Pub Date : 2023-01-11DOI: 10.30629/2658-7947-2022-27-6-63-69
R. I. Isaev, E. Mkhitaryan, I. Strazhesko, N. Vorobyeva, V. S. Ostapenko, O. Tkacheva, N. Yakhno
Introduction. Oldest old are the fastest growing age group in most countries of the world, including the Russian Federation. A signifi cant part of oldest old are feel lonely, need care and live in long term care facilities (institutionalized). Disability and institutionalization are associated with an increased risk of cognitive impairment in oldest old. The cognitive status in this group has been studied insuffi ciently in Russia. Determination of diagnostic standards for cognitive functions assessment scales in oldest old is important both for clinical practice and for scientifi c research.Objective: to evaluate cognitive functions and to determine diagnostic value for various psychological tests in persons aged ≥ 90, who live in long term care facilities (LTCF).Material and methods. The persons aged ≥ 90 years that live in LTCF (boarding houses or nursing homes) in Moscow were examined. All patients passed neuropsychological examination, which included Mini-mental State Examination (MMSE), Frontal Assessment Battery (FAB), 5-word test, clock-drawing test and verbal fl uency tests. In addition, original questionnaire was used for cognitive impairment screening.Results. Dementia was found in 69% of oldest old, who live in LTCF; frontal dysfunction in 89.1% and “hippocampal type” of memory disorders in 57.5%. The results of phonemic verbal fl uency test were normal in 6.7% only and of semantic verbal fl uency test in 8.1%. For diagnosis of dementia in institutionalized subjects sensitivity of MMSE ≤ 23 points was 97% and specifi city was 90.9%. For the FAB optimal sensitivity/specifi city ratio (98/83.7%) was at score of ≤ 14. The clock-drawing test sensitivity for dementia was 91.9% and specifi city was 69.7% at total score ≤ 6 .Conclusion. Institutionalized persons aged ≥ 90 years have a high prevalence of dementia. The above mentioned tests can be used for oldest old examination. Further studies of the relationship of cognitive impairment with other geriatric disorders in oldest old are needed.
{"title":"Cognitive status in institutionalized oldest old","authors":"R. I. Isaev, E. Mkhitaryan, I. Strazhesko, N. Vorobyeva, V. S. Ostapenko, O. Tkacheva, N. Yakhno","doi":"10.30629/2658-7947-2022-27-6-63-69","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-63-69","url":null,"abstract":"Introduction. Oldest old are the fastest growing age group in most countries of the world, including the Russian Federation. A signifi cant part of oldest old are feel lonely, need care and live in long term care facilities (institutionalized). Disability and institutionalization are associated with an increased risk of cognitive impairment in oldest old. The cognitive status in this group has been studied insuffi ciently in Russia. Determination of diagnostic standards for cognitive functions assessment scales in oldest old is important both for clinical practice and for scientifi c research.Objective: to evaluate cognitive functions and to determine diagnostic value for various psychological tests in persons aged ≥ 90, who live in long term care facilities (LTCF).Material and methods. The persons aged ≥ 90 years that live in LTCF (boarding houses or nursing homes) in Moscow were examined. All patients passed neuropsychological examination, which included Mini-mental State Examination (MMSE), Frontal Assessment Battery (FAB), 5-word test, clock-drawing test and verbal fl uency tests. In addition, original questionnaire was used for cognitive impairment screening.Results. Dementia was found in 69% of oldest old, who live in LTCF; frontal dysfunction in 89.1% and “hippocampal type” of memory disorders in 57.5%. The results of phonemic verbal fl uency test were normal in 6.7% only and of semantic verbal fl uency test in 8.1%. For diagnosis of dementia in institutionalized subjects sensitivity of MMSE ≤ 23 points was 97% and specifi city was 90.9%. For the FAB optimal sensitivity/specifi city ratio (98/83.7%) was at score of ≤ 14. The clock-drawing test sensitivity for dementia was 91.9% and specifi city was 69.7% at total score ≤ 6 .Conclusion. Institutionalized persons aged ≥ 90 years have a high prevalence of dementia. The above mentioned tests can be used for oldest old examination. Further studies of the relationship of cognitive impairment with other geriatric disorders in oldest old are needed.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45246197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.30629/2658-7947-2022-27-6-41-49
A. Trufanov, K. Markin, D. Frunza, I. Litvinenko, D. Tarumov, E. V. Kuznetsova, A. Y. Efimtsev, M. Odinak
Introduction. In the context of the search for new migraine therapy options, strict control of their eff ectiveness by means of objective examination methods is required.Objective. Objective assessment of the eff ectiveness of TMS in patients with migraine on the basis of functional magnetic resonance imaging (fMRI) data.Material and methods. Resting-state fMRI before and after a fi ve-day course of TMS of the junction of the inferior frontal and temporal lobes bilaterally was performed in 19 patients with migraine. Changes in functional connectivity (FC) of the main neuronal networks of the brain, as well as clinical parameters of pain and quality of life of the patients were assessed before and after the course of TMS.Results. A decrease in pain intensity and anxiety scores, as well as a decrease in the number of acute pain medications taken, was observed against the background of the therapy. Changes in FC aff ected three main networks: the default mode network, the salience and visual networks. At the same time, decreased effi cacy of therapy was noted in patients with higher severity of depressive symptoms and presence of neuroimaging criteria of depression.Conclusion. The study suggests the effi cacy of TMS in patients with migraine based on neuroimaging criteria. It is worth paying special attention to the presence of depressive symptoms in migraine patients.
{"title":"Evaluation of the effectiveness of migraine therapy using functional resting MRI with course rhythmic transcranial magnetic stimulation","authors":"A. Trufanov, K. Markin, D. Frunza, I. Litvinenko, D. Tarumov, E. V. Kuznetsova, A. Y. Efimtsev, M. Odinak","doi":"10.30629/2658-7947-2022-27-6-41-49","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-41-49","url":null,"abstract":"Introduction. In the context of the search for new migraine therapy options, strict control of their eff ectiveness by means of objective examination methods is required.Objective. Objective assessment of the eff ectiveness of TMS in patients with migraine on the basis of functional magnetic resonance imaging (fMRI) data.Material and methods. Resting-state fMRI before and after a fi ve-day course of TMS of the junction of the inferior frontal and temporal lobes bilaterally was performed in 19 patients with migraine. Changes in functional connectivity (FC) of the main neuronal networks of the brain, as well as clinical parameters of pain and quality of life of the patients were assessed before and after the course of TMS.Results. A decrease in pain intensity and anxiety scores, as well as a decrease in the number of acute pain medications taken, was observed against the background of the therapy. Changes in FC aff ected three main networks: the default mode network, the salience and visual networks. At the same time, decreased effi cacy of therapy was noted in patients with higher severity of depressive symptoms and presence of neuroimaging criteria of depression.Conclusion. The study suggests the effi cacy of TMS in patients with migraine based on neuroimaging criteria. It is worth paying special attention to the presence of depressive symptoms in migraine patients.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48182912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.30629/2658-7947-2022-27-6-32-40
A. Moskalenko, A. Chechetkin, A. Filatov, E. Fedotova, R. Konovalov, S. Illarioshkin
Background. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and aff ects 1% of the population above 60 years. The leading pathological features of PD include degeneration of neuromelanin (NM) containing dopaminergic neurons and iron deposition in the substantia nigra (SN) of the midbrain. Various neuroimaging methods sensitive to NM and iron can be clinically important for diagnosing and monitoring disease progression. Examples of such neuroimaging methods include transcranial sonography (TCS) and neuromelanin-sensitive magnetic resonance imaging (NM-MRI) fi rst and foremost.Aims. To compare the diagnostic signifi cance and eff ectiveness of TCS and NM-MRI in diff erentiating patients with PD from the norm and to elucidate the magnetic resonance- (MR-) morphological representation of the hyperechogenicity (HE) on midbrain during TCS by NM-MRI.Material and methods. 40 patients with PD were included in the main group, and 20 healthy volunteers of gender and age comparable with the main group were included in the control group. In the case of HE detection during TCS, this area was manually traced and automatic calculated. NM-MRI images were pre-processed using image processing program Image-J (USA) with subsequent automatic calculation of SN area. Based on the data obtained, clinical, demographic and neuroimaging correlations were estimated.Results. The sensitivity and specifi city of TCS in diff erentiating PD from the norm were 70 and 100% respectively, the sensitivity and specifi city of NM-MRI were 90.0 and 92.5% respectively. An analysis of the relationship between the HE area and the area of the SN according to NM-MRI data on the ipsilateral side showed a noticeable inverse correlation (for the right side: ρ = –0.606, p < 0.001; for the left side: ρ = –0.550; p < 0.001). Thus, in the case of an increase in the HE area, a decrease in the area of SN measured using NM-MRI is expected.Conclusion. TCS and NM-MRI are reliable biomarkers allowing highly eff ective diff erentiation of PD from normal. The pathophysiological and neuroimaging correlates of PD changes in neurodegenerative process remain not completely clear and require further clarifi cation in multicenter prospective studies.
{"title":"Clinical and neuroimaging study of patients with Parkinson’s disease using transcranial sonography and neuromelanin-sensitive magnetic resonance imaging","authors":"A. Moskalenko, A. Chechetkin, A. Filatov, E. Fedotova, R. Konovalov, S. Illarioshkin","doi":"10.30629/2658-7947-2022-27-6-32-40","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-32-40","url":null,"abstract":"Background. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and aff ects 1% of the population above 60 years. The leading pathological features of PD include degeneration of neuromelanin (NM) containing dopaminergic neurons and iron deposition in the substantia nigra (SN) of the midbrain. Various neuroimaging methods sensitive to NM and iron can be clinically important for diagnosing and monitoring disease progression. Examples of such neuroimaging methods include transcranial sonography (TCS) and neuromelanin-sensitive magnetic resonance imaging (NM-MRI) fi rst and foremost.Aims. To compare the diagnostic signifi cance and eff ectiveness of TCS and NM-MRI in diff erentiating patients with PD from the norm and to elucidate the magnetic resonance- (MR-) morphological representation of the hyperechogenicity (HE) on midbrain during TCS by NM-MRI.Material and methods. 40 patients with PD were included in the main group, and 20 healthy volunteers of gender and age comparable with the main group were included in the control group. In the case of HE detection during TCS, this area was manually traced and automatic calculated. NM-MRI images were pre-processed using image processing program Image-J (USA) with subsequent automatic calculation of SN area. Based on the data obtained, clinical, demographic and neuroimaging correlations were estimated.Results. The sensitivity and specifi city of TCS in diff erentiating PD from the norm were 70 and 100% respectively, the sensitivity and specifi city of NM-MRI were 90.0 and 92.5% respectively. An analysis of the relationship between the HE area and the area of the SN according to NM-MRI data on the ipsilateral side showed a noticeable inverse correlation (for the right side: ρ = –0.606, p < 0.001; for the left side: ρ = –0.550; p < 0.001). Thus, in the case of an increase in the HE area, a decrease in the area of SN measured using NM-MRI is expected.Conclusion. TCS and NM-MRI are reliable biomarkers allowing highly eff ective diff erentiation of PD from normal. The pathophysiological and neuroimaging correlates of PD changes in neurodegenerative process remain not completely clear and require further clarifi cation in multicenter prospective studies.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47109316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.30629/2658-7947-2022-27-6-13-21
N. Dryagina, E. Kondratyeva, A. A. Denisova, S. Kondratyev, A. N. Kondratyev
Aim of the work was to analyze the content of factors with neuroprotective, neurotoxic and apoptotic eff ects in the blood of patients with prolonged disorders of consciousness (pDOC), depending on the level of consciousness disorder and neuroprotective therapy.Material and methods. Research included 53 patients with pDOC, who were divided into 2 groups. Group 1 included 19 vegetative state/unresponsive wakefulness syndrome (VS/UWS) patients, group 2–34 minimally conscious state (MCS “minus” and “plus”) patients. Firstly at admission and then at the end of treatment course (after 1 month on average), plasma concentrations of brain neurotrophic factor (BDNF), apoptosis antigen (APO-1), apoptosisinducing ligand (Fas-L) and glutamate were studied. Control group consisted of 16 patients without measured once.Results. Decrease of BDNF serum level was revealed in patients with pDOC,which was less pronounced those who had TBI as a etiological factor of pDOC. BDNF level signifi cantly increased after a month against the background of neuroprotective therapy. Glutamate level was higher in the fi rst group (VS/UWS). No signifi cant diff erence in the content of apoptosis factors was observed.Conclusion. In patients with pDOC, decrease serum BDNF level was observed, less pronounced in TBI as etiology of pDOC. In patients who matched MCS criteria at the admission, there was a signifi cant increase of BDNF serum level during treatment course, which could indicate that patients with a higher initial level of consciousness have better potential for realizing the eff ect of neuroprotective therapy. Levels of apoptosis factors did not correspond to the consciousness level.
{"title":"Brain-derived neutrophic factor, glutamate and markers of apoptosis in the blood of patients with prolonged disorders of consciousness","authors":"N. Dryagina, E. Kondratyeva, A. A. Denisova, S. Kondratyev, A. N. Kondratyev","doi":"10.30629/2658-7947-2022-27-6-13-21","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-13-21","url":null,"abstract":"Aim of the work was to analyze the content of factors with neuroprotective, neurotoxic and apoptotic eff ects in the blood of patients with prolonged disorders of consciousness (pDOC), depending on the level of consciousness disorder and neuroprotective therapy.Material and methods. Research included 53 patients with pDOC, who were divided into 2 groups. Group 1 included 19 vegetative state/unresponsive wakefulness syndrome (VS/UWS) patients, group 2–34 minimally conscious state (MCS “minus” and “plus”) patients. Firstly at admission and then at the end of treatment course (after 1 month on average), plasma concentrations of brain neurotrophic factor (BDNF), apoptosis antigen (APO-1), apoptosisinducing ligand (Fas-L) and glutamate were studied. Control group consisted of 16 patients without measured once.Results. Decrease of BDNF serum level was revealed in patients with pDOC,which was less pronounced those who had TBI as a etiological factor of pDOC. BDNF level signifi cantly increased after a month against the background of neuroprotective therapy. Glutamate level was higher in the fi rst group (VS/UWS). No signifi cant diff erence in the content of apoptosis factors was observed.Conclusion. In patients with pDOC, decrease serum BDNF level was observed, less pronounced in TBI as etiology of pDOC. In patients who matched MCS criteria at the admission, there was a signifi cant increase of BDNF serum level during treatment course, which could indicate that patients with a higher initial level of consciousness have better potential for realizing the eff ect of neuroprotective therapy. Levels of apoptosis factors did not correspond to the consciousness level.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41525539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.30629/2658-7947-2022-27-6-22-31
G. Bisaga, M. Topuzova, V. Malko, D. Motorin, Yuliya Alekseeva, R. Badaev, T. Krinitsina, T. Alekseeva
Relevance. Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system with progressive course. High-dose chemotherapy (HDCT) with autologous haematopoietic stem cell transplantation (AHSCT) is a promising course of treatment-refractory MS. The study aimed to assess the effi cacy and safety of treating MS patients with HDCT + AHSCT.Material and methods. Were studied 10 people (5 women and 5 men) with relapsing-remitting (30%), secondary progressive (60%) and primary progressive MS (10%). Patients underwent AHSCT using cyclophosphamide + rituximab chemotherapeutic regimen.Results. In 90% of cases, at least a stabilizing eff ect is shown after the procedure. Only 10% was showed signs of demyelinating activity on MRI of the spinal cord 2 years after HDCT + AHSCT. All patients had a response to therapy according to median Expanded Disability Status Scores (EDSS). We found a positive dynamics of the average EDSS score: before treatment — 5.9 points, 6 months and 1 year after treatment — 5.1 points. There was shown a positive eff ect on dynamics of neurological status, quality of life and emotional state of patients. No treatment-related mortality and uncontrolled complications were revealed.Conclusion. Timely AHSCT contributes to minimizing the level of disability and signifi cantly improves the quality of life of patients.
{"title":"High-dose chemotherapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: intermediate results of 3 years research","authors":"G. Bisaga, M. Topuzova, V. Malko, D. Motorin, Yuliya Alekseeva, R. Badaev, T. Krinitsina, T. Alekseeva","doi":"10.30629/2658-7947-2022-27-6-22-31","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-22-31","url":null,"abstract":"Relevance. Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system with progressive course. High-dose chemotherapy (HDCT) with autologous haematopoietic stem cell transplantation (AHSCT) is a promising course of treatment-refractory MS. The study aimed to assess the effi cacy and safety of treating MS patients with HDCT + AHSCT.Material and methods. Were studied 10 people (5 women and 5 men) with relapsing-remitting (30%), secondary progressive (60%) and primary progressive MS (10%). Patients underwent AHSCT using cyclophosphamide + rituximab chemotherapeutic regimen.Results. In 90% of cases, at least a stabilizing eff ect is shown after the procedure. Only 10% was showed signs of demyelinating activity on MRI of the spinal cord 2 years after HDCT + AHSCT. All patients had a response to therapy according to median Expanded Disability Status Scores (EDSS). We found a positive dynamics of the average EDSS score: before treatment — 5.9 points, 6 months and 1 year after treatment — 5.1 points. There was shown a positive eff ect on dynamics of neurological status, quality of life and emotional state of patients. No treatment-related mortality and uncontrolled complications were revealed.Conclusion. Timely AHSCT contributes to minimizing the level of disability and signifi cantly improves the quality of life of patients.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46058668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.30629/2658-7947-2022-27-6-5-12
L. Protasova, S. G. Zapekin, G. V. Shnaider, Z. A. Naumov, E. M. Kamenskih, M. Titova
One of the latest achievements in the field of medicine is the introduction into practice of technologies using computerized training and training in Virtual Reality (VR), which create new opportunities for prevention, as well as treatment for people suff ering from various cognitive impairments.Purpose of the study. The aim is to investigate classical (conventional), computerized and VR training using neural interfaces focused on the prevention and rehabilitation of functional changes in higher nervous activity.Methods. In March 2022, a search was made for scientifi c full-text publications using the electronic databases of the RSCI, PubMed and Google Scholar. The following keywords and their combinations were used for the query: “dementia”, “aging” and “virtual reality”. Articles of interest for this review had to be peer-reviewed, published no later than 2015, and written in English or Russian.Results. The key methods of non-drug interventions in people suff ering from various cognitive impairments, the advantages and disadvantages of the techniques used were considered. It also shows the main advantages of VR technology as a simple, safe and eff ective tool. VR has great potential for personalized cognitive trainings.
{"title":"Virtual reality as a personifi cation method for training memory and attention (non-systematic review)","authors":"L. Protasova, S. G. Zapekin, G. V. Shnaider, Z. A. Naumov, E. M. Kamenskih, M. Titova","doi":"10.30629/2658-7947-2022-27-6-5-12","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-6-5-12","url":null,"abstract":"One of the latest achievements in the field of medicine is the introduction into practice of technologies using computerized training and training in Virtual Reality (VR), which create new opportunities for prevention, as well as treatment for people suff ering from various cognitive impairments.Purpose of the study. The aim is to investigate classical (conventional), computerized and VR training using neural interfaces focused on the prevention and rehabilitation of functional changes in higher nervous activity.Methods. In March 2022, a search was made for scientifi c full-text publications using the electronic databases of the RSCI, PubMed and Google Scholar. The following keywords and their combinations were used for the query: “dementia”, “aging” and “virtual reality”. Articles of interest for this review had to be peer-reviewed, published no later than 2015, and written in English or Russian.Results. The key methods of non-drug interventions in people suff ering from various cognitive impairments, the advantages and disadvantages of the techniques used were considered. It also shows the main advantages of VR technology as a simple, safe and eff ective tool. VR has great potential for personalized cognitive trainings.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49242745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.30629/2658-7947-2022-27-5-73-77
L. Novikova, A. Akopyan, K. M. Sharapova, R. F. Latypova, N. Faizullina
Wolff–Hirschhorn syndrome is a rare genetic disease associated with a chromosomal aberration of chromosome 4. A feature of the disease is the characteristic appearance of the face, anomalies in the development of internal organs and the skeleton, disorders in the motor, cognitive and psychospeech sphere, convulsive syndrome. Clinical observation presents a description of a 5-year-old 11-month-old child with a rare hereditary pathology — Wolff–Hirschhorn syndrome, who was treated in the neurological department of the Children’s Center for Psychoneurology and Epileptology of the Republican Children’s Clinical Hospital in Ufa. The disease was manifested by epilepsy, psychomotor retardation, and alalia. Multiple stigmas of dysembryogenesis were determined.
{"title":"Wolf–Hirshhorn syndrome","authors":"L. Novikova, A. Akopyan, K. M. Sharapova, R. F. Latypova, N. Faizullina","doi":"10.30629/2658-7947-2022-27-5-73-77","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-5-73-77","url":null,"abstract":"Wolff–Hirschhorn syndrome is a rare genetic disease associated with a chromosomal aberration of chromosome 4. A feature of the disease is the characteristic appearance of the face, anomalies in the development of internal organs and the skeleton, disorders in the motor, cognitive and psychospeech sphere, convulsive syndrome. Clinical observation presents a description of a 5-year-old 11-month-old child with a rare hereditary pathology — Wolff–Hirschhorn syndrome, who was treated in the neurological department of the Children’s Center for Psychoneurology and Epileptology of the Republican Children’s Clinical Hospital in Ufa. The disease was manifested by epilepsy, psychomotor retardation, and alalia. Multiple stigmas of dysembryogenesis were determined.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41454897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.30629/2658-7947-2022-27-5-69-72
A. Klimkin, M. Bedova, E. Skripchenko, N. V. Marchenko, V. Voitenkov
Motor chronic inflammatory demyelinating polyneuropathy (M-CIDP) is a form of atypical CIDP. This article presents a clinical observation of M-CIDP in a 15-year-old boy, as well as a description of laboratory and instrumental diagnostic data. The boy had a chronic development (> 2 months) of flaccid tetraparesis, predominantly of the proximal muscles of the limbs, without sensory disorders. According to electroneuromyography, there were signs of demyelinating lesions of the proximal parts of the peripheral nerves. There was an increase in the thickness of the nerves of the upper limbs according to ultrasound. In the liquor protein-cell dissociation, as well as in the blood, IgG antibodies to the surface glycoprotein S of the SARS-CoV-2 coronavirus were found. The clinical and neurophysiological picture corresponded to the reliable criteria for CIDP. The therapy with intravenous immunoglobulins had a significant positive effect in the form of an increase in the strength of the limb muscles.
{"title":"Motor chronic inflammatory demyelinating polyneuropathy in a child","authors":"A. Klimkin, M. Bedova, E. Skripchenko, N. V. Marchenko, V. Voitenkov","doi":"10.30629/2658-7947-2022-27-5-69-72","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-5-69-72","url":null,"abstract":"Motor chronic inflammatory demyelinating polyneuropathy (M-CIDP) is a form of atypical CIDP. This article presents a clinical observation of M-CIDP in a 15-year-old boy, as well as a description of laboratory and instrumental diagnostic data. The boy had a chronic development (> 2 months) of flaccid tetraparesis, predominantly of the proximal muscles of the limbs, without sensory disorders. According to electroneuromyography, there were signs of demyelinating lesions of the proximal parts of the peripheral nerves. There was an increase in the thickness of the nerves of the upper limbs according to ultrasound. In the liquor protein-cell dissociation, as well as in the blood, IgG antibodies to the surface glycoprotein S of the SARS-CoV-2 coronavirus were found. The clinical and neurophysiological picture corresponded to the reliable criteria for CIDP. The therapy with intravenous immunoglobulins had a significant positive effect in the form of an increase in the strength of the limb muscles.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42170956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.30629/2658-7947-2022-27-5-51-58
M. Maksimova, Y. Kotlyar, A. Shabalina
Introduction. Discogenic lumbosacral pain in young people has a complex and multicomponent pathogenesis. Evidence of the content of cytokines and neoangiogenesis factors in patients with acute discogenic lumbosacral radiculopathy are deficiency and often contradictory. Objective: to evaluate the cytokine and neoangiogenesis parameters in the blood of young patients with acute discogenic lumbosacral radiculopathy.Materials and methods. The study involved 49 patients (27 (55.1%) men and 22 (44.9%) women) with a mean age of 36 [27; 45] years with acute lumbosacral pain caused by degenerative changes in the spine and signs of compression of the spinal nerves, according to MRI. The control group consisted of 17 healthy individuals (10 (58.8%) men and 7 (41.2%) women) with a mean age of 33 [25; 41] years. The level of C-reactive protein was measured by an automatic biochemical analyzer Konelab 30Iprime (ThermoFisher, Finland). The levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor A (VEGF-A) in blood were determined by enzyme-linked immunosorbent assay (ELISA) on a plate ELISA analyzer Real-best (Russia) using reagent kits Cloud-Clone Corp. (USA, China).Results. Patients with acute discogenic lumbosacral radiculopathy, compared with the control group, has an increase in the levels of C-reactive protein (11.2 [7.1; 15.3] vs. 4.2 [3.5; 4.9] mg/ml; р = 0.011), TNF-α (23.1 [16.8; 29.5] vs. 9.7 [6.9; 12,5] pg/ml; р = 0.001), IL-1β (4.7 [3.1; 6.3] vs. 3.2 [2.3; 4.1] pg/ml; р = 0.041), IL-6 (11.2 [6.1; 16.3] vs. 4.5 [3.1; 5.9] pg/ml; р = 0.007), IL-8 (30. [21.9; 48.8] vs. 20.5 [8.5; 32.6] pg/ml; р = 0.023) and VEGF-A (318 [260; 570] vs.168 [100; 240] pg/ml; р = 0.002).Conclusion. The obtained results confirm the importance of pro-inflammatory factors and indicators of neoangiogenesis in the development of acute discogenic lumbosacral radiculopathy in young patients.
{"title":"Cytokines and neoangiogenesis parameters in young patients with acute discogenic lumbosacral radiculopathy","authors":"M. Maksimova, Y. Kotlyar, A. Shabalina","doi":"10.30629/2658-7947-2022-27-5-51-58","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-5-51-58","url":null,"abstract":"Introduction. Discogenic lumbosacral pain in young people has a complex and multicomponent pathogenesis. Evidence of the content of cytokines and neoangiogenesis factors in patients with acute discogenic lumbosacral radiculopathy are deficiency and often contradictory. Objective: to evaluate the cytokine and neoangiogenesis parameters in the blood of young patients with acute discogenic lumbosacral radiculopathy.Materials and methods. The study involved 49 patients (27 (55.1%) men and 22 (44.9%) women) with a mean age of 36 [27; 45] years with acute lumbosacral pain caused by degenerative changes in the spine and signs of compression of the spinal nerves, according to MRI. The control group consisted of 17 healthy individuals (10 (58.8%) men and 7 (41.2%) women) with a mean age of 33 [25; 41] years. The level of C-reactive protein was measured by an automatic biochemical analyzer Konelab 30Iprime (ThermoFisher, Finland). The levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor A (VEGF-A) in blood were determined by enzyme-linked immunosorbent assay (ELISA) on a plate ELISA analyzer Real-best (Russia) using reagent kits Cloud-Clone Corp. (USA, China).Results. Patients with acute discogenic lumbosacral radiculopathy, compared with the control group, has an increase in the levels of C-reactive protein (11.2 [7.1; 15.3] vs. 4.2 [3.5; 4.9] mg/ml; р = 0.011), TNF-α (23.1 [16.8; 29.5] vs. 9.7 [6.9; 12,5] pg/ml; р = 0.001), IL-1β (4.7 [3.1; 6.3] vs. 3.2 [2.3; 4.1] pg/ml; р = 0.041), IL-6 (11.2 [6.1; 16.3] vs. 4.5 [3.1; 5.9] pg/ml; р = 0.007), IL-8 (30. [21.9; 48.8] vs. 20.5 [8.5; 32.6] pg/ml; р = 0.023) and VEGF-A (318 [260; 570] vs.168 [100; 240] pg/ml; р = 0.002).Conclusion. The obtained results confirm the importance of pro-inflammatory factors and indicators of neoangiogenesis in the development of acute discogenic lumbosacral radiculopathy in young patients.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43397173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.30629/2658-7947-2022-27-5-59-68
V. Grigoryeva, V. Nesterova, G. Tikhomirov, O. S. Klimova, I. V. Chudakova
A 20-year-old patient was presented with subacute onset of headache, nausea and vomiting. Testing of nasal/oropharyngeal swabs indicated the presence of SARS-CoV-2 RNA, and later the antibodies to this virus were found. The treatment in the hospital for Coronavirus 19 Disease (COVID-19) provided only temporary relief, and the patient then was referred to the Regional Stroke Center (RSC) to exclude a subarachnoid hemorrhage. RSC neurologists drew attention to multiple skin nevi in the patient. Brain MRI demonstrated abnormal T1 hyperintensity in the brain leptomeninges, with leptomeningeal contrast enhancement as well as hyperintensity in amygdala regions on T1 weighted images, bilaterally. The anomaly of the Dandy-Walker malformation complex was also revealed. Cerebrospinal fluid (CSF) analysis showed elevated protein (0.52 g/L), low lymphocytosis (lymphocytes, 6 in mm3), and decreased glucose (1.8 mmol/L). Neurocutaneous melanocytosis (NCM) was diagnosed, which neurological manifestation was probably triggered by COVID-19. The patient’s vision gradually progressively worsened. In 2.5 months after the clinical manifestation of NCM, fundoscopy revealed optic discs atrophy (despite the absence of previous edema), and repeated CSF analysis showed atypical cells with characteristics corresponding to melanoma. Malignant transformation of cerebral melanocytosis was suspected, and the patient was referred to an oncological dispensary for further therapy. In the presented literature review, special attention is paid to the issues of neuroimaging, cytological and immunocytochemical diagnostics of NCM.
{"title":"Neurocutaneous melanocytosis with manifestation in adulthood","authors":"V. Grigoryeva, V. Nesterova, G. Tikhomirov, O. S. Klimova, I. V. Chudakova","doi":"10.30629/2658-7947-2022-27-5-59-68","DOIUrl":"https://doi.org/10.30629/2658-7947-2022-27-5-59-68","url":null,"abstract":"A 20-year-old patient was presented with subacute onset of headache, nausea and vomiting. Testing of nasal/oropharyngeal swabs indicated the presence of SARS-CoV-2 RNA, and later the antibodies to this virus were found. The treatment in the hospital for Coronavirus 19 Disease (COVID-19) provided only temporary relief, and the patient then was referred to the Regional Stroke Center (RSC) to exclude a subarachnoid hemorrhage. RSC neurologists drew attention to multiple skin nevi in the patient. Brain MRI demonstrated abnormal T1 hyperintensity in the brain leptomeninges, with leptomeningeal contrast enhancement as well as hyperintensity in amygdala regions on T1 weighted images, bilaterally. The anomaly of the Dandy-Walker malformation complex was also revealed. Cerebrospinal fluid (CSF) analysis showed elevated protein (0.52 g/L), low lymphocytosis (lymphocytes, 6 in mm3), and decreased glucose (1.8 mmol/L). Neurocutaneous melanocytosis (NCM) was diagnosed, which neurological manifestation was probably triggered by COVID-19. The patient’s vision gradually progressively worsened. In 2.5 months after the clinical manifestation of NCM, fundoscopy revealed optic discs atrophy (despite the absence of previous edema), and repeated CSF analysis showed atypical cells with characteristics corresponding to melanoma. Malignant transformation of cerebral melanocytosis was suspected, and the patient was referred to an oncological dispensary for further therapy. In the presented literature review, special attention is paid to the issues of neuroimaging, cytological and immunocytochemical diagnostics of NCM.","PeriodicalId":36724,"journal":{"name":"Russian Neurological Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45023183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：