Journal of Otology最新文献

{"title":"Bilateral squamous cell carcinoma of the temporal bone: A report of two cases and a systematic review of the literature","authors":"N. Hoogenes ,&nbsp;M. Tomasoni ,&nbsp;P. Merkus ,&nbsp;B.I. Lissenberg-Witte ,&nbsp;C.R. Leemans ,&nbsp;A. Deganello ,&nbsp;C.F. Smit","doi":"10.1016/j.joto.2024.07.006","DOIUrl":"10.1016/j.joto.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><div>two new cases of temporal bone squamous cell carcinoma (TBSCC) with a bilateral occurrence are presented. Furthermore, a review of the literature was performed and the yearly incidence was calculated.</div></div><div><h3>Methods</h3><div>A systematic review of the literature was conducted using PRISMA guidelines.</div></div><div><h3>Results</h3><div>Twenty-two more cases were found in literature. With a total of 24 cases, the calculated yearly incidence of bilateral TBSCC is 49:10^12 A history of chronic otitis or regional radiotherapy was found in respectively 50% and 12% of patients. In nine patients, the tumors developed synchronously (within 6 months) and in 13 metachronously.</div></div><div><h3>Conclusions</h3><div>The calculated incidence is 89 times higher than mathematically expected considering the incidence of unilateral cases. An explanation might be a history of chronic otitis or prior radiotherapy. The tumor staging of both the first tumor group and the contralateral tumor group are similar to unilateral temporal bone squamous cell carcinoma series.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 227-233"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect analysis of unilateral deaf adults wearing bone-conduction hearing aids: A case report","authors":"Chenchen Xiang ,&nbsp;Yi Wang ,&nbsp;Xiaozhu Cao ,&nbsp;Weiman Xv ,&nbsp;Jing Liu ,&nbsp;Nan Li ,&nbsp;Lumeng Han ,&nbsp;QIan Wang ,&nbsp;Fei Ji","doi":"10.1016/j.joto.2024.07.009","DOIUrl":"10.1016/j.joto.2024.07.009","url":null,"abstract":"<div><div>The prevalence of unilateral deafness (SSD) or asymmetric hearing loss (AHL) among patients with hearing impairments ranges from 7.2% to 15.0%, indicating a relatively significant proportion. However, these individuals often overlook their hearing loss, resulting in delayed or inadequate treatment. This oversight can lead to a lack of binaural summation and squelch effect, as well as the head shadow effect, which can significantly impact their speech recognition and sound localization abilities, especially in noisy environments.Recently, a groundbreaking Sound Bite™ Pinyin® Bone Conduction Hearing Aid (HA) device has been has been introduced as a viable alternative to traditional percutaneous stimulation hearing assistance devices. This innovative device harnesses bone conduction technology to convey sound vibrations directly to the inner ear via the bones of the jaw and skull, effectively bypassing the air conduction pathway that is commonly compromised in individuals with hearing loss.</div><div>This report details the evaluation and adjustment process of a HA device worn by a 31-year-old female patient who suffers from a congenital ossicular chain deformity in her right ear, while maintaining normal hearing in her left ear.The report comprehensively covers the hearing thresholds of the 31-year-old female patient on the day of fitting the hearing aid and one month later. It also presents assessments of the hearing aid's performance through the Abbreviated Profile of Hearing Aid Benefit (APHAB) questionnaire, conducted three days after adjustment, one month later, and one year later.Furthermore, the report details the evaluation of the patient's sound localization ability, comparing her performance before and after wearing the hearing aid device. Additionally, it includes measurements of her speech recognition ability for monosyllabic words and Yang Yang Ge words, which are specific tests in the Chinese language, conducted two years after the initial fitting of the hearing aid.The discovery that bone-anchored hearing devices can significantly enhance hearing thresholds in patients with unilateral conductive hearing loss represents a significant milestone. These devices not only improve speech recognition ability but also enhance sound localization in noisy environments. This improvement is accompanied by a high level of subjective satisfaction among patients, indicating a positive impact on their overall quality of life.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 207-213"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and improving countermeasures of medical disputes from the perspective of legal changes","authors":"Zhang Linlin ,&nbsp;Zhang Shimeng","doi":"10.1016/j.joto.2024.05.004","DOIUrl":"10.1016/j.joto.2024.05.004","url":null,"abstract":"<div><div>Under the background of medical disputes growing in number, scale and intensity, tracing back legal changes in medical field as a breakthrough point, this paper took a legal perspective to illustrate changes in medical dispute settlements from legislative orientation to legal system improvement. In view of the fact that early legislation in medical field was biased towards identification and punishment of doctors’ responsibility, and later intensive legislation in balancing increasing \"medical trouble\" phenomenon with limited effects and difficulties to abide by the law, this paper proposed to improve doctor-patient dispute settlements system in China referencing from foreign law experience, to reduce investigation of doctors at the judicial level, and to establish a settlement mechanism on doctors' apology at the legislative level, so as to promote a healthy development of doctor-patient relationship.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 247-250"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons learned in delayed identification of a misplaced electrode array in the vestibule","authors":"Huey Ting Diong ,&nbsp;Yuhan Wong ,&nbsp;Shermaine Png ,&nbsp;Yeow Seng Raymond Ngo","doi":"10.1016/j.joto.2024.03.003","DOIUrl":"10.1016/j.joto.2024.03.003","url":null,"abstract":"<div><div>To report a case of cochlear implantation with a misplaced electrode array in the vestibule and the causes for the delay in identification. A 23-year-old male with left single-sided deafness underwent cochlear implantation. The intraoperative assessment did not reveal any major red flags of electrode array misplacement. He did not display any vestibular symptoms postoperatively but showed poor speech performance, even though the aided tone audiometry revealed good sound detection thresholds. High-resolution computed tomography (HRCT) showed that the entire perimodiolar electrode array was situated within the vestibule, and a revision surgery was conducted. Retrospective analysis of the neural response telemetry (NRT) revealed subtle differences in responses between the misplaced and correctly placed electrode arrays. Unlike previously reported cases, the patient did not display vestibular symptoms despite the misplacement of the electrode in the vestibule due to existing weakness in otolithic function. Further investigation is warranted when a motivated patient with normal inner ear anatomy does not show benefit with the cochlear implant post-operatively.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 241-246"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of preschool hearing screening at primary healthcare centers in Riyadh, Saudi Arabia: A cross-sectional study","authors":"Ahmad A. Alanazi ,&nbsp;Rayan A. Almutairi ,&nbsp;Khalid S. Alsuhaibani ,&nbsp;Yazzan Alruwaily ,&nbsp;Hellal A. Alqudiey ,&nbsp;Mohammed A. Alabbas ,&nbsp;Shuaa R. Alanazi","doi":"10.1016/j.joto.2024.10.001","DOIUrl":"10.1016/j.joto.2024.10.001","url":null,"abstract":"<div><div>The hearing status of children should be examined throughout early childhood, even if they have passed the newborn hearing loss because hearing loss can occur at any time and may affect their ability to learn. Preschool hearing screening (PHS) is vital to continue screening throughout early childhood. The current practice of PHS in the primary healthcare centers (PHCs) in Saudi Arabia is unknown. The purpose of this study was to investigate PHS in the PHCs. This cross-sectional descriptive study used an in-person-administered questionnaire to collect data. A total of 106 out of 120 participants (male = 61; female = 45) representing the PHCs in Riyadh were interviewed. Most of the participants were aged 31–40 years and held a bachelor's degree as the highest academic qualification with limited years of experience. PHS was mostly performed through subjective measures by asking the parents (71.7%) and the child (65.1%). The audiometric evaluation was conducted for preschool children in only half of the PHCs. General practitioners and nurses usually perform PHS. Substantial gaps in the practice of PHS were identified. The lack of training and appropriate instruments and the need for audiological services were the main challenges. Incorporating robust and objective protocols for PHS into the educational system is a valuable strategy for identifying hearing loss early and reducing its impact through the establishment of effective intervention plans.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 214-219"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders","authors":"Ilmari Pyykkö ,&nbsp;Vinay ,&nbsp;Jing Zou ,&nbsp;Artur Vetkas ,&nbsp;Vinaya Manchaiah","doi":"10.1016/j.joto.2024.07.005","DOIUrl":"10.1016/j.joto.2024.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>To better understand the clinical phenotype of Ménière's disease (MD), we examined family history, thyroid disorder, migraine, and associated disorders in complaints of people living with MD.</div></div><div><h3>Method</h3><div>We designed the study as a retrospective and examined data gathered from 912 participants with MD. Their data were originally collected by the Finnish Ménière Federation (FMF). The survey data included individual case histories for environmental factors, comorbidities, disease-specific complaints, impact-related questions, cognitive complaints, health-related quality of life (HRQoL), and sense of coherence (SOC).</div></div><div><h3>Results</h3><div>We observed significant differences between those with and without sporadic occurrence, family history, thyroid disorder, and migraine-associated complaints. Family history explained 20% of variability in patient complaints. Patients with a family history of MD whose disease started at younger age experienced balance problems, more severe vertigo spells, more severe vestibular drop attacks (VDA), and less nausea, although they had good SOC. Thyroid disorder explained 14% of variability in patient complaints. MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness, balance problems, greater impact of hearing problems, cognitive complaints, and poor HRQoL. Migraine explained 12% of variability in patients’ complaints and was associated with poor SOC and cognitive balance problems. MD patients with both thyroid disorder and migraine used antidepressants more often than other groups. Logistic regression analysis showed comorbidities of ischemic brain disorder (among 7.1%), kidney insufficiency (among 1.2%), and diabetes (among 7.3%) had statistically significant but restricted association with balance and gait problems, VDA, and reduced HRQoL.</div></div><div><h3>Conclusions</h3><div>Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles, including symptoms of cognitive problems. Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 185-192"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue","authors":"Shili Zhang ,&nbsp;Caiji Wang ,&nbsp;Yuehua Qiao ,&nbsp;Xi Shi","doi":"10.1016/j.joto.2024.06.001","DOIUrl":"10.1016/j.joto.2024.06.001","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the expression patterns of cysteine string protein alpha (CSPα) and cysteine string protein beta (CSPβ) in the mammalian inner ear, with an emphasis on their temporal dynamics during the developmental stages of C57BL/6 mice.</div></div><div><h3>Methods</h3><div>We utilized immunofluorescence staining to assess the localization and distribution of CSPα and CSPβ within the inner ears of C57BL/6 mice and miniature pigs. Additionally, this method facilitated the investigation of their temporal expression profiles.</div></div><div><h3>Results</h3><div>In adult C57BL/6 mice and miniature pigs, CSPα and CSPβ were identified in the cytoplasm of inner hair cells and spiral ganglion cells, yet were absent in outer hair cells. Both proteins were found to colocalize with Ctbp2 on the basal side of the cytoplasm in inner hair cells' basilar membrane. Expression of CSPα was observed at the nerve fiber termini at the basilar membrane's base of inner and outer hair cells 10 days postnatally in C57BL/6 mice. Notably, expression of both CSPα and CSPβ in the cytoplasm of inner hair cells emerged on the 12th day post-birth, aligning with the timeline for registering cochlear potentials. The expression levels of both proteins increased with age, but were consistently absent in outer hair cells. Contrastingly, expression of CSPα and CSPβ was present in the cytoplasm of inner hair cells in miniature pigs as early as one day post-birth, yet remained absent in the three rows of outer hair cells.</div></div><div><h3>Conclusion</h3><div>CSPα and CSPβ exhibit predominant and specific expression in inner hair cells and spiral ganglion cells. A unique expression pattern was observed for CSPα, which was also present at the nerve fiber endings of both inner and outer hair cells. The developmental expression trajectory of CSPα and CSPβ in mouse inner hair cells is characterized by an initial absence, followed by a gradual increase. Moreover, the timing of expression onset between mice and miniature pigs indicates distinct temporal dynamics, suggesting a potential role in auditory development.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 193-199"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the efficacy of (R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation","authors":"Dawei Ren ,&nbsp;Xuemin Chen ,&nbsp;Hongdong Liu ,&nbsp;Menghua Li ,&nbsp;Liting Zheng ,&nbsp;Pan Yong ,&nbsp;Mohe Huang ,&nbsp;Xi Shi ,&nbsp;Yice Xu ,&nbsp;Shujin Chen ,&nbsp;Yan Zhang ,&nbsp;Wei Zhu","doi":"10.1016/j.joto.2024.07.008","DOIUrl":"10.1016/j.joto.2024.07.008","url":null,"abstract":"<div><div>Noise-induced hearing loss (NIHL) is primarily driven by inflammatory processes within the cochlea, where noise exposure triggers the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to an inflammatory cascade. The interaction between increased NLRP3 expression and NF-κB activity can further amplify cochlear inflammation. Our findings reveal that (R)-PFI-2 hydrochloride, a selective inhibitor of the SETD7 enzyme, effectively inhibits the activation of the cochlear NF-κB pathway, suppresses the release of pro-inflammatory factors, and prevents inflammasome assembly. This intervention disrupts the perpetuating cycle of inflammation, thereby alleviating damage to cochlear hair cells attributed to acoustic trauma. Consequently, (R)-PFI-2 hydrochloride emerges as a promising pharmacological candidate for NIHL, targeting and moderating the excessive immune and inflammatory responses implicated in the pathology of hearing loss.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 200-206"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of sensory impairment in older adults with dementia","authors":"Nikol Gottfriedová ,&nbsp;Martina Kovalová ,&nbsp;Eva Mrázková ,&nbsp;Ondřej Machaczka ,&nbsp;Veronika Koutná ,&nbsp;Vladimír Janout ,&nbsp;Jana Janoutová","doi":"10.1016/j.joto.2024.11.001","DOIUrl":"10.1016/j.joto.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Over 55 million people worldwide are living with dementia. The rate of cognitive decline increases with age, and loss of senses may be a contributing factor.</div></div><div><h3>Objectives</h3><div>This study aimed to analyze hearing, olfactory function, and color vision in patients with dementia.</div></div><div><h3>Materials and methods</h3><div>The sample comprised 40 patients with dementia and 37 cognitively normal controls aged 41–85 years. All participants underwent conventional pure-tone audiometry and a screening version of the Hearing Handicap Inventory for Adults, the Odorized Markers Test of olfactory function and the Ishihara color vision test. The effects of comorbidities and lifestyle factors were also assessed.</div></div><div><h3>Results</h3><div>Patients with dementia had significantly worse hearing at almost all frequencies tested and significantly greater olfactory impairment than cognitively normal controls. Color vision impairment was found in less than 8% of the sample, with no significant difference between the groups. Impairment of two senses (hearing and olfaction) was significantly more common in patients with dementia than in controls.</div></div><div><h3>Conclusion</h3><div>Individuals with dementia were found to have sensory decline, namely hearing and olfactory impairment. Color vision was rarely impaired in the sample. Participants with dementia tended to have more multisensory impairments than controls.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 220-226"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review","authors":"Jing-Ying Guo ,&nbsp;Jun-Yi Xu ,&nbsp;Shu-Sheng Gong ,&nbsp;Guo-Peng Wang","doi":"10.1016/j.joto.2024.07.007","DOIUrl":"10.1016/j.joto.2024.07.007","url":null,"abstract":"<div><div>The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated. SCs are indispensable components of the sensory epithelia, and they maintain the structural integrity and ionic environment of the inner ear. Once delicate inner ear epithelia sustain injuries (for example, due to ototoxic drugs or noise exposure), SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors, aiming at morphological and functional recovery of the inner ear. This regenerative process is extensive in non-mammals, but is limited in the mammalian inner ear, especially in the mature cochlea. This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 4","pages":"Pages 234-240"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}