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Biomedical Nanotechnology 生物医学纳米技术
Pub Date : 1900-01-01 DOI: 10.4018/978-1-7998-0326-3.ch003
Pinar Cakir Hatir
This chapter aims to provide an overview of recent studies in the field of biomedical nanotechnology, which is described as the combination of biology and nanotechnology. The field includes innovations such as the improvement of biological processes at the nanoscale, the development of specific biomaterials, and the design of accurate measurement devices. Biomedical nanotechnology also serves areas like the development of intelligent drug delivery systems and controlled release systems, tissue engineering, nanorobotics (nanomachines), lab-on-a-chip, point of care, and nanobiosensor development. This chapter will mainly cover the biomedical applications of nanotechnology under the following titles: the importance of nanotechnology, the history of nanotechnology, classification of nanostructures, inorganic, polymer and composite nanostructures, fabrication of nanomaterials, applications of nanostructures, the designs of intelligent drug delivery systems and controlled release systems, bioimaging, bioseparation, nano-biomolecules, lab-on-a-chip, point of care, nanobiosensor development, tissue engineering and the future of biomedical nanotechnology.
本章旨在概述生物医学纳米技术领域的最新研究,该领域被描述为生物学和纳米技术的结合。该领域包括诸如纳米尺度生物过程的改进、特定生物材料的开发以及精确测量设备的设计等创新。生物医学纳米技术还服务于智能药物输送系统和控制释放系统的开发、组织工程、纳米机器人、芯片实验室、护理点和纳米生物传感器开发等领域。本章主要介绍纳米技术在生物医学上的应用,题目如下:纳米技术的重要性,纳米技术的历史,纳米结构的分类,无机,聚合物和复合纳米结构,纳米材料的制造,纳米结构的应用,智能药物输送系统和控制释放系统的设计,生物成像,生物分离,纳米生物分子,芯片实验室,护理点,纳米生物传感器的发展,组织工程和生物医学纳米技术的未来。
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引用次数: 0
Active Assistive Orthotic System 主动辅助矫形系统
Pub Date : 1900-01-01 DOI: 10.4018/978-1-7998-8050-9.ch009
I. Veneva, D. Chakarov, M. Tsveov, D. Trifonov, E. Zlatanov, Pavel Venev
Active orthosis (exoskeleton) is an assistive device with a wearable structure, corresponding to the natural motions of the human. This chapter focuses on developing an active/assistive orthosis system (AOS) enhancing movement. The AOS design is inspired by the biological musculoskeletal system of human upper and lower limbs and mimics the muscle-tendon-ligament structure. The exoskeleton structure includes left and right upper limb, left and right lower limb, and central exoskeleton structure for human torso and waist and provides support, balance, and control of different segments of the body. The device was fabricated with light materials and powered by pneumatic artificial muscles that provide more than fifteen degrees of freedom for the different joints. The active orthotic systems (AOS) can operate in three modes: motion tracking system with data exchange with virtual reality; haptic and rehabilitation device; and assistive mode with active orthosis in cases of impaired muscles.
主动矫形器(外骨骼)是一种具有可穿戴结构的辅助装置,与人体的自然运动相对应。本章的重点是开发一种增强运动的主动/辅助矫形器系统(AOS)。AOS的设计灵感来自于人类上肢和下肢的生物肌肉骨骼系统,并模仿了肌肉-肌腱-韧带结构。外骨骼结构包括左右上肢、左右下肢以及人体躯干和腰部的中央外骨骼结构,对身体的不同部分提供支撑、平衡和控制。该装置由轻质材料制成,由气动人造肌肉提供动力,为不同的关节提供超过15个自由度。主动矫形系统(AOS)可以在三种模式下工作:运动跟踪系统与虚拟现实数据交换;触觉和康复装置;在肌肉受损的情况下,辅助模式与主动矫形器。
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引用次数: 0
Exocortex as a Learning Technology 外皮层作为一种学习技术
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-8431-5.CH005
M. E. Mutlu
Exocortex is a hypothetical technology where the human brain can connect to a brain implant or a computational environment which is in the state of a wearable device, using two-way brain-computer interface, in order to augment the cognitive powers of the human brain such as perception, storage, recollection and processing. Exocortex is expected to be a part of everyday life in the 2030s. Exocortex technology is supported by parallel technologies such as brain reading, uploading knowledge into the brain from the outside, brain-computer interface, brain-to-brain interface, which are now undergoing prototype applications. In this study, by discussing the potential of exocortex technology in its use for learning processes, as a result of handling it with the “learning experiences management” approach, the opportunities it provides specifically for lifelong learners are examined. In the results and recommendations section of the study, a foresight is given for the scientific research projects that can be performed for this purpose.
Exocortex是一种假想的技术,人类大脑可以通过双向脑机接口连接到处于可穿戴设备状态的大脑植入物或计算环境,以增强人类大脑的感知、存储、回忆和处理等认知能力。预计在21世纪30年代,外皮层将成为日常生活的一部分。外皮层技术由并行技术支持,如大脑阅读、从外部向大脑上传知识、脑机接口、脑对脑接口,这些技术目前正在进行原型应用。在本研究中,通过讨论外皮层技术在学习过程中使用的潜力,作为用“学习经验管理”方法处理它的结果,它为终身学习者提供了专门的机会。在研究的结果和建议部分,对可以为此目的进行的科学研究项目进行了展望。
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引用次数: 1
Industrial Exoskeletons With Gravity Compensation Elements 带有重力补偿元件的工业外骨骼
Pub Date : 1900-01-01 DOI: 10.4018/978-1-7998-1382-8.ch002
S. Jatsun, A. Yatsun
The chapter approaches the issues of modeling the process of load lifting by a person while wearing an exoskeleton. The classification of existing gravitational compensation systems for industrial exoskeletons is shown, as well as examples of its use. A mathematical model of lifting a person's load in the exoskeleton is presented, as well as numerical parameters are calculated. It is shown that the introduction of an elastic element reduces the level of energy consumption during work, and can also facilitate the level of the worker. Industrial exoskeleton prototype design is presented. A particular focus is given to studying the influence of the gravity compensator on the magnitude of the moments generated by the electric drives of the hip and knee joints. It is shown that the use of gravity compensators enables to reduce significantly the load on electric drives.
本章探讨了一个人在佩戴外骨骼时负重提升过程的建模问题。现有的工业外骨骼重力补偿系统的分类显示,以及其使用的例子。提出了人体在外骨骼中举升载荷的数学模型,并计算了其数值参数。结果表明,弹性元件的引入降低了工作时的能量消耗水平,也可以方便工人的水平。介绍了工业外骨骼的原型设计。特别着重研究了重力补偿器对由髋关节和膝关节的电驱动产生的力矩大小的影响。结果表明,使用重力补偿器可以显着减少电力驱动的负载。
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引用次数: 0
Investigation of Human Locomotion With a Powered Lower Limb Exoskeleton 基于动力下肢外骨骼的人体运动研究
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2993-4.CH002
S. Jatsun, A. Yatsun, S. Savin
In this chapter, the lower limb exoskeleton is studied. The roles of the exoskeleton both as a measurement device for studying human locomotion and as an assistive device that restores the human ability to walk are discussed. Particular attention is given to the investigation of the role of the pressure sensors and other devices that allow us to measure normal reactions at the contact points with the supporting surface and also detect these contacts. The way the geometry of the supporting surface affects the sensors system of the robot is considered, and new designs for feet sensor system are proposed. These include elastic foot, a foot with actuated sensors, and a foot with spring-damper systems.
本章对下肢外骨骼进行了研究。讨论了外骨骼作为研究人类运动的测量装置和作为恢复人类行走能力的辅助装置的作用。特别注意的是调查压力传感器和其他设备的作用,这些设备使我们能够测量与支撑表面接触点的正常反应,并检测这些接触。考虑了支撑面几何形状对机器人传感器系统的影响,提出了新的足部传感器系统设计方案。这些包括弹性脚,一个脚与驱动传感器,和一个脚与弹簧阻尼器系统。
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引用次数: 4
Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible 牙锥束计算机断层扫描用于上颌和下颌骨骨小梁质量分析
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-6243-6.CH007
T. Bobby, V. Shwetha, Vijaya Madhavi
The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.
种植体的稳定性是决定种植体治疗成功率的重要因素之一。稳定性很大程度上受上颌和下颌骨小梁骨强度的影响。因此,发现骨小梁强度是种植体成功的关键组成部分。骨小梁骨强度通常通过骨密度(BMD)来评估。最近,研究表明,除了骨的数量,骨的强度也取决于通常被称为骨小梁微结构的质量特征。由于上颌和下颌骨的骨小梁质量各不相同,因此术前评估上颌和下颌骨亚区骨小梁微结构对于稳定种植体治疗至关重要。因此,在本章中,作者采用contourlet变换对CBCT图像进行上颌和下颌骨骨小梁质量的定量分析。
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引用次数: 3
Enhanced Cellular Activity on Conducting Polymer 导电聚合物增强细胞活性
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-7838-3.CH006
Rajiv Borah, Ashok Kumar
This chapter includes detailed review of the research undertaken with conducting polymer (CP) based composites with chitosan (Ch) for tissue engineering till date. The beneficial role of electrically conductive biomaterials has been discussed with the possible strategies to overcome the shortcomings of CP alone through blending with Ch due to its excellent biocompatibility, biodegradability, and bioactivity. Additionally, this embodiment deals with the optimization and characterization of electrically conductive, biocompatible and biodegradable Polyaniline: Chitosan (PAni:Ch) nanocomposites as cell culture substrates for MDA-MB-231 and NIH 3T3 fibroblast in order to examine the combined effect of nanofiber structure and surface modification on cell-biomaterial interactions. The nanocomposites were further checked as a conductive scaffold for electrical stimulation of a neuronal model PC12 cell line in order to explore the potential of the materials in neural tissue engineering.
本章详细综述了壳聚糖导电聚合物基复合材料在组织工程中的研究进展。由于导电生物材料具有良好的生物相容性、生物可降解性和生物活性,因此讨论了导电生物材料的有益作用,以及通过与Ch共混来克服CP单独缺点的可能策略。此外,本实施例涉及导电、生物相容性和可生物降解的聚苯胺:壳聚糖(PAni:Ch)纳米复合材料作为MDA-MB-231和NIH 3T3成纤维细胞培养底物的优化和表征,以研究纳米纤维结构和表面修饰对细胞-生物材料相互作用的综合影响。为了探索纳米复合材料在神经组织工程中的潜力,我们进一步测试了纳米复合材料作为导电支架对神经元模型PC12细胞系的电刺激。
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引用次数: 0
Technological Revolution, Transhumanism, and Social Deliberation 技术革命、超人类主义和社会审议
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-7152-0.CH004
Ana Cuevas-Badallo, Daniel Labrador-Montero
The aim of this chapter is to show some of the assumptions that lie behind transhumanism. The concept of enhancement is analyzed. While, from transhumanism, human welfare depends on the enhancement of human capabilities, here it shall be argued that to begin with, a social debate over what is considered welfare is needed before we can establish what we wish to improve (enhance). This reflection must emphasize the necessity to reflect, ex ante, on what kind of technological development we want, viewing technology as a means to attain the agreed-upon type of welfare, rather than a goal in itself. On the basis of a socially open debate with an anticipatory perspective, society as a whole can establish which risks it is willing to take.
本章的目的是展示超人类主义背后的一些假设。分析了增强的概念。虽然,从超人类主义来看,人类的福利依赖于人类能力的增强,但在这里,我们应该认为,首先,在我们能够确定我们希望改善(增强)什么之前,需要一场关于什么被认为是福利的社会辩论。这种反思必须强调必须事先反思我们想要什么样的技术发展,将技术视为实现商定的福利类型的手段,而不是其本身的目标。在具有预期观点的社会公开辩论的基础上,整个社会可以确定它愿意承担哪些风险。
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引用次数: 1
What Is It Like to Be a Cyborg? 成为半机械人是什么感觉?
Pub Date : 1900-01-01 DOI: 10.4018/978-1-7998-8050-9.ch020
Kevin Warwick
In this chapter, the author describes his personal experience in experimenting as a cyborg (part biology/part technology) by having technology implanted in his body, which he lived with over a period. A look is also taken at the author's experiments into creating cyborgs by growing biological brains which are subsequently given a robot body. The experiments are dealt with in separate sections. In each case the nature of the experiment is briefly described along with the results obtained and this is followed by an indication of the experience, including personal feelings and emotions felt in and around the time of the experiments and subsequently as a result of the experiments. Although the subject can be treated scientifically from an external perspective, it is really through individual, personal experience that a true reflection can be gained on what might be possible in the future.
在本章中,作者通过将技术植入他的身体,描述了他作为一个半机械人(部分生物/部分技术)进行实验的个人经历,他与这些技术一起生活了一段时间。我们还可以看看作者通过培养生物大脑来创造机器人的实验,这些大脑随后被赋予机器人的身体。这些实验将在单独的章节中讨论。在每一种情况下,实验的性质都被简要地描述了,同时得到了结果,然后是经验的指示,包括个人的感受和情绪,在实验期间和前后以及随后的实验结果。虽然可以从外部角度科学地对待这个问题,但只有通过个人的亲身经历,才能对未来可能发生的事情进行真正的反思。
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引用次数: 0
According to Zoltan Istvan 据佐尔坦·伊斯特万说
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-8431-5.CH003
Zoltan Istvan
Radical science and technology are changing everything around us. The area of transhumanism is growing dramatically in size and impact - and the impact on our species is enormous. In just a decade, many things can change how we live our lives. The upcoming innovation will be amazing. Transhumanists believe that we must protect ourselves from our natural genes, unless they bind us to remain forever as animals. We believe that our outdated instincts can easily tempt us to know right from wrong, practical from impractical. If you look closely, the human body and its biology constantly highlights our many imperfections. Transhumanism seeks to improve the human body through science and technology - that is, to help people develop. This is a strange cultural and philosophical position for a movement. And yet, change is exactly what transhumanism aspires to.
激进的科学技术正在改变我们周围的一切。超人类主义领域的规模和影响正在急剧增长,对我们人类的影响是巨大的。在短短十年里,许多事情可以改变我们的生活方式。即将到来的创新将是惊人的。超人类主义者认为,我们必须保护自己不受自然基因的影响,除非它们把我们束缚在动物身上,让我们永远保持动物的状态。我们相信,我们过时的本能很容易诱使我们分辨是非、实际与不实际。如果你仔细观察,你会发现人体和它的生物学特性不断地突出我们的许多缺陷。超人类主义寻求通过科学技术改善人体——也就是说,帮助人们发展。对于一场运动来说,这是一种奇怪的文化和哲学立场。然而,改变正是超人类主义所渴望的。
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引用次数: 1
期刊
Research Anthology on Emerging Technologies and Ethical Implications in Human Enhancement
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