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Non-invasive Evaluation of Electromechanical Transmission in Patients with Hypertensive Response to Exercise Stress Test. 运动应激测试对高血压患者机电传导反应的无创评估。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.42027
Ahmet Ferhat Kaya, Mehmet Hasan Ozdil, Cemalettin Yilmaz, Raif Kilic, Mehmet Ozbek, Hasan Kaya

Objective: Excessive hypertensive response to exercise testing is associated with adverse cardiovascular events such as left ventricular hypertrophy and atrial fibrillation (AF). In this study, we examined the relationship between electromechanical delay and excessive hypertensive response to exercise testing.

Methods: Twenty-five people who had a hypertensive response to the exercise stress test and 28 people who were similar in age and gender with a normal blood pressure response in the exercise stress test as the control group were included in the study.

Results: There was no statistical difference between the study groups in blood pressure holter values, conventional echocardiography findings, and exercise stress test findings. Lateral PA-TDI time (the time from the beginning of the P wave measured by tissue Doppler imaging to the beginning of the A' wave), left atrial electromechanical delay, and interatrial electromechanical delay were observed to be significantly longer in the hypertensive response group to exercise stress test compared with the control group (74.0±6.3 vs. 68.8±5.7, p=0.003; 24.7±7.0 vs. 19.6±7.1, p=0.013; 36.8±8.5 vs. 30.6±6.6, p=0.003, respectively).

Conclusions: Early detection of electromechanical delay non-invasively may be useful in this patient group in predicting the development of new AF risk.

目的:对运动测试的过度高血压反应与不良心血管事件有关,如左心室肥大和心房颤动(AF)。在这项研究中,我们研究了运动测试中机电延迟与过度高血压反应之间的关系。方法:将25名对运动压力测试有高血压反应的人和28名年龄和性别相似、在运动压力测试中血压反应正常的人作为对照组纳入研究。结果:研究组之间的血压holter值、常规超声心动图检查结果和运动应激测试结果没有统计学差异。横向PA-TDI时间(从组织多普勒成像测得的P波开始到A’波开始的时间)、左心房机电延迟、,与对照组相比,运动应激试验高血压反应组的试验间机电延迟明显更长(分别为74.0±6.3对68.8±5.7,p=0.003;24.7±7.0对19.6±7.1,p=0.013;36.8±8.5对30.6±6.6,p=0.003)。结论:非侵入性早期检测机电延迟可能有助于预测新的房颤风险的发展。
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引用次数: 0
The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance. 卷叶Tinospora Cordifolia(Guduchi)的抗菌作用及其在对抗耐药性中的作用。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.84579
Kavitha Ezhilarasu, Anand Kasiranjan, Shanmuga Priya, Anand Kamaraj

Objective: Tinospora cordifolia, often known as "Guduchi," has a variety of medicinal characteristics, including those that are anti-diabetic, ant-iinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. In order to combat the MDR infections isolated from patients' bodies, the current study was conducted to evaluate and investigate the antibacterial capabilities of Tinospora cordifolia.

Methods: Using the agar well diffusion method, Tinospora cordifolia extracts (aqueous, chloroform, and ethanol) were tested for their antibacterial effectiveness against 30 MDR pathogens, and the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was used to determine the minimal inhibitory concentration. To determine whether there were any medicinally useful and significant bioactive ingredients in the plant extract, phytochemical analysis was performed.

Results: In comparison to the aqueous extract which had little effect, the antibacterial activity of ethanol and chloroform extracts exhibited a potential antimicrobial effect against most of the tested bacterial isolates. Phytochemical analysis of Tinospora cordifolia extract showed alkaloids, carbohydrates, phytosterols, saponins, tannins, proteins, flavonoids, and terpenoids.

Conclusions: Our findings show that Tinospora cordifolia plays a potential role in combating the antimicrobial resistance of clinical isolates.

目的:细叶Tinospora cordifolia,通常被称为“骨杜奇”,具有多种药用特性,包括抗糖尿病、抗炎、抗周期性、抗关节炎、抗氧化、抗过敏和抗应激。由于世界医疗系统中抗微生物耐药性的迅速上升和耐多药菌株的引入,药物开发项目面临着重大障碍。为了对抗从患者体内分离出的MDR感染,本研究旨在评估和研究堇叶Tinospora cordifolia的抗菌能力。方法:采用琼脂扩散法,分别测定了堇叶Tinospora提取物(水溶液、氯仿和乙醇)对30种MDR病原体的抗菌效果,并用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基-四氮唑溴化法测定了最低抑菌浓度。为了确定植物提取物中是否存在任何药用和重要的生物活性成分,进行了植物化学分析。结果:与几乎没有效果的水提取物相比,乙醇和氯仿提取物的抗菌活性对大多数受试菌株表现出潜在的抗菌作用。对堇叶Tinospora提取物的植物化学分析表明,生物碱、碳水化合物、植物甾醇、皂苷、单宁、蛋白质、类黄酮和萜类化合物。结论:我们的研究结果表明,球藻在对抗临床分离株的耐药性方面发挥着潜在的作用。
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引用次数: 0
Factors in Vaccine Refusal by Patients Applying for COVID-19 PCR Test. 申请新冠肺炎PCR检测的患者拒绝接种疫苗的因素。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.43959
Ferhat Arslan, Behcet Al, Gorkem Alper Solakoglu, Omer Faruk Gulsoy, Cagatay Nuhoglu, Sema Ayten

Objective: This study was designed to determine the reasons for vaccine rejection in patients who applied for the coronavirus disease-2019 (COVID-19) polymerase chain reaction (PCR) test but did not receive the vaccine.

Methods: The study was conducted prospectively in the emergency department of a tertiary hospital between 31.01.2022 and 31.05.2022. 1000 patients who applied for the COVID-19 PCR test and refused to be vaccinated were included. The COVID-19 status of the participants, reasons for their application, number of PCR tests, methods of obtaining information about the vaccine, and reasons for the rejection of the vaccine were questioned.

Results: 54.6% of the participants were male and 45.4% were female. 60.7% of the patients applied for testing due to symptoms, 25.4% due to contact with people with symptoms, and 23.9% due to travel. 43.3% of the cases had COVID-19 infection; 53.6% of them had tested an average of 2-5 times in the last year. Most of the information about the vaccine was taken from social media, television, medical publications, and people around, respectively. Of the participants, 62.0% believed that COVID-19 vaccines had side effects, 47.3% believed that it had no protection, and 30.9% believed that there was not enough study on the subject. As the age grew, the rate of learning information from social media increased.

Conclusions: The most common reasons for COVID-19 vaccine rejection were vaccine side effects, doubtful vaccine protection, and concerns about the lack of sufficient studies on the vaccine. The higher the education level, the higher the vaccine rejection rate.

目的:本研究旨在确定申请2019冠状病毒病(新冠肺炎)聚合酶链反应(PCR)检测但未接种疫苗的患者的疫苗拒绝原因。方法:该研究于2022年1月31日至2022年5月31日在一家三级医院急诊科前瞻性进行。包括1000名申请新冠肺炎PCR检测并拒绝接种疫苗的患者。对参与者的新冠肺炎状况、申请理由、PCR检测次数、获得疫苗信息的方法以及拒绝接种疫苗的原因进行了质疑。结果:54.6%的参与者为男性,45.4%为女性。60.7%的患者因症状申请检测,25.4%的患者因与有症状的人接触而申请检测,23.9%的患者因旅行而申请检测。43.3%的病例有新冠肺炎感染;53.6%的人在过去一年中平均进行了2-5次测试。关于疫苗的大部分信息分别来自社交媒体、电视、医学出版物和周围的人。在参与者中,62.0%的人认为新冠肺炎疫苗有副作用,47.3%的人认为没有保护作用,30.9%的人认为对该受试者的研究不够。随着年龄的增长,从社交媒体上学习信息的比率也在增加。结论:新冠肺炎疫苗排异最常见的原因是疫苗副作用、疫苗保护性存疑以及对缺乏足够疫苗研究的担忧。教育水平越高,疫苗排斥率就越高。
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引用次数: 0
Clarifications and Corrections Regarding 'Variations in Superficial Palmar Arch: Case Series with Clinico-anatomical Perspective'. 关于“掌浅弓变异:临床解剖学角度的病例系列”的澄清和纠正。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.25936
Ekrem Solmaz
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引用次数: 1
Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto's Thyroiditis. 甲状腺功能正常的桥本甲状腺炎患者的中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.41882
Hacer Nur Resber, Mumtaz Takir, Cundullah Torun

Objective: This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto's thyroiditis (HT) with healthy control subjects.

Methods: This was a single-center, retrospective, cross-sectional study conducted on obese patients aged 18 years and over. The medical records of patients who presented with complaints of being overweight at the obesity clinic between April 2017 and May 2019 were examined. Patients and healthy individuals were included in the study consecutively until the sample sizes reached saturation. Patients with diabetes, cardiovascular disease, chronic inflammatory disease, and malignancy were excluded from the study. The patients' anthropometric measurements, smoking status, blood examination, and thyroid ultrasounds were evaluated. The difference in means between the groups was calculated using the Mann-Whitney U test.

Results: The study included 179 participants, consisting of 93 patients and 86 healthy controls. The mean age was 46.6±14.1 years, with most females (91.6%). Although the NLR and PLR values in patients were higher than those in the control group, the difference did not reach statistical significance (p=0.427 and p=0.089, respectively). Furthermore, no significant difference was observed in NLR (p=0.191) and PLR (p=0.668) values between levothyroxine-treated and untreated patients. Correlation analysis revealed weak positive associations between C-reactive protein and thyroid peroxidase antibodies (p<0.05), neutrophils (p<0.01), platelets (p<0.01), and NLR (p<0.05).

Conclusions: The findings of this study suggest that NLR and PLR may not serve as effective indicators of systemic inflammation in patients with euthyroid HT, nor do they adequately assess the impact of levothyroxine usage on systemic inflammation.

目的:本研究旨在比较甲状腺功能正常的桥本甲状腺炎(HT)患者和健康对照组患者的中性粒细胞与淋巴细胞比率(NLR)和血小板与淋巴细胞比值(PLR)。方法:这是一项针对18岁及以上肥胖患者的单中心、回顾性、横断面研究。对2017年4月至2019年5月期间在肥胖诊所出现超重投诉的患者的医疗记录进行了检查。患者和健康个体被连续纳入研究,直到样本量达到饱和。糖尿病、心血管疾病、慢性炎症性疾病和恶性肿瘤患者被排除在研究之外。对患者的人体测量、吸烟状况、血液检查和甲状腺超声进行了评估。使用Mann-Whitney U检验计算各组之间的平均值差异。结果:该研究包括179名参与者,包括93名患者和86名健康对照。平均年龄为46.6±14.1岁,其中大多数女性(91.6%)。尽管患者的NLR和PLR值高于对照组,但差异未达到统计学意义(分别为0.427和0.089)。此外,左甲状腺素治疗和未治疗患者的NLR(p=0.191)和PLR(p=0.668)值没有显著差异。相关性分析显示,C反应蛋白和甲状腺过氧化物酶抗体之间存在微弱的正相关性(P结论:本研究的结果表明,NLR和PLR可能不能作为甲状腺功能亢进HT患者全身炎症的有效指标,也不能充分评估左甲状腺素的使用对全身炎症的影响。
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引用次数: 0
The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns. 甲状腺激素水平对新生儿动脉导管未闭的影响。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.25853
Basak Kaya, Hasan Akduman, Dilek Dilli, Semra Cetinkaya, Ahmet Oktem, Utku Arman Orun, Mehmet Tasar, Aysegul Zenciroglu

Objective: Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA closure through medical or surgical interventions in newborns.

Methods: This retrospective study was conducted on 65 newborns diagnosed with hemodynamically significant PDA (hs-PDA), with a premature rate of 81.5% (n=53). The subjects were divided into two groups according to the nature of the ductal closure as medically responsive "MR-PDA" or surgically treated "ST-PDA". The groups were compared in terms of thyroid hormone levels and other clinical parameters.

Results: Thirty-three (51%) of all 65 patients had PDA and responded to medical treatment. Gestational week, birth weight, and mode of delivery were similar between the medical and surgical treatment groups (p>0.05). Free thyroxine levels were significantly lower in the MR-PDA group than in the ST-PDA group (p=0.01).

Conclusions: Because hs-PDA is associated with increased morbidity and mortality in the neonatal period, especially in premature infants, we hypothesize that thyroid hormone levels may play a role in the closure of hs-PDA.

目的:尽管甲状腺激素在动脉导管未闭(PDA)的功能和解剖闭合中的作用是众所周知的,但它们对新生儿PDA的医学或外科闭合的影响尚不清楚。本研究旨在通过对新生儿的医疗或外科干预来评估甲状腺功能测试与PDA闭合之间的相关性。方法:对65例被诊断为血液动力学显著性PDA(hs-PDA)的新生儿进行回顾性研究,早产率为81.5%(n=53)。根据导管闭合的性质,受试者被分为两组,即医学反应性“MR-PDA”或手术治疗的“ST-PDA”。两组在甲状腺激素水平和其他临床参数方面进行了比较。结果:65例患者中有33例(51%)有PDA,对药物治疗有反应。妊娠周、出生体重和分娩方式在内科和外科治疗组之间相似(p>0.05)。MR-PDA组的游离甲状腺素水平显著低于ST-PDA组(p=0.01),我们推测甲状腺激素水平可能在hsPDA的闭合中起作用。
{"title":"The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns.","authors":"Basak Kaya,&nbsp;Hasan Akduman,&nbsp;Dilek Dilli,&nbsp;Semra Cetinkaya,&nbsp;Ahmet Oktem,&nbsp;Utku Arman Orun,&nbsp;Mehmet Tasar,&nbsp;Aysegul Zenciroglu","doi":"10.4274/MMJ.galenos.2023.25853","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.25853","url":null,"abstract":"<p><strong>Objective: </strong>Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA closure through medical or surgical interventions in newborns.</p><p><strong>Methods: </strong>This retrospective study was conducted on 65 newborns diagnosed with hemodynamically significant PDA (hs-PDA), with a premature rate of 81.5% (n=53). The subjects were divided into two groups according to the nature of the ductal closure as medically responsive \"MR-PDA\" or surgically treated \"ST-PDA\". The groups were compared in terms of thyroid hormone levels and other clinical parameters.</p><p><strong>Results: </strong>Thirty-three (51%) of all 65 patients had PDA and responded to medical treatment. Gestational week, birth weight, and mode of delivery were similar between the medical and surgical treatment groups (p>0.05). Free thyroxine levels were significantly lower in the MR-PDA group than in the ST-PDA group (p=0.01).</p><p><strong>Conclusions: </strong>Because hs-PDA is associated with increased morbidity and mortality in the neonatal period, especially in premature infants, we hypothesize that thyroid hormone levels may play a role in the closure of hs-PDA.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"38 3","pages":"187-192"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/60/medj-38-187.PMC10542982.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of Routine Antenatal Screening for Cytomegalovirus at a Tertiary Center. 三级中心的巨细胞病毒产前常规筛查结果。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.84042
Duygu Tugrul Ersak, Izzet Ozgurluk, Ayse Gulcin Bastemur, Esra Gulen Yildiz, Selcan Sinaci, Ezgi Turgut, Ozgur Kara, Atakan Tanacan, Dilek Sahin

Objective: Cytomegalovirus (CMV) is the most common viral infection. In this study, we discussed the results of pregnant women who underwent antenatal CMV screening in a tertiary center and the value of CMV antenatal screening.

Methods: For this retrospective study, the data of pregnant patients with antenatal CMV screening test results between 2019 and 2022 were obtained from hospital records. CMV immunoglobulin M (IgM), CMV IgG, anti-IgG avidity test results, amniocentesis, CMV polymerase chain reaction (PCR), and the outcome of the babies were recorded.

Results: A total of 31,912 CMV IgM and 26,969 CMV IgG tests were performed. CMV IgG seropositivity was observed in 78.99% of pregnant women, and 0.09% of the pregnant women were confirmed to have a positive CMV IgM test result. Pregnant women with positive IgM accompanying low avidity were referred to perinatology clinics for detailed ultrasonography and amniocentesis. Only 3 of the 44 pregnant women who underwent amniocentesis were confirmed to have positive CMV PCR testing.

Conclusions: CMV screening should be preserved for pregnant women with ultrasonographic findings at high risk of congenital CMV infection.

目的:巨细胞病毒(CMV)是最常见的病毒感染。在这项研究中,我们讨论了在三级中心接受产前CMV筛查的孕妇的结果以及CMV产前筛查的价值。方法:在这项回顾性研究中,从医院记录中获得2019年至2022年间产前CMV筛查结果的孕妇数据。记录CMV免疫球蛋白M(IgM)、CMV IgG、抗IgG亲和力测试结果、羊水穿刺、CMV聚合酶链式反应(PCR)和婴儿的结果。结果:共进行了31912次CMV IgM和26969次CMV IgG检测。在78.99%的孕妇中观察到CMV IgG血清阳性,0.09%的孕妇被证实CMV IgM检测结果呈阳性。IgM阳性并伴有低亲合力的孕妇被转诊到围产期诊所进行详细的超声检查和羊水穿刺。在接受羊水穿刺的44名孕妇中,只有3人被证实CMV PCR检测呈阳性。结论:对于超声检查结果为先天性巨细胞病毒感染高危的孕妇,应保留巨细胞病毒筛查。
{"title":"Results of Routine Antenatal Screening for Cytomegalovirus at a Tertiary Center.","authors":"Duygu Tugrul Ersak,&nbsp;Izzet Ozgurluk,&nbsp;Ayse Gulcin Bastemur,&nbsp;Esra Gulen Yildiz,&nbsp;Selcan Sinaci,&nbsp;Ezgi Turgut,&nbsp;Ozgur Kara,&nbsp;Atakan Tanacan,&nbsp;Dilek Sahin","doi":"10.4274/MMJ.galenos.2023.84042","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.84042","url":null,"abstract":"<p><strong>Objective: </strong>Cytomegalovirus (CMV) is the most common viral infection. In this study, we discussed the results of pregnant women who underwent antenatal CMV screening in a tertiary center and the value of CMV antenatal screening.</p><p><strong>Methods: </strong>For this retrospective study, the data of pregnant patients with antenatal CMV screening test results between 2019 and 2022 were obtained from hospital records. CMV immunoglobulin M (IgM), CMV IgG, anti-IgG avidity test results, amniocentesis, CMV polymerase chain reaction (PCR), and the outcome of the babies were recorded.</p><p><strong>Results: </strong>A total of 31,912 CMV IgM and 26,969 CMV IgG tests were performed. CMV IgG seropositivity was observed in 78.99% of pregnant women, and 0.09% of the pregnant women were confirmed to have a positive CMV IgM test result. Pregnant women with positive IgM accompanying low avidity were referred to perinatology clinics for detailed ultrasonography and amniocentesis. Only 3 of the 44 pregnant women who underwent amniocentesis were confirmed to have positive CMV PCR testing.</p><p><strong>Conclusions: </strong>CMV screening should be preserved for pregnant women with ultrasonographic findings at high risk of congenital CMV infection.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"38 3","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/88/medj-38-167.PMC10542985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41138917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Solmaz's Letter to the Editor about our article titled "Variations in Superficial Palmar Arch: Case Series with Clinico-anatomical Perspective". 对Solmaz给编辑的关于我们题为“掌浅弓变异:临床解剖学视角的病例系列”的文章的回复。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.40327
Dibakar Borthakur, Rajesh Kumar, Seema Singh
{"title":"Response to Solmaz's Letter to the Editor about our article titled \"Variations in Superficial Palmar Arch: Case Series with Clinico-anatomical Perspective\".","authors":"Dibakar Borthakur,&nbsp;Rajesh Kumar,&nbsp;Seema Singh","doi":"10.4274/MMJ.galenos.2023.40327","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.40327","url":null,"abstract":"","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"38 3","pages":"234"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/1f/medj-38-234.PMC10542977.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Morphological and Biomechanical Properties of the Scapula for Shoulder Joint. 肩关节肩胛骨的形态和生物力学特性研究。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.15483
Nilgun Tuncel Cini, Nazan Guner Sak, Serdar Babacan, Ilknur Ari

Objective: The glenopolar angle is a helpful criterion for recommending operative treatment. This study aims to determine the morphometric features of the scapula and provide essential information that supplies scapular biomechanics to produce a formula.

Methods: The study was carried out on 34 dry scapulae in the laboratory of the Anatomy Department of the Faculty of Medicine, Bursa Uludag University. We used calipers for the linear measurements and the ImageJ program for the area and angle parameters. A total of 23 parameters were evaluated in the study. Statistical analyzes were performed using SPSS 22.0 software.

Results: According to the results of the correlation analysis, the highest correlation value of (R=0.957) was found to be the distance between the superior angle (angulus superior)-top of the glenoid plane and the inferior angle (angulus inferior)-the top of the glenoid plane. To estimate the glenopolar angle, we applied linear regression analysis and developed the following formula: Glenopolar angle =115.589 - (6.401 x the distance between the coracoid process and the top of the glenoid cavity) - (0.368 x angle between the glenoid plane and the lateral edge of the scapula extending towards the endpoint of the glenoid plane) (Adjusted R2=0.667).

Conclusions: Glenopolar angle can provide information about the fracture risk of the glenoid cavity and allows orthopedic surgeons to make quick decisions about the risk in the region. We believe that the study will provide a different perspective on designing different products in industrial designs for shoulder joints, especially in implantations.

目的:眼窝角度是推荐手术治疗的有用标准。本研究旨在确定肩胛骨的形态计量特征,并为肩胛骨生物力学提供必要的信息,以制定公式。方法:在乌鲁达大学医学院解剖系实验室对34例肩胛骨干燥进行研究。我们使用卡尺进行线性测量,并使用ImageJ程序进行面积和角度参数。本研究共评估了23个参数。采用SPSS 22.0软件进行统计分析。结果:根据相关分析的结果,相关值最高的是上角(上角)-关节盂平面顶部和下角(下角)-肩盂平面顶部之间的距离(R=0.957)。为了估计关节窝角,我们应用线性回归分析,得出了以下公式:Glenopolar角=115.589-(6.401 x珊瑚突和关节盂腔顶部之间的距离)-(0.368 x关节盂平面和肩胛骨外侧边缘之间向关节盂平面终点延伸的角度)(调整后的R2=0.667)。结论:Glenopolar角可以提供信息关于关节臼腔骨折风险,并使整形外科医生能够快速决定该区域的风险。我们相信,这项研究将为肩关节工业设计中设计不同的产品提供不同的视角,尤其是在植入中。
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引用次数: 0
Oxytocin in the Treatment of Psychiatric Disorders. 催产素治疗精神疾病。
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.13707
Salim Cagatay Kagizman, Cicek Hocaoglu

Oxytocin is a peptide hormone that is most known for its role in reproduction. However, many effects other than reproduction have been defined. The lifetime prevalence of mental disorders is approximately 20%, and they have a significant ratio among the diseases that lead to disability. Treatment resistance may cause the mental disorder to become chronic and increase disability. With the examination of the oxytocinergic system, both the elucidation of the etiology of the diseases and their evaluation as a new treatment option have come to the fore. In various studies, it has been desired to create a more effective treatment model by measuring the level of oxytocin in psychiatric disorders, examining its receptor, and applying exogenous oxytocin in the treatment. In this review, an overview of oxytocin's efficacy in treatment is presented by considering the relationship between psychiatric disorders and the oxytocinergic system.

催产素是一种肽类激素,以其在生殖中的作用而闻名。然而,除了繁殖之外,还有许多其他的影响已经被定义。精神障碍的终生患病率约为20%,在导致残疾的疾病中占很大比例。治疗抵抗可能导致精神障碍成为慢性疾病,并增加残疾。随着对催产素能系统的检查,对疾病病因的阐明和对其作为一种新的治疗选择的评估都已崭露头角。在各种研究中,人们希望通过测量精神疾病中催产素的水平,检查其受体,并在治疗中应用外源性催产素来创建一个更有效的治疗模型。在这篇综述中,通过考虑精神疾病和催产素能系统之间的关系,对催产素的治疗效果进行了概述。
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引用次数: 0
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