探索性初步研究

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-23 DOI: 10.1016/j.ebr.2025.100809

Domantė Kučikienė , Johannes Jungilligens , Stefan Wolking , Yvonne Weber , Jörg Wellmer , Stoyan Popkirov

The pathophysiology of functional/dissociative seizures (FDS), also known as psychogenic nonepileptic seizures, remains incompletely understood. Current theories suggest that ictal changes in self-awareness and behavioural control are likely related to arousal-mediated disruptions of brain network dynamics, but direct electrophysiological evidence is scarce. In a proof-of-concept, the second of its kind pilot study, we explored ictal changes in EEG microstates – quasi-stable patterns of electrical activity of 50–70 ms duration that represent fundamental building blocks of large-scale brain network dynamics. Across a sample of 13 FDS patients, four microstates yielded a high mean global explained variance of 76.2 % and qualitatively resembled the well-established “canonical” microstate map topographies A-D. Repeated measure analysis of variance did not reveal any significant differences in contribution, occurrence or global field power of microstates between baseline and ictal recordings. Microstate duration, however, was significantly different between baseline and seizure recordings with shorter durations of microstates in FDS (p = 0.007). This was most pronounced for microstate D (Cohen’s d = 0.75) with the change being significant in an exploratory post hoc paired t-test (p = 0.044). Since microstate D is thought to reflect frontoparietal network activity, the findings of this pilot study can be interpreted as supportive of current theories of arousal-mediated disruptions of network activity that reduce cognitive and behavioural control during FDS.

功能性/解离性发作（FDS）的病理生理学，也被称为心因性非癫痫性发作，仍然不完全了解。目前的理论表明，自我意识和行为控制的关键变化可能与觉醒介导的大脑网络动力学中断有关，但直接的电生理证据很少。在概念验证中，我们探索了脑电图微状态的关键变化——持续50-70毫秒的准稳定电活动模式，代表了大规模大脑网络动态的基本组成部分。在13例FDS患者的样本中，4个微观状态产生了76.2%的高平均全球解释方差，并且在质量上类似于已建立的“规范”微观状态地图地形a - d。方差的重复测量分析未显示基线和临界记录之间在微状态的贡献、发生或全局场功率方面有任何显著差异。然而，微状态持续时间在基线和癫痫发作记录之间有显著差异，FDS中微状态持续时间较短（p = 0.007）。这在微观状态D中最为明显（Cohen’s D = 0.75），在探索性事后配对t检验中变化显著（p = 0.044）。由于微状态D被认为反映了额顶叶网络活动，因此这项初步研究的结果可以被解释为支持当前的理论，即觉醒介导的网络活动中断可以减少FDS期间的认知和行为控制。

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引用次数: 0

The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant 基因检测在评估小儿局灶性皮质发育不良与NPRL3变异相关的手术结果中的作用

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-16 DOI: 10.1016/j.ebr.2025.100808

Bei Li , Liang Liu , Jianyun Su , Shanshan Jia , Zhijing Wang , Xia Li , Siyu Zhao

This case report describes a 5-year-and-10-month-old female patient who developed sleep-related hypermotor epilepsy, at the age of 2, exhibiting various forms of seizures since the age of 2. Initially, the seizures were controlled for one year with multiple anti-seizure medications; however, symptoms recurred when the patient was 3 years and 5 months old, leading to an increased seizure frequency and a poor response to combined drug therapy. Long-term video-EEG revealed discharges originating from the frontal lobe, while MRI and PET-CT scans indicated FCD in the left frontal region. The patient underwent left frontal epileptogenic focus resection at the age of 6, with pathological findings confirming FCD type 1b. Whole-exome sequencing of blood and brain tissue samples revealed NPRL3 gene variants. Although she remained seizure-free for one year post-surgery, the patient experienced a relapse, with follow-up EEG revealing multifocal discharges. These findings indicate that variants in the NPRL3 gene contribute to focal cortical dysplasia (FCD) and are frequently associated with drug-resistant epilepsy. For FCD 1b patients with NPRL3 gene variants, the risks and benefits of surgery should be carefully evaluated. This report explores the role of NPRL3 gene variants in FCD1b and their impact on surgical treatment, emphasizing the importance of comprehensive preoperative assessment and individualized therapeutic strategies.

本病例报告描述了一名5岁零10个月大的女性患者，她在2岁时出现与睡眠有关的运动性癫痫，自2岁以来表现出各种形式的癫痫发作。最初，癫痫发作通过多种抗癫痫药物控制了一年；然而，当患者3岁零5个月时，症状复发，导致癫痫发作频率增加，对联合药物治疗的反应较差。长期视频脑电图显示放电来自额叶，而MRI和PET-CT扫描显示FCD在左额叶区域。患者6岁时行左侧额叶癫痫灶切除术，病理证实为FCD 1b型。血液和脑组织样本的全外显子组测序显示NPRL3基因变异。虽然术后一年无癫痫发作，但患者复发，随访脑电图显示多灶性放电。这些发现表明，NPRL3基因的变异与局灶性皮质发育不良（FCD）有关，并且经常与耐药癫痫有关。对于携带NPRL3基因变异的FCD 1b患者，应仔细评估手术的风险和益处。本报告探讨了NPRL3基因变异在FCD1b中的作用及其对手术治疗的影响，强调了术前全面评估和个体化治疗策略的重要性。

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引用次数: 0

Electroconvulsive therapy in psychoses of epilepsy – A forgotten alternative 癫痫精神病的电休克疗法——一种被遗忘的替代疗法

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-12 DOI: 10.1016/j.ebr.2025.100806

Mariana Roque Gonçalves , Alzira Silva , Celeste Silveira

This case report discusses a 35-year-old woman with refractory temporal lobe epilepsy and no prior psychiatric history who developed persecutory, erotomanic and megalomaniac ideations, auditory hallucinations, and dysphoric mood. Psychiatric symptoms, including psychosis, are well-documented in patients with epilepsy, posing unique management challenges due to potential interactions between antiepileptic and antipsychotic medications. In this case, the patient demonstrated persistent epileptiform activity on electroencephalogram despite treatment with three antiepileptic drugs. Concurrently, standard antipsychotic treatments were ineffective, suggesting drug-resistant psychosis. Notably, complete remission of psychotic symptoms was achieved with electroconvulsive therapy (ECT), a well-established intervention for various psychiatric conditions but rarely reported in the context of epilepsy-associated psychosis. This case underscores the need for novel therapeutic approaches in managing complex comorbidities like drug-resistant psychosis in epilepsy. It also highlights the potential role of ECT as a safe and effective treatment option in these challenging clinical scenarios.

本病例报告讨论了一名35岁女性难治性颞叶癫痫患者，无精神病史，表现为受迫害、性欲狂、自大狂、幻听和烦躁情绪。精神病症状，包括精神病，在癫痫患者中有充分的记录，由于抗癫痫和抗精神病药物之间潜在的相互作用，提出了独特的管理挑战。在这个病例中，患者在脑电图上表现出持续的癫痫样活动，尽管使用了三种抗癫痫药物。同时，标准的抗精神病药物治疗无效，提示耐药精神病。值得注意的是，精神病症状的完全缓解是通过电痉挛疗法（ECT）实现的，电痉挛疗法是一种公认的用于各种精神疾病的干预措施，但很少在癫痫相关精神病的背景下报道。该病例强调需要新的治疗方法来管理复杂的合并症，如癫痫中的耐药精神病。它还强调了ECT作为一种安全有效的治疗选择在这些具有挑战性的临床情况下的潜在作用。

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引用次数: 0

Assessing knowledge, attitudes, and misconceptions about epilepsy among University of Venda students: A call for enhanced education and awareness 评估文达大学学生对癫痫的知识、态度和误解：呼吁加强教育和认识

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-12 DOI: 10.1016/j.ebr.2025.100807

A.E. Ndou , L. Makhado , O.P. Netshisaulu

Epilepsy is a neurological disorder affecting individuals of all ages, often surrounded by stigma and misconceptions. Despite its prevalence, awareness about epilepsy is limited, particularly among university students. This study investigates the knowledge, attitudes, and perceptions of students at the University of Venda regarding epilepsy to identify gaps and improve educational strategies. A cross-sectional survey was conducted with students from various faculties at the University of Venda. Participants completed a structured questionnaire that collected demographic information and assessed their knowledge about epilepsy, attitudes towards individuals with the condition, and perceptions of public awareness. The survey included questions about awareness of epilepsy, understanding its causes and management, and views on the rights of people living with epilepsy. A total of 326 students participated in the survey. The survey showed that approximately 92.9% of students had heard of epilepsy, but many misconceptions remained. A significant number believed that epilepsy is untreatable and that those with the condition should not drive or participate in certain activities. Only 18.7% knew the correct management practices for seizures. Furthermore, 67% of students felt that insufficient attention was given to epilepsy, yet the study increased interest in learning more, as over 92.9% expressed a desire for additional information. The findings highlight the need for better education about epilepsy among university students to dispel myths and promote informed attitudes. Educational initiatives focused on seizure management and inclusivity could create a more supportive environment for individuals with epilepsy at the University of Venda and beyond.

癫痫是一种影响所有年龄个体的神经系统疾病，常常被污名和误解所包围。尽管癫痫病很流行，但人们对其认识有限，尤其是大学生。本研究调查了文达大学学生对癫痫的知识、态度和看法，以确定差距并改进教育策略。对文达大学各院系的学生进行了一项横断面调查。参与者完成了一份结构化问卷，收集了人口统计信息，并评估了他们对癫痫的知识、对患者的态度以及对公众意识的看法。调查的问题包括对癫痫的认识、了解其原因和管理，以及对癫痫患者权利的看法。共有326名学生参与了调查。调查显示，约92.9%的学生听说过癫痫，但仍存在许多误解。相当多的人认为癫痫是无法治愈的，患有癫痫的人不应该开车或参加某些活动。只有18.7%的人知道正确的癫痫发作管理方法。此外，67%的学生认为对癫痫的关注不够，但这项研究增加了他们学习更多知识的兴趣，超过92.9%的学生表示希望获得更多信息。研究结果强调，需要对大学生进行更好的癫痫教育，以消除误解，促进知情态度。以癫痫发作管理和包容性为重点的教育举措可以为文达大学及其他地方的癫痫患者创造一个更具支持性的环境。

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引用次数: 0

Autosomal dominant Kufs disease in a Georgian adult woman: A case report 常染色体显性库夫斯病在格鲁吉亚成年妇女：1例报告

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-10 DOI: 10.1016/j.ebr.2025.100805

Nikoloz Papiashvili , Sopio Gagua , Nana Gonjilashvili , Natela Okujava , Aleksandre Tsereteli

Progressive myoclonic epilepsies (PMEs) are a diverse group of neurodegenerative disorders characterized by myoclonus, seizures, and progressive cognitive and motor decline. This report presents a case of a subtype of PME, autosomal dominant Kufs disease (NCL type 4) documented for the first time outside of North America or Western Europe. The patient had a six-year history of progressive epilepsy that was resistant to pharmacotherapy, followed by myoclonus, cerebellar dysfunction, and cognitive deterioration. The patient’s family history revealed a similar syndrome in the mother, who passed away seven years after the onset of the disease. Genetic testing identified the heterozygous pathogenic variant NM_025219.2:c.344T > G (p.Leu115Arg) in the DNAJC5 gene. This case report broadens the geographic distribution of NCL type 4 and calls attention to the multifaceted diagnostic challenges posed by the condition.

进行性肌阵挛性癫痫（PMEs）是一种以肌阵挛、癫痫发作、进行性认知和运动能力下降为特征的神经退行性疾病。本报告报告了一例PME亚型，常染色体显性库夫斯病（NCL 4型）首次在北美或西欧以外记录。患者有6年进行性癫痫史，对药物治疗有耐药性，随后出现肌阵挛、小脑功能障碍和认知功能减退。患者的家族史显示，其母亲也有类似的综合征，她在发病七年后去世。基因检测鉴定出杂合致病变异NM_025219.2:c。344 t比;G （p.l u115arg）在DNAJC5基因中。本病例报告扩大了NCL 4型的地理分布，并引起人们对该病带来的多方面诊断挑战的关注。

引用次数: 0

The role of cannabis in epilepsy illustrated by two case reports 两个病例报告说明了大麻在癫痫中的作用

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-08 DOI: 10.1016/j.ebr.2025.100804

Santiago Philibert-Rosas , Cameron J. Brace , Sanaa Semia , Barry E. Gidal , Bradley T. Nix , Anne F. Josiah , Melanie Boly , Aaron F. Struck

Cannabis use is increasingly prevalent among individuals with epilepsy, yet its impact on seizure control remains poorly understood. While cannabidiol (CBD) has demonstrated antiseizure properties and gained FDA approval for specific epileptic syndromes, tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, may alter neuronal excitability and potentially exacerbate seizure activity. We present two illustrative case reports of male patients with focal epilepsy and chronic cannabis use who underwent treatment with antiseizure medications and responsive neurostimulation (RNS). In both cases, cannabis use was temporally associated with breakthrough seizures and poor seizure control. These cases highlight the complex and multifactorial relationship between cannabis use and seizure outcomes, including potential pharmacokinetic interactions with antiseizure medications (ASM) and the possibility that cannabis may blunt the neuromodulation effects of RNS. Given the retrospective data and limited detail on cannabis use, these findings should be interpreted with caution. As cannabis use rises among individuals with epilepsy, further research is needed to clarify its potential effects on seizures and treatment response, including neuromodulation.

大麻使用在癫痫患者中越来越普遍，但其对癫痫发作控制的影响仍然知之甚少。虽然大麻二酚（CBD）已经证明了抗癫痫的特性，并获得了FDA对特定癫痫综合征的批准，但大麻中的主要精神活性化合物四氢大麻酚（THC）可能会改变神经元的兴奋性，并可能加剧癫痫活动。我们提出两个说明性病例报告的男性患者局灶性癫痫和慢性大麻使用谁接受治疗抗癫痫药物和反应性神经刺激（RNS）。在这两种情况下，大麻的使用都暂时与突破性发作和发作控制不良有关。这些病例强调了大麻使用与癫痫发作结果之间复杂的多因素关系，包括与抗癫痫药物（ASM）的潜在药代动力学相互作用以及大麻可能减弱RNS神经调节作用的可能性。鉴于回顾性数据和关于大麻使用的有限细节，这些发现应谨慎解释。随着癫痫患者使用大麻的人数增加，需要进一步研究以阐明其对癫痫发作和治疗反应的潜在影响，包括神经调节。

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引用次数: 0

Lateralization discordance between stereo EEG and scalp EEG in temporal epilepsy: A case report 颞叶癫痫立体脑电图与头皮脑电图侧位不一致1例

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-05 DOI: 10.1016/j.ebr.2025.100803

Spencer Gunnell, Audrey Nath, Patrick Karas, Todd Masel

A 34-year-old woman with drug-resistant epilepsy underwent simultaneous scalp and stereo-EEG (sEEG) and had seven seizures, three of them without visibility on the scalp EEG. Of the four seizures seen on both sEEG and scalp EEG, the seizure onset in the scalp EEG was ipsilateral to the seizure onset in the sEEG in two seizures and contralateral to the sEEG onset in two seizures. This unusual lateralization discordance of scalp EEG and sEEG highlights the importance of bilateral lead placement in stereo EEG to accurately identify the seizure onset zone.

一名34岁的耐药癫痫女性同时接受了头皮和立体脑电图（sEEG）检查，并出现了7次癫痫发作，其中3次在头皮脑电图上没有可见性。在脑电图和头皮脑电图同时显示的四次癫痫发作中，头皮脑电图的癫痫发作与两次脑电图的癫痫发作同侧，与两次脑电图的癫痫发作对侧。这种头皮脑电图与sEEG异常的侧位不一致突出了双侧导联放置在立体脑电图中准确识别癫痫发作区域的重要性。

引用次数: 0

Brain tumours as an unrecognized etiology of infantile epileptic spasms syndrome (IESS): The role of resective epilepsy surgery 脑肿瘤作为婴儿癫痫痉挛综合征（IESS）的未知病因：切除癫痫手术的作用

IF 1.8 Q3 CLINICAL NEUROLOGY

Epilepsy and Behavior Reports

Pub Date : 2025-07-04 DOI: 10.1016/j.ebr.2025.100802

Rowan Pentz , Kevin Jones , Ronit Mesterman , Rajesh RamachandranNair , Hiroshi Otsubo , Ayako Ochi , Ivanna Yau , Elizabeth J Donner , George M Ibrahim , Puneet Jain , Robyn Whitney

Brain tumours are a rare cause of infantile epileptic spasm syndrome (IESS). Epilepsy surgery may be utilized in refractory IESS due to tumours, although reports are limited. We report an illustrative case of IESS which resolved after tumour resection and performed a literature review of all reported cases of brain tumours causing IESS with hypsarrhythmia. We present a 10-month-old girl with drug-resistant symmetric epileptic spasms (ES). Initial EEG showed symmetric hypsarrhythmia and brain MRI demonstrated a left temporal lobe tumour. Despite non-focal clinical and EEG findings, she underwent tumour resection at 21 months (ganglioglioma). She subsequently had resolution of ES and hypsarrhythmia and developmental gains. Twenty-seven published cases of brain tumours and IESS were reviewed. ES were refractory to medical management in 74 % of reported cases (17/23). ES were symmetric in 17/21 (81 %) and asymmetric in 4/21 (19 %) specified cases. Hypsarrhythmia pattern was asymmetric in 10/20 (50 %) specified cases. Of 21 surviving patients who underwent surgery, 13 (62 %) were seizure free at follow-up and only 1 (5 %) had no improvement. Developmental outcomes were available in 19/21 (90 %) surviving surgical patients and 10/19 had improvements (52 %); 6/19 had normalized development (32 %). Various tumour types were reported and a temporal or frontal location was most common. Brain tumours can cause IESS with or without clinical or EEG focality and are amenable to surgical treatment. We emphasize that the absence of focal signs should not delay surgical assessment for patients with refractory IESS and brain tumours.

脑肿瘤是婴儿癫痫痉挛综合征（IESS）的罕见病因。癫痫手术可用于肿瘤引起的难治性IESS，尽管报道有限。我们报告了一例在肿瘤切除后解决的IESS病例，并对所有报道的脑肿瘤引起IESS伴心律失常的病例进行了文献回顾。我们提出了一个10个月大的女孩耐药对称癫痫痉挛（ES）。最初的脑电图显示对称性心律失常，脑部MRI显示左侧颞叶肿瘤。尽管非局灶性临床和脑电图发现，她在21个月时接受了肿瘤切除术（神经节神经胶质瘤）。随后，她的ES和心律失常得到了缓解，并取得了发育进展。回顾了27例已发表的脑肿瘤和IESS病例。报告病例中有74%（17/23）的ES对药物治疗难治性。17/21例（81%）ES是对称的，4/21例（19%）是非对称的。10/20（50%）病例心律失常模式不对称。在21名接受手术的存活患者中，13名（62%）在随访时没有癫痫发作，只有1名（5%）没有好转。19/21（90%）存活的手术患者有发育结局，10/19有改善（52%）；6/19的发展正常化（32%）。不同类型的肿瘤被报道，颞部或额部最常见。脑肿瘤可引起IESS，伴或不伴临床或脑电图病灶，可手术治疗。我们强调，灶性征象的缺失不应延迟难治性IESS和脑肿瘤患者的手术评估。

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引用次数: 0