Background and objectives. Coronavirus Disease-2019 (COVID-19) is a respiratory infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The COVID-19 associates multi clinical symptoms such as neurological manifestations with mild to advanced progression. This study aimed to determine the clinical neurological characteristics of geriatric patients with COVID-19. Methods. The study was an observational and descriptive study on 27 geriatric patients with COVID-19. All patients’ age was over 60 years old who treated in the In-patient Department of Sanglah General Hospital, Denpasar on July 2020 to January 2021. The data had taken from medical records. Outcomes. The mean age of all patients was 70.41 (± 8.902) years which dominated by the male (51.9%). The majority of manifestations in this study were fever in 13 people (48.1%), unconsciousness in 10 people (37%), and hemiparesis in 10 people (37%), and cough in 9 people (33.3%). Conclusion. The clinical neurology characteristics of geriatric patients with COVID-19 vary, which may involve general and neurological manifestations. Promptly accurate diagnosis is necessary for further management.
{"title":"Clinical neurological characteristics of geriatic patients with Coronavirus disease 2019 (COVID-19)","authors":"A. Yolanda, A. Laksmidewi, A. Meidiary","doi":"10.37897/rjn.2022.1.9","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.9","url":null,"abstract":"Background and objectives. Coronavirus Disease-2019 (COVID-19) is a respiratory infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The COVID-19 associates multi clinical symptoms such as neurological manifestations with mild to advanced progression. This study aimed to determine the clinical neurological characteristics of geriatric patients with COVID-19. Methods. The study was an observational and descriptive study on 27 geriatric patients with COVID-19. All patients’ age was over 60 years old who treated in the In-patient Department of Sanglah General Hospital, Denpasar on July 2020 to January 2021. The data had taken from medical records. Outcomes. The mean age of all patients was 70.41 (± 8.902) years which dominated by the male (51.9%). The majority of manifestations in this study were fever in 13 people (48.1%), unconsciousness in 10 people (37%), and hemiparesis in 10 people (37%), and cough in 9 people (33.3%). Conclusion. The clinical neurology characteristics of geriatric patients with COVID-19 vary, which may involve general and neurological manifestations. Promptly accurate diagnosis is necessary for further management.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41742950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shierly, I. Sumada, Desie Yuliani, Riki Sukiandra, Chandra Wirawan
Coronavirus disease 2019 (COVID-19) has become outbreak in the world since December 2020. The higher incidence and transmission of COVID-19, the higher virulence of the disease. Besides respiratory manifestations, the most common symptoms in COVID-19 are neurological manifestations. The major neurological manifestations in COVID-19 are headache and dizziness. Headache is more common as chief complaint in emergency room and hospitalized patients than dizziness. Therefore, this review aims to outline the characteristics of headache in COVID-19. The conclusion of this review is that the characteristics of headache in COVID-19 are moderate-severe intensity, frontal-temporal region, pulsatile and tightening quality, constant duration and commonly associate with one or more COVID-19 symptoms.
{"title":"The characteristics of headache in COVID-19: A literature review","authors":"S. Shierly, I. Sumada, Desie Yuliani, Riki Sukiandra, Chandra Wirawan","doi":"10.37897/rjn.2022.1.2","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.2","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) has become outbreak in the world since December 2020. The higher incidence and transmission of COVID-19, the higher virulence of the disease. Besides respiratory manifestations, the most common symptoms in COVID-19 are neurological manifestations. The major neurological manifestations in COVID-19 are headache and dizziness. Headache is more common as chief complaint in emergency room and hospitalized patients than dizziness. Therefore, this review aims to outline the characteristics of headache in COVID-19. The conclusion of this review is that the characteristics of headache in COVID-19 are moderate-severe intensity, frontal-temporal region, pulsatile and tightening quality, constant duration and commonly associate with one or more COVID-19 symptoms.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42373738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glucose is primary source of energy substrate for the brain, however, during physiological stresses or other situations with low blood glucose, ketone bodies are another important source of energy for brain. Hypoglycemia has significant impact on the brain and symptomatic hypoglycemia is referred as Neuroglycopenia. Since the brain has minimal endogenous glycogen stores and does not generate glucose intrinsically, it requires a constant supply of glucose from the circulation. Impairment in glucose supply leads to activation of counter regulatory hormone mainly the neuroendocrine response in order to restore the energy requirement. If this response fails to secure the energy demand hypoglycemia can present clinically as headache, stroke, seizure, cognitive impairment or coma. A prompt and accurate diagnosis would allow for more precise treatment and less neuronal damage. This article focuses on common etiology, counter regulatory responses to hypoglycemia, clinical features and management of hypoglycemia.
{"title":"Neuroglycopenia: common etiologies, clinical characteristics, and management","authors":"Anshul Singh, N. Rai, A. Agrawal","doi":"10.37897/rjn.2022.1.1","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.1","url":null,"abstract":"Glucose is primary source of energy substrate for the brain, however, during physiological stresses or other situations with low blood glucose, ketone bodies are another important source of energy for brain. Hypoglycemia has significant impact on the brain and symptomatic hypoglycemia is referred as Neuroglycopenia. Since the brain has minimal endogenous glycogen stores and does not generate glucose intrinsically, it requires a constant supply of glucose from the circulation. Impairment in glucose supply leads to activation of counter regulatory hormone mainly the neuroendocrine response in order to restore the energy requirement. If this response fails to secure the energy demand hypoglycemia can present clinically as headache, stroke, seizure, cognitive impairment or coma. A prompt and accurate diagnosis would allow for more precise treatment and less neuronal damage. This article focuses on common etiology, counter regulatory responses to hypoglycemia, clinical features and management of hypoglycemia.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44266670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Recent studies have shown that SSRIs have anti-inflammatory effects, and their administration prevents their production by acting on inflammatory cytokines. Emphasizing that we did not find a study on Dapoxetine and its effect on neuropathic pain, in this study, we examined the effect of Dapoxetine on neuropathic pain in rats. Material and methods. 42 rats were divided into six groups of 7, which included: sham, control, gabapentin, Duloxetine and Dapoxetine 1 and 3. Except for the sham group, other groups were induced with neuropathy, and no drug treatment was performed in the sham group. The groups were treated with normal saline, gabapentin (30 mg/kg/day), Duloxetine at (30 mg/kg/day) and Dapoxetine (1 and 3 mg/kg/day), respectively by intraperitoneal injection. Then, thermal hyperalgesia and mechanical and thermal allodynia experiments were performed on rats. Results. The Dapoxetine-treated groups’ mean response to thermal hyperalgesia and mechanical allodynia increased on days 7 and 14. The mean response of the 3 mg/kg Dapoxetine group on day 7 was significantly higher than the control group (P <0.05). Mean response to mechanical and thermal allodynia-induced stimulation and thermal hyperactivity in the Dapoxetine group 3 mg/kg at 14 days, compared with the Dapoxetine group 1 mg/kg showed significantly better results (P <0.05). Conclusion. Dapoxetine effectively reduces the behavioral response to painful and non-painful thermal and mechanical stimuli and painful thermal and mechanical stimuli. In addition to its short-term analgesic effects, it also has long-term effects.
{"title":"The effect of Dapoxetine on Chronic Constriction Injury (CCI) induced neuralgia in rats","authors":"Akram Zare Bidakia, Mohsen Zabihib, Mohadeseh Asadic, Reza Bidakid","doi":"10.37897/rjn.2022.1.6","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.6","url":null,"abstract":"Introduction. Recent studies have shown that SSRIs have anti-inflammatory effects, and their administration prevents their production by acting on inflammatory cytokines. Emphasizing that we did not find a study on Dapoxetine and its effect on neuropathic pain, in this study, we examined the effect of Dapoxetine on neuropathic pain in rats. Material and methods. 42 rats were divided into six groups of 7, which included: sham, control, gabapentin, Duloxetine and Dapoxetine 1 and 3. Except for the sham group, other groups were induced with neuropathy, and no drug treatment was performed in the sham group. The groups were treated with normal saline, gabapentin (30 mg/kg/day), Duloxetine at (30 mg/kg/day) and Dapoxetine (1 and 3 mg/kg/day), respectively by intraperitoneal injection. Then, thermal hyperalgesia and mechanical and thermal allodynia experiments were performed on rats. Results. The Dapoxetine-treated groups’ mean response to thermal hyperalgesia and mechanical allodynia increased on days 7 and 14. The mean response of the 3 mg/kg Dapoxetine group on day 7 was significantly higher than the control group (P <0.05). Mean response to mechanical and thermal allodynia-induced stimulation and thermal hyperactivity in the Dapoxetine group 3 mg/kg at 14 days, compared with the Dapoxetine group 1 mg/kg showed significantly better results (P <0.05). Conclusion. Dapoxetine effectively reduces the behavioral response to painful and non-painful thermal and mechanical stimuli and painful thermal and mechanical stimuli. In addition to its short-term analgesic effects, it also has long-term effects.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44626700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Petre, I. Lupescu, I. Lupescu, Mihaela Marian, Adriana Octavia Dulamea
The acute confusional state is one of the most common reasons for neurologic consultation in the hospital setting and the plethora of causes can truly be daunting. The etiology can vary from structural, metabolic, toxic to systemic infections. Our purpose is to present a rare case of acute confusional state in a patient with bilateral thalamic ischemic stroke due to occlusion of the artery of Percheron (AOP). A 79-year-old woman with a history of hypertension and surgery for lumbar disc herniation, managed on antiplatelet therapy, angiotensin receptor blocker and diuretics, was admitted for acute confusion and paresthesia of all four limbs. She had disorientation in time and space, abnormal behavior, decreased muscle strength in both lower limbs (paraparesis 2/5 MRC since the surgery), paresthesia in all four limbs and was unable to walk due to generalized weakness. Laboratory analysis showed high blood levels of cholesterol and glucose. Both head CT and cerebral MRI showed bilateral ischemic changes in the thalami, suggesting an infarct along the artery of Percheron territory. However, no clear cause for the stroke could be identified. Screening for coagulation abnormalities and autoimmune disorders (lupus anticoagulant, anti-beta-2 glycoprotein, anti-cardiolipin, anti-nuclear and anti-ds DNA antibodies) came back negative. There were no pathological finds on the echocardiogram and electrocardiogram, while cervical Doppler ultrasound showed atherosclerosis without stenosis.
{"title":"Acute confusional state in a patient with bilateral thalamic ischemic stroke","authors":"I. Petre, I. Lupescu, I. Lupescu, Mihaela Marian, Adriana Octavia Dulamea","doi":"10.37897/rjn.2022.1.11","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.11","url":null,"abstract":"The acute confusional state is one of the most common reasons for neurologic consultation in the hospital setting and the plethora of causes can truly be daunting. The etiology can vary from structural, metabolic, toxic to systemic infections. Our purpose is to present a rare case of acute confusional state in a patient with bilateral thalamic ischemic stroke due to occlusion of the artery of Percheron (AOP). A 79-year-old woman with a history of hypertension and surgery for lumbar disc herniation, managed on antiplatelet therapy, angiotensin receptor blocker and diuretics, was admitted for acute confusion and paresthesia of all four limbs. She had disorientation in time and space, abnormal behavior, decreased muscle strength in both lower limbs (paraparesis 2/5 MRC since the surgery), paresthesia in all four limbs and was unable to walk due to generalized weakness. Laboratory analysis showed high blood levels of cholesterol and glucose. Both head CT and cerebral MRI showed bilateral ischemic changes in the thalami, suggesting an infarct along the artery of Percheron territory. However, no clear cause for the stroke could be identified. Screening for coagulation abnormalities and autoimmune disorders (lupus anticoagulant, anti-beta-2 glycoprotein, anti-cardiolipin, anti-nuclear and anti-ds DNA antibodies) came back negative. There were no pathological finds on the echocardiogram and electrocardiogram, while cervical Doppler ultrasound showed atherosclerosis without stenosis.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42963025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyponatremia could be found in an ischemic stroke patient. We, herein, report series of cases on ischemic stroke patients with COVID-19 who developed hyponatremia. A diagnosis of hyponatremia was made due to COVID-19 pneumonia. The patients were managed conservatively with a significant improvement during the course of hospitalization and on follow-up.
{"title":"Severe hyponatremia in ischemic stroke with COVID-19: Case report","authors":"R. Pinzon, Advent Nara Nunsiano","doi":"10.37897/rjn.2022.1.10","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.10","url":null,"abstract":"Hyponatremia could be found in an ischemic stroke patient. We, herein, report series of cases on ischemic stroke patients with COVID-19 who developed hyponatremia. A diagnosis of hyponatremia was made due to COVID-19 pneumonia. The patients were managed conservatively with a significant improvement during the course of hospitalization and on follow-up.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47526314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/aim. Mycobacterium tuberculosis (M. tuberculosis) infection can cause pulmonary and extrapulmonary tuberculosis (TB), resulted from hematogenous or lymphatic dissemination of the bacteria. Disseminated TB is characterized by the presence of two or more non-contiguous sites from the spread. Dissemination to the central nervous system (CNS TB) has several manifestations that can cause devastating neurological complications. Several predisposing factors include older age, human immunodeficiency virus (HIV) coinfection, and pharmacological immunosuppression. As the manifestation of CNS TB itself is rare, diagnosing it remains a challenge. Prompt antituberculosis treatment is needed to improve patient’s outcome. This paper aims to present a rare case of malignant disseminated TB in a young immunocompetent patient. Case. This case presents an immunocompetent 17-year-old male with weakness in the four extremities. Through comprehensive history taking and examination, the patient was diagnosed with malignant disseminated TB, presenting as cerebellar tuberculoma, tuberculous meningitis, and multiple skipped level spondylitis TB; and concurrent pulmonary TB. Then, the patient underwent a surgery for the cervical lesion and was started on antituberculosis treatment in combination with corticosteroid. After the treatment, the patient’s motoric and sensoric functions improved and he was able to urinate and defecate normally. Conclusion. This case demonstrates the importance of considering disseminated TB in the differential diagnosis of a patient with neurological deficits, regardless of the fact that the patient is young and immunocompetent. Prompt diagnosis and rapid initiation of treatment can improve the patient’s outcome.
{"title":"A malignant disseminated tuberculosis: concurrent intracranial tuberculosis with skipped multilevel spondylitis in a young immunocompetent patient","authors":"Felisitas Farica Sutantoyo, Paulus Sugianto","doi":"10.37897/rjn.2022.1.16","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.16","url":null,"abstract":"Background/aim. Mycobacterium tuberculosis (M. tuberculosis) infection can cause pulmonary and extrapulmonary tuberculosis (TB), resulted from hematogenous or lymphatic dissemination of the bacteria. Disseminated TB is characterized by the presence of two or more non-contiguous sites from the spread. Dissemination to the central nervous system (CNS TB) has several manifestations that can cause devastating neurological complications. Several predisposing factors include older age, human immunodeficiency virus (HIV) coinfection, and pharmacological immunosuppression. As the manifestation of CNS TB itself is rare, diagnosing it remains a challenge. Prompt antituberculosis treatment is needed to improve patient’s outcome. This paper aims to present a rare case of malignant disseminated TB in a young immunocompetent patient. Case. This case presents an immunocompetent 17-year-old male with weakness in the four extremities. Through comprehensive history taking and examination, the patient was diagnosed with malignant disseminated TB, presenting as cerebellar tuberculoma, tuberculous meningitis, and multiple skipped level spondylitis TB; and concurrent pulmonary TB. Then, the patient underwent a surgery for the cervical lesion and was started on antituberculosis treatment in combination with corticosteroid. After the treatment, the patient’s motoric and sensoric functions improved and he was able to urinate and defecate normally. Conclusion. This case demonstrates the importance of considering disseminated TB in the differential diagnosis of a patient with neurological deficits, regardless of the fact that the patient is young and immunocompetent. Prompt diagnosis and rapid initiation of treatment can improve the patient’s outcome.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47088908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Occipital neuralgia (ON) is a well-known cause of headache that affecting the posterior head at the occipital nerve(s) distribution. It is a multiple-factor clinical condition resulting from the pathology of the greater, lesser or third occipital nerve. Interventional therapy, such as occipital nerve block (ONB), is one of the various modalities that could be normally considered when the conservative wasn’t satisfying. Besides as effective treatment, ONB also used as an important diagnostic procedure for occipital neuralgia. Content. Currently, there is no a complete consensus among practitioners regarding the optimal therapy for occipital neuralgia although many modalities offered. ONB traditionally performed with blinded approach relying on anatomic landmarks create the higher risks of injection in the occipital artery and/or block failure. Therefore, ONB with ultrasound guidance becomes solution to improve the safety and efficacy of therapy especially in occipital neuralgia cases. Conclusion. Occipital nerve block with ultrasound guidance is recommended as primary interventional therapy for occipital neuralgia cases.
{"title":"The role of occipital nerve block with ultrasound guidance in occipital neuralgia cases","authors":"Y. Siahaan","doi":"10.37897/rjn.2022.1.4","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.4","url":null,"abstract":"Introduction. Occipital neuralgia (ON) is a well-known cause of headache that affecting the posterior head at the occipital nerve(s) distribution. It is a multiple-factor clinical condition resulting from the pathology of the greater, lesser or third occipital nerve. Interventional therapy, such as occipital nerve block (ONB), is one of the various modalities that could be normally considered when the conservative wasn’t satisfying. Besides as effective treatment, ONB also used as an important diagnostic procedure for occipital neuralgia. Content. Currently, there is no a complete consensus among practitioners regarding the optimal therapy for occipital neuralgia although many modalities offered. ONB traditionally performed with blinded approach relying on anatomic landmarks create the higher risks of injection in the occipital artery and/or block failure. Therefore, ONB with ultrasound guidance becomes solution to improve the safety and efficacy of therapy especially in occipital neuralgia cases. Conclusion. Occipital nerve block with ultrasound guidance is recommended as primary interventional therapy for occipital neuralgia cases.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42255795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background. Materials and methods. We studied 50 cases of death with ischemic stroke and 50 cases of death with hemorrhagic stroke on the cerebral vessels AS background. Outcomes. Lymphocytes are one of the atheroma components and are mainly localised at the sites of plaque rupture in close contact with macrophages and smooth muscle cells. Smooth muscle cells are able to synthesize important collagen and elastin for the vascular wall, but potentiated apoptosis of smooth muscle cells may contribute to destabilisation and plaque rupture. Smooth muscle cells apoptosis was triggered by proinflammatory factors and took place with the participation of cytotoxic T-lymphocytes (T-killers) therefore in the atherosclerotic lesions focus we registered an accumulation of multitude cytotoxic T-lymphocytes. Conclusions. The macrophages and smooth muscle cells susceptibility to apoptosis was significantly higher directly in the atheroma, but macrophage apoptosis is a useful process for the atherosclerotic plaque stability. Desquamation and endothelial cell apoptosis are interrelated processes that play an important role in atheromatous plaque formation.
{"title":"Proliferation and apoptosis of smooth muscle and endothelial cells with immune inflammation in cerebrovascular diseases on atherosclerosis background","authors":"D. S. Mankovskiy, N. Chuiko, O. Kuryk","doi":"10.37897/rjn.2022.1.5","DOIUrl":"https://doi.org/10.37897/rjn.2022.1.5","url":null,"abstract":"The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background. Materials and methods. We studied 50 cases of death with ischemic stroke and 50 cases of death with hemorrhagic stroke on the cerebral vessels AS background. Outcomes. Lymphocytes are one of the atheroma components and are mainly localised at the sites of plaque rupture in close contact with macrophages and smooth muscle cells. Smooth muscle cells are able to synthesize important collagen and elastin for the vascular wall, but potentiated apoptosis of smooth muscle cells may contribute to destabilisation and plaque rupture. Smooth muscle cells apoptosis was triggered by proinflammatory factors and took place with the participation of cytotoxic T-lymphocytes (T-killers) therefore in the atherosclerotic lesions focus we registered an accumulation of multitude cytotoxic T-lymphocytes. Conclusions. The macrophages and smooth muscle cells susceptibility to apoptosis was significantly higher directly in the atheroma, but macrophage apoptosis is a useful process for the atherosclerotic plaque stability. Desquamation and endothelial cell apoptosis are interrelated processes that play an important role in atheromatous plaque formation.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46456120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD. Aim. This study aimed to determine the role of anthocyanins in purple sweet potato extract to prevent inflammation so as to provide a neuroprotective effect on D-galactose-induced rats. Material and methods. We used a randomized posttest only control group design. 32 male Wistar rats according to eligibility criteria were randomized into control and treatment groups. The treatment group was given purple sweet potato extract at a dose of 200mg/kgBW every day for 70 days. Both groups on day 15 induced dementia using D-galactose. Anti-inflammatory activity was evaluated from the examination of NFkB levels by ELISA technique and neuroprotective effects by immunohistochemical examination of amyloid plaque deposits. Results. The mean NFkB of the treatment group (1417.55+255.82) was lower than the control group (1672.23+202.80) which was significant (p<0.05) and the amyloid plaque deposits in the treatment group were thinner than the control group. Conclusions. Administration of purple sweet potato extract to D-galactose-induced rats caused lower NFkB levels and thinner amyloid plaque deposits. The research implication is that administration of purple sweet potato extract can prevent inflammation and provide neuroprotection effects in D-galactose-induced rats.
{"title":"The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats","authors":"K. Widyastuti, A. Laksmidewi, I. Adnyana","doi":"10.37897/rjn.2021.4.14","DOIUrl":"https://doi.org/10.37897/rjn.2021.4.14","url":null,"abstract":"Background. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD. Aim. This study aimed to determine the role of anthocyanins in purple sweet potato extract to prevent inflammation so as to provide a neuroprotective effect on D-galactose-induced rats. Material and methods. We used a randomized posttest only control group design. 32 male Wistar rats according to eligibility criteria were randomized into control and treatment groups. The treatment group was given purple sweet potato extract at a dose of 200mg/kgBW every day for 70 days. Both groups on day 15 induced dementia using D-galactose. Anti-inflammatory activity was evaluated from the examination of NFkB levels by ELISA technique and neuroprotective effects by immunohistochemical examination of amyloid plaque deposits. Results. The mean NFkB of the treatment group (1417.55+255.82) was lower than the control group (1672.23+202.80) which was significant (p<0.05) and the amyloid plaque deposits in the treatment group were thinner than the control group. Conclusions. Administration of purple sweet potato extract to D-galactose-induced rats caused lower NFkB levels and thinner amyloid plaque deposits. The research implication is that administration of purple sweet potato extract can prevent inflammation and provide neuroprotection effects in D-galactose-induced rats.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44348991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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