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2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)最新文献

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Ultrasound-Based Tracking Of Partially In-Plane, Curved Needles 部分平面内弯曲针的超声跟踪
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9433804
Wanwen Chen, Kathan Nilesh Mehta, Bhumi Dinesh Bhanushali, J. Galeotti
We present a novel algorithm for needle tracking in ultrasound-guided needle insertion. Most previous research assumes that in ultrasound images the needle is a straight and bright line, but needles can bend due to the interaction with heterogeneous tissue. We utilize a novel weighted RANSAC curve fitting method combined with probabilistic Hough transform to track the curved needle robustly, and the algorithm can additionally utilize external tracking information, such as robotic kinematics, to further improve the tracking accuracy. We compared against classical tracking algorithms and a U-Net model, testing over different needle curvature and tissues. Our proposed algorithm achieves higher accuracy in tip location, shaft fitting, and tip angle. In-vivo porcine experiments with naturally bending short needles also show our method better tracked the tip location.
我们提出了一种新的超声引导下针头跟踪算法。大多数先前的研究假设,在超声图像中,针是一条笔直而明亮的线,但由于与异质组织的相互作用,针可能会弯曲。采用一种新的加权RANSAC曲线拟合方法结合概率霍夫变换对曲线针进行鲁棒跟踪,并利用机器人运动学等外部跟踪信息进一步提高跟踪精度。我们比较了经典的跟踪算法和U-Net模型,在不同的针曲率和组织上进行了测试。该算法在叶尖位置、轴配合和叶尖角度方面具有较高的精度。猪体内自然弯曲短针实验也表明,该方法能更好地追踪针尖位置。
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引用次数: 0
Statistical Shape and Pose Model of the Forearm for Custom Splint Design 用于定制夹板设计的前臂形状和位姿统计模型
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9434067
F. Danckaers, Jeroen Van Houtte, Brian G. Booth, F. Verstreken, Jan Sijbers
Custom splint design is becoming more common. However, poor 3D scan quality can negatively impact the design accuracy. This paper describes a method to build a 3D statistical shape and pose model of the forearm from 3dMD scans. The model is used to assist the registration of previously unseen forearms in a wide range of poses. We show that this model-based surface registration results in a good geometric fit, with accurate anatomical correspondences. This method could be used to upgrade low-resolution scans using a high-resolution model.
定制夹板设计正变得越来越普遍。然而,较差的3D扫描质量会对设计精度产生负面影响。本文描述了一种基于3dMD扫描建立前臂三维统计形状和姿态模型的方法。该模型用于协助在各种姿势中登记以前未见过的前臂。我们表明,这种基于模型的表面配准结果具有良好的几何拟合,具有准确的解剖对应。该方法可用于使用高分辨率模型升级低分辨率扫描。
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引用次数: 0
Automatic Size And Pose Homogenization With Spatial Transformer Network To Improve And Accelerate Pediatric Segmentation 基于空间变形网络的自动尺寸和位姿均匀化改进和加速儿童分割
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9434090
Giammarco La Barbera, P. Gori, Haithem Boussaid, Bruno Belucci, A. Delmonte, Jeanne Goulin, S. Sarnacki, L. Rouet, I. Bloch
Due to a high heterogeneity in pose and size and to a limited number of available data, segmentation of pediatric images is challenging for deep learning methods. In this work, we propose a new CNN architecture that is pose and scale invariant thanks to the use of Spatial Transformer Network (STN). Our architecture is composed of three sequential modules that are estimated together during training: (i) a regression module to estimate a similarity matrix to normalize the input image to a reference one; (ii) a differentiable module to find the region of interest to segment; (iii) a segmentation module, based on the popular UNet architecture, to delineate the object. Unlike the original UNet, which strives to learn a complex mapping, including pose and scale variations, from a finite training dataset, our segmentation module learns a simpler mapping focusing on images with normalized pose and size. Furthermore, the use of an automatic bounding box detection through STN allows saving time and especially memory, while keeping similar performance. We test the proposed method in kidney and renal tumor segmentation on abdominal pediatric CT scanners. Results indicate that the estimated STN homogenization of size and pose accelerates the segmentation (25h), compared to standard data-augmentation (33h), while obtaining a similar quality for the kidney (88.01% of Dice score) and improving the renal tumor delineation (from 85.52% to 87.12%).
由于姿态和大小的高度异质性以及可用数据数量有限,儿科图像的分割对于深度学习方法来说是具有挑战性的。在这项工作中,我们提出了一种新的CNN架构,由于使用了空间变压器网络(STN),它是位姿和尺度不变的。我们的架构由三个顺序模块组成,它们在训练过程中一起进行估计:(i)一个回归模块,用于估计相似矩阵,将输入图像归一化为参考图像;(ii)一个可微模块,用于寻找要分割的感兴趣区域;(iii)基于流行的UNet架构的分割模块,用于描绘对象。与最初的UNet不同,UNet努力从有限的训练数据集中学习复杂的映射,包括姿势和比例变化,我们的分割模块学习更简单的映射,专注于具有标准化姿势和大小的图像。此外,通过STN使用自动边界框检测可以节省时间,特别是内存,同时保持类似的性能。我们在腹部儿童CT扫描仪上测试了该方法在肾脏和肾脏肿瘤分割中的应用。结果表明,与标准数据增强(33小时)相比,估计的大小和姿态的STN均匀化加速了分割(25小时),同时对肾脏获得了相似的质量(Dice评分的88.01%),并改善了肾脏肿瘤的描绘(从85.52%提高到87.12%)。
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引用次数: 3
Enhanced Connectivity and Reduced Mind Wandering after Tactile Training in Young Adults 年轻人触觉训练后的连通性增强和走神减少
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9433916
Yu Luo, Haoyang Chen, Jicong Zhang
The intensive practice of specific cognitive activities can lead to improvements of relevant cognitive capability in human beings, which may transfer to gain in untrained activities. Although there are a growing number of studies investigating the behavioral benefits of attention training in mind wandering, few studies have directly examined the neurophysiological basis of the training effects. Here using 128-channel electroencephalography (EEG), we examined whether the tactile training can reduce the mind wandering as measured by the sustained attention to response task (SART), and how the dynamic neurophysiological connectivity changes following training in young adults. The trainees showed significantly less occurrence of mind wandering after the five-day tactile training. Furthermore, the functional connectivity within and between the frontal and parietal regions was enhanced after training. Our findings suggest that the tactile training-induced brain plasticity may provide new therapeutic strategies for attention-related disorders.
特定认知活动的强化练习可以导致人类相关认知能力的提高,这种提高可能会在未经训练的活动中转化为收益。尽管有越来越多的研究调查了注意力训练对走神的行为益处,但很少有研究直接考察了训练效果的神经生理学基础。本文利用128通道脑电图(EEG)研究了触觉训练是否能减少年轻人的持续注意反应任务(SART)测量的走神,以及训练后动态神经生理连通性的变化。经过五天的触觉训练,受训者的走神现象明显减少。此外,训练后大脑额顶叶区域内部和之间的功能连通性得到增强。我们的研究结果表明,触觉训练诱导的大脑可塑性可能为注意力相关疾病的治疗提供新的策略。
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引用次数: 0
Diffraction Tomography From Single-Molecule Localization Microscopy: Numerical Feasibility 单分子定位显微镜衍射层析成像:数值可行性
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9433998
Thanh-an Michel Pham, Emmanuel Soubies, F. Soulez, M. Unser
Single-molecule localization microscopy (SMLM) is a fluorescence microscopy technique that achieves super-resolution imaging by sequentially activating and localizing random sparse subsets of fluorophores. Each activated fluorophore emits light that then scatters through the sample, thus acting as a source of illumination from inside the sample. Hence, the sequence of SMLM frames carries information on the distribution of the refractive index of the sample. In this proof-of-concept work, we explore the possibility of exploiting this information to recover the refractive index of the imaged sample, given the localized molecules. Our results with simulated data suggest that it is possible to exploit the phase information that underlies the SMLM data.
单分子定位显微镜(SMLM)是一种荧光显微镜技术,通过顺序激活和定位荧光团的随机稀疏子集来实现超分辨率成像。每个激活的荧光团发出光,然后通过样品散射,从而作为样品内部的光源。因此,SMLM帧的序列携带了样品折射率分布的信息。在这项概念验证工作中,我们探索了利用这些信息来恢复给定局部分子的成像样品的折射率的可能性。我们对模拟数据的结果表明,利用SMLM数据背后的相位信息是可能的。
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引用次数: 1
Multi-Label Classification Based On Subcellular Region-Guided Feature Description For Protein Localisation 基于亚细胞区域导向特征描述的蛋白质定位多标签分类
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9434145
Priyanka S. Rana, E. Meijering, A. Sowmya, Yang Song
In this paper, we present a multi-label classification pipeline and a novel feature descriptor for the protein subcellular localisation. The challenge here is the development of a computational model that can classify multi-site proteins on a highly imbalanced dataset with a long-tail distribution and multi-label images. To address this challenge, we design a Location-Sorted Random Projections feature descriptor to represent image intensity and gradient of the protein of interest in reference to the correlated cellular region. Multilabel Synthetic Minority Over-sampling Technique is optimised to generate synthetic features with labels to handle class imbalance. Our method achieves the state-of-the-art performance on a large-scale public dataset and demonstrates excellent performance for the minority classes.
在本文中,我们提出了一种多标签分类管道和一种新的蛋白质亚细胞定位特征描述符。这里的挑战是开发一种计算模型,该模型可以对具有长尾分布和多标签图像的高度不平衡数据集上的多位点蛋白质进行分类。为了解决这一挑战,我们设计了一个位置排序随机投影特征描述符来表示相关细胞区域感兴趣的蛋白质的图像强度和梯度。优化了多标签合成少数派过采样技术,生成带有标签的合成特征,以解决类不平衡问题。我们的方法在大规模公共数据集上实现了最先进的性能,并在少数类上展示了出色的性能。
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引用次数: 4
A Structural Saliency-Based Approach for Automatic Intrahepatic Vascular Separation From Contrast-Enhanced Multi-Phase MR Images 基于结构显著性的多相磁共振图像肝内血管自动分离方法
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9433995
Q. Guo, Hong Song, Jingfan Fan, Danni Ai, Jian Yang, Yuanjin Gao
Intrahepatic vascular separation on contrast-enhanced Magnetic Resonance (MR) images is indispensable for the hepatic tumor surgery. This paper presents an unsupervised frame-work based on structural saliency for automatically separating portal vein (PV) and hepatic vein (HV) from contrast-enhanced multi-phase MR images. In our work, we propose a new multi-scale filter based on statistics and shape information in the region of interest, called SSIROI, with which the vascular connectivity and saliency in the 3D hepatic region can be guaranteed. Experiments are conducted on clinical contrast-enhanced MR images, and the results show that our method achieves effective separation of intrahepatic vasculature by extracting the PV and HV from multi-phase images, and our proposed SSIROI filter outperforms state-of-the-art methods.
在肝肿瘤手术中,利用磁共振造影技术分离肝内血管是必不可少的。本文提出了一种基于结构显著性的无监督框架,用于从对比增强的多相MR图像中自动分离门静脉(PV)和肝静脉(HV)。在我们的工作中,我们提出了一种新的基于感兴趣区域的统计和形状信息的多尺度滤波器,称为SSIROI,它可以保证三维肝脏区域的血管连通性和显著性。在临床磁共振增强图像上进行了实验,结果表明,我们的方法通过从多相图像中提取PV和HV,实现了肝内血管的有效分离,并且我们提出的SSIROI滤波器优于现有的方法。
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引用次数: 0
Low-Dose Dual KVP Switching Using A Static Coded Aperture 使用静态编码孔径的低剂量双KVP开关
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9434080
Angela P. Cuadros, Carlos M. Restrepo, P. Noel
This paper introduces a single-scan dual-energy coded aperture computed tomography system that enables material characterization at a reduced exposure level. Rapid kVp switching with a single-static block/unblock coded aperture relies on coded illumination with a plurality of X-ray spectra created by the kVp switching. Based on the tensor representation of the projection data, an algorithm to estimate the missing measurements in the tensor is proposed. This results in a full set of synthesized measurements that can be used with filtered back-projection or iterative reconstruction algorithms to accurately reconstruct the object in each energy channel. Simulation results validate the effectiveness of the proposed cost-effective solution to attain material characterization in low-dose dual-energy CT.
本文介绍了一种单扫描双能量编码孔径计算机断层扫描系统,该系统可以在降低暴露水平下进行材料表征。单静态块/无块编码孔径的快速kVp切换依赖于编码照明,由kVp切换产生多个x射线光谱。基于投影数据的张量表示,提出了一种估计张量中缺失量的算法。这就产生了一套完整的合成测量,可以使用滤波后的反投影或迭代重建算法来精确地重建每个能量通道中的目标。仿真结果验证了该方法在低剂量双能CT中实现材料表征的有效性。
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引用次数: 0
Towards a generalization of the MP2RAGE partial volume estimation model to account for B1+ inhomogeneities at 7T 对MP2RAGE部分体积估计模型的推广,以解释7T时B1+的不均匀性
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9434089
J. Beaumont, O. Acosta, P. Raniga, G. Gambarota, J. Fripp
Brain morphometry performed with magnetic resonance (MR) imaging is affected by partial volume (PV) effects when single voxels contain the signal from two different tissues. This paper proposes a generalization of the MP2 RAGE sequence PV estimation model which accounts for transmitted magnetic field $(B1^{+})$ inhomogeneities at 7T. Our simulation experiments demonstrated that the PV estimation error of the proposed model is significantly lower than the error obtained with the same model neglecting $B1^{+}$ inhomogeneities (p<0.0001). The accuracy and precision of the $B1^{+}$ model (acc=92.0%, prec=89.6%) was significantly increased compared to the non $B1^{+}$ model (acc=69.8%, prec=65.4%). This highlights the importance of accounting for $B1^{+}$ inhomogeneities when computing PV on MP2RAGE data, which would otherwise limit the accuracy of brain morphometry at 7T.
当单个体素包含来自两个不同组织的信号时,用磁共振(MR)成像进行的脑形态测量受到部分体积(PV)效应的影响。本文提出了考虑7T发射磁场$(B1^{+})$不均匀性的MP2 RAGE序列PV估计模型的推广。我们的仿真实验表明,该模型的PV估计误差显著低于忽略$B1^{+}$不均匀性的相同模型所获得的误差(p<0.0001)。与非$B1^{+}$模型(acc=69.8%, prec=65.4%)相比,$B1^{+}$模型的准确度和精密度(acc=92.0%, prec=89.6%)显著提高。这突出了在MP2RAGE数据上计算PV时考虑$B1^{+}$不均匀性的重要性,否则将限制7T脑形态测量的准确性。
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引用次数: 0
Two-Stream Attention Spatio-Temporal Network For Classification Of Echocardiography Videos 用于超声心动图视频分类的双流注意时空网络
Pub Date : 2021-04-13 DOI: 10.1109/ISBI48211.2021.9433773
Zishun Feng, J. Sivak, Ashok K. Krishnamurthy
There is considerable interest in AI systems that can assist a cardiologist to diagnose echocardiograms, and can also be used to train residents in classifying echocardiograms. Prior work has focused on the analysis of a single frame. Classifying echocardiograms at the video-level is challenging due to intra-frame and inter-frame noise. We propose a two-stream deep network which learns from the spatial context and optical flow for the classification of echocardiography videos. Each stream contains two parts: a Convolutional Neural Network (CNN) for spatial features and a bi-directional Long Short-Term Memory (LSTM) network with Attention for temporal. The features from these two streams are fused for classification. We verify our experimental results on a dataset of 170 (80 normal and 90 abnormal) videos that have been manually labeled by trained cardiologists. Our method provides an overall accuracy of 91.18%, with a sensitivity of 94.11% and a specificity of 88.24%.
人工智能系统可以帮助心脏病专家诊断超声心动图,也可以用于培训住院医生对超声心动图进行分类,这引起了人们的极大兴趣。先前的工作主要集中在对单个框架的分析上。由于帧内和帧间噪声的存在,在视频级对超声心动图进行分类具有挑战性。我们提出了一种从空间背景和光流学习的双流深度网络,用于超声心动图视频的分类。每个流包含两个部分:空间特征的卷积神经网络(CNN)和时间特征的双向长短期记忆(LSTM)网络。将这两个流的特征融合在一起进行分类。我们在170个(80个正常和90个异常)视频的数据集上验证了我们的实验结果,这些视频都是由训练有素的心脏病专家手动标记的。该方法的总体准确度为91.18%,灵敏度为94.11%,特异性为88.24%。
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引用次数: 1
期刊
2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI)
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