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Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals最新文献

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Nutraceuticals for Human Health and Hypersensitivity Reaction 人类健康和过敏反应的营养药品
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2970-5.CH015
Anamika Basu, Anasua Sarkar, Piyali Basak
An allergy is an overreaction of the immune system to a substance called an antigen, e.g., pollen from grasses, dust mites, etc. The drugs used for allergy in allopathy have undesirable side effects. The use of medicinal plants becomes popular due to the adverse effects of allopathic drugs. Nutraceuticals are food playing a significant role in maintaining normal physiological function. Mast cells are immunologically important cells found in almost all parts of our body, and contain histamines, leukotrienes within their granular sacs, along with those of basophils, are responsible for the symptoms of allergy. According to sources mast cell stabilizers can be classified into three categories, e.g., synthetic, semi synthetic and natural. Mast cell stabilising agents from natural resources can be obtained from different group of compounds, e.g., flavonoids, coumarins, phenols, terpenoids, alkaloids. In this book chapter, the active constituents present in them and their mode of action are highlighted using techniques of computational biology, e.g., molecular docking, etc.
过敏是免疫系统对一种叫做抗原的物质的过度反应,比如草的花粉、尘螨等。对抗疗法中用于治疗过敏的药物有不良的副作用。由于对抗性药物的副作用,药用植物的使用变得流行。营养保健品是在维持人体正常生理功能方面起重要作用的食品。肥大细胞是一种重要的免疫细胞,几乎存在于我们身体的所有部位,在它们的颗粒囊中含有组胺、白三烯,以及嗜碱性细胞,它们是过敏症状的原因。根据来源,肥大细胞稳定剂可分为三类,即合成、半合成和天然。从自然资源中获得的肥大细胞稳定剂可以从不同种类的化合物中获得,如类黄酮、香豆素、酚类、萜类、生物碱等。在这本书的章节中,使用计算生物学技术,例如分子对接等,突出了它们中存在的活性成分及其作用方式。
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引用次数: 2
Hairy Roots 多毛的根部
Pub Date : 1900-01-01 DOI: 10.4018/978-1-6684-3546-5.ch038
P. Deka
Agrobacterium rhizogenes induces hairy root disease in plants. The neoplastic (cancerous) roots produced by A. rhizogenes infection, when cultured in hormone free medium, show high growth rate and genetic stability. These genetically transformed root cultures can produce levels of secondary metabolites comparable to that of intact plants. Several elicitation methods can be used to further enhance the production and accumulation of secondary metabolites. Thus, hairy root culture offer promise for high production and productivity of valuable secondary metabolites in many plants. Hairy roots can also produce recombinant proteins from transgenic roots, and thereby hold immense potential for pharmaceutical industry. Hairy root cultures can be used to elucidate the intermediates and key enzymes involved in the biosynthesis of secondary metabolites, and for phytoremediation due to their abundant neoplastic root proliferation property. Various applications of hairy root cultures and potential problems associated with them are discussed in this chapter.
根际农杆菌诱导植物毛状根病。在无激素培养基中培养时,根瘤菌感染后产生的瘤(癌)根具有较高的生长速率和遗传稳定性。这些基因转化的根培养物可以产生与完整植物相当的次生代谢物水平。多种诱导方法可进一步促进次生代谢物的产生和积累。因此,毛状根培养为许多植物中有价值的次生代谢物的高产和高产提供了希望。毛状根还可以从转基因根中产生重组蛋白,因此在制药工业中具有巨大的潜力。毛状根培养物具有丰富的肿瘤根增殖特性,可用于阐明参与次生代谢物生物合成的中间体和关键酶,并用于植物修复。本章讨论了毛状根培养的各种应用以及与之相关的潜在问题。
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引用次数: 0
An Overview of Publications of Complementary and Alternative Medicine Research 补充和替代医学研究出版物综述
Pub Date : 1900-01-01 DOI: 10.4018/978-1-6684-3546-5.ch001
Mayuree Tangkiatkumjai
This chapter presents an overview of the quantity and quality of clinical research in CAM and publication bias. Descriptive studies and their systematic reviews on CAM, e.g., prevalence and reasons for CAM use, have been widely conducted worldwide. The findings of the efficacy of herbal medicine, traditional Chinese medicine and acupuncture for treating various illnesses, have been highly published. Publications of CAM safety are limited. A number of clinical studies of CAM in treating kidney diseases were lower than other illnesses. Studies of Ayurveda and other CAMs are still lacking. The quality of CAM publications is described based on systematic reviews of assessing CAM publications. Publication bias is explained in terms of selective publications and location bias, language bias and conflict of interest. The mainstream journals are more likely to publish positive findings. Predatory open access and recommendations for assessing predatory journals are addressed in this chapter.
本章概述了CAM和发表偏倚中临床研究的数量和质量。在世界范围内,已经广泛开展了关于辅助医学的描述性研究及其系统评价,例如,辅助医学的流行程度和使用原因。草药、中药和针灸治疗各种疾病的疗效的研究结果已被大量发表。CAM安全性的出版物是有限的。CAM治疗肾脏疾病的临床研究数量低于其他疾病。对阿育吠陀和其他cam的研究仍然缺乏。CAM出版物的质量是基于评估CAM出版物的系统评价来描述的。发表偏倚从选择性出版物和地点偏倚、语言偏倚和利益冲突三个方面来解释。主流期刊更有可能发表积极的发现。掠夺性开放获取和评估掠夺性期刊的建议将在本章中讨论。
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引用次数: 0
Analysis of Serbian Production and Export of Medicinal and Aromatic Plants 塞尔维亚药用和芳香植物的生产和出口分析
Pub Date : 1900-01-01 DOI: 10.4018/978-1-6684-3546-5.ch046
Svetlana Ignjatijević, D. Cvijanović
The emphasis of the research in this chapter was put on the analysis of production and export/import of MAP (Medical and aromatic plants) from Serbia. After reading this chapter, readers will find out that the production of MAP in a long time period has been steady, although has been present fluctuations per years. They will know that indigenous and cultivated MAPs are equally present on the market, and will notice that they are equally present in export as well, i.e. that there is no such register. They will be familiar with the positive effects of planned production and the significance of scientific and technological achievements implementation. Readers will be able to recognize the dynamics of changes in export and import of MAP. They will find out which products are the most significant in export and import and will notice the connection between the export structure of MAP sector and earned value - foreign exchange inflow. They will be able to understand the character of exchange, value of export/import and the comparative advantage of export. Readers will be especially familiar with experiences and recommendations of other authors on the development of MAP sector and directives of authors for deepening the research within this chapter. They will know the connection between a low foreign exchange inflow and types of products in export and will understand the need for new organization models and education of manufacturers.
本章的研究重点是分析塞尔维亚MAP(药用和芳香植物)的生产和进出口情况。读完这一章,读者会发现,MAP的生产在很长一段时间内是稳定的,尽管每年都有波动。他们会知道,本土和栽培的map在市场上同样存在,并且会注意到它们在出口中也同样存在,即没有这样的登记。他们将熟悉计划生产的积极作用和科技成果实施的意义。读者将能够认识到MAP输出和输入的动态变化。他们会发现哪些产品在出口和进口中最重要,并会注意到MAP部门的出口结构与赚取价值-外汇流入之间的联系。他们将能够了解交换的性质,出口/进口的价值和出口的比较优势。读者将特别熟悉其他作者关于MAP部门发展的经验和建议,以及作者对本章深入研究的指示。他们将了解低外汇流入与出口产品类型之间的联系,并将了解新的组织模式和对制造商进行教育的必要性。
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引用次数: 0
New Product Development and Regulatory Challenges in Nutraceutical Industry 营养保健品行业的新产品开发和监管挑战
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2970-5.CH013
B. Kumar, Shivom Singh, K. Srivastava, K. Wani
Functional food ingredients and dietary supplements are essential for health promotion and disease risk reduction. The demand for various food products is increasing day by day due to ever increasing population. Different multinational companies have invested to meet the demands of the people all over the world. However, some miscreants have adultered different food products that caused various concerns to the people and the government. Hence, different laws in different countries have been regulated to maintain the quality of food. However, there is major legislation and product approval challenges which should be aligned by global common regulations to move forward by reducing the scope for conflict between our regulatory approaches and by forging closer cooperation that can only be addressed by appropriate and accurate ingredients understanding, safety legislation, clinical studies benefits, advanced food processing technologies and various analytical studies. The nutraceutical revolution will direct us into a new era of medicine and health, in which the food industry will become a research oriented, analogous to the pharmaceutical industry. The present review article discusses the recent status of nutraceuticals and their importance to prevent various diseases.
功能性食品配料和膳食补充剂对促进健康和减少疾病风险至关重要。由于人口的不断增长,对各种食品的需求日益增加。不同的跨国公司进行投资,以满足世界各地人民的需求。然而,一些不法分子在不同的食品中掺假,引起了人民和政府的各种关注。因此,不同国家有不同的法律来维持食品的质量。然而,主要的立法和产品审批挑战应该与全球共同法规保持一致,通过减少我们监管方法之间的冲突范围,并通过建立更紧密的合作来推进,这些合作只能通过适当和准确的成分理解、安全立法、临床研究利益、先进的食品加工技术和各种分析研究来解决。营养保健革命将引导我们进入一个医药和健康的新时代,在这个时代,食品工业将成为一个以研究为导向的行业,类似于制药工业。本文综述了营养保健品的研究现状及其在预防各种疾病中的重要性。
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引用次数: 3
Nutraceuticals for Prevention of Chemotherapy-Induced Peripheral Neuropathy 预防化疗引起的周围神经病变的营养药品
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2970-5.CH011
M. Cascella, M. Muzio, S. Bimonte, A. Cuomo
A wide range of neurologic complications, including central neurotoxicity conditions and peripheral neurotoxicity, are associated with antineoplastic drug regimens. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and severe cancer treatment-related adverse effect, as well as the most diffuse type of neurotoxicity, because about one third of all patients who undergo chemotherapy may experience this side effect. CIPN can negatively impact the long-term quality of life of cancer survivors, and can lead to dose reduction of the chemotherapy agent, or possible cessation of treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have proven useful yet. Therefore, new alternative therapies have been considered for CIPN prevention. In this chapter, the authors analyze the potential applications of nutrients, dietary supplements and herbal products, such as single herbs, the Kampo medicine goshajinkigan and other herbal combinations, for CIPN prevention.
广泛的神经系统并发症,包括中枢神经毒性和周围神经毒性,与抗肿瘤药物方案有关。化疗诱导的周围神经病变(CIPN)是最常见和最严重的癌症治疗相关不良反应之一,也是最广泛的神经毒性类型,因为大约三分之一接受化疗的患者可能会出现这种副作用。CIPN可对癌症幸存者的长期生活质量产生负面影响,并可导致化疗药物剂量减少,或可能停止治疗。不幸的是,虽然已经提出了几种药物和方案,但没有一种预防策略被证明是有用的。因此,新的替代疗法已被考虑用于CIPN的预防。在本章中,作者分析了营养素、膳食补充剂和草药产品,如单一草药、汉布药goshajinkagan和其他草药组合,在预防CIPN方面的潜在应用。
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引用次数: 2
Food Grade Microorganisms for Nutraceutical Production for Industrial Applications 用于工业营养药品生产的食品级微生物
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2970-5.CH016
Hemansi, R. Vibhuti, R. Shukla, Rishi Gupta, J. Saini
Nutraceuticals are the food ingredients which have a proven beneficial effect on human health. These include low calories sugars, proteins and vitamins B complex, etc. Microorganisms, such as Lactococcus lactis, are ideal microbial cell factories for the production of these nutraceuticals. Developments in the genetic engineering of food-grade microorganisms have been very helpful for enhanced production or overexpression of nutraceuticals. This chapter describes the use of food grade microorganisms in industrial production of nutraceuticals. The main emphasis is on industrial production of these beneficial nutraceuticals by food grade microorganism. The diversity of microbial cell types, various approaches for improved nutraceutical production through process optimization as well as strain improvement of the producing microorganisms are discussed.
营养保健品是经证实对人体健康有益的食品成分。这些食物包括低热量的糖、蛋白质和复合维生素B等。微生物,如乳酸乳球菌,是生产这些营养保健品的理想微生物细胞工厂。食品级微生物基因工程的发展对提高营养品的生产或过表达非常有帮助。本章描述食品级微生物在营养保健品工业生产中的应用。重点是利用食品级微生物对这些有益的营养品进行工业化生产。讨论了微生物细胞类型的多样性,通过工艺优化以及生产微生物的菌株改进来改善营养品生产的各种方法。
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引用次数: 3
Nutraceutical Properties of Important Weeds in India 印度重要杂草的营养保健特性
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2970-5.CH014
Aakash Mishra, D. D. Chaudhari, H. K. Patel, B. Patel
The group of plants, apart from the forest trees, agricultural, horticultural crop and medicinal plants, certain weed plants also play important role to formulate the qualitative and quantitative food and health supplements. These plants may be very specific in producing certain compound to heal the specific ailment chronically or serve as a good nutritive food supplement. There are numbers of crop species have been fortified with multi-nutrients or with the particular nutrient supplements e.g. Rice, Wheat, Maize, Sweet Potato. Instead, weeds remained underutilized and un-exploited and also treated as unwanted species. The nutritive compounds available in these plants such as polyphenols and vitamins can be the extraction from different plant portion to formulate the fortified food or curing medicine. The weed species prevailing in the nature are one of the major sources of dietary and health supplements for humans and animals since past i.e. Amaranthus lividus, Chenopodium album and many more weed species. There is still much to explore the Indian ecologic components present in wild form of flora. Hence, this chapter will majorly contribute to highlight nutritive nutaceurtical and edible weeds prevailing in Indian ecosystems.
这组植物,除了森林树木、农业、园艺作物和药用植物外,某些杂草植物也在制定定性和定量的食品和保健补充剂中发挥重要作用。这些植物可能会产生特定的化合物来治疗特定的慢性疾病,或者作为一种很好的营养食品补充剂。有许多作物品种都添加了多种营养素或特定的营养补充剂,如水稻,小麦,玉米,甘薯。相反,杂草仍然未被充分利用和开发,并且被视为不受欢迎的物种。这些植物中含有的营养化合物,如多酚和维生素,可以从不同的植物部分中提取,以配制强化食品或固化药物。自过去以来,自然界中普遍存在的杂草是人类和动物膳食和保健补充剂的主要来源之一,即苋菜、藜草和许多其他杂草。在野生植物群中存在的印度生态成分还有很多需要探索的地方。因此,本章将重点介绍印度生态系统中普遍存在的营养、营养和食用杂草。
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引用次数: 2
Enzyme-Triggered Hydrogels for Pharmaceutical and Food Applications 用于制药和食品的酶触发水凝胶
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-5237-6.CH008
Lakshmishri Upadrasta, Vijay Kumar Garlapati, Nafisa Lakdawala, R. Banerjee
Enzyme-mediated polymeric hydrogels are drawing considerable attention in pharmaceutical and food sectors owing to their superior biocompatibility and process controllability under physiological conditions. Enzymes play a significant role in polymeric hydrogel formation through different mechanisms. Oxidases (e.g., horseradish peroxidase and tyrosinase) have demonstrated to drive the crosslinking of gel precursors by oxidizing the phenolic or acrylic moieties to free radicals. Transferases and hydrolases catalyze elongation of biopolymer chains which gradually self-assemble into hydrogels. Still more certain enzymes also participate in hydrogel formation by releasing gelation factors. Enhancement of the desired properties of certain hydrogels through the interior and exterior post-modifications has also been demonstrated by certain enzymes. Hence, in this chapter, the authors explore the different mechanisms of enzyme-mediated hydrogels preparations and its fabrication towards pharmaceutical and food sectors along with the discussion of recent trends and further prospects.
酶介导的聚合物水凝胶由于其优越的生物相容性和生理条件下的过程可控性,在制药和食品领域引起了广泛的关注。酶通过不同的机制在聚合物水凝胶的形成中起着重要的作用。氧化酶(例如,辣根过氧化物酶和酪氨酸酶)已被证明通过将酚或丙烯酸部分氧化为自由基来驱动凝胶前体的交联。转移酶和水解酶催化生物聚合物链的延伸,使其逐渐自组装成水凝胶。还有更多的酶也通过释放凝胶因子参与水凝胶的形成。某些酶也证明了通过内部和外部后修饰可以增强某些水凝胶的预期性能。因此,在本章中,作者探讨了酶介导的水凝胶制备及其在制药和食品部门的制造的不同机制,并讨论了最近的趋势和进一步的前景。
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引用次数: 0
The Scientific Communication Process in Homoeopathic Toxicology 顺势疗法毒理学的科学传播过程
Pub Date : 1900-01-01 DOI: 10.4018/978-1-6684-3546-5.ch003
G. Ramadhas, A. Sankar, N. Sugathan
The present chapter evaluates the growth of literature of Toxicology in Homoeopathy. The Scopus database is used as source for the study. Data pertaining to toxicology in homoeopathy for the period 1963 to 2017 is retrieved and analyzed. The study reveals that toxicology literature grows rapidly in the later stages than in the earlier period. The United States of America is the leading contributors at the global level and India is in second position. Among the contributors, E.J. Calabrese, Professor of Toxicology, University of Massachusetts is the most prolific author for Toxicology in Homoeopathy literature. University of Kalyani and University of Massachusetts are the leading institutions, majority of the records are published in the journal ‘Homoeopathy', which is published from the USA and major contributions are in the subject domain ‘medicine' (65.4 per cent). Most frequently repeated keywords in toxicology of homoeopathy literature are: homoeopathy, humans, non-human, unclassified drug and animals.
本章评价顺势疗法毒理学文献的发展。本研究使用Scopus数据库作为来源。检索并分析了1963年至2017年期间顺势疗法毒理学相关数据。研究表明,毒理学文献在后期比前期增长更快。美利坚合众国是全球一级的主要捐助国,印度排在第二位。其中,马萨诸塞州大学毒理学教授E.J. Calabrese是顺势疗法文献中最多产的毒理学作者。Kalyani大学和马萨诸塞大学是领先的机构,大多数记录发表在《顺势疗法》杂志上,该杂志由美国出版,主要贡献在“医学”主题领域(65.4%)。顺势疗法毒理学文献中重复频率最高的关键词是:顺势疗法、人类、非人类、未分类药物和动物。
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引用次数: 0
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Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals
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