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Impact of COVID-19 pandemic among healthcare professionals COVID-19 大流行对医护人员的影响
Pub Date : 2023-12-16 DOI: 10.25259/gjhsr_51_2023
Jessy Abraham, Maria Therese
The objectives of the study were to assess the impact of Covid-19 pandemic among healthcare professionals, to compare the level of impact of Covid-19 pandemic among different healthcare professionals, and to find the association of impact of Covid-19 pandemic with the selected demographic variables of the healthcare professionals with selected demographic variables.The research approach used was quantitative and research design adopted for the study was descriptive research design. A sample of 60 healthcare professionals was selected by stratified random sampling and the data were collected using questionnaire. The data collected were tabulated and analyzed using descriptive statistics.The result of our study showed that 5% of the healthcare professionals were mildly affected, 48.3% of healthcare professionals were moderately affected, and 46.7% of healthcare professionals were severely affected. There was no significant difference found between the levels of impact among different healthcare professionals. There is a significant association between the level of impact of Covid-19 and the type of family.Study found that Covid-19 had an impact on healthcare professionals.
本研究的目标是评估 Covid-19 大流行病对医疗保健专业人员的影响,比较 Covid-19 大流行病对不同医疗保健专业人员的影响程度,并找出 Covid-19 大流行病的影响与医疗保健专业人员选定人口统计学变量的关联。研究采用了定量研究方法,研究设计为描述性研究设计。研究通过分层随机抽样的方式选取了 60 名医护专业人员作为样本,并使用问卷收集数据。研究结果显示,5% 的医护人员受轻度影响,48.3% 的医护人员受中度影响,46.7% 的医护人员受重度影响。不同医护人员受影响的程度没有明显差异。研究发现,Covid-19 对医护人员产生了影响。
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引用次数: 0
Eating behavior of early adults: A cross-sectional analysis 早期成年人的饮食行为:横截面分析
Pub Date : 2023-12-14 DOI: 10.25259/gjhsr_28_2023
Swetha P S, P. B. Jos
The present study aims to find out the relationship between the three types of eating behavior with emotional intelligence (EI), Big Five personality traits, and frustration intolerance of early adults using online food delivery system.A sample size of 258 was collected using the technique of convenient sampling. This cross-sectional research employs Spearman’s Rank correlation and Mann–Whitney U-test for data analysis.There is negative relationship between emotional eating (EE) and EI, there is negative relationship between cognitive restraint (CR) eating and extraversion, there is negative relationship between uncontrolled eating (UE) and conscientiousness, there is positive relationship between EE and openness, there is positive relationship between CR eating and emotional intolerance (EIn), there is positive correlation between UE and entitlement, there is positive correlation between EE and discomfort intolerance, there is significant difference in the openness, agreeableness, and neuroticism of males and females using online food delivery system, and there is significant difference in the EIn of females and males using online food delivery system.The study emphasizes the relevance of healthy eating behavior in early adults for maintaining their mental health.
本研究旨在通过使用在线食品配送系统,找出成年人的三种饮食行为与情商(EI)、五大人格特质和挫折不耐之间的关系。这项横断面研究采用斯皮尔曼等级相关和曼-惠特尼 U 检验进行数据分析。情绪化进食(EE)与情绪化倾向(EI)之间存在负相关,认知克制进食(CR)与外向性之间存在负相关,失控进食(UE)与自觉性之间存在负相关,情绪化进食(EE)与开放性之间存在正相关,认知克制进食(CR)与情绪不耐受(EIn)之间存在正相关、使用网上送餐系统的男性和女性在开放性、宜人性和神经质方面存在显著差异,使用网上送餐系统的女性和男性在情绪不耐受方面存在显著差异。这项研究强调了成年人的健康饮食行为对保持心理健康的重要性。
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引用次数: 0
Effect of azithromycin administration in cases of acute bronchiolitis – A systematic review and meta-analysis 阿奇霉素给药对急性细支气管炎的影响——一项系统回顾和荟萃分析
Pub Date : 2023-09-20 DOI: 10.25259/gjhsr_60_2023
Preethi Tamilarasan, Kanimozhi Thandapani, J. Jenifer Florence Mary, Reenaa Mohan, Kalaiselvan Ganapathy
Acute Bronchiolitis is the most common viral lower respiratory tract infection in infants requiring hospitalization. Management is usually symptomatic and supportive with no specific treatment options. Although viral, Azithromycin by its anti-inflammatory properties might play a role in improving the clinical outcome. The objective was to assess the effect of azithromycin on length of hospital stay and duration of oxygen requirement in cases of acute bronchiolitis. Data sources such as PubMed and Google Scholar were systematically searched till June 2023. The meta-analysis included all published, randomized controlled trials that investigated the efficacy of Azithromycin over placebo in infants <24 months with acute bronchiolitis. Data extraction was guided by a predetermined checklist. Using RevMan 5 software, the mean length of hospital stay and duration of oxygen administration were pooled from the selected studies. The fixed-effect model was used to compare the length of hospital stay and the duration of oxygen administration in the Azithromycin and placebo group. Data analyses were performed in July 2023. The primary outcome was a comparison of the length of hospital stay in infants with Bronchiolitis receiving either azithromycin (intervention) or placebo (control). The secondary outcome was the assessment of the duration of oxygen requirement in both intervention and control groups.The initial search yielded 601 records of which 68 articles underwent full-text evaluation, which identified four articles and a total of 571 patients that were included. The findings did not favor the usage of azithromycin antibiotic in treatment of acute bronchiolitis (Mean deviation = 1.21, 95% CI 0.53–2.78, P = 0.80). An insignificant Q statistic ( P = 0.001) indicated the absence of heterogeneity (I2 = 0%). Length of hospital stay showed an overall insignificant effect as the length of stay is almost similar in both drugs (OR = 1.04 95% CI 0.49–2.23, P = 1.00). An insignificant Q statistic ( P = 1.00) indicated the absence of heterogeneity (I2 = 0%).
急性细支气管炎是婴幼儿最常见的病毒性下呼吸道感染,需要住院治疗。管理通常是对症和支持性的,没有具体的治疗方案。虽然是病毒性的,但阿奇霉素因其抗炎特性可能在改善临床结果中发挥作用。目的是评估阿奇霉素对急性细支气管炎患者住院时间和耗氧时间的影响。系统检索PubMed、Google Scholar等数据源,直至2023年6月。荟萃分析包括所有已发表的随机对照试验,这些试验研究了阿奇霉素对24个月急性细支气管炎婴儿的疗效。数据提取由预先确定的核对表指导。使用RevMan 5软件,汇总所选研究的平均住院时间和给氧时间。采用固定效应模型比较阿奇霉素组和安慰剂组的住院时间和给氧时间。数据分析于2023年7月进行。主要结局是比较接受阿奇霉素(干预)或安慰剂(对照)治疗的毛细支气管炎婴儿的住院时间。次要结果是评估干预组和对照组的需氧量持续时间。最初的检索得到601条记录,其中68篇文章进行了全文评估,确定了4篇文章和总共571名患者。研究结果不支持阿奇霉素抗生素治疗急性细支气管炎(平均偏差= 1.21,95% CI 0.53 ~ 2.78, P = 0.80)。不显著的Q统计量(P = 0.001)表明不存在异质性(I2 = 0%)。住院时间的影响总体上不显著,因为两种药物的住院时间几乎相似(OR = 1.04 95% CI 0.49-2.23, P = 1.00)。不显著的Q统计量(P = 1.00)表明不存在异质性(I2 = 0%)。
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引用次数: 0
Neutrophil-lymphocyte ratio among preeclampsia patients in India – A systematic review and meta-analysis 中性粒细胞-淋巴细胞比率在印度子痫前期患者-系统回顾和荟萃分析
Pub Date : 2023-09-20 DOI: 10.25259/gjhsr_59_2023
Deepika Velusami, Krishnamurthy Soundariya, Reena Mohan, J. Jenifer Florence Mary, Kalaiselvan Ganapathy, P. Sanjay
Preeclampsia is one of the major causes of morbidity and mortality in pregnant females in India. Early detection of preeclampsia can be of clinical utility. Neutrophil Lymphocyte Ratio (NLR) is a simple hepatological biomarker that has been used for diagnosis of preeclampsia. With this perspective in mind, the present meta-analysis was planned to evaluate NLR among preeclampsia in the Indian setting. Databases systematically searched were PubMed, MEDLINE, and Google Scholar were systematically searched till July 2023. The studies selected were all Indian published articles NLR evaluated in females of age ≥18 years and < 40 years with preeclampsia and normal health pregnant females. Data extraction was guided by a predetermined checklist. Using RevMan 5 software, the mean and standard deviation were evaluated and analyzed. The initial search yielded 103 records of which 54 articles underwent evaluation, which identified 8 articles and a total 1381 study population. Of these, 534 cases of preeclampsia and 847 normal healthy pregnant females investigated the significance of evaluation of NLR for identification of preeclampsia. The meta-analysis showed an overall significant effect in favor of the importance of NLR investigation in predicting preeclampsia (SMR = 1.04, 95% CI 0.91–1.16, p < 0.001). A significant Q statistic (p < 0.001) indicated the presence of heterogeneity (I2 = 96%). This systematic review and meta-analysis proved that NLR can be employed for detecting early preeclampsia. Further prospective studies are needed to validate the potential applicability of NLR as a diagnostic marker in clinical setup.
先兆子痫是印度孕妇发病和死亡的主要原因之一。早期发现子痫前期具有临床价值。中性粒细胞淋巴细胞比率(NLR)是一种简单的肝脏生物标志物,已被用于诊断子痫前期。考虑到这一观点,本荟萃分析计划评估印度背景下先兆子痫的NLR。系统检索的数据库为PubMed、MEDLINE和谷歌Scholar,检索截止至2023年7月。入选的研究均为印度发表的NLR研究,研究对象为年龄≥18岁的女性和<40岁先兆子痫和正常健康孕妇。数据提取由预先确定的核对表指导。利用RevMan 5软件对平均值和标准差进行评价和分析。初步检索得到103条记录,其中54篇文章进行了评估,确定了8篇文章和1381个研究人群。其中534例子痫前期和847例正常健康孕妇探讨了NLR评价对子痫前期鉴别的意义。荟萃分析显示,NLR调查在预测子痫前期的重要性方面具有总体显著作用(SMR = 1.04, 95% CI 0.91-1.16, p <0.001)。显著的Q统计量(p <0.001)表明存在异质性(I2 = 96%)。本系统综述和荟萃分析证明NLR可用于检测早期子痫前期。需要进一步的前瞻性研究来验证NLR作为临床诊断标志物的潜在适用性。
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引用次数: 0
Unkindest cut of all... unnecessary hysterectomy 最无情的切割……不必要的子宫切除术
Pub Date : 2023-09-20 DOI: 10.25259/gjhsr_64_2023
A. Bupathy
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引用次数: 0
Awareness, knowledge, and practice of performance status scale in the management of head and neck cancer patients among health-care providers in Edo state, Nigeria 尼日利亚埃多州卫生保健提供者在头颈癌患者管理中对绩效状况量表的认识、知识和实践
Pub Date : 2023-08-09 DOI: 10.25259/gjhsr_10_2023
E. Edetanlen, O. Babalola
The roles of performance status scales (PSSs) are well-documented globally and is largely, routinely, and traditionally used in the management of cancer patients in the developed countries, but this is not true in developing countries, reason largely due to lack of awareness. Therefore, the present study aimed to assess the level of awareness, knowledge, and practice of PSSs among medical practitioners in Edo state Nigeria.This descriptive cross-sectional study design recruited all medical practitioners that managed head and neck cancers (HNCs) (Family Dental Physicians, Otolaryngologist and Oral and Maxillofacial Surgeons) in Edo state between April 2019 and December 2019. Data were obtained using a self-administered questionnaire which was given to all the participants that gave written informed consent. The statistical analysis was done using the Statistical Package for the Social Sciences version 21 (IBM, Chicago, Illinois, USA).One hundred and six of the 110 randomly distributed questionnaires were retrieved, given a response rate of 96.4%. The male-to-female ratio was 2.4:1.0. The mean age was 33.3 ± 5.30 years, ranging from 25 to 46 years. Most of the respondents were within the age range of 31–40 years, while the least numbers were over 40 years. Of the total 106 respondents, less than half (46.2%) had heard of PSS. More than two-third (73.6%) of the respondents had a general poor knowledge as regard PSS. More than half (53.8%) of the respondents answered that they have never used PSS in the course of managing HNC patient. The age, gender, years of practice, type of specialty, and location of practice were not related to the knowledge of PSS by the respondents (P > 0.05). There was a significant association between awareness of PSS before this study and the knowledge of PSS among the respondents (P = 0.02).Most Medical Practitioners that manage head and neck cancer patients lack awareness and knowledge of PSSs and hence poorly utilized in the management of patients in routine practice.
绩效状态量表(pss)的作用在全球范围内得到了充分的记录,并且在发达国家主要、常规和传统地用于癌症患者的管理,但在发展中国家并非如此,主要原因是缺乏认识。因此,本研究旨在评估尼日利亚埃多州医生对pss的认识、知识和实践水平。这项描述性横断面研究设计招募了2019年4月至2019年12月期间江户州所有治疗头颈癌(HNCs)的医生(家庭牙科医生、耳鼻喉科医生和口腔颌面外科医生)。数据是通过一份自我管理的问卷获得的,该问卷发给了所有给予书面知情同意的参与者。统计分析是使用statistical Package for The Social Sciences version 21 (IBM, Chicago, Illinois, USA)完成的。随机发放问卷110份,回收问卷106份,回复率为96.4%。男女比例为2.4:1.0。平均年龄33.3±5.30岁,年龄25 ~ 46岁。大多数受访者的年龄在31-40岁之间,而40岁以上的人数最少。106名应答者中,听说过PSS的不到一半(46.2%)。超过三分之二(73.6%)的回答者对PSS的认识一般较差。超过一半(53.8%)的应答者回答在管理HNC患者的过程中从未使用过PSS。年龄、性别、执业年限、专业类型、执业地点与被调查对象的PSS知识知晓程度无显著性差异(P > 0.05)。被调查者在本研究前对PSS的认知与PSS知识之间存在显著相关(P = 0.02)。大多数管理头颈癌患者的医生缺乏对pss的认识和知识,因此在日常实践中对患者的管理中很少使用。
{"title":"Awareness, knowledge, and practice of performance status scale in the management of head and neck cancer patients among health-care providers in Edo state, Nigeria","authors":"E. Edetanlen, O. Babalola","doi":"10.25259/gjhsr_10_2023","DOIUrl":"https://doi.org/10.25259/gjhsr_10_2023","url":null,"abstract":"\u0000\u0000The roles of performance status scales (PSSs) are well-documented globally and is largely, routinely, and traditionally used in the management of cancer patients in the developed countries, but this is not true in developing countries, reason largely due to lack of awareness. Therefore, the present study aimed to assess the level of awareness, knowledge, and practice of PSSs among medical practitioners in Edo state Nigeria.\u0000\u0000\u0000\u0000This descriptive cross-sectional study design recruited all medical practitioners that managed head and neck cancers (HNCs) (Family Dental Physicians, Otolaryngologist and Oral and Maxillofacial Surgeons) in Edo state between April 2019 and December 2019. Data were obtained using a self-administered questionnaire which was given to all the participants that gave written informed consent. The statistical analysis was done using the Statistical Package for the Social Sciences version 21 (IBM, Chicago, Illinois, USA).\u0000\u0000\u0000\u0000One hundred and six of the 110 randomly distributed questionnaires were retrieved, given a response rate of 96.4%. The male-to-female ratio was 2.4:1.0. The mean age was 33.3 ± 5.30 years, ranging from 25 to 46 years. Most of the respondents were within the age range of 31–40 years, while the least numbers were over 40 years. Of the total 106 respondents, less than half (46.2%) had heard of PSS. More than two-third (73.6%) of the respondents had a general poor knowledge as regard PSS. More than half (53.8%) of the respondents answered that they have never used PSS in the course of managing HNC patient. The age, gender, years of practice, type of specialty, and location of practice were not related to the knowledge of PSS by the respondents (P > 0.05). There was a significant association between awareness of PSS before this study and the knowledge of PSS among the respondents (P = 0.02).\u0000\u0000\u0000\u0000Most Medical Practitioners that manage head and neck cancer patients lack awareness and knowledge of PSSs and hence poorly utilized in the management of patients in routine practice.\u0000","PeriodicalId":369069,"journal":{"name":"Global Journal of Health Sciences and Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124831985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the lunar cycle on mental illness – A single-center retrospective observational study 月亮周期对精神疾病的影响-一项单中心回顾性观察研究
Pub Date : 2023-08-09 DOI: 10.25259/gjhsr_39_2023
Sriramadesigan Radhakrishnan, A. Selvaraj, Perarul Sivakumar, Vasanth Kulothungan, Preethi Sathiyamoorthy
In Shakespeare’s play “Othello,” the maid Emilia tells Othello that the moon has drawn too close to the Earth — and driven men insane. The notion that a full moon can elicit strong emotions, strange behavior, and even physical disease is not merely literary. Even now, it is a deeply held notion. The goal of this study was to determine the effect of the lunar cycle on the psychiatric presentation of individuals with schizophrenia, BPAD mania, and ATPD.Case files of Schizophrenia, bipolar affective disorder (BPAD) mania and psychosis patients admitted in our hospital during full moon and new moon ± 3 days for the past 5 years will be included in the study. Name, age, sex, duration of admission, worsening of symptoms during full moon day and new moon day, any injectable given or not will be noted. These data will be collected from medical records. Telephonic verification of symptom worseness during full moon and new moon will be done.Among 207 participants 74 patients had Schizophrenia, 91 patients had BPAD mania, 25 patients had ATPD and 17 patients had acute psychosis. The exacerbation of psychiatric symptoms, chemical restraints, and admission during phases of moon was statistically associated with lunar patterns in the study population. The rest of the socio-demographic factors, duration of admission, caregiver belief, and symptom worsening noted by caregiver were all not associated with mental illness during lunar phases which is in line with most reported literature in this area.There was an association between symptom exacerbations, chemical restraints, admission with different lunar phase. There was no association for sociodemographic details, duration of admission, caregiver belief on symptom worsening, symptom worsening noted by caregiver with different lunar phases.
在莎士比亚的戏剧《奥赛罗》中,女仆艾米莉亚告诉奥赛罗,月亮离地球太近了,把人类逼疯了。满月可以引发强烈的情绪、奇怪的行为,甚至身体疾病的概念不仅仅是文学上的。即使是现在,这也是一个根深蒂固的观念。本研究的目的是确定月亮周期对精神分裂症、BPAD躁狂症和ATPD患者精神表现的影响。本研究纳入近5年在满月和新月±3天期间在我院住院的精神分裂症、双相情感障碍(BPAD)躁狂症和精神病患者的病例档案。姓名,年龄,性别,入院时间,满月日和新月日期间症状恶化情况,是否注射任何药物均需记录。这些数据将从医疗记录中收集。在满月和新月期间进行症状恶化的电话验证。207例患者中,精神分裂症74例,BPAD躁狂症91例,ATPD 25例,急性精神病17例。在研究人群中,精神症状的加重、化学约束和在月相期间入院与月相模式在统计学上相关。其余社会人口因素、入院时间、护理人员信念、护理人员注意到的症状恶化均与月相期间的精神疾病无关,这与该领域的大多数文献报道一致。症状加重、化学限制、不同月相入院之间存在相关性。社会人口统计学细节、入院时间、看护者对症状恶化的信念、不同月相看护者所注意到的症状恶化没有关联。
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引用次数: 0
Clenching exercise as additional orthodontic treatment in anterior open bite patients 握拳运动作为前牙开咬患者的辅助正畸治疗
Pub Date : 2023-08-09 DOI: 10.25259/gjhsr_27_2023
Anis Irmawati, Maria Devitha, Noor Faizah Balqis, Yassir Ahmad Azzaim, Raed Al-Mekhlafi
Anterior open bite is a complex case of malocclusion that needs complex treatment. This malocclusion has a tendency to relapse, so the difficulty level of treatment is high. Clenching exercise began to be applied as an additional myofunctional therapy that can help correct anterior open bite and stabilize treatment results.This narrative review aims to explain clenching exercise as an additional orthodontic treatment in anterior open bite patients.The most essential step in open bite treatment is the retention period because the tendency for relapse is strong and difficult to predict. Surgical treatment can be used to achieve an anterior open bite, but this treatment does not guarantee the stability of the treatment outcome. To achieve retention in anterior open bite correction, it is essential to improve muscle function after treatment.Clenching exercise can be an additional therapy in anterior open bite patients to shorten the treatment duration and maintain the stability of the treatment outcome.
前开咬是一种复杂的错牙合,需要复杂的治疗。这种错牙合有复发的倾向,治疗难度高。握拳运动开始作为一种额外的肌功能治疗,可以帮助纠正前牙开咬和稳定治疗结果。这篇叙述性回顾的目的是解释握紧锻炼作为一个额外的正畸治疗前开咬患者。在开咬治疗中最重要的一步是保留期,因为复发的趋势很强,很难预测。手术治疗可以实现前牙开咬,但这种治疗不能保证治疗结果的稳定性。为了在前牙开咬矫正中达到固位,治疗后肌肉功能的改善是至关重要的。握拳运动可作为前牙开咬患者的辅助治疗,缩短治疗时间,保持治疗结果的稳定性。
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引用次数: 0
T1 contrast versus fluid-attenuated inversion recovery contrast technique for evaluation of cerebral tuberculosis T1对比液体衰减反转恢复对比技术评价脑结核
Pub Date : 2023-08-09 DOI: 10.25259/gjhsr_15_2022
Balavaitheeswar Ramalingam, Elamparidhi Padmanaban, J. V. Raj, Pugazhendhi Sambath, Avinesh Varadane
T2-weighted (T2W) fluid-attenuated inversion recovery (FLAIR), a traditional magnetic resonance imaging (MRI) technique, is regarded as one of the most effective methods for examining brain disorders. The identification of brain pathologies can be significantly aided by T2 FLAIR and T1 post-contrast imaging. However, lesion enhancement is occasionally inconspicuous on T1-weighted image. Hence, for the evaluation of brain disorders, a MRI approach known as FLAIR contrast would combine the benefits of T2W FLAIR with contrast-enhancement on a single picture.After obtaining clearance from the Institution’s Ethics Committee, contrast-enhanced MRI (CE-MRI) brain of 20 patients was taken for the study. CE-MRI was performed using 1.5 Tesla Intera PHILIPS with intravenous administration of gadolinium at approximately 0.1 mL/kg/body at a rate of 10 mL/15 s.This study showed a better appreciation of lesion conspicuity when compared to prior T1 contrast images. However, there was no significant difference in the number of lesions, lesion extension, and degree of contrast-enhancement on comparison with T1 contrast images.T1 FLAIR contrast shows a better appreciation of lesion conspicuity when compared to T1 contrast images. Post-contrast FLAIR imaging is a valuable adjunct to post-contrast T1W imaging and effectively delineates cerebral tubercular pathologies. However, T1 FLAIR cannot be used as a replacement for conventional T1 fat saturated post-contrast imaging.
t2加权(T2W)流体衰减反转恢复(FLAIR)是一种传统的磁共振成像(MRI)技术,被认为是检查脑部疾病最有效的方法之一。T2 FLAIR和T1造影后成像对脑部病变的识别有重要帮助。然而,病变强化有时在t1加权图像上不明显。因此,对于脑部疾病的评估,一种被称为FLAIR对比的MRI方法将T2W FLAIR的优点与单幅图像的对比增强相结合。在获得该机构伦理委员会的批准后,取20例患者的大脑进行对比增强MRI (CE-MRI)研究。使用1.5 Tesla Intera PHILIPS进行增强磁共振成像,以大约0.1 mL/kg/体的速度静脉注射钆,速度为10 mL/15 s。这项研究表明,与先前的T1对比图像相比,对病变显著性有了更好的认识。但与T1对比图相比,病变数量、病变范围、增强程度均无明显差异。与T1对比图像相比,T1 FLAIR对比能更好地显示病变的显著性。对比后FLAIR成像是一种有价值的辅助对比后T1W成像和有效地描绘脑结核病理。然而,T1 FLAIR不能替代传统的T1饱和脂肪成像。
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引用次数: 0
The effect of paracetamol on the parasitological diagnosis of Plasmodium falciparum malaria 对乙酰氨基酚在恶性疟原虫疟疾寄生虫学诊断中的作用
Pub Date : 2023-08-09 DOI: 10.25259/gjhsr_9_2023
Mohamed Magzob, Ashraf Al Sammani, Ahmed Al Siddiq
Up until the present time, malaria represents an immense public health problem worldwide with a significant morbidity and mortality rate in many developing countries including Sudan. The use of antipyretics and analgesics in the settings of malaria has been a matter of contention over a vast period of time. Now, it is widely believed among the public and some health professionals in Sudan that the antipyretic and analgesic paracetamol disturbs the accuracy of the parasitological diagnosis of malaria. This study investigates the magnitude and effects of that belief through a descriptive study and examines the actual effect of paracetamol on the parasitological diagnosis of falciparum malaria through a clinical trial.This is a conjoined study that includes a prospective and descriptive study and a randomized, placebo-controlled, double-blind, and parallel-group clinical trial. The descriptive study included 846 participants from various states in Sudan. The targeted study subjects were the public and health professionals and the study was conducted utilizing an online-based questionnaire. The clinical trial included 325 patients with uncomplicated falciparum attending two primary healthcare outpatient clinics in Gezira state, Sudan. The patients were randomly allocated to receive either placebo tablets or 500 mg of oral paracetamol after the first blood smear sample was taken. The second blood smear samples were taken 2 h after taking treatment. Parasite density estimation and other parasitological data were obtained from each sample before and after treatment.The majority of the public thinks that paracetamol affects the parasitological diagnosis of malaria (76.21%, n = 330/433). Personal experience and family and friends were the most dominant information sources for the public (31.20% and 28.01% respectively), while scholarly articles were the most common source of information for the health professional group (45.03%, n = 186/413). No significant differences between the parasitological findings acquired before and after taking the treatments among both the paracetamol group (P = 0.22) and the placebo group (P = 0.12). The parasite density mean for the paracetamol group differed by 16.31 P/μL after taking paracetamol, while the placebo group parasite density mean differed by 15.34 P/μL. The treatments did not inflict impacts on the advanced microscopic features of Plasmodium falciparum blood smears.Paracetamol does not affect the parasitological diagnosis of falciparum malaria.
到目前为止,疟疾是全世界一个巨大的公共卫生问题,在包括苏丹在内的许多发展中国家发病率和死亡率很高。在疟疾的情况下使用退烧药和镇痛药一直是一个有争议的问题,在很长一段时间。现在,苏丹的公众和一些保健专业人员普遍认为,解热镇痛的扑热息痛干扰了疟疾寄生虫学诊断的准确性。本研究通过一项描述性研究调查了这种信念的程度和影响,并通过临床试验检验了扑热息痛对恶性疟疾寄生虫学诊断的实际效果。这是一项联合研究,包括一项前瞻性描述性研究和一项随机、安慰剂对照、双盲、平行组临床试验。这项描述性研究包括来自苏丹各州的846名参与者。目标研究对象是公众和卫生专业人员,研究采用基于在线的调查问卷进行。该临床试验包括325名在苏丹Gezira州的两家初级卫生保健门诊就诊的无并发症恶性疟原虫患者。在第一次血液涂片取样后,患者被随机分配服用安慰剂片或口服500毫克扑热息痛。治疗2 h后取第二次血涂片。对每个样本进行处理前后的寄生虫密度估算和其他寄生虫学数据。大多数公众认为扑热息痛影响疟疾的寄生虫学诊断(76.21%,n = 330/433)。个人经历和家人朋友是公众最主要的信息来源(分别为31.20%和28.01%),而学术文章是卫生专业人群最常见的信息来源(45.03%,n = 186/413)。扑热息痛组与安慰剂组治疗前后的寄生虫学检查结果差异无统计学意义(P = 0.22)。扑热息痛组和安慰剂组的寄生虫密度差异分别为16.31 P/μL和15.34 P/μL。这些治疗对恶性疟原虫血液涂片的高级显微特征没有影响。对乙酰氨基酚不影响恶性疟疾的寄生虫学诊断。
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Global Journal of Health Sciences and Research
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