Pub Date : 2018-11-07DOI: 10.17650/2222-1468-2018-8-3-53-60
Andrew G. Gianoukakis, Corina E. Dutcus, N. Batty, Matthew Guo, Mahadi Ali Baig
We present an updated analysis of lenvatinib in radioiodine-refractory differentiated thyroid cancer (RR-DTC) with new duration of response (DOR) data unavailable for the primary analysis. In this randomized, double-blind, multicenter, placebo-controlled phase 3 study, patients ≥18 years old with measurable, pathologically confirmed RR-DTC with independent radiologic confirmation of disease progression within the previous 13 months were randomized 2:1 to oral lenvatinib 24 mg/day or placebo. The main outcome measures for this analysis are DOR and progression-free survival (PFS). The median DOR for all lenvatinib responders (patients with complete or partial responses; objective response rate: 60.2 %; 95 % confidence interval (CI) 54.2–66.1) was 30.0 months (95 % CI 18.4–36.7) and was generally similar across subgroups. DOR was shorter in patients with greater disease burden and with brain and liver metastases. Updated median PFS was longer in the overall lenvatinib group vs placebo (19.4 vs 3.7 months; hazard ratio (HR) 0.24; 99 % CI 0.17–0.35; nominal P <0.0001). In lenvatinib responders, median PFS was 33.1 months (95 % CI 27.8–44.6) vs 7.9 months (95 % CI 5.8–10.7) in nonresponders. The median DOR of 30.0 months seen with patients who achieved complete or partial responses with lenvatinib (60.2 %) demonstrates that lenvatinib responders can have prolonged, durable and clinically meaningful responses. Prolonged PFS (33.1 months) was also observed in these lenvatinib responders.
{"title":"Увеличенная длительность ответа на терапию ленватинибом у пациентов с раком щитовидной железы","authors":"Andrew G. Gianoukakis, Corina E. Dutcus, N. Batty, Matthew Guo, Mahadi Ali Baig","doi":"10.17650/2222-1468-2018-8-3-53-60","DOIUrl":"https://doi.org/10.17650/2222-1468-2018-8-3-53-60","url":null,"abstract":"We present an updated analysis of lenvatinib in radioiodine-refractory differentiated thyroid cancer (RR-DTC) with new duration of response (DOR) data unavailable for the primary analysis. In this randomized, double-blind, multicenter, placebo-controlled phase 3 study, patients ≥18 years old with measurable, pathologically confirmed RR-DTC with independent radiologic confirmation of disease progression within the previous 13 months were randomized 2:1 to oral lenvatinib 24 mg/day or placebo. The main outcome measures for this analysis are DOR and progression-free survival (PFS). The median DOR for all lenvatinib responders (patients with complete or partial responses; objective response rate: 60.2 %; 95 % confidence interval (CI) 54.2–66.1) was 30.0 months (95 % CI 18.4–36.7) and was generally similar across subgroups. DOR was shorter in patients with greater disease burden and with brain and liver metastases. Updated median PFS was longer in the overall lenvatinib group vs placebo (19.4 vs 3.7 months; hazard ratio (HR) 0.24; 99 % CI 0.17–0.35; nominal P <0.0001). In lenvatinib responders, median PFS was 33.1 months (95 % CI 27.8–44.6) vs 7.9 months (95 % CI 5.8–10.7) in nonresponders. The median DOR of 30.0 months seen with patients who achieved complete or partial responses with lenvatinib (60.2 %) demonstrates that lenvatinib responders can have prolonged, durable and clinically meaningful responses. Prolonged PFS (33.1 months) was also observed in these lenvatinib responders.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"8 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49067324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-07DOI: 10.17650/2222-1468-2018-8-3-61-71
F. Carta, A. Figus, N. Chuchueva, Daniela Quartu, G. Sambiagio, R. Loche, C. Gerosa, R. Puxeddu
The study objective is to evaluate the utilisation and effectiveness of intensive care unit (ICU) in the postoperative period as to its potential benefits to the head and neck reconstruction services. Materials and methods . This is a retrospective study on 143 consecutive patients who underwent 144 major head and neck microvascular reconstructive procedures performed by a single surgeon, that focused on perioperative management and on the relation between admission to ICU and complications/outcomes. Results. Thirty-four (23.6 %) patients were admitted to ICU during the early postoperative period. Admission to ICU was not associated with lower incidence of complications compared to direct admission to the Head and Neck ward: 29.4 % vs 27.3 % (p = 0.807709). Conclusion. Routinely early postoperative admission to ICU seems not to improve outcomes and/or reduce complications, and, as a consequence, ICU admission should be restricted to selected patients only.
本研究的目的是评估重症监护病房(ICU)在术后期间的使用和有效性，以及其对头颈部重建服务的潜在益处。材料和方法。这是一项回顾性研究，对连续143例患者进行了144次头颈部微血管重建术，由一名外科医生进行，重点是围手术期管理和ICU入院与并发症/结果的关系。结果。34例(23.6%)患者在术后早期入住ICU。与直接入住头颈病房相比，入住ICU与更低的并发症发生率无关:29.4% vs 27.3% (p = 0.807709)。结论。常规的术后早期ICU住院似乎不能改善预后和/或减少并发症，因此，ICU住院应仅限于选定的患者。
{"title":"The effect of admission to intensive care unit on outcomes and complication rates after head and neck reconstruction","authors":"F. Carta, A. Figus, N. Chuchueva, Daniela Quartu, G. Sambiagio, R. Loche, C. Gerosa, R. Puxeddu","doi":"10.17650/2222-1468-2018-8-3-61-71","DOIUrl":"https://doi.org/10.17650/2222-1468-2018-8-3-61-71","url":null,"abstract":"The study objective is to evaluate the utilisation and effectiveness of intensive care unit (ICU) in the postoperative period as to its potential benefits to the head and neck reconstruction services. Materials and methods . This is a retrospective study on 143 consecutive patients who underwent 144 major head and neck microvascular reconstructive procedures performed by a single surgeon, that focused on perioperative management and on the relation between admission to ICU and complications/outcomes. Results. Thirty-four (23.6 %) patients were admitted to ICU during the early postoperative period. Admission to ICU was not associated with lower incidence of complications compared to direct admission to the Head and Neck ward: 29.4 % vs 27.3 % (p = 0.807709). Conclusion. Routinely early postoperative admission to ICU seems not to improve outcomes and/or reduce complications, and, as a consequence, ICU admission should be restricted to selected patients only.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"8 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48265550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-22DOI: 10.17650/2222-1468-2016-6-2-60-64
Рамил Суфиахметович Гараев, Л. Н. Залялютдинова, В. Р. Гильмутдинова, Р. Ш. Хасанов
It has been held studying of the remote results of treatment of 80 patients sick of a bazalioma by 30 % glyciphon ointment in the Republican Oncologic Dispensary of the Ministry of Health of Republic of Tatarstan. It is established that daily use of glyciphon ointment during the 20– 30 days cures patients with primary tumours, both single, and initially-plural I and II stages, in 98,3 % cases. The preparation is effective at recidivations of bazalioma arising after radiotherapy, surgical treatment, criotherapy. The using at recidivations after the combined treatment is inexpedient. Reduction of an exposition of ointment from 24 hours till 6 hours gives good clinical effect with absence of relapses of recidivations of tumors.
{"title":"Glycifon ointment for basal cell carcinoma: treatment experience","authors":"Рамил Суфиахметович Гараев, Л. Н. Залялютдинова, В. Р. Гильмутдинова, Р. Ш. Хасанов","doi":"10.17650/2222-1468-2016-6-2-60-64","DOIUrl":"https://doi.org/10.17650/2222-1468-2016-6-2-60-64","url":null,"abstract":"It has been held studying of the remote results of treatment of 80 patients sick of a bazalioma by 30 % glyciphon ointment in the Republican Oncologic Dispensary of the Ministry of Health of Republic of Tatarstan. It is established that daily use of glyciphon ointment during the 20– 30 days cures patients with primary tumours, both single, and initially-plural I and II stages, in 98,3 % cases. The preparation is effective at recidivations of bazalioma arising after radiotherapy, surgical treatment, criotherapy. The using at recidivations after the combined treatment is inexpedient. Reduction of an exposition of ointment from 24 hours till 6 hours gives good clinical effect with absence of relapses of recidivations of tumors.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"6 1","pages":"60-64"},"PeriodicalIF":0.0,"publicationDate":"2016-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67775560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-30DOI: 10.17650/2222-1468-2016-6-1-46-54
A. Shabunin, D. Dolidze, S. Podvyaznikov, K. Mel’nik, R. Mumladze, A. Vardanyan, I. N. Lebedinskiy, Z. A. Bagateliya, N. N. Gogitidze
Background. In the year 2014 in Russia there were about 10 thousand patients with newly diagnosed thyroid cancer (TC), the bulk of which need surgical treatment. Currently, special requirements to the quality of surgical intervention, which is determined by the radicalness, minimum number of complications and a good cosmetic result. Materials and methods. In this paper we present the treatment results of 76 patients with differentiated TC, who received surgical treatment at S.P. Botkin City Clinical Hospital in 2012–2015. All patients underwent an extrafascial operation under general anesthesia in volume thyroidectomy with central lymph node dissection. The operation was carried out with reduced low-traumatic approach length 4–5 sm in front the neck without crossing prelaringeal muscules. For prophylaxis of laryngeal paresis, visualization and indenification laryngeal nerves were performed, with using magnifying devices and neuromyography. To prevent the development of hypoparathyroidism, visualization and preservation of the parathyroid glands was also conducted. To this end, among other measures, a photodynamic method of parathyroid gland visualization using a photosensitizer, a blue light source and local spectroscopy was employed. Results. In the postoperative period, there were 3 (3.9 %) cases of transient hypoparathyroidism. On the scale of intervention POSAS (Patient and observer scar assessment scale) 68 (89.5 %) patient was recognized as a excellent, and 8 (10.5 %) as good. Conclusion. Thus, thyroidectomy and central neck dissection with reduced low-traumatic approach using the suggested methodological approaches gives completeness of our surgical intervention, possibility to avoid the development of permanent specific complications, and better functional and aesthetic results.
背景。2014年，俄罗斯约有1万名新诊断的甲状腺癌(TC)患者，其中大部分需要手术治疗。目前，对手术干预的质量有特殊的要求，主要取决于手术的根治性、并发症的最少性和良好的美容效果。材料和方法。本文报告2012-2015年在S.P. Botkin市临床医院接受手术治疗的76例分化型TC患者的治疗结果。所有患者均在全麻下行筋膜外手术，行甲状腺大体积切除术合并中央淋巴结清扫术。手术在颈部前方减少低创伤入路长度4-5厘米，不穿过肋前肌。为了预防喉瘫，使用放大装置和神经肌图对喉神经进行了可视化和识别。为了防止甲状旁腺功能减退症的发展，还进行了甲状旁腺的可视化和保存。为此，除其他措施外，采用光敏剂、蓝色光源和局部光谱的甲状旁腺可视化光动力学方法。结果。术后3例(3.9%)出现一过性甲状旁腺功能减退。在干预量表POSAS (Patient and observer scar assessment scale)上，68例(89.5%)评价为优，8例(10.5%)评价为良。结论。因此，采用建议的低创伤入路甲状腺切除术和中央性颈部清扫术使我们的手术干预更加完整，有可能避免永久性特定并发症的发生，并获得更好的功能和美学效果。
{"title":"Reduced low-traumatic access thyroidectomy with central neck dissection","authors":"A. Shabunin, D. Dolidze, S. Podvyaznikov, K. Mel’nik, R. Mumladze, A. Vardanyan, I. N. Lebedinskiy, Z. A. Bagateliya, N. N. Gogitidze","doi":"10.17650/2222-1468-2016-6-1-46-54","DOIUrl":"https://doi.org/10.17650/2222-1468-2016-6-1-46-54","url":null,"abstract":"Background. In the year 2014 in Russia there were about 10 thousand patients with newly diagnosed thyroid cancer (TC), the bulk of which need surgical treatment. Currently, special requirements to the quality of surgical intervention, which is determined by the radicalness, minimum number of complications and a good cosmetic result. Materials and methods. In this paper we present the treatment results of 76 patients with differentiated TC, who received surgical treatment at S.P. Botkin City Clinical Hospital in 2012–2015. All patients underwent an extrafascial operation under general anesthesia in volume thyroidectomy with central lymph node dissection. The operation was carried out with reduced low-traumatic approach length 4–5 sm in front the neck without crossing prelaringeal muscules. For prophylaxis of laryngeal paresis, visualization and indenification laryngeal nerves were performed, with using magnifying devices and neuromyography. To prevent the development of hypoparathyroidism, visualization and preservation of the parathyroid glands was also conducted. To this end, among other measures, a photodynamic method of parathyroid gland visualization using a photosensitizer, a blue light source and local spectroscopy was employed. Results. In the postoperative period, there were 3 (3.9 %) cases of transient hypoparathyroidism. On the scale of intervention POSAS (Patient and observer scar assessment scale) 68 (89.5 %) patient was recognized as a excellent, and 8 (10.5 %) as good. Conclusion. Thus, thyroidectomy and central neck dissection with reduced low-traumatic approach using the suggested methodological approaches gives completeness of our surgical intervention, possibility to avoid the development of permanent specific complications, and better functional and aesthetic results.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"6 1","pages":"46-54"},"PeriodicalIF":0.0,"publicationDate":"2016-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67775594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-30DOI: 10.17650/2222-1468-2016-6-1-68-70
Ю. Ю. Трунин, А.В. Голанов, Василь Костюченко, М.В. Галкин, Е. А. Хухлаева, А. Н. Коновалов
Piloid astrocytoma (PA) is a glioma that is most frequently encountered in children (WHO grade I). According to most authors, stereotactic radiation (radiotherapy and radiosurgery) is an effective method to control tumor growth in patients with incomplete removal of PA and its recurrence. The authors describe a clinical case of a female patient with PA of the midbrain; during the first 7 months after radiation she showed an obvious enlargement of the tumor, as evidenced by magnetic resonance imaging (MRI), with its further regression without any antitumor treatment. A follow-up of the patient and a regular evaluation of her clinical status and MRI changes, as compared to the similar clinical cases and literature data, may suggest that PA enlargement early after radiotherapy is generally pseudoprogression rather than true progression of the tumor. An understanding of this phenomenon will be able to improve the assessment of radiotherapy results in patients with PA and to rule out unnecessary antitumor treatment in this category of patients.
{"title":"Enlarged piloid astrocytoma of the midbrain: recurrence or pseudoprogression? A clinical case","authors":"Ю. Ю. Трунин, А.В. Голанов, Василь Костюченко, М.В. Галкин, Е. А. Хухлаева, А. Н. Коновалов","doi":"10.17650/2222-1468-2016-6-1-68-70","DOIUrl":"https://doi.org/10.17650/2222-1468-2016-6-1-68-70","url":null,"abstract":"Piloid astrocytoma (PA) is a glioma that is most frequently encountered in children (WHO grade I). According to most authors, stereotactic radiation (radiotherapy and radiosurgery) is an effective method to control tumor growth in patients with incomplete removal of PA and its recurrence. The authors describe a clinical case of a female patient with PA of the midbrain; during the first 7 months after radiation she showed an obvious enlargement of the tumor, as evidenced by magnetic resonance imaging (MRI), with its further regression without any antitumor treatment. A follow-up of the patient and a regular evaluation of her clinical status and MRI changes, as compared to the similar clinical cases and literature data, may suggest that PA enlargement early after radiotherapy is generally pseudoprogression rather than true progression of the tumor. An understanding of this phenomenon will be able to improve the assessment of radiotherapy results in patients with PA and to rule out unnecessary antitumor treatment in this category of patients.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"6 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2016-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67775750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-08DOI: 10.17650/2222-1468-2015-5-2-8-13
Евгений Лхамацыренович Чойнзонов, Ирина Олеговна Спивакова, М. Р. Мухамедов, Ж. А. Старцева, Ольга Черемисина, И. Г. Фролова, Денис Кульбакин, П. В. Суркова
Cancer of the larynx and laryngopharynx, which is accessible to visual and instrumental examination, remains the most relevant and complicated problem among head and neck malignances as before. Investigations show that the incidence of cancer at these sites in Russia in the last decade has risen from 4.5 to 9.67 %. This is a severe and poor prognostic form of cancer, which is characterized by its nonspecific early clinical manifestations, complex anatomic and topographic structure, and a high rate of regional metastases. The mainstay of treatment for head and neck cancer involves 3 components: surgery, chemotherapy, and radiotherapy (RT), which are performed alone or in combination. The most commonly used technique is combined, frequently crippling due to organ-removing operations. The clinical introduction of current radio modifiers, local and deep hyperthermia systems, is a promising approach to improving the results of treatment, to enhancing the radiation damage of RT, and to achieving the tumor regression sufficient for surgical intervention without augmenting the early and late toxicity inherent in chemoradiation treatment. The results of the performed study of 35 patients with T2–3N0–2M0 laryngeal and laryngopharyngeal cancer proved the high efficiency of local hyperthermia in treating malignancies in this region during both preoperative (grades III– IV therapeutic pathomorphism) and radical beam RT.
{"title":"Эффективность применения лучевой терапии на фоне локальной гипертермии в лечении рака гортани и гортаноглотки","authors":"Евгений Лхамацыренович Чойнзонов, Ирина Олеговна Спивакова, М. Р. Мухамедов, Ж. А. Старцева, Ольга Черемисина, И. Г. Фролова, Денис Кульбакин, П. В. Суркова","doi":"10.17650/2222-1468-2015-5-2-8-13","DOIUrl":"https://doi.org/10.17650/2222-1468-2015-5-2-8-13","url":null,"abstract":"Cancer of the larynx and laryngopharynx, which is accessible to visual and instrumental examination, remains the most relevant and complicated problem among head and neck malignances as before. Investigations show that the incidence of cancer at these sites in Russia in the last decade has risen from 4.5 to 9.67 %. This is a severe and poor prognostic form of cancer, which is characterized by its nonspecific early clinical manifestations, complex anatomic and topographic structure, and a high rate of regional metastases. The mainstay of treatment for head and neck cancer involves 3 components: surgery, chemotherapy, and radiotherapy (RT), which are performed alone or in combination. The most commonly used technique is combined, frequently crippling due to organ-removing operations. The clinical introduction of current radio modifiers, local and deep hyperthermia systems, is a promising approach to improving the results of treatment, to enhancing the radiation damage of RT, and to achieving the tumor regression sufficient for surgical intervention without augmenting the early and late toxicity inherent in chemoradiation treatment. The results of the performed study of 35 patients with T2–3N0–2M0 laryngeal and laryngopharyngeal cancer proved the high efficiency of local hyperthermia in treating malignancies in this region during both preoperative (grades III– IV therapeutic pathomorphism) and radical beam RT.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"5 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2015-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67774814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-19DOI: 10.17650/2222-1468-2015-1-15-18
З. А.-Г. Раджабова, Д. А. Ракитина, А. В. Гурин, Н. И. Коркола, Р. А. Нажмудинов, И. В. Дунаевский
The problem of restoring tissue defects after radical surgery for malignant tumors of the head and neck remains relevant, as there is no standardized approach for solving this problem. This article describes the various options for plastics of combined through defects of the floor of the mouth, of angle of the mouth, of the upper and lower lips, of lateral parts of the neck. The use of a particular type of arterialized flap depended on the depth and character of the existing tissue defect. The use of this methodology allowed to reach satisfactory cosmetic and functional results, as well as improve the quality of patient’s life.
{"title":"Реконструктивно-пластические операции у пациентов со злокачественными новообразованиями языка, слизистой дна полости рта, виды пластики","authors":"З. А.-Г. Раджабова, Д. А. Ракитина, А. В. Гурин, Н. И. Коркола, Р. А. Нажмудинов, И. В. Дунаевский","doi":"10.17650/2222-1468-2015-1-15-18","DOIUrl":"https://doi.org/10.17650/2222-1468-2015-1-15-18","url":null,"abstract":"The problem of restoring tissue defects after radical surgery for malignant tumors of the head and neck remains relevant, as there is no standardized approach for solving this problem. This article describes the various options for plastics of combined through defects of the floor of the mouth, of angle of the mouth, of the upper and lower lips, of lateral parts of the neck. The use of a particular type of arterialized flap depended on the depth and character of the existing tissue defect. The use of this methodology allowed to reach satisfactory cosmetic and functional results, as well as improve the quality of patient’s life.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"5 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2015-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67774995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-15DOI: 10.17650/2222-1468-2012-0-1-42-45
И. Ю. Суровцев, В. Н. Королев, К. И. Кулаев, К. С. Зуйков, А. С. Аладин
The given paper attempts to objectify the course of a tumor process in patients diagnosed as having throat cancer during radiation or chemoradiation therapy. The authors propose a diagnostic algorithm which enables one not only to see the actual extent of a tumor, but also to estimate the degree of its resorption; hence, to more accurately plan special treatment and to timely change the treatment policy.
{"title":"МОНИТОРИНГ РАКА ГОРТАНИ В ПРОЦЕССЕ СПЕЦИАЛЬНОГО ЛЕЧЕНИЯ","authors":"И. Ю. Суровцев, В. Н. Королев, К. И. Кулаев, К. С. Зуйков, А. С. Аладин","doi":"10.17650/2222-1468-2012-0-1-42-45","DOIUrl":"https://doi.org/10.17650/2222-1468-2012-0-1-42-45","url":null,"abstract":"The given paper attempts to objectify the course of a tumor process in patients diagnosed as having throat cancer during radiation or chemoradiation therapy. The authors propose a diagnostic algorithm which enables one not only to see the actual extent of a tumor, but also to estimate the degree of its resorption; hence, to more accurately plan special treatment and to timely change the treatment policy.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"1 1","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2015-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67774024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-01DOI: 10.17650/2222-1468-2012-0-2-88-91
Bill E. Cham
Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics, the efficiency of which administered via intravenous, intraperitoneal, and intratumoral routes is higher than that of many other antitumor agents. Early investigations have established the efficiency of topical BEC applications as a treatment option for non-melanoma skin cancers. There have recently been two clinical cases that count in favor of the fact that the cream formulation Curaderm containing BEC has a very high efficacy in the treatment of large non-melanoma skin cancers that are incurable by other existing methods. Also, Curaderm treatment shows a splendid cosmetic effect.
{"title":"ЛЕЧЕБНЫЙ ЭФФЕКТ СОЛАСОДИН-РАМНОЗИЛОВЫХ ГЛИКОЗИДОВ ПРИ КРУПНЫХ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЯХ КОЖИ (ДВА КЛИНИЧЕСКИХ СЛУЧАЯ)","authors":"Bill E. Cham","doi":"10.17650/2222-1468-2012-0-2-88-91","DOIUrl":"https://doi.org/10.17650/2222-1468-2012-0-2-88-91","url":null,"abstract":"Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics, the efficiency of which administered via intravenous, intraperitoneal, and intratumoral routes is higher than that of many other antitumor agents. Early investigations have established the efficiency of topical BEC applications as a treatment option for non-melanoma skin cancers. There have recently been two clinical cases that count in favor of the fact that the cream formulation Curaderm containing BEC has a very high efficacy in the treatment of large non-melanoma skin cancers that are incurable by other existing methods. Also, Curaderm treatment shows a splendid cosmetic effect.","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"111 1","pages":"88-91"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67774827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.17650/2222-1468-2015-1-8-14
E. Prozorenko, V. Karakhan, A. Bekyashev, V. Alyoshin, D. M. Belov, D. Naskhletashvili, N. V. Sevyan, A. Mitrofanov
{"title":"SURGICAL TACTICS REGARDING CEREBRAL METASTASES WITH HEMORRHAGES","authors":"E. Prozorenko, V. Karakhan, A. Bekyashev, V. Alyoshin, D. M. Belov, D. Naskhletashvili, N. V. Sevyan, A. Mitrofanov","doi":"10.17650/2222-1468-2015-1-8-14","DOIUrl":"https://doi.org/10.17650/2222-1468-2015-1-8-14","url":null,"abstract":"","PeriodicalId":36598,"journal":{"name":"Opuholi Golovy i Sei","volume":"5 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67774672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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