Melinda Siswanto, Gabriella Thimoty, Jonathan Hendrik Bera
Tuberculosis (TB) is an infectious disease mainly caused by Mycobacteria tuberculosis. It affects the respiratory system and may spread to the other organ. Due to the nature of the bacteria, infection of this species may cause a long-term TB, causing it a challenge for a full clearance. The disease has existed throughout the history, and BCG vaccine has been developed to control the spreading. Most developed countries have successfully eradicated TB. However, Indonesia is currently ranked second place for this disease, making it as a pressing matter to eradicate. This study is conducted to investigate and gather deep insights about the problems in eradicating TB in Indonesia. Identify part of the biodesign method is employed in the study to elucidate the complexity of healthcare issue of TB in Indonesia. The study discovered that there are three pillars’ sectors need to be addressed: education, healthcare facilities and services, and government. For successful eradication, synergistic approach to all pillars at the same time are essential. The needs statements formulated in this study could be the stem of innovation in TB.
{"title":"Implementation of Biodesign process to Identify Unmet Needs of Tuberculosis Patients in Indonesia","authors":"Melinda Siswanto, Gabriella Thimoty, Jonathan Hendrik Bera","doi":"10.54250/IJLS.V3I1.123","DOIUrl":"https://doi.org/10.54250/IJLS.V3I1.123","url":null,"abstract":"Tuberculosis (TB) is an infectious disease mainly caused by Mycobacteria tuberculosis. It affects the respiratory system and may spread to the other organ. Due to the nature of the bacteria, infection of this species may cause a long-term TB, causing it a challenge for a full clearance. The disease has existed throughout the history, and BCG vaccine has been developed to control the spreading. Most developed countries have successfully eradicated TB. However, Indonesia is currently ranked second place for this disease, making it as a pressing matter to eradicate. This study is conducted to investigate and gather deep insights about the problems in eradicating TB in Indonesia. Identify part of the biodesign method is employed in the study to elucidate the complexity of healthcare issue of TB in Indonesia. The study discovered that there are three pillars’ sectors need to be addressed: education, healthcare facilities and services, and government. For successful eradication, synergistic approach to all pillars at the same time are essential. The needs statements formulated in this study could be the stem of innovation in TB.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130694075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Hartiadi, gisella edny, J. Rebecca, Sheryl Sheryl, Audrey Amira Crystalia
Indonesia sits in the heart of the largest biodiversity hotspot -Indo-Pacific region. Indonesia has access to endless resources of bioactive compounds from marine animals and plants. Marine sponges have been extensively studied over the years due to their nature of being exposed to various microorganisms. Xestospongia sp. establishes a symbiotic relationship with diverse microorganisms, leading to the synthesis of abundant bioactive resources which capable of inhibiting the growth of pathogenic bacteria. Publications from the last ten years were retrieved from PubMed and included in this review article. Bioactive compounds produced by Xestospongia sp. were effective in inhibiting gram-negative bacteria- P. aeruginosa, A. baumanii, E. coli, K. pneumoniae, P. aeruginosa, S. epidermis, S. typhi- and gram-positive bacteria -M. Intracellulare, S. aureus, S. pneumoniae, B. subtilis, V. anguaillarum. In addition, extracts were able to inhibit the growth of multidrug-resistance P. aeruginosa and methicillin-resistant S. aureus (MRSA). C. albicans, C. tropicalis, C. neofarmans, A. niger, Epidermophyton sp., M. gypseum, T. rubrum, T. mentagrophytes were susceptible to Xestospongia sp. extracts. The growth of chloroquine-resistant and susceptible strains of P. falciparum were inhibited by Xestospongia sp. with similar zones of inhibitions. The antimicrobial properties were contributed by the composition of chemically complex compounds such as phenolics, steroids and alkaloids; each of which exhibits a unique mechanism of action. The vast range of antimicrobial activity exhibited by Xestospongia sp. extracts implies their promising role in clinical settings for the treatment of infectious diseases including tuberculosis and malaria.
{"title":"A Review on the Antimicrobial Properties of Giant Barrel Sponge- Xestospongia sp.","authors":"L. Hartiadi, gisella edny, J. Rebecca, Sheryl Sheryl, Audrey Amira Crystalia","doi":"10.54250/IJLS.V2I2.55","DOIUrl":"https://doi.org/10.54250/IJLS.V2I2.55","url":null,"abstract":"Indonesia sits in the heart of the largest biodiversity hotspot -Indo-Pacific region. Indonesia has access to endless resources of bioactive compounds from marine animals and plants. Marine sponges have been extensively studied over the years due to their nature of being exposed to various microorganisms. Xestospongia sp. establishes a symbiotic relationship with diverse microorganisms, leading to the synthesis of abundant bioactive resources which capable of inhibiting the growth of pathogenic bacteria. Publications from the last ten years were retrieved from PubMed and included in this review article. Bioactive compounds produced by Xestospongia sp. were effective in inhibiting gram-negative bacteria- P. aeruginosa, A. baumanii, E. coli, K. pneumoniae, P. aeruginosa, S. epidermis, S. typhi- and gram-positive bacteria -M. Intracellulare, S. aureus, S. pneumoniae, B. subtilis, V. anguaillarum. In addition, extracts were able to inhibit the growth of multidrug-resistance P. aeruginosa and methicillin-resistant S. aureus (MRSA). C. albicans, C. tropicalis, C. neofarmans, A. niger, Epidermophyton sp., M. gypseum, T. rubrum, T. mentagrophytes were susceptible to Xestospongia sp. extracts. The growth of chloroquine-resistant and susceptible strains of P. falciparum were inhibited by Xestospongia sp. with similar zones of inhibitions. The antimicrobial properties were contributed by the composition of chemically complex compounds such as phenolics, steroids and alkaloids; each of which exhibits a unique mechanism of action. The vast range of antimicrobial activity exhibited by Xestospongia sp. extracts implies their promising role in clinical settings for the treatment of infectious diseases including tuberculosis and malaria. ","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130227326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glebionis coronaria, formerly Chrysanthemum coronarium, is one of the medicinal herbs that belong to the Asteraceae family. This review paper aims to provide information regarding the botanical description, distribution, and phytochemical properties which contribute to the medicinal properties of Glebionis coronaria. Various studies have reported the presence of tannins, vitamins, macro- and microelements, beta-carotene, carbohydrates, protein, and other bioactive compounds in the plant’s essential oil, extract, or plant parts. Researchers have uncovered the potential pharmaceutical activities of the plant, including antibacterial, antifungal, antioxidant, anti-inflammatory, anti-cholesterol, to the potential anticancer properties. Based on the scientific evidence collected, G. coronaria has the potential to be used in many clinical areas for medicinal purposes. However, appropriate clinical testing should be pursued to evaluate the medicinal effects of this plant.
{"title":"A Review of Phytochemical Properties and Therapeutic Activities of Glebionis coronaria","authors":"Evelyn Jeanette Wijaya, Joshua Nathanael, Orlando Carolan, Shakila Angjaya Adiyanto, Wiranata Buntaran Bun, Agnes Anania Triavika Sahamastuti","doi":"10.54250/IJLS.V2I2.40","DOIUrl":"https://doi.org/10.54250/IJLS.V2I2.40","url":null,"abstract":"Glebionis coronaria, formerly Chrysanthemum coronarium, is one of the medicinal herbs that belong to the Asteraceae family. This review paper aims to provide information regarding the botanical description, distribution, and phytochemical properties which contribute to the medicinal properties of Glebionis coronaria. Various studies have reported the presence of tannins, vitamins, macro- and microelements, beta-carotene, carbohydrates, protein, and other bioactive compounds in the plant’s essential oil, extract, or plant parts. Researchers have uncovered the potential pharmaceutical activities of the plant, including antibacterial, antifungal, antioxidant, anti-inflammatory, anti-cholesterol, to the potential anticancer properties. Based on the scientific evidence collected, G. coronaria has the potential to be used in many clinical areas for medicinal purposes. However, appropriate clinical testing should be pursued to evaluate the medicinal effects of this plant.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124093265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavisiony Gracius Hewis, Giovanni Batista Christian Daeli, Kenjiro Tanoto, C. Carlos, Agnes Anania Triavika Sahamastuti
Traditional medicine is widely used worldwide due to its benefits and healthier components that these natural herbs provide. Natural products are substances produced or retrieved from living organisms found in nature and often can exert biological or pharmacological activity, thus making them a potential alternative for synthetic drugs. Natural products, especially plant-derived products, have been known to possess many beneficial effects and are widely used for the treatment of various diseases and conditions. Dysphania ambrosioides is classified as an annual or short-lived perennial herb commonly found in Central and South America with a strong aroma and a hairy characteristic. Major components in this herb are ascaridole, p-cymene, α-terpinene, terpinolene, carvacrol, and trans-isoascaridole. Active compounds isolated from this herb are found to exert various pharmacological effects including schistosomicidal, nematicidal, antimalarial, antileishmanial, cytotoxic, antibacterial, antiviral, antifungal, antioxidant, anticancer, and antibiotic modulatory activity. This review summarizes the phytochemical compounds found in the Dysphania ambrosioides, together with their pharmacological and toxicological effects.
{"title":"A Review of Botany, Phytochemical, and Pharmacological Effects of Dysphania ambrosioides","authors":"Lavisiony Gracius Hewis, Giovanni Batista Christian Daeli, Kenjiro Tanoto, C. Carlos, Agnes Anania Triavika Sahamastuti","doi":"10.54250/IJLS.V2I2.42","DOIUrl":"https://doi.org/10.54250/IJLS.V2I2.42","url":null,"abstract":"Traditional medicine is widely used worldwide due to its benefits and healthier components that these natural herbs provide. Natural products are substances produced or retrieved from living organisms found in nature and often can exert biological or pharmacological activity, thus making them a potential alternative for synthetic drugs. Natural products, especially plant-derived products, have been known to possess many beneficial effects and are widely used for the treatment of various diseases and conditions. Dysphania ambrosioides is classified as an annual or short-lived perennial herb commonly found in Central and South America with a strong aroma and a hairy characteristic. Major components in this herb are ascaridole, p-cymene, α-terpinene, terpinolene, carvacrol, and trans-isoascaridole. Active compounds isolated from this herb are found to exert various pharmacological effects including schistosomicidal, nematicidal, antimalarial, antileishmanial, cytotoxic, antibacterial, antiviral, antifungal, antioxidant, anticancer, and antibiotic modulatory activity. This review summarizes the phytochemical compounds found in the Dysphania ambrosioides, together with their pharmacological and toxicological effects.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"1795 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129628158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erika Chriscensia, Elizabeth Chrestella Wibowo, Gregorius Enriko, Owen Chrisfian Wijaya, Agnes Anania Triavika Sahamastuti
Key lime or Citrus aurantifolia has been well known for its functions, either as food or medicine. This fruit has a greenish-yellow color with a sour and bitter taste and distributed initially from East Asia. This review summarizes the phytochemical screening, therapeutic effects, and adverse effects of key lime. Most parts of the plant contain phytochemicals, such as phenols, flavonoids, steroids, terpenoids, and alkaloids, with other varying compounds like saponin, tannin, anthraquinone, glycosides, and carbohydrates that may be due to the country where the plant is grown, or the extraction methods. Some studies have been conducted to evaluate the therapeutic effects of key lime, including antibacterial, antioxidant, anticancer or antitumor, anti-cholesterol, anti-larvae, anti-mosquito, antidiabetic, anti-inflammatory, and anticholinesterase. Key lime also may cause some adverse effects, such as phytophotodermatitis. It may lead to toxicity manifested in conditions such as edema, inflammation, or necrosis in some organs in the body, an increase in lymphocytes & liver enzymes, and a decrease in hemoglobin.
{"title":"Phytochemical Screening, Therapeutic Benefits, and Adverse Effects of Citrus aurantifolia - A Review","authors":"Erika Chriscensia, Elizabeth Chrestella Wibowo, Gregorius Enriko, Owen Chrisfian Wijaya, Agnes Anania Triavika Sahamastuti","doi":"10.54250/IJLS.V2I2.41","DOIUrl":"https://doi.org/10.54250/IJLS.V2I2.41","url":null,"abstract":"Key lime or Citrus aurantifolia has been well known for its functions, either as food or medicine. This fruit has a greenish-yellow color with a sour and bitter taste and distributed initially from East Asia. This review summarizes the phytochemical screening, therapeutic effects, and adverse effects of key lime. Most parts of the plant contain phytochemicals, such as phenols, flavonoids, steroids, terpenoids, and alkaloids, with other varying compounds like saponin, tannin, anthraquinone, glycosides, and carbohydrates that may be due to the country where the plant is grown, or the extraction methods. Some studies have been conducted to evaluate the therapeutic effects of key lime, including antibacterial, antioxidant, anticancer or antitumor, anti-cholesterol, anti-larvae, anti-mosquito, antidiabetic, anti-inflammatory, and anticholinesterase. Key lime also may cause some adverse effects, such as phytophotodermatitis. It may lead to toxicity manifested in conditions such as edema, inflammation, or necrosis in some organs in the body, an increase in lymphocytes & liver enzymes, and a decrease in hemoglobin.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124068611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The increasing fast food production led to decreased consumption of dietary fiber food and increased risk of obesity and cardiovascular disease. Hence, this study aimed to utilize durian seed flour in making a healthy cookie product and observe the effect of different durian seed flour formulation (0%, 25%, 50%) to the organoleptic properties of the cookies. The cookies were analysed through sensory analysis and further statistical analysis. The addition of different formulations of durian seed flour did not significantly affect the aroma, taste, aftertaste, and overall liking of the cookies, however, it did significantly affect the texture of the cookies. The formulated cookies made with the addition of durian seed flour had better overall organoleptic attributes especially in the texture attribute. Nevertheless, it is recommended to conduct chemical and rheological analysis for further characterization of the durian seed flour and its effect in the cookies for further studies.
{"title":"Development of Healthier Cookie Product by Utilizing Different Formulations of Durian Seed Flour","authors":"Rayyane Mazaya Syifa Insani, A. Dhama","doi":"10.54250/IJLS.V2I2.56","DOIUrl":"https://doi.org/10.54250/IJLS.V2I2.56","url":null,"abstract":"The increasing fast food production led to decreased consumption of dietary fiber food and increased risk of obesity and cardiovascular disease. Hence, this study aimed to utilize durian seed flour in making a healthy cookie product and observe the effect of different durian seed flour formulation (0%, 25%, 50%) to the organoleptic properties of the cookies. The cookies were analysed through sensory analysis and further statistical analysis. The addition of different formulations of durian seed flour did not significantly affect the aroma, taste, aftertaste, and overall liking of the cookies, however, it did significantly affect the texture of the cookies. The formulated cookies made with the addition of durian seed flour had better overall organoleptic attributes especially in the texture attribute. Nevertheless, it is recommended to conduct chemical and rheological analysis for further characterization of the durian seed flour and its effect in the cookies for further studies.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130846951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Hartiadi, Immaculata Titis Winiati, Samirah, Cristina Gómez
Introduction: Cancer is one of the leading cause of death worldwide. Chemotherapy remains the most widely used approach to treat cancer. However, due to the lack of specificity, drug resistance, and undesirable side effects, the discovery of novel anticancer drugs is still a priority in cancer research. Bacteria are one of the major contributors for anticancer compounds as bacteria are able to produce secondary metabolites which may have cytotoxic activity. Method: A literature study was conducted to identify the isolates in i3L-USAID bacteria database that were potential candidates for novel anticancer drugs. The selected bacteria were cultured and their secondary metabolites were extracted. Cytotoxic activity of the extracts was assessed through morphological observation and MTT assay on HeLa and 3T3 fibroblast cell lines. Results: Aneurinibacillus sp. and Ochrobactrum sp. were selected. Ochrobactrum sp. extract significantly suppressed the growth of HeLa cells at 1000 µg/ml (p < 0.05) while it did not have any effect on 3T3 cells. Despite able to suppress the HeLa cell proliferation, Aneurinibacillus sp. extract significantly enhanced the growth of 3T3 fibroblast at the 1000 µg/ml (p < 0.05). The cytotoxicity activity was corroborated by cell death observed on HeLa cells treated with high concentrations of the extracts Conclusion: Secondary metabolites from Aneurinibacillus sp. and Ochrobactrum sp. could only exert cytotoxic effect at high concentration which is unfavourable for anticancer compounds. Although the extracts resulted in a reduction of HeLa cells proliferation, the extracts did not inhibit proliferation of 3T3, suggesting selectivity for non-tumorigenic over tumorigenic cells.
{"title":"Cytotoxicity Evaluation of Bacteria Extract Isolated from Indonesia Sheep Manures and Fungal Fruiting Body","authors":"L. Hartiadi, Immaculata Titis Winiati, Samirah, Cristina Gómez","doi":"10.54250/IJLS.V2I1.31","DOIUrl":"https://doi.org/10.54250/IJLS.V2I1.31","url":null,"abstract":"Introduction: Cancer is one of the leading cause of death worldwide. Chemotherapy remains the most widely used approach to treat cancer. However, due to the lack of specificity, drug resistance, and undesirable side effects, the discovery of novel anticancer drugs is still a priority in cancer research. Bacteria are one of the major contributors for anticancer compounds as bacteria are able to produce secondary metabolites which may have cytotoxic activity. Method: A literature study was conducted to identify the isolates in i3L-USAID bacteria database that were potential candidates for novel anticancer drugs. The selected bacteria were cultured and their secondary metabolites were extracted. Cytotoxic activity of the extracts was assessed through morphological observation and MTT assay on HeLa and 3T3 fibroblast cell lines. Results: Aneurinibacillus sp. and Ochrobactrum sp. were selected. Ochrobactrum sp. extract significantly suppressed the growth of HeLa cells at 1000 µg/ml (p < 0.05) while it did not have any effect on 3T3 cells. Despite able to suppress the HeLa cell proliferation, Aneurinibacillus sp. extract significantly enhanced the growth of 3T3 fibroblast at the 1000 µg/ml (p < 0.05). The cytotoxicity activity was corroborated by cell death observed on HeLa cells treated with high concentrations of the extracts Conclusion: Secondary metabolites from Aneurinibacillus sp. and Ochrobactrum sp. could only exert cytotoxic effect at high concentration which is unfavourable for anticancer compounds. Although the extracts resulted in a reduction of HeLa cells proliferation, the extracts did not inhibit proliferation of 3T3, suggesting selectivity for non-tumorigenic over tumorigenic cells.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128488453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To compare the efficacy of SSRI medication alone and SSRI+CBT combined. Methods: NCBI Pubmed, DARE, CSDR and NGC were searched October-November 2019. The population size, as well as the base and endpoint CGAS mean and standard deviation from the three studies included, are recorded. Statistical analysis was done in RStudio with the "meta" package. Results: For the SSRI only, the effect size was -1.82 with a 95% confidence interval between -2.28 and -1.37. For the SSRI and CBT combined, the effect size was -1.68 with a 95% confidence interval between -2.39 and -0.98. The effect size for both SSRI and SSRI + CBT didn't cross the null effect line, but the heterogeneity exceeds 50%. The result for the comparison of post SSRI vs. SSRI + CBT showed the effect size of -0.05 with a 95% confidence interval between -0.23 and 0.12. The size effect did cross the null effect line, but the heterogeneity was less than 50%. Conclusion: Both methods were shown to be effective. However, due to statistical inconsistencies, it couldn’t be concluded whether the combination of SSRI and CBT is better than treatment with SSRI alone.
{"title":"Meta-Analysis: Effectiveness of SSRIs vs SSRIs in conjunction with CBT in treating depression in young adolescents","authors":"Gabriele Mustika Kresnia, Winda Hasuki, Nanda Rizqia Pradana Ratnasari","doi":"10.54250/IJLS.V2I1.35","DOIUrl":"https://doi.org/10.54250/IJLS.V2I1.35","url":null,"abstract":" \u0000Objective: To compare the efficacy of SSRI medication alone and SSRI+CBT combined. \u0000Methods: NCBI Pubmed, DARE, CSDR and NGC were searched October-November 2019. The population size, as well as the base and endpoint CGAS mean and standard deviation from the three studies included, are recorded. Statistical analysis was done in RStudio with the \"meta\" package. \u0000Results: For the SSRI only, the effect size was -1.82 with a 95% confidence interval between -2.28 and -1.37. For the SSRI and CBT combined, the effect size was -1.68 with a 95% confidence interval between -2.39 and -0.98. The effect size for both SSRI and SSRI + CBT didn't cross the null effect line, but the heterogeneity exceeds 50%. The result for the comparison of post SSRI vs. SSRI + CBT showed the effect size of -0.05 with a 95% confidence interval between -0.23 and 0.12. The size effect did cross the null effect line, but the heterogeneity was less than 50%. \u0000Conclusion: Both methods were shown to be effective. However, due to statistical inconsistencies, it couldn’t be concluded whether the combination of SSRI and CBT is better than treatment with SSRI alone.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114225580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alfredo Oktavianto Natasutedja, Erika Lumbantobing, Emita Josephine, L. Carol, D. Junaedi, S. Normasiwi, Agus Budiawan Naro Putra
Andaliman (Zanthoxylum acanthopodium) is a specialty spice widely found in the Provinces of North Sumatra and Aceh, Indonesia. The fruit is usually used by Batak people in North Sumatra as a food ingredient to cook Batak’s cuisine such as arsik, tombur, and naniura. It is also used as one of the ingredients to make Indonesian spicy sauce called sambal. Andaliman fruit is reported to eliminate the undesirable smell in fish and raw meat. Moreover, it could also reduce total volatile base nitrogen content in fish which helps to prevent spoilage. Furthermore, andaliman has been reported to contain bioactive compounds which act as antioxidant, antimicrobial, anti-inflammatory, anti-aging, anti-acne, and anti-halitosis effects. This review focuses on the botanical aspects of and health potential exhibited by andaliman.
{"title":"Botanical Aspects, Phytochemicals and Health Benefits of Andaliman (Zanthoxylum acanthopodium)","authors":"Alfredo Oktavianto Natasutedja, Erika Lumbantobing, Emita Josephine, L. Carol, D. Junaedi, S. Normasiwi, Agus Budiawan Naro Putra","doi":"10.54250/IJLS.V2I1.32","DOIUrl":"https://doi.org/10.54250/IJLS.V2I1.32","url":null,"abstract":"Andaliman (Zanthoxylum acanthopodium) is a specialty spice widely found in the Provinces of North Sumatra and Aceh, Indonesia. The fruit is usually used by Batak people in North Sumatra as a food ingredient to cook Batak’s cuisine such as arsik, tombur, and naniura. It is also used as one of the ingredients to make Indonesian spicy sauce called sambal. Andaliman fruit is reported to eliminate the undesirable smell in fish and raw meat. Moreover, it could also reduce total volatile base nitrogen content in fish which helps to prevent spoilage. Furthermore, andaliman has been reported to contain bioactive compounds which act as antioxidant, antimicrobial, anti-inflammatory, anti-aging, anti-acne, and anti-halitosis effects. This review focuses on the botanical aspects of and health potential exhibited by andaliman.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116725986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current epidemic caused by a novel coronavirus SARS-CoV2 as well as two previously documented pandemic caused by SARS-CoV and MERS-CoV imposes that a spillover of an animal coronavirus to humans is a continuous threat. The zoonotic nature of the infection contributes to the unpredictability of the pandemic. In such situations, the availability of the ‘off the shelf’ vaccines that target the conserved region of the coronavirus might help in preventing the spread of the diseases. Therefore, efforts to generate such vaccines should be considered as a priority. The whole genome of SARS-CoV2 is readily available in the public database one month after the first case was identified. The platform technology known as the “genome to vaccine” approach would provide useful start to identify parts of the virus proteome which can be the candidate for vaccine components. This study used an immunoinformatic approach to identify T cell epitopes from SARS-CoV2 ORF1ab polyprotein in an attempt to design a genome-derived epitope-based universal coronavirus vaccine.
{"title":"What do T cells see in SARS-CoV2?","authors":"Marsia Gustiananda","doi":"10.54250/ijls.v2i1.36","DOIUrl":"https://doi.org/10.54250/ijls.v2i1.36","url":null,"abstract":"The current epidemic caused by a novel coronavirus SARS-CoV2 as well as two previously documented pandemic caused by SARS-CoV and MERS-CoV imposes that a spillover of an animal coronavirus to humans is a continuous threat. The zoonotic nature of the infection contributes to the unpredictability of the pandemic. In such situations, the availability of the ‘off the shelf’ vaccines that target the conserved region of the coronavirus might help in preventing the spread of the diseases. Therefore, efforts to generate such vaccines should be considered as a priority. The whole genome of SARS-CoV2 is readily available in the public database one month after the first case was identified. The platform technology known as the “genome to vaccine” approach would provide useful start to identify parts of the virus proteome which can be the candidate for vaccine components. This study used an immunoinformatic approach to identify T cell epitopes from SARS-CoV2 ORF1ab polyprotein in an attempt to design a genome-derived epitope-based universal coronavirus vaccine.","PeriodicalId":375737,"journal":{"name":"Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122678172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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