Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.266988
Adisak Wongkajornsilpa, R. Phimolsarnti, Chandhanarat Chandhanayingyong, S. Waikakul, P. Chotiyarnwong
Objective: To evaluate the effect of pH on the apoptosis and necrosis rate of giant cell tumor of bone (GCTB) cells during thermoablation. Materials and Methods: GCTB tissues were collected from 15 patients. Cells were incubated at 25 ºC , 37 ºC, 45 ºC, and 50 ºC, with the variation of the pH at 4.7, 5.6, 6.5, 7.4, 8.3, and 9.2 for 20 minutes (in triplicate for each condition). The effect of thermoablation and pH variation on GCTB cells death was evaluated by staining with Annexin V-FITC and propidium iodide solution after 3 days of incubation. The fluorescence intensity was evaluated by flow cytometry to evaluate the percentage of tumor cells death. Results: Thermoablation alone increased the percentage of tumor cells death. However, when combined with an increase in pH, the percentage of GCTB cells death increased more. Conversely, lowering the pH did not increase the tumor cells death compared with thermoablation treatment alone, while changing the pH alone had only a low effect on increasing the percentage of GCTB cells death. Conclusion: Thermoablation the temperature between 37 ºC and 45 ºC plus a pH level slightly higher than physiologic pH (between 7.4 and 8.3) for 20 minutes increased GCTB cell death. However, determining the optimum condition to kill tumor cells while causing minimal harm to normal cells requires more study.
{"title":"Effect of Thermoablation with pH Change on Giant Cell Tumor of Bone: An In Vitro Study","authors":"Adisak Wongkajornsilpa, R. Phimolsarnti, Chandhanarat Chandhanayingyong, S. Waikakul, P. Chotiyarnwong","doi":"10.33192/smj.v76i6.266988","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266988","url":null,"abstract":"Objective: To evaluate the effect of pH on the apoptosis and necrosis rate of giant cell tumor of bone (GCTB) cells during thermoablation.\u0000Materials and Methods: GCTB tissues were collected from 15 patients. Cells were incubated at 25 ºC , 37 ºC, 45 ºC, and 50 ºC, with the variation of the pH at 4.7, 5.6, 6.5, 7.4, 8.3, and 9.2 for 20 minutes (in triplicate for each condition). The effect of thermoablation and pH variation on GCTB cells death was evaluated by staining with Annexin V-FITC and propidium iodide solution after 3 days of incubation. The fluorescence intensity was evaluated by flow cytometry to evaluate the percentage of tumor cells death.\u0000Results: Thermoablation alone increased the percentage of tumor cells death. However, when combined with an increase in pH, the percentage of GCTB cells death increased more. Conversely, lowering the pH did not increase the tumor cells death compared with thermoablation treatment alone, while changing the pH alone had only a low effect on increasing the percentage of GCTB cells death.\u0000Conclusion: Thermoablation the temperature between 37 ºC and 45 ºC plus a pH level slightly higher than physiologic pH (between 7.4 and 8.3) for 20 minutes increased GCTB cell death. However, determining the optimum condition to kill tumor cells while causing minimal harm to normal cells requires more study.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"49 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.267251
Siranya Paecharoen, Thanutchaporn Kritsanapraneet
Objective: To determine the distribution of foot arch type, associated symptoms, and factors associated with moderate to severe pain Materials and Methods: The cross-sectional study was collected data from 5th year medical students, Faculty of Medicine, Thammasat University in academic year 2020. The distribution of foot arch type used the footprint and classified by Harris imprint index (HII), Chippaux-Smirak index (CSI), Staheli index (SI). The associated symptoms were collected into pain and tightness. Pain score was rated by the volunteer using numeric rating scale (NRS) at each foot/leg separately. Results: A total of ninety-eight medical students (196 feet) were recruited and analyzed. The distribution of foot arch type by HII, CSI and SI were 1) bilateral normal arched feet: 42.9%, 67.3%, 54.1% 2) bilateral pes planus: 8.2%, 12.2%, 21.4% 3) bilateral pes cavus: 25.5%, 6.1%, 5.1% 4) unilateral pes planus: 2%, 9.2%,15.3% 5) unilateral pes cavus: 21.4%, 5.1%, 4.1%, respectively. The most commonly associated symptom of pes planus was midfoot pain (17%) while pes cavus and normal arched foot were hindfoot pain (22.4% and 17.3%). The factor associated with moderate to severe pain was BMI ≥ 23 kg/m2 (OR = 3.23, 95%CI 1.63 - 6.41, p-value = 0.001). Conclusion: Bilateral normal arched feet were mostly found. Midfoot pain in pes planus and hindfoot pain in pes cavus and normal arched foot were the greatest symptoms. BMI was a risk factor.
{"title":"Distribution of Foot Arch Type and Associated Symptoms in Medical Students at Faculty of Medicine, Thammasat University","authors":"Siranya Paecharoen, Thanutchaporn Kritsanapraneet","doi":"10.33192/smj.v76i6.267251","DOIUrl":"https://doi.org/10.33192/smj.v76i6.267251","url":null,"abstract":"Objective: To determine the distribution of foot arch type, associated symptoms, and factors associated with moderate to severe pain\u0000Materials and Methods: The cross-sectional study was collected data from 5th year medical students, Faculty of Medicine, Thammasat University in academic year 2020. The distribution of foot arch type used the footprint and classified by Harris imprint index (HII), Chippaux-Smirak index (CSI), Staheli index (SI). The associated symptoms were collected into pain and tightness. Pain score was rated by the volunteer using numeric rating scale (NRS) at each foot/leg separately.\u0000Results: A total of ninety-eight medical students (196 feet) were recruited and analyzed. The distribution of foot arch type by HII, CSI and SI were 1) bilateral normal arched feet: 42.9%, 67.3%, 54.1% 2) bilateral pes planus: 8.2%, 12.2%, 21.4% 3) bilateral pes cavus: 25.5%, 6.1%, 5.1% 4) unilateral pes planus: 2%, 9.2%,15.3% 5) unilateral pes cavus: 21.4%, 5.1%, 4.1%, respectively. The most commonly associated symptom of pes planus was midfoot pain (17%) while pes cavus and normal arched foot were hindfoot pain (22.4% and 17.3%). The factor associated with moderate to severe pain was BMI ≥ 23 kg/m2 (OR = 3.23, 95%CI 1.63 - 6.41, p-value = 0.001).\u0000Conclusion: Bilateral normal arched feet were mostly found. Midfoot pain in pes planus and hindfoot pain in pes cavus and normal arched foot were the greatest symptoms. BMI was a risk factor.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"44 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.266822
Chatchawan Sutthipongkiat, Watcharee Attatippaholkun, Sudarat Srisamutnak, S. Waikakul, P. Chotiyarnwong
Objective: To compare plasma selenium levels in primary bone tumor patients with clinically healthy Thai subjects. Materials and Methods: A cross-sectional study on plasma selenium of primary bone tumor patients aged above 12 years old was obtained at Siriraj Hospital. The plasma samples were used for selenium assay by Electrothermal Atomic Absorption spectrometry method. The plasma selenium levels were compared with the clinically healthy Thai subjects or within primary bone tumor groups (age: below or above 30 years, gender: male or female, benign or malignant tumor, metastasis or non-metastasis). Results: One hundred and nine primary bone tumor patients were included in this study. Plasma selenium level in clinically healthy Thai subjects aged more than 30 years old was significantly higher than a primary bone tumor group (121.71 ± 19.96 g/L vs 111.88 ± 23.62 g/L, mean difference -9.83, p-value = 0.017). The plasma selenium levels within the primary bone tumor patients did not exhibit significant differences when compared across genders, age groups below and above 30 years old, benign and malignant tumors, or between metastatic and non-metastatic tumor cases. Conclusion: A patient with a history of malignant bone tumors tends to have a lower level of plasma selenium than normal people. However, the study of selenium supplementation for those who have a higher risk of developing malignant bone tumors is needed in the future.
{"title":"Lower Plasma Selenium Level in Primary Malignant Bone Tumors: A Survey Research","authors":"Chatchawan Sutthipongkiat, Watcharee Attatippaholkun, Sudarat Srisamutnak, S. Waikakul, P. Chotiyarnwong","doi":"10.33192/smj.v76i6.266822","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266822","url":null,"abstract":"Objective: To compare plasma selenium levels in primary bone tumor patients with clinically healthy Thai subjects.\u0000Materials and Methods: A cross-sectional study on plasma selenium of primary bone tumor patients aged above 12 years old was obtained at Siriraj Hospital. The plasma samples were used for selenium assay by Electrothermal Atomic Absorption spectrometry method. The plasma selenium levels were compared with the clinically healthy Thai subjects or within primary bone tumor groups (age: below or above 30 years, gender: male or female, benign or malignant tumor, metastasis or non-metastasis).\u0000Results: One hundred and nine primary bone tumor patients were included in this study. Plasma selenium level in clinically healthy Thai subjects aged more than 30 years old was significantly higher than a primary bone tumor group (121.71 ± 19.96 g/L vs 111.88 ± 23.62 g/L, mean difference -9.83, p-value = 0.017). The plasma selenium levels within the primary bone tumor patients did not exhibit significant differences when compared across genders, age groups below and above 30 years old, benign and malignant tumors, or between metastatic and non-metastatic tumor cases.\u0000Conclusion: A patient with a history of malignant bone tumors tends to have a lower level of plasma selenium than normal people. However, the study of selenium supplementation for those who have a higher risk of developing malignant bone tumors is needed in the future.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"50 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to develop and compare machine learning models (MLMs) for predicting venous thromboembolism (VTE) in patients undergoing surgery for spinal metastasis. The study evaluates the predictive capabilities of MLMs for preoperative and postoperative VTE within different time frames. Materials and Methods: A total of 334 patients undergoing surgery for spinal metastasis were included, with a mean age of 57.6 years and 57.2% being male. The investigation assessed postoperative VTE prevalence within 30 and 90 days, with pulmonary embolism (PE) and deep vein thrombosis (DVT) rates at 20% and 80%, respectively. Key patient-related factors—age, body mass index, preoperative ambulatory status, albumin level, hemoglobin level, partial thromboplastin time, and operative time—were considered potential predictors of VTE. Results: The postoperative VTE prevalence was 8.98% within 30 days and 13.47% within 90 days. Age, body mass index, preoperative ambulatory status, albumin level, hemoglobin level, partial thromboplastin time, and operative time emerged as significant VTE predictors. The gradient boosted tree algorithm was the best-performing MLM for predicting VTE within 90 days, with AUC values of 0.77 preoperatively and 0.71 postoperatively. For predicting VTE within 30 days, the support vector machine model was most effective, with AUCs of 0.72 preoperatively and 0.68 postoperatively. Conclusion: Predictive analytics and MLMs effectively predict preoperative and postoperative VTE in patients undergoing surgery for spinal metastasis. Identified key factors and MLM performance metrics offer valuable insights for risk assessment and preventive measures in this patient population.
{"title":"Development of Machine Learning Algorithms for Predicting Preoperative and Postoperative venous Thromboembolism in Patients Undergoing Surgery for Spinal Metastasis","authors":"Borriwat Santipas, Apisun Chanajit, Sirichai Wilartratsami, Piyalitt Ittichaiwong, Kanyakorn Veerakanjana, Panya Luksanapruksa","doi":"10.33192/smj.v76i6.266959","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266959","url":null,"abstract":"Objective: This study aims to develop and compare machine learning models (MLMs) for predicting venous thromboembolism (VTE) in patients undergoing surgery for spinal metastasis. The study evaluates the predictive capabilities of MLMs for preoperative and postoperative VTE within different time frames.\u0000Materials and Methods: A total of 334 patients undergoing surgery for spinal metastasis were included, with a mean age of 57.6 years and 57.2% being male. The investigation assessed postoperative VTE prevalence within 30 and 90 days, with pulmonary embolism (PE) and deep vein thrombosis (DVT) rates at 20% and 80%, respectively. Key patient-related factors—age, body mass index, preoperative ambulatory status, albumin level, hemoglobin level, partial thromboplastin time, and operative time—were considered potential predictors of VTE.\u0000Results: The postoperative VTE prevalence was 8.98% within 30 days and 13.47% within 90 days. Age, body mass index, preoperative ambulatory status, albumin level, hemoglobin level, partial thromboplastin time, and operative time emerged as significant VTE predictors. The gradient boosted tree algorithm was the best-performing MLM for predicting VTE within 90 days, with AUC values of 0.77 preoperatively and 0.71 postoperatively. For predicting VTE within 30 days, the support vector machine model was most effective, with AUCs of 0.72 preoperatively and 0.68 postoperatively.\u0000Conclusion: Predictive analytics and MLMs effectively predict preoperative and postoperative VTE in patients undergoing surgery for spinal metastasis. Identified key factors and MLM performance metrics offer valuable insights for risk assessment and preventive measures in this patient population.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"57 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141274689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.266370
Tinh Laoharojanaphand, C. Chotigavanichaya, T. Ariyawatkul, J. Wongcharoenwatana, Perajit Eamsobhana
Objective: To measure and compare the incidence of cast-related pressure injuries at the heel between sponge-incorporated long leg cast and multilayer padding cast following orthopedic lower extremity surgery. Materials and Methods: Patients aged 1 to 18 years who were scheduled for elective lower extremity soft tissue surgery were recruited. They were equally randomized into two groups: sponge padding cast (Group 1) and multilayer padding cast (Group 2). A multilayer padding cast, consisting of five layers of Webril®, was applied to the heel and bony prominence areas. At the 2nd and 4th weeks postoperatively, cast-related heel pressure injuries were evaluated using the 2016 National Pressure Ulcer Advisory Panel (NPUAP) staging system. Changes in alignment and other complications were also recorded. Results: 100 patients were recruited. At two weeks postoperatively, the incidence of cast-related heel pressure injuries in Group 1 was 4/46 cases (8.7%), with all cases being stage 1. In Group 2, there were 6/54 cases (11.1%), with 3 cases in stage 1 and 3 cases in deep tissue pressure injury (p=0.479). At four weeks postoperatively, Group 1 had 6/46 cases (13%), with 4/46 cases (8.7%) being stage 1 and 2/46 cases (4.3%) being deep tissue pressure injuries. Group 2 had 6/54 cases (11.1%) (p>0.99), with all cases being stage 1. There was no statistical difference in loss of alignment. No serious complications, such as compartment syndrome or neurovascular injury, were found. Conclusion: The incidence of cast-related heel pressure injury was comparable between sponge padding cast and a multilayer cotton padding cast.
{"title":"Sponge-incorporated VS Multilayer Padding Long Leg Cast to Prevent Pediatric Heel Pressure Injury: A Randomized Controlled Trial","authors":"Tinh Laoharojanaphand, C. Chotigavanichaya, T. Ariyawatkul, J. Wongcharoenwatana, Perajit Eamsobhana","doi":"10.33192/smj.v76i6.266370","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266370","url":null,"abstract":"Objective: To measure and compare the incidence of cast-related pressure injuries at the heel between sponge-incorporated long leg cast and multilayer padding cast following orthopedic lower extremity surgery.\u0000Materials and Methods: Patients aged 1 to 18 years who were scheduled for elective lower extremity soft tissue surgery were recruited. They were equally randomized into two groups: sponge padding cast (Group 1) and multilayer padding cast (Group 2). A multilayer padding cast, consisting of five layers of Webril®, was applied to the heel and bony prominence areas. At the 2nd and 4th weeks postoperatively, cast-related heel pressure injuries were evaluated using the 2016 National Pressure Ulcer Advisory Panel (NPUAP) staging system. Changes in alignment and other complications were also recorded.\u0000Results: 100 patients were recruited. At two weeks postoperatively, the incidence of cast-related heel pressure injuries in Group 1 was 4/46 cases (8.7%), with all cases being stage 1. In Group 2, there were 6/54 cases (11.1%), with 3 cases in stage 1 and 3 cases in deep tissue pressure injury (p=0.479). At four weeks postoperatively, Group 1 had 6/46 cases (13%), with 4/46 cases (8.7%) being stage 1 and 2/46 cases (4.3%) being deep tissue pressure injuries. Group 2 had 6/54 cases (11.1%) (p>0.99), with all cases being stage 1. There was no statistical difference in loss of alignment. No serious complications, such as compartment syndrome or neurovascular injury, were found.\u0000Conclusion: The incidence of cast-related heel pressure injury was comparable between sponge padding cast and a multilayer cotton padding cast.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.266954
Pasin Tangadulrat, N. Adulkasem, J. Wongcharoenwatana, T. Ariyawatkul, C. Chotigavanichaya, Perajit Eamsobhana
Objective: Distraction osteogenesis (DO) is a well-known technique. The traditional method utilized the lengthening frequency of four times a day (QID). Many mechanical factors may affect the DO outcome. However, the effect of distraction frequency has not been proven clinically. Therefore, we aim to investigate whether the BID and QID lengthening frequency affect the healing index and complications of the DO. Materials and Methods: We retrospectively reviewed patients who had undergone DO from 2010 – 2021. The patient was divided into BID and QID groups. Demographics, lengthening outcomes, and complications between the two groups were compared. We used the inverse probability of treatment weighting (IPTW) to determine the effect of treatment. Results: The median healing index (HI) of the patients whose lengthening was done QID is 41.36 (IQR 32.72 - 67.68) days/cm, and BID is 49.12 (IQR 35.28 - 62.54) days/cm, which did not differ significantly. The Odds ratio of achieving HI < 45 days/cm for patients receiving QID lengthening compare to BID is 1.12 (95% CI 0.31-3.99, p = 0.862 ). The IPTW did not show a difference in average treatment effects between QID and BID lengthening. The rates of minor and major complications were not significantly different between the two groups (26.1% in QID group and 32.1% in BID group). Conclusion: The frequency of QID and BID lengthening results in comparable HI and complications for patients who undergo DO. However, prospective research is needed to evaluate the effect of frequency differences in a clinical setting.
目的：牵引成骨（DO）是一种著名的技术。传统方法采用每天四次（QID）的延长频率。许多机械因素可能会影响牵引成骨的效果。然而，牵引频率的影响尚未得到临床证实。因此，我们旨在研究 BID 和 QID 拉伸频率是否会影响 DO 的愈合指数和并发症：我们回顾性研究了 2010-2021 年间接受 DO 的患者。将患者分为 BID 组和 QID 组。比较了两组患者的人口统计学特征、延长结果和并发症。我们使用逆治疗概率加权法（IPTW）来确定治疗效果：结果：采用 QID 延长术的患者的中位愈合指数（HI）为 41.36（IQR 32.72 - 67.68）天/厘米，而采用 BID 延长术的患者的中位愈合指数（HI）为 49.12（IQR 35.28 - 62.54）天/厘米，两者没有显著差异。与 BID 相比，接受 QID 延长术的患者达到 HI < 45 天/厘米的几率比为 1.12 (95% CI 0.31-3.99, p = 0.862)。IPTW显示，QID和BID延长术的平均治疗效果没有差异。两组的轻微和严重并发症发生率无明显差异（QID 组为 26.1%，BID 组为 32.1%）：结论：对于接受 DO 的患者来说，QID 和 BID 延长术的频率导致的 HI 和并发症具有可比性。然而，需要进行前瞻性研究，以评估频率差异在临床环境中的影响。
{"title":"Does The Lengthening Frequency Affect The Outcome of Distraction Osteogenesis? Comparing Two Times a Day with Four Times a Day Lengthening Protocol","authors":"Pasin Tangadulrat, N. Adulkasem, J. Wongcharoenwatana, T. Ariyawatkul, C. Chotigavanichaya, Perajit Eamsobhana","doi":"10.33192/smj.v76i6.266954","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266954","url":null,"abstract":"Objective: Distraction osteogenesis (DO) is a well-known technique. The traditional method utilized the lengthening frequency of four times a day (QID). Many mechanical factors may affect the DO outcome. However, the effect of distraction frequency has not been proven clinically. Therefore, we aim to investigate whether the BID and QID lengthening frequency affect the healing index and complications of the DO.\u0000Materials and Methods: We retrospectively reviewed patients who had undergone DO from 2010 – 2021. The patient was divided into BID and QID groups. Demographics, lengthening outcomes, and complications between the two groups were compared. We used the inverse probability of treatment weighting (IPTW) to determine the effect of treatment.\u0000Results: The median healing index (HI) of the patients whose lengthening was done QID is 41.36 (IQR 32.72 - 67.68) days/cm, and BID is 49.12 (IQR 35.28 - 62.54) days/cm, which did not differ significantly. The Odds ratio of achieving HI < 45 days/cm for patients receiving QID lengthening compare to BID is 1.12 (95% CI 0.31-3.99, p = 0.862 ). The IPTW did not show a difference in average treatment effects between QID and BID lengthening. The rates of minor and major complications were not significantly different between the two groups (26.1% in QID group and 32.1% in BID group).\u0000Conclusion: The frequency of QID and BID lengthening results in comparable HI and complications for patients who undergo DO. However, prospective research is needed to evaluate the effect of frequency differences in a clinical setting.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"6 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.33192/smj.v76i6.266228
Wacharapol Tepa, P. Lertwanich, Napasakorn Chuensiri
Objective: To determine the effects of plyometric training programs on neuromuscular and knee functions during the late phase rehabilitation following anterior cruciate ligament (ACL) reconstruction. Materials and Methods: Thirty participants, post-ACL reconstruction, were randomly assigned at their 6-month follow-up visit into two groups: 15 participants in each group (resistance or plyometric training group). Each group underwent two training sessions weekly for 8 weeks. The participants were assessed at baseline and after completed the training period for the single leg 6-meter timed hop, knee joint position sense, static and dynamic balance, isokinetic muscle strength and the International Knee Documentation Committee Subjective Knee Form. Results: Post an 8-week training period, both groups showed improvements in the single leg 6-meter timed hop. Notably, the limb symmetry index for this hop in the plyometric group was significantly higher than the resistance group {18.2% (10.2, 26.1) vs 6.2% (-2.0, 14.5) respectively}. The plyometric group also demonstrated significantly better knee joint position sense {-3.1° (-4.3, -1.9) vs -0.8° (-2.0, 0.4) respectively}and the unipedal stance on a stable surface with eyes closed {13.9 sec (2.7, 25.2) vs -2.6 sec (-14.3, 9.1) respectively} than the resistance group. Conclusion: Plyometric training in the late phase of ACL rehabilitation program has proven to be a suitable and effective approach for enhancing neuromuscular and knee functions.
{"title":"Effects of Supervised Plyometric Training on Neuromuscular and Knee Functions for Late Phase Rehabilitation Program in Patients with Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial","authors":"Wacharapol Tepa, P. Lertwanich, Napasakorn Chuensiri","doi":"10.33192/smj.v76i6.266228","DOIUrl":"https://doi.org/10.33192/smj.v76i6.266228","url":null,"abstract":"Objective: To determine the effects of plyometric training programs on neuromuscular and knee functions during the late phase rehabilitation following anterior cruciate ligament (ACL) reconstruction.\u0000Materials and Methods: Thirty participants, post-ACL reconstruction, were randomly assigned at their 6-month follow-up visit into two groups: 15 participants in each group (resistance or plyometric training group). Each group underwent two training sessions weekly for 8 weeks. The participants were assessed at baseline and after completed the training period for the single leg 6-meter timed hop, knee joint position sense, static and dynamic balance, isokinetic muscle strength and the International Knee Documentation Committee Subjective Knee Form.\u0000Results: Post an 8-week training period, both groups showed improvements in the single leg 6-meter timed hop. Notably, the limb symmetry index for this hop in the plyometric group was significantly higher than the resistance group {18.2% (10.2, 26.1) vs 6.2% (-2.0, 14.5) respectively}. The plyometric group also demonstrated significantly better knee joint position sense {-3.1° (-4.3, -1.9) vs -0.8° (-2.0, 0.4) respectively}and the unipedal stance on a stable surface with eyes closed {13.9 sec (2.7, 25.2) vs -2.6 sec (-14.3, 9.1) respectively} than the resistance group.\u0000Conclusion: Plyometric training in the late phase of ACL rehabilitation program has proven to be a suitable and effective approach for enhancing neuromuscular and knee functions.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This comparative study of the second and third waves of the COVID-19 pandemic aimed to: 1) examine the mental health status of hospital staff; 2) describe the associations among various factors that affect mental health; and 3) investigate the impact of COVID-19. Materials and Methods: Data were collected from Siriraj Hospital staff using online questionnaires including demographics, staff characteristics, health behavior, readiness to handle COVID-19; COVID-19 impact; and the Thai version of the Depression Anxiety Stress Scales–21 (DASS-21). Results: Depression, anxiety, and stress scores were significantly higher in the third wave. Living in a high-surveillance area, social distancing difficulties, health behaviors, and office work all impacted mental health in both waves. Demographics, infection exposure outside the hospital, awareness of social distancing, and readiness to work from home impacted only the second wave. Direct work with COVID-19 patients impacted only the third wave. The common stressors included living expenses, daily life changes, and disease prevention costs in both waves, with COVID-19 news having a greater impact in the third wave. Main daily life impacts were income, transportation, and disease prevention equipment in both waves, with food becoming more important in the third wave. Conclusion: Mental health should be prioritized especially in severe waves, focusing on staff at high risk of infection, experiencing social distancing challenges, daily life changes, and having health problems. Disease protection should also be emphasized early on.
{"title":"Factors Affecting the Mental Health of Thai Medical Staff during the Second and Third Waves of the COVID-19 Pandemic: An Online Cross-sectional Survey","authors":"Rungarun Anupansupsai, Nattha Saisavoey, Suroj Supavekin, Woraphat Ratta-apha, Juthawadee Lortrakul, Somboon Hataiyusuk","doi":"10.33192/smj.v76i5.267324","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267324","url":null,"abstract":"Objective: This comparative study of the second and third waves of the COVID-19 pandemic aimed to: 1) examine the mental health status of hospital staff; 2) describe the associations among various factors that affect mental health; and 3) investigate the impact of COVID-19.\u0000Materials and Methods: Data were collected from Siriraj Hospital staff using online questionnaires including demographics, staff characteristics, health behavior, readiness to handle COVID-19; COVID-19 impact; and the Thai version of the Depression Anxiety Stress Scales–21 (DASS-21).\u0000Results: Depression, anxiety, and stress scores were significantly higher in the third wave. Living in a high-surveillance area, social distancing difficulties, health behaviors, and office work all impacted mental health in both waves. Demographics, infection exposure outside the hospital, awareness of social distancing, and readiness to work from home impacted only the second wave. Direct work with COVID-19 patients impacted only the third wave. The common stressors included living expenses, daily life changes, and disease prevention costs in both waves, with COVID-19 news having a greater impact in the third wave. Main daily life impacts were income, transportation, and disease prevention equipment in both waves, with food becoming more important in the third wave.\u0000Conclusion: Mental health should be prioritized especially in severe waves, focusing on staff at high risk of infection, experiencing social distancing challenges, daily life changes, and having health problems. Disease protection should also be emphasized early on.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"3 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.33192/smj.v76i5.267706
Parm Tohroonglert, Valeerat Swatesutipan
Objective: Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms Long form (ICIQ-FLUTS LF) is a robust psychometric tool to assess the severity of lower urinary tract symptoms (LUTS) in women. A Thai language version of the ICIQ-FLUTS LF is available, but it had not been validated yet. This study aimed to validate the ICIQ-FLUTS LF questionnaire in Thai and to identify the correlation between the ICIQ-FLUTS LF and the IPSS. Materials and Methods: We recruited 130 females, 50 with LUTS were recruited from patients visiting the Urology Clinic to assess the test with known group validity. They completed the ICIQ-FLUTS LF twice, two weeks apart, and the IPSS once. Meanwhile, 80 without LUTS (control group) were recruited from relatives of the patients to increase the consistency of the statistical analysis, completed the ICIQ-FLUTS LF. Then validity and reliability were determined using statistical analysis. Results: Convergent validity showed a moderate correlation between ICIQ-FLUTS LF and IPSS for both storage and voiding symptoms, with Pearson’s correlation coefficient 0.49, 0.66; P<0.001, respectively. Construct validity, using the Wilcoxon signed-rank test, demonstrated statistically significant difference between the target group and the control group (P<0.001). The Thai version of the ICIQ-FLUTS LF showed good internal consistency, with Cronbach’s alpha coefficients 0.76-0.79 and Test–retest reliability strong, with weighted kappa values 0.63 to 0.90. Conclusion: The Thai version of the ICIQ-FLUTS LF shows good validity and reliable measures of females with LUTS, and is simple to use. This questionnaire in the Thai version can be used in clinical practice and academic research.
{"title":"Validity and Reliability of the Thai version of the International Consultation on Incontinence Questionnaire – Female Lower Urinary Tract Symptoms Long Form (ICIQ-FLUTS LF) and Its Correlation with the IPSS","authors":"Parm Tohroonglert, Valeerat Swatesutipan","doi":"10.33192/smj.v76i5.267706","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267706","url":null,"abstract":"Objective: Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms Long form (ICIQ-FLUTS LF) is a robust psychometric tool to assess the severity of lower urinary tract symptoms (LUTS) in women. A Thai language version of the ICIQ-FLUTS LF is available, but it had not been validated yet. This study aimed to validate the ICIQ-FLUTS LF questionnaire in Thai and to identify the correlation between the ICIQ-FLUTS LF and the IPSS.\u0000Materials and Methods: We recruited 130 females, 50 with LUTS were recruited from patients visiting the Urology Clinic to assess the test with known group validity. They completed the ICIQ-FLUTS LF twice, two weeks apart, and the IPSS once. Meanwhile, 80 without LUTS (control group) were recruited from relatives of the patients to increase the consistency of the statistical analysis, completed the ICIQ-FLUTS LF. Then validity and reliability were determined using statistical analysis.\u0000Results: Convergent validity showed a moderate correlation between ICIQ-FLUTS LF and IPSS for both storage and voiding symptoms, with Pearson’s correlation coefficient 0.49, 0.66; P<0.001, respectively. Construct validity, using the Wilcoxon signed-rank test, demonstrated statistically significant difference between the target group and the control group (P<0.001). The Thai version of the ICIQ-FLUTS LF showed good internal consistency, with Cronbach’s alpha coefficients 0.76-0.79 and Test–retest reliability strong, with weighted kappa values 0.63 to 0.90.\u0000Conclusion: The Thai version of the ICIQ-FLUTS LF shows good validity and reliable measures of females with LUTS, and is simple to use. This questionnaire in the Thai version can be used in clinical practice and academic research.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"274 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vape use is increasing among the youth and there is a catchphrase that vape is the solution to conventional tobacco smoking. Some case reports show the impact of vape use in the form of lung injury. However, there are no studies that definitively determine how many cases and what kind of problems in the lungs and airways can be caused by the use of vape and this is the purpose of our research. This systematic review article used several databases with the keywords "Vape OR E-cigarette" and "Disease." We screened and eliminated articles based on the PEOS framework. The included articles were analyzed for risk of bias using the JBI critical appraisal tool. A total of 16 articles were included and involved 313 patients in this review. Several case reports show the incidence of pulmonary infections in vape users, lung damage (EVALI), respiratory failure, burning throat, and various other events associated with vape use. The duration of vape use also varies before the appearance of the disease and the earliest use duration is six months and the longest is up to years. Vape use poses a risk of lung and airway disease and requires further study to accurately determine the degree of risk of the impact of vape use on lung and airway health. In conclusion, vape circulation vigilance needs to be considered because the impacts can cause health issues and interfere with the achievement of health goals for all.
{"title":"Lung and Airway Disease Caused by E-Cigarette (Vape): A Systematic Review","authors":"Arya Marganda Simanjuntak, Mokhammad Raihan Eka Putra, Nindy Putri Amalia, Anastasya Hutapea, Suyanto Suyanto, Indi Esha Siregar","doi":"10.33192/smj.v76i5.267185","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267185","url":null,"abstract":"Vape use is increasing among the youth and there is a catchphrase that vape is the solution to conventional tobacco smoking. Some case reports show the impact of vape use in the form of lung injury. However, there are no studies that definitively determine how many cases and what kind of problems in the lungs and airways can be caused by the use of vape and this is the purpose of our research. This systematic review article used several databases with the keywords \"Vape OR E-cigarette\" and \"Disease.\" We screened and eliminated articles based on the PEOS framework. The included articles were analyzed for risk of bias using the JBI critical appraisal tool. A total of 16 articles were included and involved 313 patients in this review. Several case reports show the incidence of pulmonary infections in vape users, lung damage (EVALI), respiratory failure, burning throat, and various other events associated with vape use. The duration of vape use also varies before the appearance of the disease and the earliest use duration is six months and the longest is up to years. Vape use poses a risk of lung and airway disease and requires further study to accurately determine the degree of risk of the impact of vape use on lung and airway health. In conclusion, vape circulation vigilance needs to be considered because the impacts can cause health issues and interfere with the achievement of health goals for all.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"24 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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