Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-64-68
M. Moiseeva, N. V. Bagisheva, I. Viktorova, A. Mordyk
The article describes the follow-up over a clinical case of the patient with COPD, pulmonary hypertension (PH), and history of pulmonary tuberculosis. According to the guidelines, treatment of the patient with PH which developed due to bronchopulmonary pathology was focused on constant bronchodilator therapy to reduce hypoxemia and to achieve additional vasodilating effect on vessels of the pulmonary circulation, as well as on non-invasive high-flow oxygen therapy which inhibited the progression of PH (it prevented mortality).
{"title":"Clinical Case of Pulmonary Hypertension Secondary to Chronic Obstructive Pulmonary Disease in the Patient with History of Pulmonary Tuberculosis","authors":"M. Moiseeva, N. V. Bagisheva, I. Viktorova, A. Mordyk","doi":"10.58838/2075-1230-2023-101-5-64-68","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-64-68","url":null,"abstract":"The article describes the follow-up over a clinical case of the patient with COPD, pulmonary hypertension (PH), and history of pulmonary tuberculosis. According to the guidelines, treatment of the patient with PH which developed due to bronchopulmonary pathology was focused on constant bronchodilator therapy to reduce hypoxemia and to achieve additional vasodilating effect on vessels of the pulmonary circulation, as well as on non-invasive high-flow oxygen therapy which inhibited the progression of PH (it prevented mortality).","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"1983 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-26-30
I. Burmistrova, E. Vaniev, A. Samoylova, O. Lovacheva, I. A. Vasilyeva
The objective: to evaluate the efficacy of chemotherapy regimens for isoniazid resistant pulmonary tuberculosis (Hr-TB): short-course regimen consisting of 4 components (non-injection) and the regimen consisting of 5 components (standard regimen).Subjects and Methods. Medical records of 292 pulmonary tuberculosis patients with resistance to isoniazid were retrospectively studied. In 89 patients (Group A), the regimen containing rifampicin, pyrazinamide, ethambutol, and levofloxacin was used – a 4-component non-injection regimen (180±20 doses). In 203 patients (Group B), the regimen containing rifampicin, pyrazinamide, ethambutol, levofloxacin, and amikacin/kanamycin was used - a 5-component standard regimen (270 doses).Results. The efficacy of treatment of isoniazid resistant pulmonary tuberculosis was similar, while a short-term 4-component (non-injection) regimen is 4.5 times less expensive versus the standard 5-component regimen. Treatment success made 88.8% and 88.2% respectively, p>0.05.
{"title":"Efficacy of Various Approaches to Treatment of Patients with Isoniazid Resistant Pulmonary Tuberculosis","authors":"I. Burmistrova, E. Vaniev, A. Samoylova, O. Lovacheva, I. A. Vasilyeva","doi":"10.58838/2075-1230-2023-101-5-26-30","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-26-30","url":null,"abstract":"The objective: to evaluate the efficacy of chemotherapy regimens for isoniazid resistant pulmonary tuberculosis (Hr-TB): short-course regimen consisting of 4 components (non-injection) and the regimen consisting of 5 components (standard regimen).Subjects and Methods. Medical records of 292 pulmonary tuberculosis patients with resistance to isoniazid were retrospectively studied. In 89 patients (Group A), the regimen containing rifampicin, pyrazinamide, ethambutol, and levofloxacin was used – a 4-component non-injection regimen (180±20 doses). In 203 patients (Group B), the regimen containing rifampicin, pyrazinamide, ethambutol, levofloxacin, and amikacin/kanamycin was used - a 5-component standard regimen (270 doses).Results. The efficacy of treatment of isoniazid resistant pulmonary tuberculosis was similar, while a short-term 4-component (non-injection) regimen is 4.5 times less expensive versus the standard 5-component regimen. Treatment success made 88.8% and 88.2% respectively, p>0.05.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"678 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-69-76
M. Lozovskaya, I. Y. Motov, G. A. Novik
The article presents the review of 61 publications. The topic is highly relevant due to the fact that clinical trials of drugs and chemotherapy regimens usually enroll adults, while children participate only in a small number of them. Often in clinical practice, anti-tuberculosis drugs are prescribed to children off-label. The frequency of adverse reactions in children varies widely depending on approaches to their reporting. The most severe and frequent adverse events are associated with liver injury. In recent years, clinical trials of fluoroquinolones, bedaquiline, and delamanid were run in pediatric patients with drug resistant tuberculosis demonstrating satisfactory tolerability and safety of these drugs.
{"title":"Tolerability of Tuberculosis Chemotherapy in Children","authors":"M. Lozovskaya, I. Y. Motov, G. A. Novik","doi":"10.58838/2075-1230-2023-101-5-69-76","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-69-76","url":null,"abstract":"The article presents the review of 61 publications. The topic is highly relevant due to the fact that clinical trials of drugs and chemotherapy regimens usually enroll adults, while children participate only in a small number of them. Often in clinical practice, anti-tuberculosis drugs are prescribed to children off-label. The frequency of adverse reactions in children varies widely depending on approaches to their reporting. The most severe and frequent adverse events are associated with liver injury. In recent years, clinical trials of fluoroquinolones, bedaquiline, and delamanid were run in pediatric patients with drug resistant tuberculosis demonstrating satisfactory tolerability and safety of these drugs.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"1975 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-51-58
I. F. Shlyk, D. Kudlay, E. Kampos, N. Nikolenko, I. M. Franchuk
The objective: to evaluate effectiveness of treatment of infiltrative pulmonary tuberculosis patients with exudative or productive types of the tissue inflammatory reaction when additional immunotherapy with recombinant IFN-γ is used.Subjects and Methods. 127 infiltrative tuberculosis patients were enrolled in the study, of them 66 had an exudative type of the inflammatory reaction (2 Groups OG-1 and GS-1 were formed), 61 had a proliferative type (2 Groups OG-2 and GS-2 were formed). Patients from OG-1 and OG-2 Groups additionally received different regimens with recombinant interferon-γ.Result: Comprehensive treatment of infiltrative tuberculosis including intramuscular administration (according to a certain regimen) of recombinant IFN-γ contributes to achievement of pronounced positive changes of clinical and radiological symptoms in patients with both exudative and productive types of the tissue inflammatory reaction. In the groups treated with recombinant IFN-γ, restoration of the cellular immune response, cellular cooperation, normalization of the cytokine profile and increased phagocytosis activity were confirmed by the results of laboratory tests.
{"title":"Specific Features of Pulmonary Tuberculosis Patients Treatment with Interferon-Gamma Depending on the Nature of the Tissue Inflammatory Reaction","authors":"I. F. Shlyk, D. Kudlay, E. Kampos, N. Nikolenko, I. M. Franchuk","doi":"10.58838/2075-1230-2023-101-5-51-58","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-51-58","url":null,"abstract":"The objective: to evaluate effectiveness of treatment of infiltrative pulmonary tuberculosis patients with exudative or productive types of the tissue inflammatory reaction when additional immunotherapy with recombinant IFN-γ is used.Subjects and Methods. 127 infiltrative tuberculosis patients were enrolled in the study, of them 66 had an exudative type of the inflammatory reaction (2 Groups OG-1 and GS-1 were formed), 61 had a proliferative type (2 Groups OG-2 and GS-2 were formed). Patients from OG-1 and OG-2 Groups additionally received different regimens with recombinant interferon-γ.Result: Comprehensive treatment of infiltrative tuberculosis including intramuscular administration (according to a certain regimen) of recombinant IFN-γ contributes to achievement of pronounced positive changes of clinical and radiological symptoms in patients with both exudative and productive types of the tissue inflammatory reaction. In the groups treated with recombinant IFN-γ, restoration of the cellular immune response, cellular cooperation, normalization of the cytokine profile and increased phagocytosis activity were confirmed by the results of laboratory tests.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"2019 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-45-50
T. Kononova, O. Urazova, V. Serebryakova, S. Chumakova, O. A. Vasilyeva, A. E. Sanina
The objective: to evaluate the role of IL-23 in the development of Th17 lymphocytes in patients with different clinical and pathogenetic forms of pulmonary tuberculosis.Subjects and Methods. 165 pulmonary tuberculosis patients were examined. Venous blood was used for tests. Mononuclear leukocytes were isolated by centrifugation and monocytes were extracted and transformed into dendritic cells. The concentration of IL-23 in the supernatants of culture suspensions of dendritic cells was determined by ELISA. Immunophenotyping of Th17 lymphocytes (CD4+CD161+IL-17A+ cells) was performed by flow cytometry. Real-time PCR was used to determine the expression of the RORC2 transcription factor gene in lymphocytes.Results. In patients with infiltrative drug susceptible and drug resistant pulmonary tuberculosis against the background of normal production of IL-23 by dendritic cells, an increase in blood level of Th17 lymphocytes and the level of mRNA of the RORC2 transcription factor gene was registered. The course of disseminated pulmonary tuberculosis (regardless of drug susceptibility and resistance) is associated with pronounced decrease in the concentration of IL-23 in vitro and the absence of response from Th17 lymphocytes.
{"title":"The Role of IL-23 in the Development of Th17 Lymphocytes in Pulmonary Tuberculosis Patients","authors":"T. Kononova, O. Urazova, V. Serebryakova, S. Chumakova, O. A. Vasilyeva, A. E. Sanina","doi":"10.58838/2075-1230-2023-101-5-45-50","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-45-50","url":null,"abstract":"The objective: to evaluate the role of IL-23 in the development of Th17 lymphocytes in patients with different clinical and pathogenetic forms of pulmonary tuberculosis.Subjects and Methods. 165 pulmonary tuberculosis patients were examined. Venous blood was used for tests. Mononuclear leukocytes were isolated by centrifugation and monocytes were extracted and transformed into dendritic cells. The concentration of IL-23 in the supernatants of culture suspensions of dendritic cells was determined by ELISA. Immunophenotyping of Th17 lymphocytes (CD4+CD161+IL-17A+ cells) was performed by flow cytometry. Real-time PCR was used to determine the expression of the RORC2 transcription factor gene in lymphocytes.Results. In patients with infiltrative drug susceptible and drug resistant pulmonary tuberculosis against the background of normal production of IL-23 by dendritic cells, an increase in blood level of Th17 lymphocytes and the level of mRNA of the RORC2 transcription factor gene was registered. The course of disseminated pulmonary tuberculosis (regardless of drug susceptibility and resistance) is associated with pronounced decrease in the concentration of IL-23 in vitro and the absence of response from Th17 lymphocytes.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"2010 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-20-25
A. V. Mikheev, S. N. Trushin
The objective: to analyze results of surgical treatment of the patients with spontaneous pneumothorax.Subjects and Methods. Medical records of patients with spontaneous pneumothorax (SP) who were treated in Surgical Thoracic Department of Ryazan Regional Clinical Hospital from 1998 to 2021 were retrospectively analyzed. The article describes the experience of treatment of 738 cases of spontaneous pneumothorax within one medical center. The evolution of tactics and principles of surgical treatment over a 23-year period is presented. The incidence of spontaneous pneumothorax and efficacy of different surgical options were analyzed. The recurrence of spontaneous pneumothorax was recorded in the following cases: after pleural cavity drainage – in 19.7%, after videothoracoscopic resection of bullous parts of the lung in combination with subtotal parietal pleurectomy – in 2.1%.
{"title":"Many years of experience of spontaneous pneumothorax treatment within one medical center","authors":"A. V. Mikheev, S. N. Trushin","doi":"10.58838/2075-1230-2023-101-5-20-25","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-20-25","url":null,"abstract":"The objective: to analyze results of surgical treatment of the patients with spontaneous pneumothorax.Subjects and Methods. Medical records of patients with spontaneous pneumothorax (SP) who were treated in Surgical Thoracic Department of Ryazan Regional Clinical Hospital from 1998 to 2021 were retrospectively analyzed. The article describes the experience of treatment of 738 cases of spontaneous pneumothorax within one medical center. The evolution of tactics and principles of surgical treatment over a 23-year period is presented. The incidence of spontaneous pneumothorax and efficacy of different surgical options were analyzed. The recurrence of spontaneous pneumothorax was recorded in the following cases: after pleural cavity drainage – in 19.7%, after videothoracoscopic resection of bullous parts of the lung in combination with subtotal parietal pleurectomy – in 2.1%.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"405 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-24DOI: 10.58838/2075-1230-2023-101-5-59-63
A. V. Kukurika, L. Parolina
The article presents a long-term follow-up of a family nidus of tuberculosis infection demonstrating the incidence among adult contacts including 6 years after taking off the register of dispensary follow-up.
{"title":"Long-term Follow-up of Family Nidus of Tuberculosis Infection","authors":"A. V. Kukurika, L. Parolina","doi":"10.58838/2075-1230-2023-101-5-59-63","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-5-59-63","url":null,"abstract":"The article presents a long-term follow-up of a family nidus of tuberculosis infection demonstrating the incidence among adult contacts including 6 years after taking off the register of dispensary follow-up.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"355 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-27DOI: 10.58838/2075-1230-2023-101-1s-32-38
E. M. Zhukova, N. V. Stavitskaya, E. Yu. Pushkareva, O. A. Smolentseva
The objective: to evaluate the main eff ects of surfactant inhalations during the intensive phase of chemotherapy with the regimen containing bedaquiline and linezolid in HIV-infected patients with multiple drug resistant tuberculosis. Subjects and Methods. A single-center, open-label, controlled prospective cohort study was conducted. 80 patients with MDR-TB/HIV were enrolled in the study and randomized into two groups: ST+ Group included 40 patients who in addition to anti-tuberculosis therapy containing bedaquiline and linezolid during the intensive phase received inhalation of the suspension of Surfactant-BL according to a certain regimen. The course of 28 inhalations took 2 months, the total dose of surfactant was 700 mg. ST- Group included 40 patients who received anti-tuberculosis therapy only. To assess the severity of respiratory symptoms in patients, we used our own scoring. All patients also received antiretroviral therapy. Results. In the ST+ Group versus ST- Group, there was a decrease in the severity of tuberculosis clinical manifestations and timing of their relief, higher frequency of cavity healing by 21.2%, and faster sputum conversion by 28.6%. These rates are higher than in ST- Group and this is a short period of 10 weeks. None of the patients developed adverse reactions to surfactant inhalations. Patients tolerated well the combination of surfactant therapy, MDR TB chemotherapy containing bedaquiline and linezolid, and ART.
{"title":"Inhalation Surfactant Therapy within Comprehensive Treatment of HIV-Infected Patients with Multiple Drug Resistant Tuberculosis","authors":"E. M. Zhukova, N. V. Stavitskaya, E. Yu. Pushkareva, O. A. Smolentseva","doi":"10.58838/2075-1230-2023-101-1s-32-38","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-1s-32-38","url":null,"abstract":"The objective: to evaluate the main eff ects of surfactant inhalations during the intensive phase of chemotherapy with the regimen containing bedaquiline and linezolid in HIV-infected patients with multiple drug resistant tuberculosis. Subjects and Methods. A single-center, open-label, controlled prospective cohort study was conducted. 80 patients with MDR-TB/HIV were enrolled in the study and randomized into two groups: ST+ Group included 40 patients who in addition to anti-tuberculosis therapy containing bedaquiline and linezolid during the intensive phase received inhalation of the suspension of Surfactant-BL according to a certain regimen. The course of 28 inhalations took 2 months, the total dose of surfactant was 700 mg. ST- Group included 40 patients who received anti-tuberculosis therapy only. To assess the severity of respiratory symptoms in patients, we used our own scoring. All patients also received antiretroviral therapy. Results. In the ST+ Group versus ST- Group, there was a decrease in the severity of tuberculosis clinical manifestations and timing of their relief, higher frequency of cavity healing by 21.2%, and faster sputum conversion by 28.6%. These rates are higher than in ST- Group and this is a short period of 10 weeks. None of the patients developed adverse reactions to surfactant inhalations. Patients tolerated well the combination of surfactant therapy, MDR TB chemotherapy containing bedaquiline and linezolid, and ART.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"8 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-27DOI: 10.58838/2075-1230-2023-101-1s-26-31
Zh. A. Laushkina, S. V. Sklyuev, D. V. Krasnov, D. A. Skvortsov, N. V. Stavitskaya
The objective: to study the frequency and nature of postoperative complications, immediate and postponed results of resection interventions in pulmonary tuberculosis patients depending on the presence and pathomorphological parameters of local infl ammatory changes in the bronchial tree. Subjects and Methods. 147 pulmonary tuberculosis patients who underwent pulmonary resection were enrolled in the prospective cohort study. Main Group ( n =49) included patients with local infl ammatory changes in the bronchi before surgery; Comparison Group ( n =98) included patients with no infl ammatory changes in the bronchi. Results. The presence of local infl ammatory changes in the bronchial tree detected by bronchoscopy, did not have a signifi cant impact on the development of complications during surgical treatment - neither on their number nor on structure. The incidence of complications of resection interventions depends on severity of tuberculosis lesions in the lung.
{"title":"Immediate and postponed results of resection interventions in pulmonary tuberculosis patients with local inflammatory changes in the bronchial tree","authors":"Zh. A. Laushkina, S. V. Sklyuev, D. V. Krasnov, D. A. Skvortsov, N. V. Stavitskaya","doi":"10.58838/2075-1230-2023-101-1s-26-31","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-1s-26-31","url":null,"abstract":"The objective: to study the frequency and nature of postoperative complications, immediate and postponed results of resection interventions in pulmonary tuberculosis patients depending on the presence and pathomorphological parameters of local infl ammatory changes in the bronchial tree. Subjects and Methods. 147 pulmonary tuberculosis patients who underwent pulmonary resection were enrolled in the prospective cohort study. Main Group ( n =49) included patients with local infl ammatory changes in the bronchi before surgery; Comparison Group ( n =98) included patients with no infl ammatory changes in the bronchi. Results. The presence of local infl ammatory changes in the bronchial tree detected by bronchoscopy, did not have a signifi cant impact on the development of complications during surgical treatment - neither on their number nor on structure. The incidence of complications of resection interventions depends on severity of tuberculosis lesions in the lung.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"9 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-27DOI: 10.58838/2075-1230-2023-101-1s-39-44
O. A. Serov, O. A. Smolentseva
The objective: to study the impact of transcranial mesodiencephalic modulation on eff ectiveness of comprehensive treatment of pulmonary tuberculosis patients with various comorbidities. Subjects and Methods. 48 patients who received standard regimens of anti-tuberculosis chemotherapy participated in the study; the patients were divided into two groups. In Group 1, patients additionally underwent sessions of mesodiencephalic modulation (MDM), while in Group 2, no MDM was administered. Results. Two months after the start of the study, in Group 1, positive radiological changes were recorded more often – in 91,7% (22/24), in Group 2, positive changes were observed in 62,5% (15/24) of patients ( p =0,047; χ2); the same pattern was observed with positive changes of laboratory rates – 91,7% (22/24) versus 66,7% (16/24), ( p =0,033; χ2), respectively. In patients of Group 1 compared to Group 2, symptoms of tuberculosis and comorbid conditions fully disappeared or became less intensive in 79,2% (19/24) versus 41,7% (10/24), ( p =0,009; χ2). In Group 1, adverse drug reactions were registered in 16,7% (4/24), in Group 2 – 43,5% (10/24), ( p =0,05; χ2).
{"title":"Evaluation of effectiveness of transcranial mesodiencephalic modulation within comprehensive treatment of pulmonary tuberculosis patients with various comorbidities","authors":"O. A. Serov, O. A. Smolentseva","doi":"10.58838/2075-1230-2023-101-1s-39-44","DOIUrl":"https://doi.org/10.58838/2075-1230-2023-101-1s-39-44","url":null,"abstract":"The objective: to study the impact of transcranial mesodiencephalic modulation on eff ectiveness of comprehensive treatment of pulmonary tuberculosis patients with various comorbidities. Subjects and Methods. 48 patients who received standard regimens of anti-tuberculosis chemotherapy participated in the study; the patients were divided into two groups. In Group 1, patients additionally underwent sessions of mesodiencephalic modulation (MDM), while in Group 2, no MDM was administered. Results. Two months after the start of the study, in Group 1, positive radiological changes were recorded more often – in 91,7% (22/24), in Group 2, positive changes were observed in 62,5% (15/24) of patients ( p =0,047; χ2); the same pattern was observed with positive changes of laboratory rates – 91,7% (22/24) versus 66,7% (16/24), ( p =0,033; χ2), respectively. In patients of Group 1 compared to Group 2, symptoms of tuberculosis and comorbid conditions fully disappeared or became less intensive in 79,2% (19/24) versus 41,7% (10/24), ( p =0,009; χ2). In Group 1, adverse drug reactions were registered in 16,7% (4/24), in Group 2 – 43,5% (10/24), ( p =0,05; χ2).","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136263079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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