Journal of Rangpur Medical College最新文献

{"title":"Eating Disorders: Reviews on Update in Diagnosis and Management","authors":"Md. Shakhawat Hossain, Md Mahfuj Ul Anwar, -. Maknunnahar, Md Abdul Motin, Md Shafiul Alam, J. Hossain, Md. Naushad Ali, A. Rana","doi":"10.3329/jrpmc.v7i2.62648","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62648","url":null,"abstract":"Eating disorders are common and frequently missed behavioral disorders associated with significant physical, mental and social morbidity and mortality. Among psychiatric illness, mortality rate of anorexia nervosa and bulimia nervosa is about 10% and 1% at 10 years of diagnosis respectively. All clinicians should ask about eating habits (such as dieting, binge-eating, and weight control behaviors etc) and weight concerns in high risk groups, even when they have no concerns about eating or weight. The DSM-5 and ICD-11 list 6 distinct eating disorders: 1) Anorexia nervosa, 2) Bulimia nervosa, 3) Binge-eating disorder (BED), 4) Avoidant/restrictive food intake disorder (ARFID), 5) Rumination disorder and 6) Pica. Since the incidence of eating disordered patients in appears to be rising, it is a time demanding issue to deliver multidisciplinary treatment for them. As eating disorders frequently involve multi-system disorders such as gastrointestinal, neurological and endocrine, early screening and assessment of patients with eating disorders is essential. Treatments for eating disorders depend on its types and focus on behavioral change, targeting normalizes the weight and eating habits. Depending on the severity of malnutrition and associated medical conditions, eating disorders may be treated with patient education , cognitive behavioral therapy (CBT), family-based treatment (FBT), specialist supportive clinical management (SSCM) and Pharmacotherapy (TCAs, MAOIs, and SSRIs). \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:63-68","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128385444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Serum Creatinine and Urea in Adult Female Individuals and their Correlations with BMI","authors":"Safina Akhter, C. Sarkar, Atm Zoadur Rahim Zahid, Neaz Ahmed","doi":"10.3329/jrpmc.v7i2.62636","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62636","url":null,"abstract":"Background: The World Health Organization has announced overweight and obesity as a global epidemic that has strong associations with renal function impairment. \u0000Objectives: To evaluate the serum creatinine and urea status in adult female individuals with previous normal renal function and to observe the correlation of serum creatinine and urea with body mass index (BMI). \u0000Methods: This cross-sectional analytical study was conducted in the Department of Physiology, Rangpur Medical College, Rangpur. After briefing about the objectives, adult female subjects who met the inclusion and exclusion criteria were enrolled in the study with permission. The study included 90 subjects who were divided into three groups- apparently healthy adult females with normal weight (Group-A), apparently healthy overweight adult females (Group-B), and apparently healthy obese adult females (Group-C). The subjects were selected from different areas of Rangpur city. Their body mass index, serum creatinine, and urea were measured. For statistical analysis, one way ANOVA (post-Hoc) test and Pearson’s correlation coefficient test were performed as applicable by computer-based SPSS-25.0 for windows. Regarding the interpretation of results, p_0.05 was accepted as significant. \u0000Results: The mean serum creatinine level was significantly (p_0.001) higher in overweight and obese female adults than in normal-weight female adults. It was also significantly (p_0.05) higher in obese female adults than in overweight female adults. Again, the mean serum urea level was significantly (p_0.05) higher in overweight female adults than normal-weight female adults and in obese female adults than in overweight female adults. It was also significantly (p_0.001) higher in obese female adults than in normal-weight female adults. This study also found highly significant (p_0.001) positive correlation of serum creatinine (r=0.499) and urea (r=0.396) with body mass index. \u0000Conclusion: Serum creatinine and urea were elevated in overweight and obese female adults and both parameters were positively correlated with BMI. Regular body mass index screening is recommended to assess body weight easily and effectively. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:25-30","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115447359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Services Provided Through Community Clinic: Access and Utilization by Rural People","authors":"Sarowat Hossain, S. Alam, Mahabubul Islam, Shahgahan Miah, Md. Abu Hanifa, Z. H. Sarker, Taslim Fatema, Munira Begum, Labib Hasan","doi":"10.3329/jrpmc.v7i2.62640","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62640","url":null,"abstract":"Background: Community clinics (CC) have been restarted in 2009 by the government of Bangladesh through a project called “Revitalization of Community Health Care Initiatives in Bangladesh” (RCHCIB) to accomplish the ambitious project of establishing 18,000 community clinics. Since then 10,723 Community clinics have been established and they provide free health and family planning services to rural people (for every 6000 population one CC). \u0000Objective: The study aimed to assess the prevalence of access and utilization of services provided through community clinics by rural people. \u0000Methods: This cross-sectional descriptive study was conducted in Palashbari, Gaibandha district from 15th March 2019 to 20th April 2019. 568 respondents were selected conveniently from the catchment area of 6 community clinics (CCs). Data were collected by face-to-face interviews with a pretested structured questionnaire. \u0000Results: Among 568 respondents, majority ware in the age group of 31-50 years (45.4%),female (83%) and housewives (76.8%).93.5% of the respondents visited community clinics. And 85.6% were benefited from the community clinic service. Maternal and child health service utilization was poor (pregnancy registration 27.6%, ANC and PNC 45.2%, family planning services 49.3%) and there is no normal delivery service in the community clinic. 66.2% of the respondents availed EPI Services, 45.8% received Health Education, 65.3% received Vitamin-A Supplementation, 59.9% availed Child Care Services, 71.7% received Treatment of Minor Illness and Diseases, 17.4% availed Referral Services. \u0000Conclusion: The CCs are well located in terms of access. According to the Respondents' services provided by the community, the clinic was average. Maternal and child health services, pregnancy, and birth registration were below the mark. There is no normal delivery service and according to the respondent’s opinion referral system was also poor. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:20-24","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114688990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Effect of Body Mass Index on Pregnancy Outcomes in Normal and Overweight Women","authors":"Tasnim Sarwar, Tamanna Hamid","doi":"10.3329/jrpmc.v7i2.62642","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62642","url":null,"abstract":"Background: Maternal obesity is associated with various antepartum, intrapartum, postpartum, and neonatal complications. Increasing rates of overweight among pregnant women become a significant public health concern with various implications for prenatal care and supervision of delivery. \u0000Objective: The study aimed to determine the adverse maternal and fetal outcomes in primigravid overweight and obese women delivering singleton babies. \u0000Methods: A prospective comparative study was conducted for one year at the Department of Obstetrics and Gynecology, Combined Military Hospital, Rangpur, during the period between July 2019 to June 2020. Primigravid women with a singleton uncomplicated pregnancy with a cephalic presentation at _37 weeks of gestation with accurate information regarding height and weight recorded at the booking visit were included in the study. Comparisons were made between 50 primigravidas with BMI _25 and 50 uncomplicated primigravidas with BMI between 18.5 - 24.99. Statistical analysis was done using SPSS version 16.0. Data were analyzed by the Pearson Chi-square test and Fisher’s exact test. \u0000Results: There was a significant increase in risk of developing gestational hypertension (RR=3.667; CI=1.63-8.27), preeclampsia (RR=7; CI=0.89- 54.83), gestational diabetes (RR=7; CI=0.89-54.83), failed induction of labour (RR=5.50; CI=1.28-23.55), failure to progress (R=6, CI= 1.41-25.44), macrosomia (RR=8, CI=1.04-61.62), NICU admissions (RR=2.45; CI=1.37-4.39), perineal lacerations (RR=7; CI=0.89-54.83), wound infection (RR=8;CI=1.04-61.62) among overweight mothers compared to non-obese mothers. \u0000Conclusions: It is concluded that obesity defined by Asian Indian guidelines (BMI _25 kg/m2) is associated with adverse maternal and fetal outcomes. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:31-34","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125373253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometric Design and Outcome of Transposition Flaps for Scalp Reconstruction","authors":"Md. Shahin Shah, Md Abdul Hamid, Md Hamidul Islam","doi":"10.3329/jrpmc.v7i2.62646","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62646","url":null,"abstract":"Background: The scalp is a unique part of the human body and various etiological factors, such as tumor extirpation, avulsion, infection, burns, or trauma, can lead to scalp defects. Primary closure, skin grafting, local flaps, tissue expansion or free tissue transfer is modalities available for scalp reconstruction. Local flap coverage is best option for full thickness loss with exposed bone. Among various local flap transposition flap is reasonable and flexible option with good outcome for scalp reconstruction. \u0000Objective: The purpose of this study was to evaluate the geometric design of transposition flap for scalp reconstruction concerning the dimension of the defect and outcome the surgery. \u0000Methods: This was a prospective observational study, conducted in the Burn & Plastic Surgery department of Rangpur medical college hospital, Rangpur and different private hospitals of Rangpur city over a period of three years from June 2018 to July 2021 through purposive sampling. All aged patients having single full thickness scalp wound with loss of pericranium were included in this study. In all cases transposition flaps were used. All the flaps were elevated through sub galeal lose areolar plane. Flap donor site was covered with split thickness skin graft taken from thigh. Surgical technique, patient factors and outcome were evaluated. \u0000Results: A total 50 patients were operated. The age range was 07-68 years, among them 36% patient were in the age range of 21 – 30 years. 80% patients in this series were male. In this series 64 % patients were construction and electric worker by profession. Electric burn was the main (64%) cause of soft tissue defect of scalp. The majority (46%) of the patients had a wound dimension of 51-70 cm2, smallest was (5x6) = 30cm2 and largest was (9x15) = 135cm2, indicating that extent of soft tissue defects in this series is quite extensive. 12 (24%) patients had complication and all were due to infection, seven patients had infection in flap recipient site, 2 patients had infection in flap donor site and 3 patients developed infection in skin donor site. There was no flap loss in our study. \u0000Conclusion: Sound knowledge of flap geometry and clear evaluation of the defect is mandatory for successful reconstruction of scalp defect. A local transposition flap with donor site skin grafting is reliable option for reconstruction of full thickness scalp defect in most instances. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:52-57","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116411015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Lipid Profiles of Primary Open Angle Glaucoma Patients Treated with Topical Timolol","authors":"Md. Mizanur Rahman, Md Mufakh Kharul Islam, M. K. Hossain, A. Mamun, N. Khan, Md Shafiqul Islam","doi":"10.3329/jrpmc.v7i2.62644","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62644","url":null,"abstract":"Background: Primary open-angle glaucoma (POAG) and atherosclerosis both are fairly common diseases among elderly persons, any adverse changes in serum lipids as a result of glaucoma therapy can increase the risk of coronary heart disease many folds. As topical beta blockers are also widely used and often the first line therapy in many patients requiring treatment for glaucoma for a long time, there is also a possible risk that _-blockers such as timolol adversely affect serum lipid profiles. \u0000Objective: The study aimed to evaluate the effect of topical timolol on serum lipid profiles. \u0000Methods: This cross-sectional observational study was performed in the department of ophthalmology, Bangabandhu Sheikh Mujib Medical University With convenience type of sampling technique 40 patients with newly diagnosed cases of primary open-angle glaucoma were selected. Baseline fasting lipid profiles were estimated and then timolol maleate 0.5%, 1 drop 12 hourly in both eyes were prescribed. At follow-up after 4 and 12 weeks, again fasting lipid profiles were estimated of the same patients. \u0000Results: In this study the baseline mean TC, HDL, LDL & TG were 175.4±19.28 , 46.63±5.33, 104.98±18.49,120.48±28.30 (mg/dl±SD) respectively. Baseline TC/HDL was 3.81±0.06. At follow up after 4 weeks there were increased level of TC, LDL,TG, TC/HDL by 0.45% (P=0.822), 0.8% (P=0.807) 1.82%(P=0.375), and 3.14%(P=0.307) respectively and HDL level decreased by 2.68%(P=0.232). At follow-up, after 12 weeks in comparison to baseline lipid levels, there was an increased level of TC, LDL, TG, and TC/HDL by 0.98% (P=0.959), 3% (P=0.996), 2.8% (P=0.104), and 17.0%(P=0.001) respectively and HDL level decreased by 13.61%(P=0.001). \u0000Conclusion: Topical timolol significantly lowers the plasma HDL level. Since the low level of HDL is strongly associated with an increased risk of myocardial infarction, our study cautions against the use of timolol in patients with a previous history of coronary heart disease. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:40-46","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124789535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Stature from Arm Span: A Prospective Study Among Medical Students of Rangpur Medical College","authors":"Riada Sultana, Selina Anwar, Shamima Islam, -. Maknunnahar","doi":"10.3329/jrpmc.v7i2.62645","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62645","url":null,"abstract":"Background: Arm span is one of the most reliable body parameters for predicting the stature of an individual. It is useful in an age-related loss in stature and in identifying individuals with disproportionate growth abnormalities and skeletal dysplasia. \u0000Objectives: The present study was undertaken to determine whether there is any correlation between stature and arm span and estimate stature from arm span by using multiplication factor and assess the effectiveness of the above estimation by comparing the ‘estimated’ values with the measured values. \u0000Methods: This is a cross-sectional analytical study done in the Department of Anatomy, Rangpur Medical College, Rangpur, from January to December 2018 on purposively selected 700 medical students (350 male and 350 female). Arm span along with their stature was measured directly from the subjects by using an anthropometric technique by a measuring tape. Multiplication factors were estimated for estimating stature and comparison were made between measured and estimated stature using paired “t” test. \u0000Results: The mean normal value of arm span was 170.48±7.38 cm in males and 156.13±5.98 cm in females and the stature was 168.93±0.06 cm in males and 156.23±0.05 cm in females. The multiplication factor was estimated for the same hand measurements with the stature. A significant positive correlation was found in the case of arm span with stature. \u0000Conclusion: Arm span is a valid measure of stature for both adult males and females. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:47-51","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130897764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriological Study on Surgical Site Infection in Rangpur Medical College and Hospital","authors":"Md Hamidul Islam, Minim Parvin Mishu, Nusrat Afroze, M. Mahmud, Md Shariful Islam, Md. Shahin Shah","doi":"10.3329/jrpmc.v7i2.62639","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62639","url":null,"abstract":"Background: Surgical site infections (SSIs) is a major problem in both developed and developing countries. In developing countries like Bangladesh, infection in surgical patients has been appearing as a serious risk due to insurgence of drug resistance. Surgical site infections (SSIs) contribute significantly to increased health care costs in terms of prolonged hospital stay and lost working days. The problem was largely unexplored in Rangpur Medical College and Hospital, Rangpur. \u0000Objective: The aim of the study was to evaluate the bacteriological study on surgical site infections in Rangpur Medical College & Hospital. \u0000Methods: This cross-sectional observational study was conducted in the Department of Surgery at Rangpur Medical College Hospital. 72 patients of all ages, sex who developed surgical site infection were included through purposive sampling for observation and clinical follow up and wound swab was microbiologically evaluated. \u0000Results: Of the 72 cases, SSI developed 30.6% (22) following elective surgery and 69.4% (50) following emergency surgery. 7 cases were associated with co-morbid conditions like diabetes mellitus (2), malignancy (4) and tuberculosis (1). Most common organisms were Escherichia coli (30 /54) followed by Staphylococcous aureus (14/54), Pseudomonas (07/54) and Klebsiella (03/54).The antibiogram pattern of the organism isolated from wound swab of SSIs were analyzed with commonly used antibiotics. Resistance of Escherichia coli to Amoxycillin, Cotrimoxazole, Doxycycline and Nalidixic acid were 100%, 91.5%, 71.4% and 60.5% respectively. In case of, Staphylococcus aureus 87.5% were resistant to penicillin and Cotrimoxazole. Resistance of Pseudomonas spp. to Ciprofloxacin, Ceftazidime and Gentamicin were 31.2%. 6.3% and 50% respectively. In case of Klebsiella spp, it showed that 100% strains were resistant to Amoxycillin like Esch. coli but all strains were sensitive to both Ceftriaxon and Imipenem. \u0000Conclusion: The study emphasizes the need for the evidence-based infection control and antibiotic prescription policies in the hospital. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:12-19","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116492955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox: A Contemporary Review for Healthcare Professionals","authors":"Shahed Jahan, SM Nurun Nabi","doi":"10.3329/jrpmc.v7i2.62637","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62637","url":null,"abstract":"Abstract not available \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:1-3","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"430 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122868396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Serum Lipid Profile and Aminotransferases (ALT and AST) in Non-obese, Non-diabetic Nonalcoholic Fatty Liver Disease","authors":"Asm Mazedul Islam, M. Muttalib, Md Nazrul Islam, M. Haque, Mohammad Rafiqul Hoque, -. Maknunnahar","doi":"10.3329/jrpmc.v7i2.62643","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62643","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver diseases characterized by simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is the most common cause of cryptogenic cirrhosis. NAFLD is associated with obesity, insulin resistance, hypertension, type 2 diabetes mellitus, and dyslipidemia. \u0000Objective: The study aimed to assess the changes in lipid profile and aminotransferases (ALT and AST) in Non-alcoholic fatty liver disease (NAFLD). \u0000Methods: This observational cross-sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in cooperation with the Centre for Nuclear Medicine and Ultrasound, Mymensingh from January 2012 to June 2013 after the approval of the protocol. A total of 120 subjects were included through purposive sampling, among them, 60 subjects were with fatty liver disease (group-I) and another 60 were without fatty liver (group-II) with ultrasonography. The sampling method was purposive (non-random). Relevant laboratory investigations were performed by using established methods to achieve the objectives. \u0000Results: The majority of the subjects with NAFLD (33.33%) were in 51-60 years (in Group-I). Mean serum total cholesterol, triacylglycerol, LDL-cholesterol, and HDL-cholesterol were 203.33±21.83, 184.41±33.31, 126.28±18.75, and 40.17±6.32 mg/dl in group-I and 167.65±9.83, 128.77±11.65, 101.74±9.29 and 40.16±3.55 mg/dl in group-II respectively. Significant differences were found in the case of total cholesterol (p<0.001), triacylglycerol (p<0.001), and LDL-cholesterol (<0.001), but no significant difference was found in the case of HDL-cholesterol (p>0.05). Serum ALT and AST were 49.43±16.98, 45.20±13.56 U/L in group-I and 32.83±4.54, 28.68±4.31 U/L in the group- II respectively. Significant differences were found in case of ALT (p <0.001) and AST (p <0.001). \u0000Conclusion: Nonalcoholic fatty liver disease is associated with dyslipidemia and with the elevation of serum ALT and AST. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:35-39","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132538669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}