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Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer. 体外受精和胚胎移植前自然月经周期中早期分泌和中期分泌子宫内膜的转录组模式。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-07-17 DOI: 10.5468/ogs.22315
Sung Pil Choo, Inha Lee, Jae-Hoon Lee, Dowon Lee, Hyemin Park, Joo Hyun Park, SiHyun Cho, Young Sik Choi

Objective: This study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET).

Methods: Thirty patients whose endometrial tissues were obtained from the ESP or MSP of a natural menstrual cycle immediately before IVF-ET were included. Endometrial dating was histologically confirmed as ESP (cycle days 16-18) or MSP (cycle days 19-21), according to the noyes criteria. The patients were divided into two groups depending on the IVF-ET outcome: pregnant (n=14; 7 in ESP and 7 in MSP) or non-pregnant (n=16; 8 in ESP and 8 in MSP). Differentially expressed genes (DEGs) in the MSP, compared to the ESP, were identified using NanoString nCounter (NanoString Technologies, Seattle, WA, USA) data for both the pregnant and non-pregnant groups.

Results: Thirteen DEGs in the pregnant group and 11 DEGs in the non-pregnant group were identified in the MSP compared to those in the ESP. In both groups, adrenoceptor alpha 2A, interleukin 1 receptor-associated kinase 2, a disintegrin and metalloproteinase with thrombospondin repeats 15 (ADAMTS15), serpin family E member 1, integrin subunit beta 3, transmembrane protein 252 (TMEM252), huntingtin associated protein 1, C2 calcium-dependent domain containing 4A, and integrin subunit alpha 2 were upregulated in the MSP, compared to the ESP. TMEM37, galactosidase beta 1 like 2, Rho family GTPase 3, and cytochrome P450 family 24 subfamily A member 1 were upregulated in the MSP only in the pregnant group. ADAMTS8 was downregulated and monoamine oxidase A was upregulated in the MSP only in the non-pregnant group.

Conclusion: Transcriptomic patterns in the endometrium immediately before IVF-ET appear to differ according to the IVF-ET outcome. These novel DEGs, which have not been previously studied, may have functional significance during the window of implantation and serve as potential biomarkers of endometrial receptivity.

目的:本研究旨在评估体外受精-胚胎移植(IVF-ET)前自然月经周期早期分泌期(ESP)和中期分泌期(MSP)的子宫内膜转录组模式。根据noyes标准,子宫内膜测年在组织学上被确认为ESP(周期第16-18天)或MSP(周期第19-21天)。根据IVF-ET结果将患者分为两组:妊娠组(n=14;ESP组7例,MSP组7例)或非妊娠组(n=16;ESP组8例,MSPs组8例)。与ESP相比,MSP中的差异表达基因(DEG)是使用NanoString nCounter(NanoStringTechnologies,Seattle,WA,USA)对妊娠组和非妊娠组的数据进行鉴定的。结果:与ESP相比,MSP中鉴定出妊娠组的13个DEG和非妊娠组的11个DEG。在这两组中,肾上腺素受体α2A、白细胞介素1受体相关激酶2、具有血小板反应蛋白重复序列的去整合素和金属蛋白酶15(ADAMTS15)、丝氨酸蛋白酶家族E成员1、整合素亚单位β3、跨膜蛋白252(TMEM252),与ESP相比,亨廷顿蛋白相关蛋白1、含有C2钙依赖性结构域的4A和整合素亚基α2在MSP中上调。TMEM37、半乳糖苷酶β1样2、Rho家族GTPase 3和细胞色素P450家族24亚家族A成员1仅在妊娠组中在MSP上调。仅在非妊娠组中,MSP中ADAMTS8下调,单胺氧化酶A上调。结论:IVF-ET前子宫内膜的转录组模式根据IVF-ET的结果而不同。这些以前没有研究过的新型DEG可能在植入窗口期具有功能意义,并作为子宫内膜容受性的潜在生物标志物。
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引用次数: 0
Feasibility of fetoscopic laser coagulation in triplet pregnancy. 胎儿镜激光凝固治疗三胎妊娠的可行性。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-07-26 DOI: 10.5468/ogs.23111
You Mi Hong, Hye-Sung Won, Ah Hyun Lee, Mi-Young Lee

Objective: To report the experiences of triplet pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) treated with fetoscopic laser coagulation at a single center.

Methods: Herein, we conducted a retrospective analysis to investigate the management and perinatal outcomes of triplet pregnancies with TTTS treated at a single institution between 2017 and 2022.

Results: Seven of the 98 triplet pregnancies (7.1%) encountered were complicated by TTTS, and all were dichorionic triamniotic triplets. Of the seven triplet pregnancies complicated by TTTS, four were treated with fetoscopic laser coagulation at our center, at a median gestational age of 20 weeks. No procedure-related complications or maternal complications were observed. The survival rate was higher and perinatal outcomes were better in fetoscopic laser coagulation cases than in other management cases. Four donor and four recipient triplets survived, with a median gestational age of 33 weeks at delivery. Although there were no cases of poor neonatal outcomes, one case was diagnosed with white matter injury, suspected to be hypoxic-ischemic encephalopathy on postnatal investigation.

Conclusion: Fetoscopic laser coagulation is a feasible treatment option for triplet TTTS, provided the attending specialists have extensive experience with this technique.

目的:报告单中心激光凝固治疗三胎妊娠合并双胎输血综合征(TTTS)的经验。方法:在本文中,我们进行了一项回顾性分析,以调查2017年至2022年间在单一机构接受TTTS治疗的三胞胎妊娠的管理和围产期结果。结果:98例三胞胎中有7例(7.1%)合并TTTS,均为二型三胞胎。在7例合并TTTS的三胞胎妊娠中,有4例在我们的中心接受了胎儿镜激光凝固治疗,中位胎龄为20周。未观察到与手术相关的并发症或母体并发症。与其他治疗病例相比,胎儿镜激光凝固病例的存活率更高,围产期结局更好。四个供体和四个受体三胞胎存活下来,分娩时的中位胎龄为33周。尽管没有新生儿预后不良的病例,但有一例在产后调查中被诊断为白质损伤,疑似缺氧缺血性脑病。结论:如果主治专家对该技术有丰富的经验,胎儿激光凝固是治疗三重TTTS的可行选择。
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引用次数: 0
High prevalence of hypovitaminosis D3 among pregnant women in central Iran: correlation with newborn vitamin D3 levels and negative association with gestational age. 伊朗中部孕妇低维生素D3的高患病率:与新生儿维生素D3水平的相关性以及与胎龄的负相关。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-07-31 DOI: 10.5468/ogs.22251
Fatemeh Dorreh, Roghayeh Ahmadi, Abdorrahim Absalan, Afsaneh Akhondzadeh, Nazila Najdi, Kazem Ghaffari

Objective: Hypovitaminosis D3 is a significant concern among pregnant women and their newborns because vitamin D3 (Vit-D3) plays a crucial role in embryonic growth, development, and health. This study aimed to evaluate the Vit-D3 status of a group of pregnant Iranian women and its association with newborn Vit-D3 levels, medical and clinical indices after delivery.

Methods: A total of 206 pregnant women and their newborns were assessed for Vit-D3 levels and their correlation with gestational age. Mean±standard deviation (SD) or the orders (non-parametric tests) of variables were compared, and correlation estimations were performed to elucidate any differences or associations between groups, with a confidence interval of at least 0.95.

Results: The mean±SD of mothers' age and gestational age were 29.65±6.18 years and 35.59±1.6 weeks, respectively. Neonatal Vit-D3 levels were associated with maternal age. Using a 30 ng/mL cutoff point for serum Vit-D3 levels, 83.5% of pregnant women and 84.7% of newborns had hypovitaminosis D3. The average Vit-D3 levels of mothers and newborns at delivery time were 23.5±8.07 ng/mL and 20.76±9.14 ng/mL, respectively. Newborn Vit-D3 levels were positively correlated with maternal Vit-D3 serum levels (R=0.744; P<0.001) and gestational age (R=0.161; P=0.022). In newborns, head circumference was inversely correlated with bilirubin level (R=-0.302; P<0.001) but directly associated with weight (R=0.640; P<0.001).

Conclusion: Hypovitaminosis D3 remains a significant challenge for pregnant Iranian women. Maternal Vit-D3 levels provide for the newborn's needs, particularly in the late stages of pregnancy. Therefore, Vit-D3 supplementation and regular monitoring are essential for pregnant women and their newborns.

目的:维生素D3(Vit-D3)在胚胎生长、发育和健康中起着至关重要的作用,因此维生素D3缺乏症在孕妇及其新生儿中备受关注。本研究旨在评估一组伊朗孕妇的维生素D3状况及其与新生儿维生素D3水平、产后医学和临床指标的关系。方法:对206名孕妇及其新生儿进行维生素D3水平及其与胎龄的相关性评估。比较变量的平均值±标准差(SD)或阶数(非参数检验),并进行相关估计,以阐明各组之间的任何差异或关联,置信区间至少为0.95。结果:母亲年龄和胎龄的平均值?SD分别为29.65±6.18岁和35.59±1.6周。新生儿维生素D3水平与母亲年龄相关。使用血清维生素D3水平的30 ng/mL截止点,83.5%的孕妇和84.7%的新生儿患有维生素D3缺乏症。分娩时母亲和新生儿的平均维生素D3水平分别为23.5±8.07 ng/mL和20.76±9.14 ng/mL。新生儿维生素D3水平与母体维生素D3血清水平呈正相关(R=0.744;P结论:维生素D3缺乏症对伊朗孕妇来说仍然是一个重大挑战。母体维生素D3水平满足了新生儿的需求,尤其是在妊娠晚期。因此,补充维生素D3和定期监测对孕妇及其新生儿至关重要。
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引用次数: 0
Differential trend of mild and severe preeclampsia among nulliparous women: a population-based study of South Korea. 未产妇轻度和重度先兆子痫的差异趋势:一项基于韩国人群的研究。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-09-01 Epub Date: 2023-06-29 DOI: 10.5468/ogs.23033
Seyoung Kim, Ji Yeon Lee, Tammie Kim, Eunseon Gwak, Seung-Ah Choe

We explored the annual risks of mild and severe preeclampsia (PE) among nulliparous women. Using the National Health Information Database of South Korea, 1,317,944 nulliparous women who gave live births were identified. Mild PE increased from 0.9% in 2010 to 1.4% in 2019 (P for trend=0.006), while severe PE decreased from 0.4% in 2010 to 0.3% in 2019 (P=0.049). The incidence of all types of PE (mild and severe) showed no linear change (P=0.514). Adjusted odds ratio (OR) of severe PE decreased in 2013 (0.68; 95% confidence interval [CI]: 0.60, 0.77) and beyond compared to that in 2010, while the OR of mild PE increased in 2017 (1.14; 95% CI: 1.06, 1.22) and beyond. Mild PE was found to be less likely to progress to the severe form since 2010; however, the overall risk of PE among women did not change.

我们探讨了未产妇中轻度和重度先兆子痫(PE)的年度风险。利用韩国国家健康信息数据库,确定了1317944名活产未产妇。轻度PE从2010年的0.9%上升到2019年的1.4%(趋势P=0.006),而重度PE从2010的0.4%下降到2019的0.3%(P=0.049)。所有类型的PE(轻度和重度)的发病率都没有线性变化(P=0.514)。与2010年相比,2013年重度PE的调整后比值比(OR)下降(0.68;95%置信区间[CI]:0.60,0.77)及以上,而轻度PE的OR在2017年及以后增加(1.14;95%CI:1.061.22)。自2010年以来,轻度PE发展为严重PE的可能性较小;然而,女性患PE的总体风险没有改变。
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引用次数: 0
Diagnostic accuracy of hand-held colposcope (Gynocular) in comparison with standard colposcope in patients with abnormal cervical cytology or visual inspection with acetic acid positivity: a cross over randomized controlled study. 手持式阴道镜(Gynocular)与标准阴道镜在宫颈细胞学异常或目测醋酸阳性患者中的诊断准确性:一项交叉随机对照研究。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 DOI: 10.5468/ogs.23089
Sowmiya Jayabalan, Murali Subbaiah, Latha Chaturvedula

Objective: To compare the diagnostic accuracy of a handheld colposcope (Gynocular) versus a standard colposcope in women with abnormal cervical cytology or visual Inspection with acetic acid positivity.

Methods: This crossover randomized clinical trial was conducted in Pondicherry, India, and included 230 women who were referred for colposcopy. Swede scores were calculated using both colposcopes, and a cervical biopsy was performed from the most visually abnormal areas. Swede scores were compared with the histopathological diagnosis, which was used as the reference standard. The level of agreement between the two colposcopes was calculated using Kappa (κ) statistics.

Results: The level of agreement of Swede scores between the standard and Gynocular colposcopes was 62.56%, and the κ statistic was 0.43 (P<0.001). Cervical intraepithelial neoplasia (CIN) 2+ (CIN 2, CIN 3, CIN 3+) was diagnosed in 40 (17.4%) women. There were no significant differences between the two colposcopes in terms of sensitivity, specificity, or predictive value for detecting CIN 2+ lesions.

Conclusion: The diagnostic accuracy of Gynocular colposcopy was similar to that of standard colposcopy for detecting CIN 2+ lesions. Gynocular colposcopes showed a good level of agreement with standard colposcopes when the Swede score was used.

目的:比较手持式阴道镜(妇科)与标准阴道镜对宫颈细胞学异常或目视检查为醋酸阳性的妇女的诊断准确性。方法:这项交叉随机临床试验在印度本地治里进行,纳入230名接受阴道镜检查的妇女。使用阴道镜计算瑞典评分,并从最视觉异常的区域进行宫颈活检。将瑞典评分与组织病理学诊断进行比较,作为参考标准。采用Kappa (κ)统计计算两组阴道镜的一致性水平。结果:标准阴道镜与阴道镜瑞典评分的一致性为62.56%,κ统计量为0.43 (p)。结论:阴道镜对CIN 2+病变的诊断准确率与标准阴道镜相近。当使用瑞典评分时,阴道镜与标准阴道镜显示出良好的一致性。
{"title":"Diagnostic accuracy of hand-held colposcope (Gynocular) in comparison with standard colposcope in patients with abnormal cervical cytology or visual inspection with acetic acid positivity: a cross over randomized controlled study.","authors":"Sowmiya Jayabalan,&nbsp;Murali Subbaiah,&nbsp;Latha Chaturvedula","doi":"10.5468/ogs.23089","DOIUrl":"https://doi.org/10.5468/ogs.23089","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic accuracy of a handheld colposcope (Gynocular) versus a standard colposcope in women with abnormal cervical cytology or visual Inspection with acetic acid positivity.</p><p><strong>Methods: </strong>This crossover randomized clinical trial was conducted in Pondicherry, India, and included 230 women who were referred for colposcopy. Swede scores were calculated using both colposcopes, and a cervical biopsy was performed from the most visually abnormal areas. Swede scores were compared with the histopathological diagnosis, which was used as the reference standard. The level of agreement between the two colposcopes was calculated using Kappa (κ) statistics.</p><p><strong>Results: </strong>The level of agreement of Swede scores between the standard and Gynocular colposcopes was 62.56%, and the κ statistic was 0.43 (P<0.001). Cervical intraepithelial neoplasia (CIN) 2+ (CIN 2, CIN 3, CIN 3+) was diagnosed in 40 (17.4%) women. There were no significant differences between the two colposcopes in terms of sensitivity, specificity, or predictive value for detecting CIN 2+ lesions.</p><p><strong>Conclusion: </strong>The diagnostic accuracy of Gynocular colposcopy was similar to that of standard colposcopy for detecting CIN 2+ lesions. Gynocular colposcopes showed a good level of agreement with standard colposcopes when the Swede score was used.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":"66 4","pages":"300-306"},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/32/ogs-23089.PMC10375214.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9889395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of follow-up observation using human epididymis protein 4, a tumor marker, in patients with ovarian cancer. 肿瘤标志物人附睾蛋白4对卵巢癌患者随访观察的评价。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 DOI: 10.5468/ogs.23024
Masaya Uno, Rie Matsuo, Naoki Maezawa, Tomoyasu Kato

Objective: We evaluated the usefulness of human epididymis protein 4 (HE4), a tumor marker, during and after treatment in patients with ovarian cancer (OC).

Methods: We included Japanese patients newly diagnosed with OC treated at the National Cancer Center Hospital between 2014 and 2021. The HE4 levels were measured in the serum stored during diagnosis. To evaluate the concordance between HE4 and the imaging results, we employed sequential pairs of blood sampling points and the results of imaging examinations. We compared the timing of the elevated HE4 levels, imaging diagnoses, and elevated cancer antigen 125 (CA125) levels in patients with recurrence. The Ethics Review Committee of our institution (2021-056) reviewed this study.

Results: Forty-eight patients with epithelial OC were eligible for enrollment. The sensitivity, specificity, and positive and negative predictive values of HE4 (criterion, 70 pmol/L) for disease progression during the follow-up period were 79.4%, 59.1%, 32.5%, and 92.0%, respectively (time point, n=317). We evaluated the relationship between HE4 and CA125 variability and disease status (recurrence or no recurrence). For recurrence, the sensitivity and negative predictive value of HE4 (criterion, 70 pmol/L), CA125 (criterion, 35 U/mL), and combination of HE4 and CA125 were 77.8%, 85.2%, and 92.6% and 75.0%, 82.6%, and 88.9%, respectively (n=48). Among the 27 patients who exhibited recurrence, 16 and nine showed earlier increased HE4 levels than the relevant imaging and CA125 levels, respectively.

Conclusion: HE4 may be a valuable marker for follow-up during and after OC therapy. A complementary role for HE4 and CA125 measurements was suggested for follow-up observations.

目的:评价肿瘤标志物人附睾蛋白4 (HE4)在卵巢癌(OC)患者治疗期间和治疗后的作用。方法:我们纳入了2014年至2021年间在国立癌症中心医院治疗的新诊断为OC的日本患者。检测诊断期间储存的血清中HE4水平。为了评估HE4与影像学结果的一致性,我们采用了连续对的采血点和影像学检查结果。我们比较了复发患者HE4水平升高的时间、影像学诊断和癌抗原125 (CA125)水平升高的时间。本研究所伦理审查委员会(2021-056)对本研究进行了审查。结果:48例上皮性OC患者符合入组条件。随访期间HE4(标准70 pmol/L)对疾病进展的敏感性、特异性和阳性、阴性预测值分别为79.4%、59.1%、32.5%和92.0%(时间点,n=317)。我们评估了HE4和CA125变异与疾病状态(复发或无复发)之间的关系。对于复发,HE4(判据,70 pmol/L)、CA125(判据,35 U/mL)和HE4与CA125联合检测的敏感性和阴性预测值分别为77.8%、85.2%、92.6%和75.0%、82.6%、88.9% (n=48)。在27例复发患者中,16例和9例HE4水平较相关影像学和CA125水平升高较早。结论:HE4可能是卵巢癌治疗期间和治疗后随访的有价值的指标。建议在后续观察中补充HE4和CA125测量。
{"title":"Evaluation of follow-up observation using human epididymis protein 4, a tumor marker, in patients with ovarian cancer.","authors":"Masaya Uno,&nbsp;Rie Matsuo,&nbsp;Naoki Maezawa,&nbsp;Tomoyasu Kato","doi":"10.5468/ogs.23024","DOIUrl":"https://doi.org/10.5468/ogs.23024","url":null,"abstract":"<p><strong>Objective: </strong>We evaluated the usefulness of human epididymis protein 4 (HE4), a tumor marker, during and after treatment in patients with ovarian cancer (OC).</p><p><strong>Methods: </strong>We included Japanese patients newly diagnosed with OC treated at the National Cancer Center Hospital between 2014 and 2021. The HE4 levels were measured in the serum stored during diagnosis. To evaluate the concordance between HE4 and the imaging results, we employed sequential pairs of blood sampling points and the results of imaging examinations. We compared the timing of the elevated HE4 levels, imaging diagnoses, and elevated cancer antigen 125 (CA125) levels in patients with recurrence. The Ethics Review Committee of our institution (2021-056) reviewed this study.</p><p><strong>Results: </strong>Forty-eight patients with epithelial OC were eligible for enrollment. The sensitivity, specificity, and positive and negative predictive values of HE4 (criterion, 70 pmol/L) for disease progression during the follow-up period were 79.4%, 59.1%, 32.5%, and 92.0%, respectively (time point, n=317). We evaluated the relationship between HE4 and CA125 variability and disease status (recurrence or no recurrence). For recurrence, the sensitivity and negative predictive value of HE4 (criterion, 70 pmol/L), CA125 (criterion, 35 U/mL), and combination of HE4 and CA125 were 77.8%, 85.2%, and 92.6% and 75.0%, 82.6%, and 88.9%, respectively (n=48). Among the 27 patients who exhibited recurrence, 16 and nine showed earlier increased HE4 levels than the relevant imaging and CA125 levels, respectively.</p><p><strong>Conclusion: </strong>HE4 may be a valuable marker for follow-up during and after OC therapy. A complementary role for HE4 and CA125 measurements was suggested for follow-up observations.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":"66 4","pages":"290-299"},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/d2/ogs-23024.PMC10375218.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9892609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triglyceride and glucose index for identifying abnormal insulin sensitivity in women with polycystic ovary syndrome. 甘油三酯和葡萄糖指数鉴别多囊卵巢综合征女性异常胰岛素敏感性。
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 DOI: 10.5468/ogs.23103
Seeun Kwon, Aram Heo, Sungwook Chun

Objective: We aimed to evaluate whether triglyceride and glucose (TyG) indices are useful in identifying insulin sensitivity/resistance in women with polycystic ovary syndrome (PCOS).

Methods: One hundred and seventy-two Korean women aged 18-35 years who were diagnosed with PCOS were included in this study. Fasting-state insulin sensitivity assessment indices (ISAIs) derived from a combination of fasting insulin and glucose levels were calculated for all study participants, and abnormal insulin sensitivity was defined as any of the evaluated ISAIs being out of the established normal range. Correlation analysis was conducted to assess the relationship between the TyG index and other clinical and biochemical parameters. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff value of the TyG index for identifying abnormal insulin sensitivity, and unpaired t-tests were used to compare biochemical parameters between individuals with a TyG index below the cutoff and individuals with a TyG index above the cutoff value.

Results: All clinical parameters, except age and other insulin resistance-related biochemical parameters, were significantly related to the TyG index. The ROC curve analysis revealed an optimal TyG cutoff value of 8.126 (sensitivity, 0.807; specificity, 0.683) for identifying abnormal insulin sensitivity. In the comparative analysis, all ISAIs and parameters derived from the lipid profiles differed significantly between the TyG groups.

Conclusion: The TyG index is a feasible surrogate marker for predicting insulin sensitivity/resistance in women with PCOS.

目的:我们旨在评估甘油三酯和葡萄糖(TyG)指标是否有助于识别多囊卵巢综合征(PCOS)女性的胰岛素敏感/抵抗。方法:选取122名年龄在18-35岁的韩国女性为研究对象。对所有研究参与者计算空腹胰岛素和葡萄糖水平组合得出的空腹状态胰岛素敏感性评估指数(isis),并将任何评估的isis超出既定正常范围定义为胰岛素敏感性异常。通过相关分析评价TyG指数与其他临床生化指标的关系。采用受试者工作特征(Receiver operating characteristic, ROC)曲线分析确定TyG指数识别胰岛素敏感性异常的最佳临界值,并采用非配对t检验比较TyG指数低于临界值和高于临界值个体的生化参数。结果:除年龄等胰岛素抵抗相关生化参数外,其余临床参数均与TyG指数有显著相关性。ROC曲线分析显示,最佳TyG截断值为8.126(敏感性为0.807;特异性(0.683)。在比较分析中,TyG组之间的所有isis和来自脂质谱的参数都有显著差异。结论:TyG指数可作为预测PCOS患者胰岛素敏感/抵抗的替代指标。
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引用次数: 2
The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia. 子痫前期的补体系统:在COVID-19感染和hiv相关子痫前期中其激活和内皮损伤的综述
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 DOI: 10.5468/ogs.22175
Mikyle David, Thajasvarie Naicker

This review assesses the complement system and its activation, with the pathological features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus (HIV) infection and preeclampsia (PE). The complement system is the first defensive response by the host innate immune system to viral pathogens, including SARS-CoV-2. SARS-CoV-2 entry results in the release of pro-inflammatory cytokines and chemical mediators to create a "cytokine storm". Endothelial cell (EC) dysfunction and cell-mediated injury are also present. These factors cause an exacerbated inflammatory state. During HIV infection and PE, various complement components are elevated, causing a hyper-inflammatory state. Furthermore, EC dysfunction and cell-mediated injury are also present. The similarities in pathological aspects of these three disorders may emanate from excessive complement activation. This review serves as a platform for further research on the complement system, coronavirus disease 2019, HIV infection and PE.

本文综述了补体系统及其激活、严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)、人类免疫缺陷病毒(HIV)感染和先兆子痫(PE)的病理特征。补体系统是宿主先天免疫系统对包括SARS-CoV-2在内的病毒性病原体的第一个防御反应。SARS-CoV-2进入导致释放促炎细胞因子和化学介质,形成“细胞因子风暴”。内皮细胞(EC)功能障碍和细胞介导的损伤也存在。这些因素导致炎症状态加剧。在HIV感染和PE期间,各种补体成分升高,引起高炎症状态。此外,EC功能障碍和细胞介导的损伤也存在。这三种疾病在病理方面的相似之处可能源于过度的补体激活。本综述为进一步研究补体系统、2019冠状病毒病、HIV感染和PE提供了平台。
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引用次数: 2
Relationship between female sexual function, vaginal volume, vaginal resting tone, and pelvic floor muscle strength in women with stress urinary incontinence. 压力性尿失禁女性性功能、阴道容积、阴道静息张力和盆底肌力的关系
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 DOI: 10.5468/ogs.23057
Ui-Jae Hwang, Min-Seok Lee

Objective: Vaginal morphology and pelvic floor muscle (PFM) strength may influence sexual stimulation, sensation, and orgasmic response. This study aimed to determine the relationship between female sexual function and PFM strength and vaginal morphology (represented by vaginal resting tone and vaginal volume) in women with stress urinary incontinence (SUI).

Methods: Forty-two subjects with SUI were recruited for the study. Female sexual function was measured using the female sexual function index (FSFI) questionnaire. PFM strength was measured by digital palpation. Vaginal resting tone (mmHg) and vaginal volume (mL) were measured using a perineometer. The significance of the correlations between female sexual function and PFM function and hip muscle strength was assessed using Pearson's correlation coefficients. If a significant correlation between vaginal morphology and FSFI score was confirmed using Pearson's correlation, the cutoff value was confirmed through a decision tree.

Results: PFM strength was significantly correlated with desire (r=0.397), arousal (r=0.388), satisfaction (r=0.326), and total (r=0.315) FSFI scores. Vaginal resting tone (r=-0.432) and vaginal volume (r=0.332) were significantly correlated with the FSFI pain score. The cutoff point of vaginal resting tone for the presence of pain-related sexual dysfunction was >15.2 mmHg.

Conclusion: PFM strength training should be the first strategy to improve female sexual function. Additionally, because of the relationship between vaginal morphology and pain-related sexual dysfunction, surgical procedures to achieve vaginal rejuvenation should be carefully considered.

目的:阴道形态和盆底肌(PFM)强度可能影响性刺激、感觉和性高潮反应。本研究旨在确定女性压力性尿失禁(SUI)患者PFM强度和阴道形态(以阴道静息张力和阴道体积为代表)与女性性功能的关系。方法:选取42例SUI患者进行研究。采用女性性功能指数(FSFI)问卷测量女性性功能。通过指诊测量PFM强度。阴道静息张力(mmHg)和阴道容积(mL)用会阴计测量。采用Pearson相关系数评估女性性功能与PFM功能及髋部肌力的相关性。如果使用Pearson相关性证实阴道形态与FSFI评分之间存在显著相关性,则通过决策树确定截断值。结果:PFM强度与欲望(r=0.397)、觉醒(r=0.388)、满意度(r=0.326)、FSFI总分(r=0.315)呈显著相关。阴道静息张力(r=-0.432)和阴道体积(r=0.332)与FSFI疼痛评分显著相关。存在疼痛性性功能障碍的阴道静息张力临界值>15.2 mmHg。结论:PFM力量训练应作为改善女性性功能的首选策略。此外,由于阴道形态与疼痛性性功能障碍之间的关系,应仔细考虑实现阴道年轻化的外科手术。
{"title":"Relationship between female sexual function, vaginal volume, vaginal resting tone, and pelvic floor muscle strength in women with stress urinary incontinence.","authors":"Ui-Jae Hwang,&nbsp;Min-Seok Lee","doi":"10.5468/ogs.23057","DOIUrl":"https://doi.org/10.5468/ogs.23057","url":null,"abstract":"<p><strong>Objective: </strong>Vaginal morphology and pelvic floor muscle (PFM) strength may influence sexual stimulation, sensation, and orgasmic response. This study aimed to determine the relationship between female sexual function and PFM strength and vaginal morphology (represented by vaginal resting tone and vaginal volume) in women with stress urinary incontinence (SUI).</p><p><strong>Methods: </strong>Forty-two subjects with SUI were recruited for the study. Female sexual function was measured using the female sexual function index (FSFI) questionnaire. PFM strength was measured by digital palpation. Vaginal resting tone (mmHg) and vaginal volume (mL) were measured using a perineometer. The significance of the correlations between female sexual function and PFM function and hip muscle strength was assessed using Pearson's correlation coefficients. If a significant correlation between vaginal morphology and FSFI score was confirmed using Pearson's correlation, the cutoff value was confirmed through a decision tree.</p><p><strong>Results: </strong>PFM strength was significantly correlated with desire (r=0.397), arousal (r=0.388), satisfaction (r=0.326), and total (r=0.315) FSFI scores. Vaginal resting tone (r=-0.432) and vaginal volume (r=0.332) were significantly correlated with the FSFI pain score. The cutoff point of vaginal resting tone for the presence of pain-related sexual dysfunction was >15.2 mmHg.</p><p><strong>Conclusion: </strong>PFM strength training should be the first strategy to improve female sexual function. Additionally, because of the relationship between vaginal morphology and pain-related sexual dysfunction, surgical procedures to achieve vaginal rejuvenation should be carefully considered.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":"66 4","pages":"327-335"},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/a7/ogs-23057.PMC10375215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10267434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis. 2019冠状病毒病妊娠期感染及不良妊娠结局:系统综述和荟萃分析
IF 1.9 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-07-01 Epub Date: 2023-05-17 DOI: 10.5468/ogs.22323
Yeonsong Jeong, Min-A Kim

The coronavirus disease 2019 (COVID-19) outbreak which started in December 2019 rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review and meta-analysis compared pregnancy outcomes according to COVID-19 disease status. The MEDLINE, EMBASE, and Cochrane Library databases were searched for relevant articles published between December 1, 2019, and October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed pregnancy outcomes in women with or without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant women (39,716 [2.4%] diagnosed with COVID-19) were retrieved. COVID-19-infected pregnant women had a higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42-1.78), preeclampsia (OR, 1.41; 95% CI, 1.30-1.53), low birth weight (OR, 1.52; 95% CI, 1.30-1.79), cesarean delivery (OR, 1.20; 95% CI, 1.10-1.30), stillbirth (OR, 1.71; 95% CI, 1.39-2.10), fetal distress (OR, 2.49; 95% CI, 1.54-4.03), neonatal intensive care unit admission (OR, 2.33; 95% CI, 1.72-3.16), perinatal mortality (OR, 1.96; 95% CI, 1.15-3.34), and maternal mortality (OR, 6.15; 95% CI, 3.74-10.10). There were no significant differences in total miscarriage, preterm premature rupture of membranes, postpartum hemorrhage, cholestasis, or chorioamnionitis according to infection. This review demonstrates that COVID-19 infection during pregnancy can lead to adverse pregnancy outcomes. This information could aid researchers and clinicians in preparing for another pandemic caused by newly discovered respiratory viruses. The findings of this study may assist with evidence-based counseling and help clinicians manage pregnant women with COVID-19.

2019年12月开始的2019冠状病毒病(COVID-19)疫情迅速发展成为全球卫生问题。孕妇易患呼吸道感染,并可能出现不良后果。本系统综述和荟萃分析比较了COVID-19疾病状态下的妊娠结局。在MEDLINE、EMBASE和Cochrane图书馆数据库中检索2019年12月1日至2022年10月19日之间发表的相关文章。主要纳入标准是任何基于人群的、横断面的、队列的或病例对照的研究,这些研究评估了有或没有实验室确诊的COVID-19妇女的妊娠结局。纳入69项研究,包括1,606,543名孕妇(诊断为COVID-19的39,716名[2.4%])。covid -19感染孕妇早产风险较高(优势比[OR], 1.59;95%可信区间[CI], 1.42-1.78),先兆子痫(OR, 1.41;95% CI, 1.30-1.53),低出生体重(OR, 1.52;95% CI, 1.30-1.79),剖宫产(OR, 1.20;95% CI, 1.10-1.30),死产(OR, 1.71;95% CI, 1.39-2.10),胎儿窘迫(OR, 2.49;95% CI, 1.54-4.03),新生儿重症监护病房入院(OR, 2.33;95% CI, 1.72-3.16),围产期死亡率(OR, 1.96;95% CI, 1.15-3.34)和孕产妇死亡率(OR, 6.15;95% ci, 3.74-10.10)。总流产、早产、胎膜早破、产后出血、胆汁淤积、绒毛膜羊膜炎的感染情况差异无统计学意义。本综述表明,妊娠期感染COVID-19可导致不良妊娠结局。这些信息可以帮助研究人员和临床医生为新发现的呼吸道病毒引起的另一场大流行做准备。这项研究的结果可能有助于基于证据的咨询,并帮助临床医生管理感染COVID-19的孕妇。
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引用次数: 4
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Obstetrics and Gynecology Science
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