Pub Date : 2022-11-03DOI: 10.3329/jrpmc.v7i2.62643
Asm Mazedul Islam, M. Muttalib, Md Nazrul Islam, M. Haque, Mohammad Rafiqul Hoque, -. Maknunnahar
Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver diseases characterized by simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is the most common cause of cryptogenic cirrhosis. NAFLD is associated with obesity, insulin resistance, hypertension, type 2 diabetes mellitus, and dyslipidemia. Objective: The study aimed to assess the changes in lipid profile and aminotransferases (ALT and AST) in Non-alcoholic fatty liver disease (NAFLD). Methods: This observational cross-sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in cooperation with the Centre for Nuclear Medicine and Ultrasound, Mymensingh from January 2012 to June 2013 after the approval of the protocol. A total of 120 subjects were included through purposive sampling, among them, 60 subjects were with fatty liver disease (group-I) and another 60 were without fatty liver (group-II) with ultrasonography. The sampling method was purposive (non-random). Relevant laboratory investigations were performed by using established methods to achieve the objectives. Results: The majority of the subjects with NAFLD (33.33%) were in 51-60 years (in Group-I). Mean serum total cholesterol, triacylglycerol, LDL-cholesterol, and HDL-cholesterol were 203.33±21.83, 184.41±33.31, 126.28±18.75, and 40.17±6.32 mg/dl in group-I and 167.65±9.83, 128.77±11.65, 101.74±9.29 and 40.16±3.55 mg/dl in group-II respectively. Significant differences were found in the case of total cholesterol (p<0.001), triacylglycerol (p<0.001), and LDL-cholesterol (<0.001), but no significant difference was found in the case of HDL-cholesterol (p>0.05). Serum ALT and AST were 49.43±16.98, 45.20±13.56 U/L in group-I and 32.83±4.54, 28.68±4.31 U/L in the group- II respectively. Significant differences were found in case of ALT (p <0.001) and AST (p <0.001). Conclusion: Nonalcoholic fatty liver disease is associated with dyslipidemia and with the elevation of serum ALT and AST. J Rang Med Col. September 2022; Vol. 7, No. 2:35-39
{"title":"Study of Serum Lipid Profile and Aminotransferases (ALT and AST) in Non-obese, Non-diabetic Nonalcoholic Fatty Liver Disease","authors":"Asm Mazedul Islam, M. Muttalib, Md Nazrul Islam, M. Haque, Mohammad Rafiqul Hoque, -. Maknunnahar","doi":"10.3329/jrpmc.v7i2.62643","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62643","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver diseases characterized by simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is the most common cause of cryptogenic cirrhosis. NAFLD is associated with obesity, insulin resistance, hypertension, type 2 diabetes mellitus, and dyslipidemia. \u0000Objective: The study aimed to assess the changes in lipid profile and aminotransferases (ALT and AST) in Non-alcoholic fatty liver disease (NAFLD). \u0000Methods: This observational cross-sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in cooperation with the Centre for Nuclear Medicine and Ultrasound, Mymensingh from January 2012 to June 2013 after the approval of the protocol. A total of 120 subjects were included through purposive sampling, among them, 60 subjects were with fatty liver disease (group-I) and another 60 were without fatty liver (group-II) with ultrasonography. The sampling method was purposive (non-random). Relevant laboratory investigations were performed by using established methods to achieve the objectives. \u0000Results: The majority of the subjects with NAFLD (33.33%) were in 51-60 years (in Group-I). Mean serum total cholesterol, triacylglycerol, LDL-cholesterol, and HDL-cholesterol were 203.33±21.83, 184.41±33.31, 126.28±18.75, and 40.17±6.32 mg/dl in group-I and 167.65±9.83, 128.77±11.65, 101.74±9.29 and 40.16±3.55 mg/dl in group-II respectively. Significant differences were found in the case of total cholesterol (p<0.001), triacylglycerol (p<0.001), and LDL-cholesterol (<0.001), but no significant difference was found in the case of HDL-cholesterol (p>0.05). Serum ALT and AST were 49.43±16.98, 45.20±13.56 U/L in group-I and 32.83±4.54, 28.68±4.31 U/L in the group- II respectively. Significant differences were found in case of ALT (p <0.001) and AST (p <0.001). \u0000Conclusion: Nonalcoholic fatty liver disease is associated with dyslipidemia and with the elevation of serum ALT and AST. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:35-39","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132538669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-03DOI: 10.3329/jrpmc.v7i2.62638
Md Shahed Morshed, Md. Firoj Hossain, M. A. Hannan, Md Ahamedul Kabir, Mobarak Hosen, Satyajit Mallick, M. J. Alam, Mohammad Nurul Amin, M. Faruque, S. Rahman
Background: Risk stratification is an essential and first component of the pre-Ramadan assessment of patients with diabetes mellitus (DM) who wish to fast. Limited data are reported from Bangladesh regarding risk stratification of people with DM who wish to fast. Objective: To determine the risk status of people with DM who wish to fast during Ramadan. Methods: This cross-sectional observational study was done among Muslim people of DM with at least one year of experience of Ramadan in previous years after their diagnosis. Along with baseline characteristics, the individual 14 risk elements of the International Diabetes Federation and Diabetes & Ramadan International Alliance (IDF-DAR) risk calculator- 2021 were assessed. Patients were categorized into low, moderate, and high risk with a total score of 0-3, 3.5-6, and ≥6.5 respectively. Moderate and high-risk patients were counseled about their risk of fasting and requested to reconsider their wishes. Results: Among 569 participants, (mean age 50.97±12.02 years, male-female ratio 36.2:63.8) 37.8%, 38.8%, and 23.4% had high, moderate, and low risk respectively. Risk scores were significantly higher in older age (p<0.001), male sex (p=0.024), residence in Chattagram than Rajshahi division (p=0.009) as well as housewife and businessman than other occupations (p=0.012). Despite knowing the risks of fasting, 88.8% of people with high risk and 96.8% of people with moderate risks still wished to fast. The people who still wished to fast despite knowing their risks of fasting had significantly lower percent of macrovascular disease (p=0.039), lower creatinine levels (p<0.001), with a lower percent of dipstick proteinuria (p=0.010), and use of insulin (p=0.021) than those who changed their decision. Conclusions: Nearly 90% of persons with DM with moderate/high risk for fasting still wished to fast despite their exemption. These at-risk population needs guidance, monitoring, and follow-up for safe fasting. J Rang Med Col. September 2022; Vol. 7, No. 2:4-11
背景:风险分层是希望斋戒的糖尿病(DM)患者斋月前评估的重要和首要组成部分。孟加拉国关于希望禁食的糖尿病患者的风险分层报告的数据有限。目的:了解糖尿病患者在斋月期间斋戒的危险状况。方法:这项横断面观察研究是在穆斯林糖尿病患者中进行的，他们在诊断后的前几年至少有一年的斋月经历。除了基线特征外，还评估了国际糖尿病联合会和糖尿病与斋月国际联盟(IDF-DAR)风险计算器- 2021中的14个风险要素。患者分为低危、中危和高危，总分分别为0-3分、3.5-6分和≥6.5分。中度和高危患者被告知他们禁食的风险，并被要求重新考虑他们的意愿。结果:569名参与者中(平均年龄50.97±12.02岁，男女比36.2:63.8)，高、中、低风险分别为37.8%、38.8%和23.4%。年龄较大(p<0.001)、性别为男性(p=0.024)、居住在查塔格拉姆区(p=0.009)、家庭主妇和商人的风险评分显著高于其他职业(p=0.012)。尽管知道禁食的风险，88.8%的高风险人群和96.8%的中度风险人群仍然希望禁食。与改变决定的人相比，尽管知道自己有禁食的风险，但仍然希望禁食的人患大血管疾病的比例(p=0.039)、肌酐水平(p<0.001)较低、尿量蛋白尿(p=0.010)和胰岛素使用(p=0.021)的比例明显较低。结论:近90%的糖尿病中/高风险禁食患者尽管得到了豁免，但仍希望禁食。这些高危人群需要安全禁食方面的指导、监测和随访。J Rang Med Col. 2022年9月;第七卷2:4-11
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Pub Date : 2022-11-03DOI: 10.3329/jrpmc.v7i2.62649
Md Helal Miah, Tania Begum, Md Shafiul Alam, A. Mondol, Md Mahfuj Ul Anwar
Bangladesh is an example of a highly populous, agricultural country where melioidosis may be a significantly underdiagnosed cause of infection and death. Melioidosis is caused by a highly pathogenic, soil-borne, Gram-negative bacterium, Burkholderia pseudomallei. Diabetes mellitus is the most common risk factor. Disease manifestations vary from pneumonia or localized abscess to acute septicemia or arthritis. Culture is considered the current gold- standard for diagnosis. For the intensive phase (10 to 14 days), ceftazidime or meropenem is the drug of choice. For the eradication phase (3 to 6 months), oral trimethoprim/ sulfamethoxazole is the drug of choice. Surgery (drainage of abscess) has an important role in the management of melioidosis. A 48-year-old male, health worker of an NGO, working at Cox’s Bazar presented with fever for 1 month and gradual increasing pain and swelling of the left knee for 7 days followed by cellulitis and multiple abscess formation in the left leg. B. pseudomallei isolated from blood culture and successfully treated with meropenem. J Rang Med Col. September 2022; Vol. 7, No. 2:69-72
孟加拉国是一个人口众多的农业国家，类鼻疽病可能是一个严重未被诊断的感染和死亡原因。类meliosis是由一种高致病性的，土壤传播的革兰氏阴性细菌，假氏伯克氏菌引起的。糖尿病是最常见的危险因素。疾病表现多样，从肺炎或局部脓肿到急性败血症或关节炎。文化被认为是目前诊断的金标准。在强化期(10至14天)，可选择头孢他啶或美罗培南。在根除阶段(3至6个月)，口服甲氧苄啶/磺胺甲恶唑是首选药物。手术(脓肿引流)在类鼻疽的治疗中起着重要作用。一名48岁男性，非政府组织卫生工作者，在Cox 's Bazar工作，发烧1个月，左膝疼痛和肿胀逐渐加重，持续7天，随后出现蜂窝组织炎和左腿多发脓肿。从血培养中分离出假假芽孢杆菌，并用美罗培南成功治疗。J Rang Med Col. 2022年9月;第7卷第2章69-72节
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