Pub Date : 2024-07-04DOI: 10.58838/2075-1230-2024-102-3-18-23
Yu. M. Markelov, E. V. Pakhomova, T. Sunchalina
The objective: to determine the effectiveness of detection of patients with pulmonary tuberculosis and prevention of its spread by sputum microscopy in clinical diagnostic laboratories of general medical services of the Republic of Karelia.Results. A reduction in the number of sputum microscopy tests in clinical laboratories of GMS and decrease in the positivity rate to 0.66% was revealed. Among new tuberculosis patients with rifampicin resistance, 51% had abundant bacterial excretion (AFB 2+ and 3+); according to sputum microscopy, tuberculous mycobacteria susceptible to rifampicin were isolated in 38%. In the Republic of Karelia, 31.7% of tuberculosis patients were detected in in-patient units of GMS: 60% of them had cavities, and 28.8% had abundant bacterial excretion (AFB 2+ and 3+). The poor quality of sputum microscopy is the cause of late detection of tuberculosis in the Republic of Karelia and promotes the spread of MDR tuberculosis strains among the population, including nosocomial infection.
{"title":"Problems of Detecting Tuberculosis by Sputum Microscopy in General Medical Services in the Republic of Karelia","authors":"Yu. M. Markelov, E. V. Pakhomova, T. Sunchalina","doi":"10.58838/2075-1230-2024-102-3-18-23","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-3-18-23","url":null,"abstract":"The objective: to determine the effectiveness of detection of patients with pulmonary tuberculosis and prevention of its spread by sputum microscopy in clinical diagnostic laboratories of general medical services of the Republic of Karelia.Results. A reduction in the number of sputum microscopy tests in clinical laboratories of GMS and decrease in the positivity rate to 0.66% was revealed. Among new tuberculosis patients with rifampicin resistance, 51% had abundant bacterial excretion (AFB 2+ and 3+); according to sputum microscopy, tuberculous mycobacteria susceptible to rifampicin were isolated in 38%. In the Republic of Karelia, 31.7% of tuberculosis patients were detected in in-patient units of GMS: 60% of them had cavities, and 28.8% had abundant bacterial excretion (AFB 2+ and 3+). The poor quality of sputum microscopy is the cause of late detection of tuberculosis in the Republic of Karelia and promotes the spread of MDR tuberculosis strains among the population, including nosocomial infection.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.58838/2075-1230-2024-102-3-12-17
T. Tayutina, D. Kudlay, L. Shovkun, N. Nikolenko, E. Kampos
The objective: to evaluate the effect of chronic obstructive pulmonary disease on the severity of silent myocardial ischemia in patients with arterial hypertension.Subjects and Methods. Examinations and follow-up of 194 COPD patients who were undergoing outpatient follow-up and treatment were analyzed. Those patients suffered from COPD with concurrent arterial hypertension or isolated arterial hypertension.Results. Holter ECG monitoring should be done in all COPD patients regardless of severity of the disease and presence of comorbid conditions. This is due to the high prevalence of silent myocardial ischemia in such patients.
{"title":"Assessing the Impact of Chronic Obstructive Pulmonary Disease on Severity of Silent Myocardial Ischemia in Patients with Arterial Hypertension","authors":"T. Tayutina, D. Kudlay, L. Shovkun, N. Nikolenko, E. Kampos","doi":"10.58838/2075-1230-2024-102-3-12-17","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-3-12-17","url":null,"abstract":"The objective: to evaluate the effect of chronic obstructive pulmonary disease on the severity of silent myocardial ischemia in patients with arterial hypertension.Subjects and Methods. Examinations and follow-up of 194 COPD patients who were undergoing outpatient follow-up and treatment were analyzed. Those patients suffered from COPD with concurrent arterial hypertension or isolated arterial hypertension.Results. Holter ECG monitoring should be done in all COPD patients regardless of severity of the disease and presence of comorbid conditions. This is due to the high prevalence of silent myocardial ischemia in such patients.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.58838/2075-1230-2024-102-2-86-96
N. V. Yukhimenko, S. Sterlikova, M. Gubkina, S. Kayukova
The review analyzes 69 publications, of which 45 are devoted to studying gut microbiota in tuberculosis patients. The review presents data on the effect of gut microbiota disorders on the development of tuberculosis, severity and relapse rate. It covers the issues of changes in gut microbiota composition during anti-tuberculosis therapy and the effect of their management with probiotics on the tolerability of anti-tuberculosis therapy and effectiveness of treatment, including children.
{"title":"Gut Microbiota and Pulmonary Tuberculosis (Literature Review)","authors":"N. V. Yukhimenko, S. Sterlikova, M. Gubkina, S. Kayukova","doi":"10.58838/2075-1230-2024-102-2-86-96","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-86-96","url":null,"abstract":"The review analyzes 69 publications, of which 45 are devoted to studying gut microbiota in tuberculosis patients. The review presents data on the effect of gut microbiota disorders on the development of tuberculosis, severity and relapse rate. It covers the issues of changes in gut microbiota composition during anti-tuberculosis therapy and the effect of their management with probiotics on the tolerability of anti-tuberculosis therapy and effectiveness of treatment, including children.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141019352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.58838/2075-1230-2024-102-2-78-85
O. A. But, L. Telegina, S. S. Pirogov, A. Vodoleev, D. Sukhin, A. Kaprin
The most severe manifestation of COVID-19 is bilateral pneumonia with development of acute respiratory distress syndrome accompanied by cytokine storm, pulmonary edema and death of the patient. In a number of patients, occurrence of mucormycosis of mucous membranes was one of the stages of the lethal outcome development. The arctile presents a clinical case of mucormycosis of the tracheobronchial tree detected by bronchoscopy several days before death in a patient with COVID-19 who was on mechanical ventilation. The endoscopic signs (endoscopic image) are described.
{"title":"Endoscopic Changes of Tracheobronchial Tree Caused by Mucormycosis in Patients with a Novel Coronavirus Infection","authors":"O. A. But, L. Telegina, S. S. Pirogov, A. Vodoleev, D. Sukhin, A. Kaprin","doi":"10.58838/2075-1230-2024-102-2-78-85","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-78-85","url":null,"abstract":"The most severe manifestation of COVID-19 is bilateral pneumonia with development of acute respiratory distress syndrome accompanied by cytokine storm, pulmonary edema and death of the patient. In a number of patients, occurrence of mucormycosis of mucous membranes was one of the stages of the lethal outcome development. The arctile presents a clinical case of mucormycosis of the tracheobronchial tree detected by bronchoscopy several days before death in a patient with COVID-19 who was on mechanical ventilation. The endoscopic signs (endoscopic image) are described.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"10 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141021469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.58838/2075-1230-2024-102-2-52-61
M. I. Romanova, A. I. Gayda, A. Abramchenko, G. Mozhokina, O. Lovacheva
The objective: to study effectiveness of surgical methods for treatment of various forms of destructive pulmonary tuberculosis (meta-analysis).Subjects and Methods. A systematic search was performed in electronic bibliographic databases, including PubMed and Google Scholar. Cohort studies published from January 1, 2019 to June 20, 2023 were selected, those studies were aimed to assess effectiveness of surgical treatment in patients with destructive tuberculosis using resections of various volume. For meta-analysis, 9 studies published in 2019 - 2023 were selected.Results. The effectiveness of comprehensive treatment with resections of various volume in destructive pulmonary tuberculosis patients made 85.3%. The success of surgical treatment in patients with fibrous cavernous pulmonary tuberculosis was somewhat less – 80.3%. At the same time, the incidence of postoperative complications in patients with fibrous cavernous pulmonary tuberculosis was higher and could reach 42.5%, while in the group patients with destructive tuberculosis, it was 27.3%. Some postoperative complications required repeated operations. The ratio of surgeries to patients was the following: 3263 surgical interventions per 1564 patients (average 2.08 surgeries per patient). Hospital lethality among patients with fibrous cavernous pulmonary tuberculosis after surgical treatment was 2.6%, and tuberculosis mortality within 5 years after surgery was 4.8%. The relapse rate among patients with fibrous cavernous pulmonary tuberculosis after surgical treatment was 7.1%.
{"title":"Effectiveness of Surgical Treatment of Patients with Destructive Pulmonary Tuberculosis (Meta-Analysis)","authors":"M. I. Romanova, A. I. Gayda, A. Abramchenko, G. Mozhokina, O. Lovacheva","doi":"10.58838/2075-1230-2024-102-2-52-61","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-52-61","url":null,"abstract":"The objective: to study effectiveness of surgical methods for treatment of various forms of destructive pulmonary tuberculosis (meta-analysis).Subjects and Methods. A systematic search was performed in electronic bibliographic databases, including PubMed and Google Scholar. Cohort studies published from January 1, 2019 to June 20, 2023 were selected, those studies were aimed to assess effectiveness of surgical treatment in patients with destructive tuberculosis using resections of various volume. For meta-analysis, 9 studies published in 2019 - 2023 were selected.Results. The effectiveness of comprehensive treatment with resections of various volume in destructive pulmonary tuberculosis patients made 85.3%. The success of surgical treatment in patients with fibrous cavernous pulmonary tuberculosis was somewhat less – 80.3%. At the same time, the incidence of postoperative complications in patients with fibrous cavernous pulmonary tuberculosis was higher and could reach 42.5%, while in the group patients with destructive tuberculosis, it was 27.3%. Some postoperative complications required repeated operations. The ratio of surgeries to patients was the following: 3263 surgical interventions per 1564 patients (average 2.08 surgeries per patient). Hospital lethality among patients with fibrous cavernous pulmonary tuberculosis after surgical treatment was 2.6%, and tuberculosis mortality within 5 years after surgery was 4.8%. The relapse rate among patients with fibrous cavernous pulmonary tuberculosis after surgical treatment was 7.1%. ","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"2014 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.58838/2075-1230-2024-102-1-70-76
E. V. Egorov, T. A. Naumova, A. I. Gayda, Kh. B. Dadasheva, O. Lovacheva
The article describes a clinical case of generalized tuberculosis manifested by tuberculous spondylodiscitis and disseminated pulmonary tuberculosis with extensive drug resistance and bilateral multiple destruction. The chemotherapy regimen compiled according to the sensitivity pattern of the pathogen, sequential implantation of two endobronchial valves and their long-term (18 months) synergic effect made it possible to cure pulmonary tuberculosis with healing of all multiple bilateral destruction. The same chemotherapy regimens allowed achieving cure of tuberculous spondylodiscitis. Co-infection of hepatitis C provided no negative impact on the treatment course.
{"title":"Comprehensive Treatment of Generalized Tuberculosis with Endobronchial Valves","authors":"E. V. Egorov, T. A. Naumova, A. I. Gayda, Kh. B. Dadasheva, O. Lovacheva","doi":"10.58838/2075-1230-2024-102-1-70-76","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-70-76","url":null,"abstract":"The article describes a clinical case of generalized tuberculosis manifested by tuberculous spondylodiscitis and disseminated pulmonary tuberculosis with extensive drug resistance and bilateral multiple destruction. The chemotherapy regimen compiled according to the sensitivity pattern of the pathogen, sequential implantation of two endobronchial valves and their long-term (18 months) synergic effect made it possible to cure pulmonary tuberculosis with healing of all multiple bilateral destruction. The same chemotherapy regimens allowed achieving cure of tuberculous spondylodiscitis. Co-infection of hepatitis C provided no negative impact on the treatment course.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"61 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141042534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.58838/2075-1230-2024-102-2-44-51
G. Yakovlev, P. Ionov, D. V. Alkaz, T. Basek, G. Boyarkin, A. Elkin
The objective: to specify indications for extrapleural thoracoplasty in patients with destructive pulmonary tuberculosis and comorbid HIV infection.Subjects and Methods. Results of surgical treatment of 78 destructive pulmonary tuberculosis patients were studied. Those patients underwent extrapleural thoracoplasty in Pulmonary Tuberculosis Surgery Unit of City Tuberculosis Hospital No. 2 in St. Petersburg from 2009 to 2022.Results. The article clarifies the indications for extrapleural thoracoplasty in patients with destructive pulmonary tuberculosis and comorbid HIV infection, in whom contraindications to pulmonary resections have been identified. Medical records of 78 patients with destructive tuberculosis were retrospectively analyzed, the patients were divided into two groups according to their HIV status. It has been established that with combination of adequate preoperative preparation and postoperative management, rational anti-tuberculosis chemotherapy and ART, extrapleural thoracoplasty for HIV-positive patients can be performed in accordance with general practice.
{"title":"Indications for Extrapleural Thoracoplasty in HIV-Positive Patients with Destructive Pulmonary Tuberculosis","authors":"G. Yakovlev, P. Ionov, D. V. Alkaz, T. Basek, G. Boyarkin, A. Elkin","doi":"10.58838/2075-1230-2024-102-2-44-51","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-44-51","url":null,"abstract":"The objective: to specify indications for extrapleural thoracoplasty in patients with destructive pulmonary tuberculosis and comorbid HIV infection.Subjects and Methods. Results of surgical treatment of 78 destructive pulmonary tuberculosis patients were studied. Those patients underwent extrapleural thoracoplasty in Pulmonary Tuberculosis Surgery Unit of City Tuberculosis Hospital No. 2 in St. Petersburg from 2009 to 2022.Results. The article clarifies the indications for extrapleural thoracoplasty in patients with destructive pulmonary tuberculosis and comorbid HIV infection, in whom contraindications to pulmonary resections have been identified. Medical records of 78 patients with destructive tuberculosis were retrospectively analyzed, the patients were divided into two groups according to their HIV status. It has been established that with combination of adequate preoperative preparation and postoperative management, rational anti-tuberculosis chemotherapy and ART, extrapleural thoracoplasty for HIV-positive patients can be performed in accordance with general practice.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141037732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.58838/2075-1230-2024-102-2-36-42
P. I. Eliseev, E. Nikishova, A. Y. Krupskaya, V. I. Shtraukh, E. Khimova, A. Maryandyshev
The objective: to evaluate results of M. tuberculosis detection and testing drug susceptibility to rifampicin using molecular genetic methods in tuberculosis patients with a negative sputum smear microscopy result.Subjects and Methods. Pulmonary tuberculosis patients registered in Arkhangelsk Region from 2016 to 2020 were enrolled in the study; those patients were notified as new cases and relapses with a negative sputum smear microscopy result before treatment and had results of molecular genetic testing (MGT) (Xpert MTB/RIF MTB/RIF) and BACTEC MGIT 960 available.Results. 479 people (40%) were registered as pulmonary tuberculosis cases with a negative sputum smear microscopy result. MGT was performed in 327 (68%) patients. A positive result of MGT was received in 120 (37%) patients, a positive result of BACTEC MGIT 960 was received in 165 (50%) people. Concordance of results was observed in 70% of cases. In 136 (41%) people, both tests did not detect Mycobacterium tuberculosis, in 95 (29%) both tests showed a positive result. Discrepancies between the results of two tests were observed in 30% of cases. In 71 (22%) cases, culture growth was observed in BACTEC MGIT 960 with negative results of MGT. In 8% of cases, DNA of Mycobacterium tuberculosis was detected, but there was no culture growth on the nutrient medium. 43/120 (36%) cases of resistance to rifampicin were detected. The median time from sputum collection to initiation of MDR-TB treatment based on sputum MGT results made 18 (IQR 10–29) days. Molecular genetic testing makes it possible to promptly detect the majority of TB patients with a negative sputum smear result, and reduce the time for drug susceptibility testing, which allows this testing to be used as the first test when examining for pulmonary TB.
{"title":"Detection of M. tuberculosis Using Cartridge-Based Technology in Patients with Negative Sputum Microscopy Results in a Regional Laboratory","authors":"P. I. Eliseev, E. Nikishova, A. Y. Krupskaya, V. I. Shtraukh, E. Khimova, A. Maryandyshev","doi":"10.58838/2075-1230-2024-102-2-36-42","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-36-42","url":null,"abstract":"The objective: to evaluate results of M. tuberculosis detection and testing drug susceptibility to rifampicin using molecular genetic methods in tuberculosis patients with a negative sputum smear microscopy result.Subjects and Methods. Pulmonary tuberculosis patients registered in Arkhangelsk Region from 2016 to 2020 were enrolled in the study; those patients were notified as new cases and relapses with a negative sputum smear microscopy result before treatment and had results of molecular genetic testing (MGT) (Xpert MTB/RIF MTB/RIF) and BACTEC MGIT 960 available.Results. 479 people (40%) were registered as pulmonary tuberculosis cases with a negative sputum smear microscopy result. MGT was performed in 327 (68%) patients. A positive result of MGT was received in 120 (37%) patients, a positive result of BACTEC MGIT 960 was received in 165 (50%) people. Concordance of results was observed in 70% of cases. In 136 (41%) people, both tests did not detect Mycobacterium tuberculosis, in 95 (29%) both tests showed a positive result. Discrepancies between the results of two tests were observed in 30% of cases. In 71 (22%) cases, culture growth was observed in BACTEC MGIT 960 with negative results of MGT. In 8% of cases, DNA of Mycobacterium tuberculosis was detected, but there was no culture growth on the nutrient medium. 43/120 (36%) cases of resistance to rifampicin were detected. The median time from sputum collection to initiation of MDR-TB treatment based on sputum MGT results made 18 (IQR 10–29) days. Molecular genetic testing makes it possible to promptly detect the majority of TB patients with a negative sputum smear result, and reduce the time for drug susceptibility testing, which allows this testing to be used as the first test when examining for pulmonary TB. ","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.58838/2075-1230-2024-102-2-62-67
O. S. Sheloumova, N. V. Zolotova
The objective: to analyze changes in psycho-emotional status of children ill with respiratory tuberculosis (RTB) in the perioperative period while the children were provided with psychological support.Subjects and Methods. 15 respiratory tuberculosis patients aged 7−12 years who received psychological support during surgical treatment were enrolled in the study. The data of psychological examination in the preoperative, early postoperative and late postoperative periods are presented.Results. In the preoperative period, the vast majority of children with respiratory tuberculosis showed a higher level of neuropsychic tension (86.7% of patients) and anxiety (73.3% of patients). When psychological support was provided during surgical treatment, the program of which was based on EMDR approach and mindfulness, in the early postoperative period, there was a significant decrease in the number of children with a high level of neuropsychic tension – from 86.7% to 46.7% (p<0. 01). At the beginning of the late postoperative period, parameters of psychoemotional status in the overwhelming majority of children were within the range of normal values.
{"title":"Psychological Support during Surgical Treatment of Children Ill with Respiratory Tuberculosis","authors":"O. S. Sheloumova, N. V. Zolotova","doi":"10.58838/2075-1230-2024-102-2-62-67","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-2-62-67","url":null,"abstract":"The objective: to analyze changes in psycho-emotional status of children ill with respiratory tuberculosis (RTB) in the perioperative period while the children were provided with psychological support.Subjects and Methods. 15 respiratory tuberculosis patients aged 7−12 years who received psychological support during surgical treatment were enrolled in the study. The data of psychological examination in the preoperative, early postoperative and late postoperative periods are presented.Results. In the preoperative period, the vast majority of children with respiratory tuberculosis showed a higher level of neuropsychic tension (86.7% of patients) and anxiety (73.3% of patients). When psychological support was provided during surgical treatment, the program of which was based on EMDR approach and mindfulness, in the early postoperative period, there was a significant decrease in the number of children with a high level of neuropsychic tension – from 86.7% to 46.7% (p<0. 01). At the beginning of the late postoperative period, parameters of psychoemotional status in the overwhelming majority of children were within the range of normal values.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"78 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.58838/2075-1230-2024-102-1-34-39
N. V. Yatskevich, E. Gurbanova, G. L. Gurevich, E. M. Skryagina
The objective: to evaluate the safety of 39and 24-week treatment regimens in the patients with rifampicin-resistant tuberculosis (RR-TB).Subjects and Methods. Cohorts of patients with RR-TB were treated with the following regimens: 550 patients received modified short course treatment regimens (mSCT), and 139 patients were treated with BPaLM regimen. Serious adverse events (SAEs) and adverse events of special interest (AESI) of grade 3 or higher were assessed according to the EndTB Severity Grading Scale, Version 5.Results. In mSCT cohort, 113 SAEs were reported, in BPaLM cohort, 12 SAEs were reported, at least 1 SAE was reported in 16.0% and 7.2% of patients, respectively. In mSCT cohort, 37 AESI were reported in 5.8% of patients. Of the 150 SAEs/AESI reported in mSCT cohort, 78.7% have resolved, 4.0% are being resolved, 0.7% have resolved with sequelae, and 2.7% have not resolved. Of the 12 SAEs in BPaLM cohort, 66.7% have resolved, 16.7% are being resolved, and 8.3% have resolved with sequelae. Drugs were discontinued in 16.8% of SAEs, 8.1% of AESI in mSCT cohort, and 25.0% of SAEs in BPaLM cohort. In mSCT cohort, 21 patients died during treatment, only in 6 patients the influence of anti-tuberculosis drugs on the fatal outcome could not be ruled out, in 15 cases there was no such a correlation. In BPaLM cohort, 1 patient died due to progression of concomitant cancer.Conclusions. SAEs/AESI rarely occur with mSCT and BPaLM regimens and rarely lead to treatment discontinuation. Appropriate monitoring and management of SAEs/AESI is an important component of clinical practice.
{"title":"Evaluation of Safety of 9and 6-Week Treatment Regimens in Patients with Rifampicin-Resistant Tuberculosis in the Republic of Belarus","authors":"N. V. Yatskevich, E. Gurbanova, G. L. Gurevich, E. M. Skryagina","doi":"10.58838/2075-1230-2024-102-1-34-39","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-34-39","url":null,"abstract":"The objective: to evaluate the safety of 39and 24-week treatment regimens in the patients with rifampicin-resistant tuberculosis (RR-TB).Subjects and Methods. Cohorts of patients with RR-TB were treated with the following regimens: 550 patients received modified short course treatment regimens (mSCT), and 139 patients were treated with BPaLM regimen. Serious adverse events (SAEs) and adverse events of special interest (AESI) of grade 3 or higher were assessed according to the EndTB Severity Grading Scale, Version 5.Results. In mSCT cohort, 113 SAEs were reported, in BPaLM cohort, 12 SAEs were reported, at least 1 SAE was reported in 16.0% and 7.2% of patients, respectively. In mSCT cohort, 37 AESI were reported in 5.8% of patients. Of the 150 SAEs/AESI reported in mSCT cohort, 78.7% have resolved, 4.0% are being resolved, 0.7% have resolved with sequelae, and 2.7% have not resolved. Of the 12 SAEs in BPaLM cohort, 66.7% have resolved, 16.7% are being resolved, and 8.3% have resolved with sequelae. Drugs were discontinued in 16.8% of SAEs, 8.1% of AESI in mSCT cohort, and 25.0% of SAEs in BPaLM cohort. In mSCT cohort, 21 patients died during treatment, only in 6 patients the influence of anti-tuberculosis drugs on the fatal outcome could not be ruled out, in 15 cases there was no such a correlation. In BPaLM cohort, 1 patient died due to progression of concomitant cancer.Conclusions. SAEs/AESI rarely occur with mSCT and BPaLM regimens and rarely lead to treatment discontinuation. Appropriate monitoring and management of SAEs/AESI is an important component of clinical practice.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"22 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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