Pub Date : 2024-06-06DOI: 10.18192/osurj.v3i1.7164
Amro Habash, Aastha Sah
An estimated 10,800 people of Indigenous ancestry in Canada live with dementia [1], for which the most predominant cause is Alzheimer’s disease [2]. While there are no known interventions that can cure Alzheimer's, both pharmacological and therapeutic treatments are widely employed [2]. While these treatment avenues have been widely implemented among the general Canadian population, there is a knowledge gap with regards to how the differing circumstances and cultural approaches of the Indigenous community impact how they interface with these treatments [3]. As such, the proposed study would investigate and summarize the existing literature on how these unique circumstances and cultural perspectives could impact access to care and influence the perception, diagnosis, and treatment of Alzheimer’s in Indigenous communities. Given the general higher susceptibility of Indigenous populations to Alzheimer’s due to a higher prevalence of modifiable risk factors [4], it is hypothesized that the unique circumstances and cultural perspectives of the Indigenous community will, similarly, reflect poorer treatment outcomes for Alzheimer’s in Indigenous populations than the general Canadian population. The methodology employed by this study would be a systematic review, serving as a general, but reproducible, outlook on the current state of research in this subject area and as a foundation for further research. The proposed study would serve to determine the best approaches to and need for implementing accessible and culturally-sensitive care for Alzheimer’s disease in Indigenous communities. The insights gained would allow for further understanding and integration of the underrepresented Indigenous perspective within the healthcare system.
{"title":"Alzheimer au travers les cultures: Examiner l'impact des circonstances des communautés autochtones et des perspectives culturelles sur le traitement.","authors":"Amro Habash, Aastha Sah","doi":"10.18192/osurj.v3i1.7164","DOIUrl":"https://doi.org/10.18192/osurj.v3i1.7164","url":null,"abstract":"An estimated 10,800 people of Indigenous ancestry in Canada live with dementia [1], for which the most predominant cause is Alzheimer’s disease [2]. While there are no known interventions that can cure Alzheimer's, both pharmacological and therapeutic treatments are widely employed [2]. While these treatment avenues have been widely implemented among the general Canadian population, there is a knowledge gap with regards to how the differing circumstances and cultural approaches of the Indigenous community impact how they interface with these treatments [3].\u0000As such, the proposed study would investigate and summarize the existing literature on how these unique circumstances and cultural perspectives could impact access to care and influence the perception, diagnosis, and treatment of Alzheimer’s in Indigenous communities. \u0000Given the general higher susceptibility of Indigenous populations to Alzheimer’s due to a higher prevalence of modifiable risk factors [4], it is hypothesized that the unique circumstances and cultural perspectives of the Indigenous community will, similarly, reflect poorer treatment outcomes for Alzheimer’s in Indigenous populations than the general Canadian population.\u0000The methodology employed by this study would be a systematic review, serving as a general, but reproducible, outlook on the current state of research in this subject area and as a foundation for further research.\u0000The proposed study would serve to determine the best approaches to and need for implementing accessible and culturally-sensitive care for Alzheimer’s disease in Indigenous communities. The insights gained would allow for further understanding and integration of the underrepresented Indigenous perspective within the healthcare system. ","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.18192/osurj.v3i1.6989
Engluy Khov, R. McKay, Manisha A. Kulkarni
Purpose: Ixodes scapularis, also known as the eastern blacklegged tick, is associated with the vector-borne Lyme disease in North America. With climate change, warming temperatures have increased the number of areas suitable for ticks, and contributed to the expansion of tick species in Canada. The purpose of this project was to identify recent trends in tick range expansion and species diversity in Ontario by analyzing 2019 to 2022 data from the web-based tick surveillance platform, eTick.ca. Method: The eTick.ca web platform allows the public to submit tick photos for identification. We extracted data from the tick submissions for Ontario between mid-2019 to 2022 including information on the type of species, host types, travel history, and location. Microsoft Excel was used to generate distribution tables and graphs of tick submissions by species, month/year and host type for Ontario. Geographic Information Systems (ArcGIS) and SaTScan software were used to identify spatial clusters of tick submissions adjusting for the human population size using Ontario census subdivisions. Result: A total of 14,611 tick photo submissions were recorded between 2020 to 2022, excluding those with a history of recent travel. The year 2021 had the highest number of submissions (n=7339). Dermacentor species comprised the majority of submissions (n=9498, 65%), followed by I. scapularis (n=4810, 33%) and other species (n=303, 2%) between 2020-2022. Ticks were most commonly discovered on a human host (n=10,084), followed by animal hosts (n=3485), and free in environments (n=1042). Additionally, the majority of species were found in the adult stage (n=12,821, 88%), followed by unknown (n=1539, 10%) and immature stages (n=251, 2%). Clusters of I. scapularis were present in the Eastern, Central, and Southern Ontario regions, while clusters of Dermacentor sp. were present in Southern and Central Ontario regions. Conclusion: Spatial and temporal variations in tick submissions in Ontario were identified over the 3.5 year period since the implementation of eTick in the province. Data from eTick can be used to identify hotspots of human-tick exposure.
{"title":"The Analysis of eTick Submission in Ontario","authors":"Engluy Khov, R. McKay, Manisha A. Kulkarni","doi":"10.18192/osurj.v3i1.6989","DOIUrl":"https://doi.org/10.18192/osurj.v3i1.6989","url":null,"abstract":"\u0000Purpose: Ixodes scapularis, also known as the eastern blacklegged tick, is associated with the vector-borne Lyme disease in North America. With climate change, warming temperatures have increased the number of areas suitable for ticks, and contributed to the expansion of tick species in Canada. The purpose of this project was to identify recent trends in tick range expansion and species diversity in Ontario by analyzing 2019 to 2022 data from the web-based tick surveillance platform, eTick.ca. \u0000 \u0000 \u0000Method: The eTick.ca web platform allows the public to submit tick photos for identification. We extracted data from the tick submissions for Ontario between mid-2019 to 2022 including information on the type of species, host types, travel history, and location. Microsoft Excel was used to generate distribution tables and graphs of tick submissions by species, month/year and host type for Ontario. Geographic Information Systems (ArcGIS) and SaTScan software were used to identify spatial clusters of tick submissions adjusting for the human population size using Ontario census subdivisions. \u0000 \u0000 \u0000Result: A total of 14,611 tick photo submissions were recorded between 2020 to 2022, excluding those with a history of recent travel. The year 2021 had the highest number of submissions (n=7339). Dermacentor species comprised the majority of submissions (n=9498, 65%), followed by I. scapularis (n=4810, 33%) and other species (n=303, 2%) between 2020-2022. Ticks were most commonly discovered on a human host (n=10,084), followed by animal hosts (n=3485), and free in environments (n=1042). Additionally, the majority of species were found in the adult stage (n=12,821, 88%), followed by unknown (n=1539, 10%) and immature stages (n=251, 2%). Clusters of I. scapularis were present in the Eastern, Central, and Southern Ontario regions, while clusters of Dermacentor sp. were present in Southern and Central Ontario regions. \u0000 \u0000 \u0000Conclusion: Spatial and temporal variations in tick submissions in Ontario were identified over the 3.5 year period since the implementation of eTick in the province. Data from eTick can be used to identify hotspots of human-tick exposure. \u0000","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.18192/osurj.v3i1.7163
A.-S. Walker
Meet Mrs. Rodriguez, a 72 year-old retired school teacher, now living by herself, who was recently diagnosed with Alzheimer’s Disease (AD). AD represents the cause of 60% to 80% of Dementias [7], a broad term that encompasses conditions describing symptoms associated with progressive deterioration of cognitive activity, and of which the prevalence increases over the age of 65 years old [12] [7].
{"title":"D’un diagnostic de la maladie d'Alzheimer à une solution","authors":"A.-S. Walker","doi":"10.18192/osurj.v3i1.7163","DOIUrl":"https://doi.org/10.18192/osurj.v3i1.7163","url":null,"abstract":"Meet Mrs. Rodriguez, a 72 year-old retired school teacher, now living by herself, who was recently diagnosed with Alzheimer’s Disease (AD). AD represents the cause of 60% to 80% of Dementias [7], a broad term that encompasses conditions describing symptoms associated with progressive deterioration of cognitive activity, and of which the prevalence increases over the age of 65 years old [12] [7].","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-04DOI: 10.18192/osurj.v2i1.4173
Gurvir Rai, Anokhee Thakker, H. Patel
Obstructive Sleep Apnea (OSA) is a common sleep disorder in mammals which is characterized by the repeated collapse of the upper airway. It is a known cause of hypertension, cardiovascular disease, and, in some cases, death. OSA is commonly treated by medical devices and surgeries. Although effective, these treatments are associated with unwanted side-effects and further complications. In recent years, the role of medicinal marijuana has grown as a potential treatment for sleep disorders. Further research must be conducted to determine the efficacy and safety of cannabis as a treatment for OSA.
{"title":"Medicinal Marijuana: A Promising Potential Treatment for Obstructive Sleep Apnea","authors":"Gurvir Rai, Anokhee Thakker, H. Patel","doi":"10.18192/osurj.v2i1.4173","DOIUrl":"https://doi.org/10.18192/osurj.v2i1.4173","url":null,"abstract":"Obstructive Sleep Apnea (OSA) is a common sleep disorder in mammals which is characterized by the repeated collapse of the upper airway. It is a known cause of hypertension, cardiovascular disease, and, in some cases, death. OSA is commonly treated by medical devices and surgeries. Although effective, these treatments are associated with unwanted side-effects and further complications. In recent years, the role of medicinal marijuana has grown as a potential treatment for sleep disorders. Further research must be conducted to determine the efficacy and safety of cannabis as a treatment for OSA.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130129793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-31DOI: 10.18192/osurj.v1i1.3666
Erin Nguyen, Antonia T. Pandelieva, R. Chica
Red fluorescent proteins (RFPs) are genetically-encoded fluorophores that are widely used for in vivo imaging. For all applications of RFPs, brighter variants are desired. Previously, we improved the brightness of mRojoA, a red-shifted mutant of the widely-used RFP mCherry, by designing a triple-decker motif of aromatic rings around its chromophore. This yielded the brighter variant mRojo-VHSV, which contains a triple-decker motif consisting of His and Tyr side chains that pack against the chromophore. This improved chromophore packing resulted in an approximately 3-fold brightness increase at physiological pH. However, the His side chain in the triple-decker motif of mRojo-VHSV adopted a perpendicular arrangement to the other two, which may result in a suboptimal packing arrangement. To further improve chromophore packing in mRojo-VHSV, we performed saturation mutagenesis of residues surrounding its triple-decker motif (positions 62, 97, 165, and 199). Using a microplate fluorescence screening assay, a total of 376 colonies were screened for improved brightness. The brightest mutant found, L199M, was expressed and purified, and its spectral properties were characterized in detail. We found that the quantum yield of this variant was improved by two-fold, resulting in a two-fold brightness increase compared to mRojo-VHSV as well as a 5.3-fold increase in brightness compared to mRojoA. The L199M improved variant is the basis for continued engineering with the goal of further improving the spectral properties of this family of RFPs.
{"title":"Increasing the brightness of red fluorescent proteins by saturation mutagenesis","authors":"Erin Nguyen, Antonia T. Pandelieva, R. Chica","doi":"10.18192/osurj.v1i1.3666","DOIUrl":"https://doi.org/10.18192/osurj.v1i1.3666","url":null,"abstract":"Red fluorescent proteins (RFPs) are genetically-encoded fluorophores that are widely used for in vivo imaging. For all applications of RFPs, brighter variants are desired. Previously, we improved the brightness of mRojoA, a red-shifted mutant of the widely-used RFP mCherry, by designing a triple-decker motif of aromatic rings around its chromophore. This yielded the brighter variant mRojo-VHSV, which contains a triple-decker motif consisting of His and Tyr side chains that pack against the chromophore. This improved chromophore packing resulted in an approximately 3-fold brightness increase at physiological pH. However, the His side chain in the triple-decker motif of mRojo-VHSV adopted a perpendicular arrangement to the other two, which may result in a suboptimal packing arrangement. To further improve chromophore packing in mRojo-VHSV, we performed saturation mutagenesis of residues surrounding its triple-decker motif (positions 62, 97, 165, and 199). Using a microplate fluorescence screening assay, a total of 376 colonies were screened for improved brightness. The brightest mutant found, L199M, was expressed and purified, and its spectral properties were characterized in detail. We found that the quantum yield of this variant was improved by two-fold, resulting in a two-fold brightness increase compared to mRojo-VHSV as well as a 5.3-fold increase in brightness compared to mRojoA. The L199M improved variant is the basis for continued engineering with the goal of further improving the spectral properties of this family of RFPs.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127925208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-27DOI: 10.18192/osurj.v1i1.3777
M. Porteous, Sheida Rabipour, P. Davidson
Studies have shown that cognitive functions decline with increasing age. As the population of older adults (OA) has grown, interest in cognitive training programs (CTP) has steadily expanded. The present study investigated whether CTP can lead to improvements in the performance of OA on cognitive tasks. Thirty-five adults (OA; 60-87 years) were recruited to complete 25 sessions of a CTP over five weeks, with assessments completed before and after the program. Thirty-two young adults (YA; 17-27 years) were also recruited to complete one assessment for baseline comparison with OA. During assessments, participants were evaluated using tasks of executive function, including the N-back task of working memory and Flanker task of inhibition. The response time (RT) and hit rates of YA and OA on these tasks were examined at baseline, as well as changes in OA pre- and post-training. Repeated measures analysis of variance indicated a reduction of pre- and post-training RT for the Flanker task. There was no post-training change in RT on the N-back task. While OA hit rates did not change significantly pre- and post-assessment on the Flanker task, they showed increased hit rates post-training in the N-back task. In both tasks, OA and YA hit rates and RT were significantly different, with YA demonstrating lower RT and hit rate compared to OA. Follow-up studies will determine whether other factors can also lead to improvement. Determining whether CTP can improve cognitive performance in OA can help determine the potential of such approaches to prevent or rehabilitate age-related cognitive decline.
{"title":"Examining cognitive training and executive function in older adults","authors":"M. Porteous, Sheida Rabipour, P. Davidson","doi":"10.18192/osurj.v1i1.3777","DOIUrl":"https://doi.org/10.18192/osurj.v1i1.3777","url":null,"abstract":"Studies have shown that cognitive functions decline with increasing age. As the population of older adults (OA) has grown, interest in cognitive training programs (CTP) has steadily expanded. The present study investigated whether CTP can lead to improvements in the performance of OA on cognitive tasks. Thirty-five adults (OA; 60-87 years) were recruited to complete 25 sessions of a CTP over five weeks, with assessments completed before and after the program. Thirty-two young adults (YA; 17-27 years) were also recruited to complete one assessment for baseline comparison with OA. During assessments, participants were evaluated using tasks of executive function, including the N-back task of working memory and Flanker task of inhibition. The response time (RT) and hit rates of YA and OA on these tasks were examined at baseline, as well as changes in OA pre- and post-training. Repeated measures analysis of variance indicated a reduction of pre- and post-training RT for the Flanker task. There was no post-training change in RT on the N-back task. While OA hit rates did not change significantly pre- and post-assessment on the Flanker task, they showed increased hit rates post-training in the N-back task. In both tasks, OA and YA hit rates and RT were significantly different, with YA demonstrating lower RT and hit rate compared to OA. Follow-up studies will determine whether other factors can also lead to improvement. Determining whether CTP can improve cognitive performance in OA can help determine the potential of such approaches to prevent or rehabilitate age-related cognitive decline.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131834414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-23DOI: 10.18192/osurj.v1i1.3684
Léa Caya-Bissonnette
The underlying processes allowing for decision-making has been a question of interest for many neuroscientists. The lateral intraparietal cortex, or LIP, was shown to accumulate context and sensory information to compute a decision variable. The following review will present the work of Kumano, Suda and Uka who studied the link between context and sensory information during decision-making. To do so, a monkey was trained to associate the color of a fixating dot to one of two tasks. The tasks consisted in either indicating the motion or the depth of themajority of the dots on a screen. The local field potential of the LIP neurons was recorded, and the researchers found a role of context during the stimulus presentation in regards to decision formation. The results have important implication for mental disorders involving malfunction in decision processes.
{"title":"The effect of context on sensory accumulation involved in decision-making","authors":"Léa Caya-Bissonnette","doi":"10.18192/osurj.v1i1.3684","DOIUrl":"https://doi.org/10.18192/osurj.v1i1.3684","url":null,"abstract":"The underlying processes allowing for decision-making has been a question of interest for many neuroscientists. The lateral intraparietal cortex, or LIP, was shown to accumulate context and sensory information to compute a decision variable. The following review will present the work of Kumano, Suda and Uka who studied the link between context and sensory information during decision-making. To do so, a monkey was trained to associate the color of a fixating dot to one of two tasks. The tasks consisted in either indicating the motion or the depth of themajority of the dots on a screen. The local field potential of the LIP neurons was recorded, and the researchers found a role of context during the stimulus presentation in regards to decision formation. The results have important implication for mental disorders involving malfunction in decision processes.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"69 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120863924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-23DOI: 10.18192/osurj.v1i1.3693
Benjamin Puzantian
A black hole with zero angular momentum is said to be stationary and under certain conditions such a black hole can represented as a sphere. This review examines Hawking’s topology theorem, the Schwarzschild metric, novel solutions to Einstein’s equations, resonances of hyperbolic orbits around the event horizon for spherical, stationary black holes, and analyzes their importance. It is suggested, that in the spherical stationary black hole case, the Fourier analysis can be used to find the resonances due to Geometric scattering of hyperbolic orbits and thus the outgoing energy fields from the event horizon can be found more precisely; allowing for the adequate signal processing analysis to be found for such a field.
{"title":"A spherically topological analysis of stationary black holes","authors":"Benjamin Puzantian","doi":"10.18192/osurj.v1i1.3693","DOIUrl":"https://doi.org/10.18192/osurj.v1i1.3693","url":null,"abstract":"A black hole with zero angular momentum is said to be stationary and under certain conditions such a black hole can represented as a sphere. This review examines Hawking’s topology theorem, the Schwarzschild metric, novel solutions to Einstein’s equations, resonances of hyperbolic orbits around the event horizon for spherical, stationary black holes, and analyzes their importance. It is suggested, that in the spherical stationary black hole case, the Fourier analysis can be used to find the resonances due to Geometric scattering of hyperbolic orbits and thus the outgoing energy fields from the event horizon can be found more precisely; allowing for the adequate signal processing analysis to be found for such a field.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"os-53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127791624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-23DOI: 10.18192/osurj.v1i1.3702
Carl Zhou
In cases where it is necessary to generate random numbers that obey specific distributions, some of those distributions can be expressed as mathematical functions while others cannot. This is especially the case for epidemiological, medical, and pharmaceutical investigations, where more accurate methods, utilising actual distribution (from survey and experimental data) to generate random numbers may be required. In this study, three methods are analyzed to demonstrate simple computation examples. These methods include: inverse transform,acceptance-rejection, and Monte-Carlo simulations. Their applications are explored from a data analysis point of view. Additionally, this article discusses a flexible and practical approach of statistical measures optimization, which approximates the solution by fitting the statistical measures.
{"title":"Expressing the randomity of events – An analysis of random number generation with given distributions","authors":"Carl Zhou","doi":"10.18192/osurj.v1i1.3702","DOIUrl":"https://doi.org/10.18192/osurj.v1i1.3702","url":null,"abstract":"In cases where it is necessary to generate random numbers that obey specific distributions, some of those distributions can be expressed as mathematical functions while others cannot. This is especially the case for epidemiological, medical, and pharmaceutical investigations, where more accurate methods, utilising actual distribution (from survey and experimental data) to generate random numbers may be required. In this study, three methods are analyzed to demonstrate simple computation examples. These methods include: inverse transform,acceptance-rejection, and Monte-Carlo simulations. Their applications are explored from a data analysis point of view. Additionally, this article discusses a flexible and practical approach of statistical measures optimization, which approximates the solution by fitting the statistical measures.","PeriodicalId":375767,"journal":{"name":"University of Ottawa Science Undergraduate Research Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128003829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：