Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1459
Burhan Ma’arif, S. Suryanto, Arianti Lestari, Asna Defi Batrisyia
Curcumin is a compound from the turmeric rhizome plant (Curcuma longa), which has immunostimulating activity. This activity has been tested pre-clinically in vitro, in vivo, and in silico. It can be used as raw material for drugs in the development of new drugs to prevent the SARS-CoV 2 virus. The purpose of this study was to examine the immunostimulatory activity of turmeric in vitro, in vivo, and in silico and to explore the mechanism of curcumin compounds as immunostimulants. The method used in this systematic review is Systematic-Meta Analysis by identifying articles from several journal databases (Google Scholar, ResearchGate, ScienceDirect, and Garuda Dikti). Furthermore, the article selection process used a PRISMA guideline flow chart. This process found 15 articles as the main reference, five articles containing in vitro research, five in vivo, and five in silico from the turmeric rhizome plant. In vitro, preclinical tests show that curcumin compounds have an immunostimulating effect characterized by the occurrence of proliferation and activation in several types of immune system cells. In vivo study was proven by increased phagocytic activity and increased leukocyte production in experimental animals. Whereas in silico was demonstrated by the binding of various SARS-CoV 2 receptors.
{"title":"Systematic Review: Potential of Curcumin Compounds as Immunostimulants in the Prevention of SARS-CoV 2 Virus","authors":"Burhan Ma’arif, S. Suryanto, Arianti Lestari, Asna Defi Batrisyia","doi":"10.18860/planar.v1i0.1459","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1459","url":null,"abstract":"Curcumin is a compound from the turmeric rhizome plant (Curcuma longa), which has immunostimulating activity. This activity has been tested pre-clinically in vitro, in vivo, and in silico. It can be used as raw material for drugs in the development of new drugs to prevent the SARS-CoV 2 virus. The purpose of this study was to examine the immunostimulatory activity of turmeric in vitro, in vivo, and in silico and to explore the mechanism of curcumin compounds as immunostimulants. The method used in this systematic review is Systematic-Meta Analysis by identifying articles from several journal databases (Google Scholar, ResearchGate, ScienceDirect, and Garuda Dikti). Furthermore, the article selection process used a PRISMA guideline flow chart. This process found 15 articles as the main reference, five articles containing in vitro research, five in vivo, and five in silico from the turmeric rhizome plant. In vitro, preclinical tests show that curcumin compounds have an immunostimulating effect characterized by the occurrence of proliferation and activation in several types of immune system cells. In vivo study was proven by increased phagocytic activity and increased leukocyte production in experimental animals. Whereas in silico was demonstrated by the binding of various SARS-CoV 2 receptors. \u0000","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115835110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1452
Abdul Hakim, Novia Maulina, A. Syahrir, Qoyyimatul Bayyinah
The development of drug production is relatively rapid, causing several drugs that have almost the same shape, name, and packaging. This can cause medication errors in the form of errors in administering drugs to patients. Drugs that are nearly the same shape and name are known as LASA (Look Alike Sound Alike) drugs. This study aimed to determine the profile of the LASA drug storage and service system at pharmacies in Besuki District, Situbondo Regency. This research includes qualitative research through in-depth interviews and direct observation. The sample used in this study is a saturated sample. The results showed that the LASA drug storage system in pharmacies throughout Besuki District, Situbondo Regency only implemented a system of giving the distance between drugs one and other drugs, while other provisions for storing Lasa drugs were not carried out. The LASA drug service system is carried out by conducting double checks, memorizing various LASA drugs, and contacting doctors to clarify prescriptions for LASA drugs. Based on these results, it can be concluded that pharmacies in Besuki District, Situbondo Regency, do not meet the criteria in the LASA drug storage system. Meanwhile, in the LASA drug service system, pharmacies throughout Besuki District, Situbondo Regency have met the requirements for LASA drug services.
{"title":"Profile of Storage System of LASA Drug Services in a Pharmacy, Besuki District, Situbondo Regency","authors":"Abdul Hakim, Novia Maulina, A. Syahrir, Qoyyimatul Bayyinah","doi":"10.18860/planar.v1i0.1452","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1452","url":null,"abstract":"The development of drug production is relatively rapid, causing several drugs that have almost the same shape, name, and packaging. This can cause medication errors in the form of errors in administering drugs to patients. Drugs that are nearly the same shape and name are known as LASA (Look Alike Sound Alike) drugs. This study aimed to determine the profile of the LASA drug storage and service system at pharmacies in Besuki District, Situbondo Regency. This research includes qualitative research through in-depth interviews and direct observation. The sample used in this study is a saturated sample. The results showed that the LASA drug storage system in pharmacies throughout Besuki District, Situbondo Regency only implemented a system of giving the distance between drugs one and other drugs, while other provisions for storing Lasa drugs were not carried out. The LASA drug service system is carried out by conducting double checks, memorizing various LASA drugs, and contacting doctors to clarify prescriptions for LASA drugs. Based on these results, it can be concluded that pharmacies in Besuki District, Situbondo Regency, do not meet the criteria in the LASA drug storage system. Meanwhile, in the LASA drug service system, pharmacies throughout Besuki District, Situbondo Regency have met the requirements for LASA drug services.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116043181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1453
Bella Corry Jayati, R. Annisa, Alif Firman Firdausy, D. Megawati, B. Fauziyah
Virgin Coconut Oil (VCO) is one of the natural ingredients used as antioxidants because of the high saturated fatty acids that cause VCO to be resistant to oxidation. In this research, a combination of zinc oxide (ZnO) and titanium dioxide (TiO2) sunscreen cream formulation was carried out with the addition of VCO as an antioxidant. The purpose of this study was to determine the effect of adding VCO to physical stability and SPF values of sunscreen cream combination of zinc oxide (ZnO) and titanium dioxide (TiO2). Sunscreen cream made 5 formulas, namely F1 (7% VCO), F2 (8% VCO), F3 (ZnO + TiO2), F4 (ZnO + TiO2 + VCO 7%) and F5 (ZnO + TiO2 + VCO 8%). The results showed that sunscreen cream formulas 1,2,4, and 5 had good physical-chemical characteristics and were stable during the storage period. While formula 3 produces white cast and is unstable in storage with temperature changes. The formula for sunscreen cream that produces the best SPF value is F5 (ZnO + TiO2 + VCO 8%) with the ultra protection type.
{"title":"Effect of Addition Virgin Coconut Oil (VCO) on Physical Stability and SPF Value of Sunscreen Cream Combination of Zinc Oxide and Titanium Dioxide","authors":"Bella Corry Jayati, R. Annisa, Alif Firman Firdausy, D. Megawati, B. Fauziyah","doi":"10.18860/planar.v1i0.1453","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1453","url":null,"abstract":"Virgin Coconut Oil (VCO) is one of the natural ingredients used as antioxidants because of the high saturated fatty acids that cause VCO to be resistant to oxidation. In this research, a combination of zinc oxide (ZnO) and titanium dioxide (TiO2) sunscreen cream formulation was carried out with the addition of VCO as an antioxidant. The purpose of this study was to determine the effect of adding VCO to physical stability and SPF values of sunscreen cream combination of zinc oxide (ZnO) and titanium dioxide (TiO2). Sunscreen cream made 5 formulas, namely F1 (7% VCO), F2 (8% VCO), F3 (ZnO + TiO2), F4 (ZnO + TiO2 + VCO 7%) and F5 (ZnO + TiO2 + VCO 8%). The results showed that sunscreen cream formulas 1,2,4, and 5 had good physical-chemical characteristics and were stable during the storage period. While formula 3 produces white cast and is unstable in storage with temperature changes. The formula for sunscreen cream that produces the best SPF value is F5 (ZnO + TiO2 + VCO 8%) with the ultra protection type.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125203111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1497
Yen yen Ari Indrawijaya, S. Sumarno, W. Suryaningtyas, N. Husna
Hydrocephalus is a condition characterized by a dynamic imbalance between formation and absorption of cerebrospinal fluid that increases the size of intracranial space of the brain and, in some situations, an extension of the outer space of the brain with or without increased ventricular size. This study aimed to examine the use of diuretics and identify drug therapy problems in hospitalized children with hydrocephalus through the medical record. The study design is observational retrospective with time-limited sampling based on data in medical records at 2010-2013 periods, found 17 of 70 patients using diuretics therapy. There are three categories of diuretic which are used were mannitol (70.6%), acetazolamide (23.5%), and a combination of mannitol and acetazolamide (5.9%). Diuretics can be used for pre-op, post-op, and pre & post-op on all types of hydrocephalus. Still, the specific use of diuretics may be caused by variations in comorbid diagnoses, clinical data, and laboratory data for each patient. Adverse drug reactions are potentially dominant in DTP analysis, and these are 7 of 17 patients. Monitoring of serum electrolytes such as sodium and potassium is needed because it decreases are potential adverse drug reactions of diuretics.
{"title":"Drug Utilization Study of Diuretics in Children with Hydrocephalus","authors":"Yen yen Ari Indrawijaya, S. Sumarno, W. Suryaningtyas, N. Husna","doi":"10.18860/planar.v1i0.1497","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1497","url":null,"abstract":"Hydrocephalus is a condition characterized by a dynamic imbalance between formation and absorption of cerebrospinal fluid that increases the size of intracranial space of the brain and, in some situations, an extension of the outer space of the brain with or without increased ventricular size. This study aimed to examine the use of diuretics and identify drug therapy problems in hospitalized children with hydrocephalus through the medical record. The study design is observational retrospective with time-limited sampling based on data in medical records at 2010-2013 periods, found 17 of 70 patients using diuretics therapy. There are three categories of diuretic which are used were mannitol (70.6%), acetazolamide (23.5%), and a combination of mannitol and acetazolamide (5.9%). Diuretics can be used for pre-op, post-op, and pre & post-op on all types of hydrocephalus. Still, the specific use of diuretics may be caused by variations in comorbid diagnoses, clinical data, and laboratory data for each patient. Adverse drug reactions are potentially dominant in DTP analysis, and these are 7 of 17 patients. Monitoring of serum electrolytes such as sodium and potassium is needed because it decreases are potential adverse drug reactions of diuretics.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131453213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1456
A. P. Febriyanti, Nurshalati Tahar, Badriani Badriani, Nur Syamsi Dhuha, Munifah Wahyudin, Khaerani Khaerani, Dwi Wahyuni Leboe
The main problems in geriatric patients with type 2 diabetes mellitus are polypharmacy and poor medication adherence, leading to increased morbidity and mortality. This study aims to compare the effectiveness of pillbox versus medication reminder charts in improving medication adherence among geriatric patients with Type 2 Diabetes Mellitus. The design of this study is an experimental, randomized controlled trial-pre test-post test control group design. The study subjects were geriatric patients with type 2 Diabetes Mellitus, conducted by random application technique. The study complied with all clinical research requirements by the Declaration of Helsinki. Ethics committee approval was obtained from UIN Alauddin Makassar. The instrument used in questionnaires to measure patients’ medication adherence using MMAS-8 and WHOQOL-BREEF to measure patients’ quality of life has been tested for validity and reliability. The result shows that pillbox can improve medication adherence (P=0,03) and improve quality of life (P=0,60); WHOQOL-BREEF questionnaire score of patients with pillbox intervention was increased 13.7619 while the WHOQOL-BREEF questionnaire score of patients with medication chart intervention was increased by 1.1402. The pillbox is the best tool in improving medication adherence and quality of life among geriatric patients with type 2 Diabetes Mellitus.
{"title":"A Comparative Study to Enhance Medication Adherence: Pillbox vs Medication Reminder Chart","authors":"A. P. Febriyanti, Nurshalati Tahar, Badriani Badriani, Nur Syamsi Dhuha, Munifah Wahyudin, Khaerani Khaerani, Dwi Wahyuni Leboe","doi":"10.18860/planar.v1i0.1456","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1456","url":null,"abstract":"The main problems in geriatric patients with type 2 diabetes mellitus are polypharmacy and poor medication adherence, leading to increased morbidity and mortality. This study aims to compare the effectiveness of pillbox versus medication reminder charts in improving medication adherence among geriatric patients with Type 2 Diabetes Mellitus. The design of this study is an experimental, randomized controlled trial-pre test-post test control group design. The study subjects were geriatric patients with type 2 Diabetes Mellitus, conducted by random application technique. The study complied with all clinical research requirements by the Declaration of Helsinki. Ethics committee approval was obtained from UIN Alauddin Makassar. The instrument used in questionnaires to measure patients’ medication adherence using MMAS-8 and WHOQOL-BREEF to measure patients’ quality of life has been tested for validity and reliability. The result shows that pillbox can improve medication adherence (P=0,03) and improve quality of life (P=0,60); WHOQOL-BREEF questionnaire score of patients with pillbox intervention was increased 13.7619 while the WHOQOL-BREEF questionnaire score of patients with medication chart intervention was increased by 1.1402. The pillbox is the best tool in improving medication adherence and quality of life among geriatric patients with type 2 Diabetes Mellitus.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114079853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1461
Burhan Ma’arif, F. A. Muslikh, Destiya Argo Pamuji Fihuda, S. Syarifuddin, B. Fauziyah
Women who experience menopause will experience estrogen deficiency, which will impact their health, one of which will increase the risk of neurodegenerative. Phytoestrogen compounds in Marsilea crenata can provide activity after binding to their receptors or ER-dependent pathways. The research was conducted in silico with the molecular docking method using the ERα (1A52) receptor. In silico analysis was carried out on the metabolite profiling compound of the 96% ethanol extract of M. crenata leaves from the previous study. Sample preparation was carried out using the Biovia Discovery Studio 2021 application to separate macromolecules and native ligands and prepared to get a 3D structure using ChemDraw Ultra 12.0. then analyzed its pharmacokinetics and pharmacodynamics with the SwissADME webtool. Furthermore, the geometry of the compound was optimized using Avogadro 1.0.1, and molecular docking of the compound to the 1A52 receptor was carried out using Autodock vina (PyRx 0.8). The interaction visualization stage was carried out with Biovia Discovery Studio 2021, and a toxicity test was carried out using the ProTox II online tool. The results of the in-silico study showed that six compounds met the pharmacokinetic and pharmacodynamic criteria, toxicity, and had similar pharmacophore distances and amino acid binding with native 17β-estradiol, a 1A52 agonist with anti-neuroinflammatory effect. So, 96% ethanol extract of M. crenata leaves is predicted to potentially inhibit PD progression with an anti-neuroinflammatory mechanism.
经历更年期的女性会经历雌激素缺乏，这会影响她们的健康，其中之一会增加神经退行性疾病的风险。马蹄莲植物雌激素化合物在与其受体或er依赖途径结合后可提供活性。本研究采用ERα (1A52)受体的分子对接方法在硅片上进行。对前人研究中提取的水仙叶96%乙醇提取物的代谢物谱化合物进行了硅晶分析。使用Biovia Discovery Studio 2021应用程序进行样品制备，分离大分子和天然配体，并使用ChemDraw Ultra 12.0准备获得3D结构。然后利用SwissADME网络工具分析其药代动力学和药效学。此外，利用Avogadro 1.0.1优化化合物的几何结构，并利用Autodock vina (PyRx 0.8)进行化合物与1A52受体的分子对接。交互可视化阶段使用Biovia Discovery Studio 2021进行，毒性测试使用ProTox II在线工具进行。结果表明，6个化合物符合药代动力学和药效学标准，毒性，药效团距离和氨基酸结合与天然17β-雌二醇相似，17β-雌二醇是一种具有抗神经炎症作用的1A52激动剂。因此，96%乙醇提取物可通过抗神经炎症机制抑制帕金森病的进展。
{"title":"Prediction of Compounds from 96% Ethanol Extract of Marsilea crenata Presl. Leaves in Increasing Estrogen Receptor-α Activation","authors":"Burhan Ma’arif, F. A. Muslikh, Destiya Argo Pamuji Fihuda, S. Syarifuddin, B. Fauziyah","doi":"10.18860/planar.v1i0.1461","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1461","url":null,"abstract":"Women who experience menopause will experience estrogen deficiency, which will impact their health, one of which will increase the risk of neurodegenerative. Phytoestrogen compounds in Marsilea crenata can provide activity after binding to their receptors or ER-dependent pathways. The research was conducted in silico with the molecular docking method using the ERα (1A52) receptor. In silico analysis was carried out on the metabolite profiling compound of the 96% ethanol extract of M. crenata leaves from the previous study. Sample preparation was carried out using the Biovia Discovery Studio 2021 application to separate macromolecules and native ligands and prepared to get a 3D structure using ChemDraw Ultra 12.0. then analyzed its pharmacokinetics and pharmacodynamics with the SwissADME webtool. Furthermore, the geometry of the compound was optimized using Avogadro 1.0.1, and molecular docking of the compound to the 1A52 receptor was carried out using Autodock vina (PyRx 0.8). The interaction visualization stage was carried out with Biovia Discovery Studio 2021, and a toxicity test was carried out using the ProTox II online tool. The results of the in-silico study showed that six compounds met the pharmacokinetic and pharmacodynamic criteria, toxicity, and had similar pharmacophore distances and amino acid binding with native 17β-estradiol, a 1A52 agonist with anti-neuroinflammatory effect. So, 96% ethanol extract of M. crenata leaves is predicted to potentially inhibit PD progression with an anti-neuroinflammatory mechanism.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115258546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1455
R. Annisa, Alif Firman Firdausy, Ihda Mahila Alawiyah, Farianda Reformasiska
Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a thermodynamically stable drug administration unit with the capacity to increase the solubility of active pharmaceutical ingredients (API) and bioavailability. In addition, dayak onion extract is an active ingredient developed to increase the effectiveness of therapy. The aims to formulate, characterize, and investigate stability. Moreover, the HLB approach was used to formulate SNEDDS from dayak onion extract, with a component ratio of palm oil, a combination of surfactants (hydrophilic Tween 80, Tween 20) and lipophilic (Span 20 and Transcutol) and PEG 400 as co-surfactants. A total of sixty formulas were used, with an HLB range of 11-15 and a ratio of 1:8:1, 1:7:2, and 2:7:1, followed by evaluating product characteristics. Furthermore, two formulas were selected, including F13 (HLB 13) and F34 (HLB 14), at ratios 1:8:1 and 1:7:2. The results showed particle size ranging from 10-200 nm, percent transmittance of <90%, while the viscosity and pH values were stable at various dilutions. The evaluation for thermodynamics indicates an unstable preparation. Therefore, the SNEDDS formula of dayak onion extract using long-chain triglycerides (palm oil) was ineffective.
{"title":"Formulation and Characterization of SNEDDS of Dayak Onion Extract with Comparative Variations of Surfactants, Co-Surfactants, and Palm Oil","authors":"R. Annisa, Alif Firman Firdausy, Ihda Mahila Alawiyah, Farianda Reformasiska","doi":"10.18860/planar.v1i0.1455","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1455","url":null,"abstract":"Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a thermodynamically stable drug administration unit with the capacity to increase the solubility of active pharmaceutical ingredients (API) and bioavailability. In addition, dayak onion extract is an active ingredient developed to increase the effectiveness of therapy. The aims to formulate, characterize, and investigate stability. Moreover, the HLB approach was used to formulate SNEDDS from dayak onion extract, with a component ratio of palm oil, a combination of surfactants (hydrophilic Tween 80, Tween 20) and lipophilic (Span 20 and Transcutol) and PEG 400 as co-surfactants. A total of sixty formulas were used, with an HLB range of 11-15 and a ratio of 1:8:1, 1:7:2, and 2:7:1, followed by evaluating product characteristics. Furthermore, two formulas were selected, including F13 (HLB 13) and F34 (HLB 14), at ratios 1:8:1 and 1:7:2. The results showed particle size ranging from 10-200 nm, percent transmittance of <90%, while the viscosity and pH values were stable at various dilutions. The evaluation for thermodynamics indicates an unstable preparation. Therefore, the SNEDDS formula of dayak onion extract using long-chain triglycerides (palm oil) was ineffective.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123813024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1460
Burhan Ma’arif, F. A. Muslikh, Luqman Alfani Najib, Ria Ramadhani Dwi Atmaja, Meilina Ratna Dianti
Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogens are emerging as potential estrogen alternatives with minimal side effects. This study aimed to predict the antiosteoporosis activity of the compounds from 96% ethanol extract of Chyrsophyllum cainito L. leaves through in silico study on 3OLS protein, an X-ray protein of ERβ. In silico analysis was carried out on the compounds from metabolite profiling results of 96% ethanol extract of C. cainito leaves from previous studies. The structure of compounds resulting from metabolite profiling of 96% ethanol extract of C. cainito leaves was made using Avogadro 1.0.1 software, geometry optimization with Chemdraw molecular docking was carried out using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2021 software was used to visualize the structure of compounds against 3OLS proteins. The physicochemical characteristics of the compounds were analyzed using the SwissADME webtool. From the result, it was known that there were seven compounds in the leaves of C. cainito, which were suspected to be phytoestrogens that had ERβ agonist properties against 3OLS protein. It was an ERβ agonist because the compound had similar parameters to 17β-estradiol in its interaction with the 3OLS protein, which had a pharmacophore distance of about 10,862, and bound to the amino acids His 475 and Glu 305 or Arg 346. The 96% ethanol extract of C. cainito leaves contained seven compounds thought to be phytoestrogen with an ERβ agonist that handled its antiosteoporosis activity.
{"title":"In Silico Antiosteoporosis Activity of 96% Ethanol Extract of Chrysophyllum cainito L. Leaves","authors":"Burhan Ma’arif, F. A. Muslikh, Luqman Alfani Najib, Ria Ramadhani Dwi Atmaja, Meilina Ratna Dianti","doi":"10.18860/planar.v1i0.1460","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1460","url":null,"abstract":"Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogens are emerging as potential estrogen alternatives with minimal side effects. This study aimed to predict the antiosteoporosis activity of the compounds from 96% ethanol extract of Chyrsophyllum cainito L. leaves through in silico study on 3OLS protein, an X-ray protein of ERβ. In silico analysis was carried out on the compounds from metabolite profiling results of 96% ethanol extract of C. cainito leaves from previous studies. The structure of compounds resulting from metabolite profiling of 96% ethanol extract of C. cainito leaves was made using Avogadro 1.0.1 software, geometry optimization with Chemdraw molecular docking was carried out using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2021 software was used to visualize the structure of compounds against 3OLS proteins. The physicochemical characteristics of the compounds were analyzed using the SwissADME webtool. From the result, it was known that there were seven compounds in the leaves of C. cainito, which were suspected to be phytoestrogens that had ERβ agonist properties against 3OLS protein. It was an ERβ agonist because the compound had similar parameters to 17β-estradiol in its interaction with the 3OLS protein, which had a pharmacophore distance of about 10,862, and bound to the amino acids His 475 and Glu 305 or Arg 346. The 96% ethanol extract of C. cainito leaves contained seven compounds thought to be phytoestrogen with an ERβ agonist that handled its antiosteoporosis activity.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114722663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1458
R. Mutiah, Humaira Ramzi, Jesi Aulia Bustami
The high prevalence of cancer in the world makes many researchers look for alternative therapies that can be used to treat cancer. One of them is by using traditional plants, namely Calotropis gigantea R.Br. This is due to alkaloids, glycosides, and tannins in plants that function as anticancer. The purpose of this study was to dig deeper into information related to the phytochemistry and pharmacology effect of Calotropis gigantea as an anticancer therapy and can be used as a reference for the development of traditional medicines. The method used is PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses), with inclusion and exclusion criteria, 11 articles were selected for review. The results showed that Calotropis Gigantea contains Calotropin, Calotroposide A, oxypregnane oligoglycoside compounds, which inhibit cancer cell growth through the mechanism of apoptosis induction and ROS inhibition. From this systematic review, it can be recommended that the plant Calotropis gigantea can be further developed into standardized herbal medicine and phytopharmaceuticals.
世界上癌症的高发病率使得许多研究人员寻找可用于治疗癌症的替代疗法。其中一种是利用传统植物，即卡罗通斯·吉安特茶。这是由于植物中的生物碱、糖苷和单宁具有抗癌作用。本研究旨在深入挖掘巨茶甘露的植物化学和药理抗癌作用的相关信息，为中药开发提供参考。采用PRISMA (Preferred Reporting Items for Systematic Reviews and meta - analysis)方法，按照纳入和排除标准，共选择11篇文章进行综述。结果表明，巨茶卡罗tropis含有卡罗tropin、卡罗troposide A、氧孕烷寡糖苷类化合物，通过诱导凋亡和抑制ROS的机制抑制癌细胞生长。通过对该植物的系统评价，建议将巨角甘露进一步开发为标准化的中草药和植物药。
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Pub Date : 2021-12-05DOI: 10.18860/planar.v1i0.1457
R. Mutiah, Alpionita Marsyah, Azian Firman Saputra
Chrysanthemum sp. is a plant often used by the community as an ornamental plant, drink, and traditional medicine. This study aims to examine the plant Chrysanthemum sp. from the aspect of phytochemical and pharmacological activity. The review method used in this study is the PRISMA method. Sources of data obtained using databases electronic from PubMed and Google Scholar. This review shows that plants Chrysanthemum sp. have phytochemical and pharmacological potential. The compounds contained in theplant Chrysanthemum sp. are morphine, genistein, hydantoin, limonene, g-terpinene, a-pinene, a-terpenyl acetate, 4-terpenyl acetate, a-calacorene, a-cedrene, b-bourbobene, elemol, 2- hexenal, and orphenadrine. Chrysanthemum sp. plants have anticancer, antibacterial, antioxidant, antifungal, analgesic, anti-inflammatory, and anticonsulvan activities.
{"title":"Systematic Review: Phytochemical Content and Pharmacological Effects of Chrysanthemum sp.","authors":"R. Mutiah, Alpionita Marsyah, Azian Firman Saputra","doi":"10.18860/planar.v1i0.1457","DOIUrl":"https://doi.org/10.18860/planar.v1i0.1457","url":null,"abstract":"Chrysanthemum sp. is a plant often used by the community as an ornamental plant, drink, and traditional medicine. This study aims to examine the plant Chrysanthemum sp. from the aspect of phytochemical and pharmacological activity. The review method used in this study is the PRISMA method. Sources of data obtained using databases electronic from PubMed and Google Scholar. This review shows that plants Chrysanthemum sp. have phytochemical and pharmacological potential. The compounds contained in theplant Chrysanthemum sp. are morphine, genistein, hydantoin, limonene, g-terpinene, a-pinene, a-terpenyl acetate, 4-terpenyl acetate, a-calacorene, a-cedrene, b-bourbobene, elemol, 2- hexenal, and orphenadrine. Chrysanthemum sp. plants have anticancer, antibacterial, antioxidant, antifungal, analgesic, anti-inflammatory, and anticonsulvan activities.","PeriodicalId":365916,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132854042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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