Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.07.004
Mohammad H. Shaheen , Syed Raza , Bassam AlZuraiqi , Mohammad Ghazi Abdoh , Essam Saleh
Objective
To report a rare case of otogenic tension pneumocephalus as a complication of a diffuse leptomeningeal glioneuronal tumor in a patient with a ventriculoperitoneal (V. P.) shunt.
Patients
Twenty-three- year-old man with a confirmed diffuse leptomeningeal glioneuronal tumor diagnosis was treated for temporal bone defect and considerable pneumocephalus one year after V. P. shunt.
Intervention(s)
The patient underwent a Transmastoid, retrolabyrinthine approach. The defect was closed with temporalis facia graft and conchal cartilage as a double-layer closure, and then DuraSeal® was placed over the repaired area.
Main outcome measure(s)
Resolution of the pneumocephalus.
Results
There was a significant reduction in the pneumocephalus on the first day post-operatively.
Conclusions
Spontaneous or secondary pneumocephalus development should be considered in patients with brain tumors, hydrocephalus, and patients who undergo V.P. shunt insertion.
{"title":"Spontaneous Pneumocephalus associated with leptomeningeal glioneuronal tumor in an adult; A rare case report","authors":"Mohammad H. Shaheen , Syed Raza , Bassam AlZuraiqi , Mohammad Ghazi Abdoh , Essam Saleh","doi":"10.1016/j.joto.2024.07.004","DOIUrl":"10.1016/j.joto.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To report a rare case of otogenic tension pneumocephalus as a complication of a diffuse leptomeningeal glioneuronal tumor in a patient with a ventriculoperitoneal (V. P.) shunt.</div></div><div><h3>Patients</h3><div>Twenty-three- year-old man with a confirmed diffuse leptomeningeal glioneuronal tumor diagnosis was treated for temporal bone defect and considerable pneumocephalus one year after V. P. shunt.</div></div><div><h3>Intervention(s)</h3><div>The patient underwent a Transmastoid, retrolabyrinthine approach. The defect was closed with temporalis facia graft and conchal cartilage as a double-layer closure, and then DuraSeal® was placed over the repaired area.</div></div><div><h3>Main outcome measure(s)</h3><div>Resolution of the pneumocephalus.</div></div><div><h3>Results</h3><div>There was a significant reduction in the pneumocephalus on the first day post-operatively.</div></div><div><h3>Conclusions</h3><div>Spontaneous or secondary pneumocephalus development should be considered in patients with brain tumors, hydrocephalus, and patients who undergo V.P. shunt insertion.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 144-147"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.07.001
Yan Wang , Yingying Liu , Yi Xie , Jun Luan , Rongrong Liu , Yongjia Zhu , Ying Ma , Yi Fan , Yan Sun , Wenjing Shang , Fengchan Han
Objectives
Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells. Cisplatin, an antitumor drug, can cause various side effects, including ototoxicity. The aim of this study was to investigate the effects of Fscn2 on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.
Methods
Two-week-old Fscn2+/+ mice and Fscn2−/− mice were treated with two doses of cisplatin, with a 3-day recovery period in between. ABR (auditory evoked brain stem response) thresholds were measured and cochlear pathology was observed at 3 weeks of age.
Results
Both Fscn2+/+ and Fscn2−/− mice showed hearing loss under the effect of cisplatin, but the impairment was more severe in Fscn2−/− mice. Further experiments showed that the percentages of outer hair cell (OHC) and spiral ganglion neuron (SGN) loss were significantly higher in cisplatin-treated Fscn2−/− mice compared to Fscn2+/+ mice. Additionally, knockdown of Fscn2 in HEI-OC1 cells worsened cisplatin-induced cell apoptosis.
Conclusion
FSCN2 mediates reduction of CDDP induced ototoxicity by inhibiting cell apoptosis.
{"title":"Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice","authors":"Yan Wang , Yingying Liu , Yi Xie , Jun Luan , Rongrong Liu , Yongjia Zhu , Ying Ma , Yi Fan , Yan Sun , Wenjing Shang , Fengchan Han","doi":"10.1016/j.joto.2024.07.001","DOIUrl":"10.1016/j.joto.2024.07.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Deletion of <em>Fscn2</em> gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells. Cisplatin, an antitumor drug, can cause various side effects, including ototoxicity. The aim of this study was to investigate the effects of <em>Fscn2</em> on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.</div></div><div><h3>Methods</h3><div>Two-week-old <em>Fscn2</em><sup><em>+/+</em></sup> mice and <em>Fscn2</em><sup><em>−/−</em></sup> mice were treated with two doses of cisplatin, with a 3-day recovery period in between. ABR (auditory evoked brain stem response) thresholds were measured and cochlear pathology was observed at 3 weeks of age.</div></div><div><h3>Results</h3><div>Both <em>Fscn2</em><sup><em>+/+</em></sup> and <em>Fscn2</em><sup><em>−/−</em></sup> mice showed hearing loss under the effect of cisplatin, but the impairment was more severe in <em>Fscn2</em><sup><em>−/−</em></sup> mice. Further experiments showed that the percentages of outer hair cell (OHC) and spiral ganglion neuron (SGN) loss were significantly higher in cisplatin-treated <em>Fscn2</em><sup><em>−/−</em></sup> mice compared to <em>Fscn2</em><sup><em>+/+</em></sup> mice. Additionally, knockdown of <em>Fscn2</em> in HEI-OC1 cells worsened cisplatin-induced cell apoptosis.</div></div><div><h3>Conclusion</h3><div>FSCN2 mediates reduction of CDDP induced ototoxicity by inhibiting cell apoptosis.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 133-139"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.04.003
Rong Wang , Weiwei Han , Li Li , Lulu Li , Xiaoxia Liu , Yunqin Wu , Weinv Fan
Objective
To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.
Methods
In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared.
Results
The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV.
Conclusions
Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.
{"title":"Preliminary study of the role of inner ear proteins in vestibular neuritis","authors":"Rong Wang , Weiwei Han , Li Li , Lulu Li , Xiaoxia Liu , Yunqin Wu , Weinv Fan","doi":"10.1016/j.joto.2024.04.003","DOIUrl":"10.1016/j.joto.2024.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.</div></div><div><h3>Methods</h3><div>In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared.</div></div><div><h3>Results</h3><div>The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV.</div></div><div><h3>Conclusions</h3><div>Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 140-143"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thiamine responsive megaloblastic anemia (TRMA), also known as Roger's syndrome, is an exceptionally rare autosomal recessive disorder stemming from mutations in the SLC19A2 gene responsible for encoding a thiamine carrier protein.
This syndrome manifests as the classic triad of megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Here, we present the case of a one-and-a-half-year-old male infant born to non-consanguineous parents in India, a region where TRMA cases are seldom reported. At five months of age, the child exhibited the characteristic symptoms, prompting immediate treatment involving thiamine therapy, insulin administration, and blood transfusions. Notably, the child exhibited significant improvement in all aspects except for hearing loss, which conventional hearing aids failed to alleviate. However, following a cochlear implant procedure conducted within a few months, the child regained hearing abilities. This case underscores the importance of early recognition and intervention in the form of cochlear implant, demonstrating the potential to reverse TRMA symptoms and provide affected individuals with a substantially improved quality of life.
{"title":"Thiamine responsive megaloblastic Anemia and deafness: A rare case of Roger's syndrome with successful hearing rehabilitation by cochlear implantation","authors":"Hetal Marfatia, Anoushka Sahai, Kartik Narkhede, Monankita Sharma","doi":"10.1016/j.joto.2024.05.001","DOIUrl":"10.1016/j.joto.2024.05.001","url":null,"abstract":"<div><div>Thiamine responsive megaloblastic anemia (TRMA), also known as Roger's syndrome, is an exceptionally rare autosomal recessive disorder stemming from mutations in the SLC19A2 gene responsible for encoding a thiamine carrier protein.</div><div>This syndrome manifests as the classic triad of megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Here, we present the case of a one-and-a-half-year-old male infant born to non-consanguineous parents in India, a region where TRMA cases are seldom reported. At five months of age, the child exhibited the characteristic symptoms, prompting immediate treatment involving thiamine therapy, insulin administration, and blood transfusions. Notably, the child exhibited significant improvement in all aspects except for hearing loss, which conventional hearing aids failed to alleviate. However, following a cochlear implant procedure conducted within a few months, the child regained hearing abilities. This case underscores the importance of early recognition and intervention in the form of cochlear implant, demonstrating the potential to reverse TRMA symptoms and provide affected individuals with a substantially improved quality of life.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 163-165"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.02.002
Qingqing Xia , Shuoshuo Kang , Qian Wang , Mengdi Hong , Aiting Chen , Wei Chen , Fei Ji , Jianan Li , Shiming Yang
Purpose
To analyze the effect of right versus left long-term single-sided deafness (SSD) on sound source localization (SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral cochlear implantation (UCI) from the perspective of SSL.
Methods
This study included 25 patients with SSD, 11 patients with UCI, and 30 participants with normal hearing (NH). Their SSL ability was tested by obtaining their average root mean square (RMS) error values of SSL test.
Results
The results showed that the RMS error value of SSD, UCI and NH groups were 52.26 ± 20.25°, 69.84 ± 12.14° and 4.27 ± 2.66°, respectively. The ability of SSL was better in the SSD-L group than that in the SSD-R group, and no significant difference existed in the SSD-R and the UCI group.
Conclusion
When bilateral deafness patients select unilateral treatment, right-side cochlear implantation may be more beneficial in terms of SSL, which means that the central auditory cortex in long-term SSD patients is affected differently based on which side their deafness occurs.
{"title":"The effect of right versus left long-term single-sided deafness on sound source localization","authors":"Qingqing Xia , Shuoshuo Kang , Qian Wang , Mengdi Hong , Aiting Chen , Wei Chen , Fei Ji , Jianan Li , Shiming Yang","doi":"10.1016/j.joto.2024.02.002","DOIUrl":"10.1016/j.joto.2024.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze the effect of right versus left long-term single-sided deafness (SSD) on sound source localization (SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral cochlear implantation (UCI) from the perspective of SSL.</div></div><div><h3>Methods</h3><div>This study included 25 patients with SSD, 11 patients with UCI, and 30 participants with normal hearing (NH). Their SSL ability was tested by obtaining their average root mean square (RMS) error values of SSL test.</div></div><div><h3>Results</h3><div>The results showed that the RMS error value of SSD, UCI and NH groups were 52.26 ± 20.25°, 69.84 ± 12.14° and 4.27 ± 2.66°, respectively. The ability of SSL was better in the SSD-L group than that in the SSD-R group, and no significant difference existed in the SSD-R and the UCI group.</div></div><div><h3>Conclusion</h3><div>When bilateral deafness patients select unilateral treatment, right-side cochlear implantation may be more beneficial in terms of SSL, which means that the central auditory cortex in long-term SSD patients is affected differently based on which side their deafness occurs.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 158-162"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.09.001
Supriya Mathew, Chandni Jain
Purpose
The present systematic review examined imaging findings in the Auditory Neuropathy Spectrum Disorder (ANSD) population.
Methods
Electronic databases such as Pub Med, Google Scholar, J Gate, and Science Direct were used to conduct a literature search. The articles retrieved through the literature search were assessed in two stages. In the first stage, title and abstract screening were done; in the second stage, a full-length article review was done. From the 379 shortlisted records, 19 articles were chosen for the full-length review.
Results
The selected articles performed imaging using Computerized tomography (CT) and magnetic resonance imaging (MRI). In most studies, cochlear nerve deficiency (CND) was the most prevalent anomaly in the ANSD group. Also, MRI was the imaging modality of choice recommended in most studies. It was also noted that CND was a characteristic feature of unilateral ANSD.
Conclusion
From this systematic review, it is clear that integrating imaging studies into diagnostic protocol would help to understand the underlying pathology better and expedite decision-making and intervention for ANSD patients.
{"title":"A systematic review on the imaging findings in auditory neuropathy spectrum disorder","authors":"Supriya Mathew, Chandni Jain","doi":"10.1016/j.joto.2024.09.001","DOIUrl":"10.1016/j.joto.2024.09.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The present systematic review examined imaging findings in the Auditory Neuropathy Spectrum Disorder (ANSD) population.</div></div><div><h3>Methods</h3><div>Electronic databases such as Pub Med, Google Scholar, J Gate, and Science Direct were used to conduct a literature search. The articles retrieved through the literature search were assessed in two stages. In the first stage, title and abstract screening were done; in the second stage, a full-length article review was done. From the 379 shortlisted records, 19 articles were chosen for the full-length review.</div></div><div><h3>Results</h3><div>The selected articles performed imaging using Computerized tomography (CT) and magnetic resonance imaging (MRI). In most studies, cochlear nerve deficiency (CND) was the most prevalent anomaly in the ANSD group. Also, MRI was the imaging modality of choice recommended in most studies. It was also noted that CND was a characteristic feature of unilateral ANSD.</div></div><div><h3>Conclusion</h3><div>From this systematic review, it is clear that integrating imaging studies into diagnostic protocol would help to understand the underlying pathology better and expedite decision-making and intervention for ANSD patients.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 166-172"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.05.002
Haiqiao Du , Jianan Li , Wei Chen , Weiwei Guo , Shiming Yang
Cochlear implantation (CI) is currently recognized as the most effective treatment for severe to profound sensorineural deafness and is considered one of the most successful neural prostheses. Since its inception in 1961, cochlear implantation has expanded its range of applications to encompass younger newborns, older people, and individuals with unilateral hearing loss. In addition, it has improved its surgical methods to minimize the occurrence of complications. Furthermore, notable advancements have been made in the design of electrodes, techniques for speech processing, and software for programming. Nevertheless, inflammation, fibrosis, and even ossification are observed in the cochlea of nearly all cochlear implant (CI) patients. These tissue responses might have a negative impact on the performance of the implants, residual hearing, and the results of post-operative CI rehabilitation. Animal models are significant translational tools that offer essential preclinical data for possible therapeutics. Thus, this study concentrates on the existing animal models used for cochlear implantation, highlights the advancements made in research, and offers insights into potential future research areas.
{"title":"Animal models of cochlear implant: Classification and update","authors":"Haiqiao Du , Jianan Li , Wei Chen , Weiwei Guo , Shiming Yang","doi":"10.1016/j.joto.2024.05.002","DOIUrl":"10.1016/j.joto.2024.05.002","url":null,"abstract":"<div><div>Cochlear implantation (CI) is currently recognized as the most effective treatment for severe to profound sensorineural deafness and is considered one of the most successful neural prostheses. Since its inception in 1961, cochlear implantation has expanded its range of applications to encompass younger newborns, older people, and individuals with unilateral hearing loss. In addition, it has improved its surgical methods to minimize the occurrence of complications. Furthermore, notable advancements have been made in the design of electrodes, techniques for speech processing, and software for programming. Nevertheless, inflammation, fibrosis, and even ossification are observed in the cochlea of nearly all cochlear implant (CI) patients. These tissue responses might have a negative impact on the performance of the implants, residual hearing, and the results of post-operative CI rehabilitation. Animal models are significant translational tools that offer essential preclinical data for possible therapeutics. Thus, this study concentrates on the existing animal models used for cochlear implantation, highlights the advancements made in research, and offers insights into potential future research areas.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 173-177"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.07.002
Yi Du , Xingjian Liu , Yu Wang , Zhengyan Xu , Fei Ji , Lili Ren , Ziming Wu
Objective
This study aimed to develop and evaluate a novel software tool for robust analysis of the Visually Enhanced Vestibular-Ocular Reflex (VVOR) and video head impulse test (vHIT) saccades.
Methods
A retrospective study was conducted on 94 patients with Meniere's Disease (MD), unilateral vestibular hypofunction (UVH), and vestibular migraine (VM). The MATLAB-based VVOR Analysis System and Saccades All in One software were utilized for data processing. New techniques, VVOR_diff and VVOR_cycle, were deployed for saccade parameter extraction.
Results
Saccade incidence rates, examined through vHIT, VVOR_diff, and VVOR_cycle, exhibited distinct patterns in MD, UVH, and VM patients. Frequent instances of multiple saccades within a single cycle were noted on the affected side in MD and UVH patients. Statistically significant differences in saccade gain and incidence rates between the affected and unaffected sides were evident in MD and UVH patients. Notably, high inter-method and intra-method correlations suggested consistency across different methods and potential interactions within one.
Conclusion
The software proved effective in extracting saccades and reducing noise in VVOR data, thereby enhancing the evaluation of vestibular function and potentially improving diagnostic accuracy for vestibular disorders.
目的：本研究旨在开发和评估一种新的软件工具，用于视觉增强前庭-眼反射（VVOR）和视频头脉冲测试（vHIT）跳频的稳健分析。方法：对94例梅尼埃病（MD）合并单侧前庭功能减退（UVH）和前庭偏头痛（VM）患者进行回顾性研究。利用基于matlab的VVOR分析系统和Saccades All in One软件进行数据处理。采用VVOR_diff和VVOR_cycle新技术提取眼动参数。结果：通过vHIT、VVOR_diff和VVOR_cycle检测，眼跳发生率在MD、UVH和VM患者中表现出不同的模式。在一个周期内，MD和UVH患者患侧经常出现多次扫视。在MD和UVH患者中，受影响侧和未受影响侧的扫视增益和发病率有统计学上的显著差异。值得注意的是，方法间和方法内的高度相关性表明不同方法之间的一致性和一种方法内部潜在的相互作用。结论：该软件可有效提取VVOR数据中的眼跳和降低噪声，从而增强对前庭功能的评估，有可能提高前庭功能障碍的诊断准确性。
{"title":"Comparing saccades in Visually Enhanced Vestibular-Ocular Reflex and video head impulse test in vestibular assessment","authors":"Yi Du , Xingjian Liu , Yu Wang , Zhengyan Xu , Fei Ji , Lili Ren , Ziming Wu","doi":"10.1016/j.joto.2024.07.002","DOIUrl":"10.1016/j.joto.2024.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop and evaluate a novel software tool for robust analysis of the Visually Enhanced Vestibular-Ocular Reflex (VVOR) and video head impulse test (vHIT) saccades.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted on 94 patients with Meniere's Disease (MD), unilateral vestibular hypofunction (UVH), and vestibular migraine (VM). The MATLAB-based VVOR Analysis System and Saccades All in One software were utilized for data processing. New techniques, VVOR_diff and VVOR_cycle, were deployed for saccade parameter extraction.</div></div><div><h3>Results</h3><div>Saccade incidence rates, examined through vHIT, VVOR_diff, and VVOR_cycle, exhibited distinct patterns in MD, UVH, and VM patients. Frequent instances of multiple saccades within a single cycle were noted on the affected side in MD and UVH patients. Statistically significant differences in saccade gain and incidence rates between the affected and unaffected sides were evident in MD and UVH patients. Notably, high inter-method and intra-method correlations suggested consistency across different methods and potential interactions within one.</div></div><div><h3>Conclusion</h3><div>The software proved effective in extracting saccades and reducing noise in VVOR data, thereby enhancing the evaluation of vestibular function and potentially improving diagnostic accuracy for vestibular disorders.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 148-157"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prevalence of tinnitus is increasing worldwide along with the aging population. The absence of a gold standard for diagnosis and treatment makes it difficult to assess the health status of a patient with tinnitus.
The aim was to determine the prevalence of tinnitus among older adults in Almaty city and to evaluate the healthcare experience among the respondents who received treatment for tinnitus.
Methods
A cross-sectional study was conducted among people aged 18 years and above in Almaty city. The data were collected using a questionnaire sent via a Google form and/or as a printed version. Fully completed responses were received from 851 respondents. The questionnaire consists of 31 questions. Simple and multiple logistic regression analyses were performed to identify the risk factors of tinnitus.
Results
The prevalence of tinnitus in Almaty was 23.3%. The data showed that smoking and sleep regimen were associated with tinnitus. Older respondents indicated more symptoms associated with tinnitus than younger respondents did. Additional consultation was needed as part of the treatment of tinnitus. In addition, 49.4% of the respondents indicated a need of a support group for people with tinnitus. The respondents also indicated that the access to appropriate resources for the treatment of tinnitus was poor.
Conclusion
Similar to other studies, this analysis confirmed that tinnitus is prevalent in the adult population of Almaty city. Future activities should include measures for the improvement of public awareness of the risk factors of tinnitus, and multidisciplinary teamwork among healthcare specialists should be improved.
{"title":"Tinnitus prevalence and care experience among population of Almaty city","authors":"Akbota Seitkali , Lyazzat Kosherbayeva , Aigul Medeulova , Nurgul Alekenova , Dinmukhamed Ayaganov , Gulnara Kandygulova","doi":"10.1016/j.joto.2024.02.003","DOIUrl":"10.1016/j.joto.2024.02.003","url":null,"abstract":"<div><div>The prevalence of tinnitus is increasing worldwide along with the aging population. The absence of a gold standard for diagnosis and treatment makes it difficult to assess the health status of a patient with tinnitus.</div><div>The aim was to determine the prevalence of tinnitus among older adults in Almaty city and to evaluate the healthcare experience among the respondents who received treatment for tinnitus.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among people aged 18 years and above in Almaty city. The data were collected using a questionnaire sent via a Google form and/or as a printed version. Fully completed responses were received from 851 respondents. The questionnaire consists of 31 questions. Simple and multiple logistic regression analyses were performed to identify the risk factors of tinnitus.</div></div><div><h3>Results</h3><div>The prevalence of tinnitus in Almaty was 23.3%. The data showed that smoking and sleep regimen were associated with tinnitus. Older respondents indicated more symptoms associated with tinnitus than younger respondents did. Additional consultation was needed as part of the treatment of tinnitus. In addition, 49.4% of the respondents indicated a need of a support group for people with tinnitus. The respondents also indicated that the access to appropriate resources for the treatment of tinnitus was poor.</div></div><div><h3>Conclusion</h3><div>Similar to other studies, this analysis confirmed that tinnitus is prevalent in the adult population of Almaty city. Future activities should include measures for the improvement of public awareness of the risk factors of tinnitus, and multidisciplinary teamwork among healthcare specialists should be improved.</div></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 127-132"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.joto.2024.03.001
Deven P. Curtis , Anthony N. Baumann , Natasha Salmen , Anita Jeyakumar
Objectives
The movement towards personalization of cochlear implantation has continued to generate interest about variabilities in cochlear size. In a recent meta-analysis, Atalay et al. (2022) examined organ of corti length, cochlear lateral wall, and “A” value and found that most covariates, other than congenital sensorineural hearing loss, did not impact cochlear size via these measurements. However, no meta-analysis exists on how patient-specific variables could impact other cochlear size measurements, such as cochlear height (CH), and “B” value (defined as the distance between opposite lateral walls and perpendicular to “A” value). The purpose of this systematic review and meta-analysis is to examine how patient-specific variables impact additional cochlear size measurements to assist clinical decision-making.
Databases reviewed
A systematic review for cochlear size measurements using PRISMA methodology was performed using PubMed, CINAHL, and MEDLINE from database inception to October 1st, 2022.
Methods
Search terms used included English, cochlea, size, histology, anatomy, and human. Inclusion criteria were measurements for human cochlea, full-text articles, and articles in English. Primary measurements were “B” value and CH, as these measurements differ from the recent meta-analysis on this topic. Cochlear duct length (CDL) was also included. A random-effects continuous model for meta-analysis was performed. Measurements were stratified by gender (male/female) and disease type (sensorineural hearing loss (SNHL)/conductive hearing loss (CHL)).
Results
A total of 7 articles met final inclusion criteria from a total of 674 articles received on initial search, resulting in 2263 total human cochleae. There was a statistical difference between male CDL (n = 681 cochlea) compared to female CDL (n = 657) from four articles (p < 0.001; Cohen's d effect size (ES):0.421; 95% confidence intervals (CI): 0.171, 0.671). The frequency weighted mean for male CDL was 33.5 mm ± 1.8 mm and the frequency weighted mean for female CDL was 32.4 mm ± 1.5 mm with an unstandardized mean difference of 0.854 mm. There was no statistical difference between male “B” value (n = 329) and female “B” value (n = 349) for cochlea from two studies (p = 0.184; Cohen's d ES: 0.410; 95% CI: 0.194, 1.014). The frequency weighted mean for male “B” value was 6.5 mm ± 0.1 mm and the frequency weighted mean for female “B” value was 6.4 mm ± 0.1 mm with an unstandardized mean difference of 0.126 mm. There was no statistical difference between CH for SNHL (n = 282) and CHL (n = 275) from two studies (p = 0.486; ES: 0.085; 95% CI: 0.323, 0.153, F ig. 3). The frequency weighted mean for SNHL CH was 4.6 mm ± 0.8 mm and the frequency weighted mean for CHL CH was 4.3 mm ± 0.8 mm with an unstandardized mean difference of 0.032 mm.
{"title":"Investigating Additional Cochlear Parameters: A follow-up systematic review and meta-analysis","authors":"Deven P. Curtis , Anthony N. Baumann , Natasha Salmen , Anita Jeyakumar","doi":"10.1016/j.joto.2024.03.001","DOIUrl":"10.1016/j.joto.2024.03.001","url":null,"abstract":"<div><h3>Objectives</h3><div>The movement towards personalization of cochlear implantation has continued to generate interest about variabilities in cochlear size. In a recent meta-analysis, Atalay et al. (2022) examined organ of corti length, cochlear lateral wall, and “A” value and found that most covariates, other than congenital sensorineural hearing loss, did not impact cochlear size via these measurements. However, no meta-analysis exists on how patient-specific variables could impact other cochlear size measurements, such as cochlear height (CH), and “B” value (defined as the distance between opposite lateral walls and perpendicular to “A” value). The purpose of this systematic review and meta-analysis is to examine how patient-specific variables impact additional cochlear size measurements to assist clinical decision-making.</div></div><div><h3>Databases reviewed</h3><div>A systematic review for cochlear size measurements using PRISMA methodology was performed using PubMed, CINAHL, and MEDLINE from database inception to October 1st, 2022.</div></div><div><h3>Methods</h3><div>Search terms used included English, cochlea, size, histology, anatomy, and human. Inclusion criteria were measurements for human cochlea, full-text articles, and articles in English. Primary measurements were “B” value and CH, as these measurements differ from the recent meta-analysis on this topic. Cochlear duct length (CDL) was also included. A random-effects continuous model for meta-analysis was performed. Measurements were stratified by gender (male/female) and disease type (sensorineural hearing loss (SNHL)/conductive hearing loss (CHL)).</div></div><div><h3>Results</h3><div>A total of 7 articles met final inclusion criteria from a total of 674 articles received on initial search, resulting in 2263 total human cochleae. There was a statistical difference between male CDL (n = 681 cochlea) compared to female CDL (n = 657) from four articles (p < 0.001; Cohen's d effect size (ES):0.421; 95% confidence intervals (CI): 0.171, 0.671). The frequency weighted mean for male CDL was 33.5 mm ± 1.8 mm and the frequency weighted mean for female CDL was 32.4 mm ± 1.5 mm with an unstandardized mean difference of 0.854 mm. There was no statistical difference between male “B” value (n = 329) and female “B” value (n = 349) for cochlea from two studies (p = 0.184; Cohen's d ES: 0.410; 95% CI: 0.194, 1.014). The frequency weighted mean for male “B” value was 6.5 mm ± 0.1 mm and the frequency weighted mean for female “B” value was 6.4 mm ± 0.1 mm with an unstandardized mean difference of 0.126 mm. There was no statistical difference between CH for SNHL (n = 282) and CHL (n = 275) from two studies (p = 0.486; ES: 0.085; 95% CI: 0.323, 0.153, F ig. 3). The frequency weighted mean for SNHL CH was 4.6 mm ± 0.8 mm and the frequency weighted mean for CHL CH was 4.3 mm ± 0.8 mm with an unstandardized mean difference of 0.032 mm.</div></div><div><h3>Conclusion</h3><div>Male CDL is stati","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"19 3","pages":"Pages 178-183"},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号