Pub Date : 2012-02-01DOI: 10.1097/01.NEP.0000413137.57602.7E
Ajay K. Singh
{"title":"Cancer and the Kidney: Need for Knowledge","authors":"Ajay K. Singh","doi":"10.1097/01.NEP.0000413137.57602.7E","DOIUrl":"https://doi.org/10.1097/01.NEP.0000413137.57602.7E","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131733046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-02-01DOI: 10.1097/01.NEP.0000413139.42355.1C
M. Hogan
{"title":"DOPPS Practice Monitor: TrendsReassuring, but Early","authors":"M. Hogan","doi":"10.1097/01.NEP.0000413139.42355.1C","DOIUrl":"https://doi.org/10.1097/01.NEP.0000413139.42355.1C","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134555478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-02-01DOI: 10.1097/01.NEP.0000413135.11861.94
Janelle Weaver
Blood levels of two receptors that bind to tumor necrosis factoralpha (TNF ) strongly predict early and late stages of kidney function decline in patients with type 1 and type 2 diabetes, reported two studies published online ahead of print by the Journal of the American Society of Nephrology. Type 1 diabetes patients with the highest concentrations of tumor necrosis factor receptor 2 (TNFR2) had a 60% 12-year cumulative incidence of chronic kidney disease (CKD) Stage 3 or higher, while the 12-year cumulative incidence of end-stage renal disease (ESRD) was 54% for type 2 diabetes patients with the highest concentrations of tumor necrosis factor receptor 1 (TNFR1). “Before, nobody considered that these markers are useful for diagnostic purposes, and now it looks like they are the best,” said lead investigator Andrzej S. Krolewski, MD, PhD, Head of the Section on Genetics and Epidemiology at the Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School. “You can just measure their levels and predict what will happen within six to 12 years in the future. None of the other markers is able to do this.” While previous studies showed that the risk of developing diabetes is linked to levels of proinfl ammatory cytokines, such as TNF , it was not known whether chronic infl ammation also contributes to diabetes-related kidney decline. “We have been on a long quest for In Diabetes, TNF Receptors Indicate Risk for Renal Decline
肿瘤坏死因子受体2 (TNFR2)浓度最高的1型糖尿病患者12年累积慢性肾脏疾病(CKD) 3期及以上发生率为60%，而肿瘤坏死因子受体1 (TNFR1)浓度最高的2型糖尿病患者12年累积终末期肾脏疾病(ESRD)发生率为54%。“以前，没有人认为这些标记物对诊断有用，现在看来它们是最好的，”首席研究员Andrzej S. Krolewski博士说，他是乔斯林糖尿病中心遗传和流行病学部门的负责人，也是哈佛医学院的医学副教授。“你可以测量它们的水平，并预测未来6到12年内会发生什么。其他标记都无法做到这一点。”虽然先前的研究表明，患糖尿病的风险与炎性细胞因子(如肿瘤坏死因子)的水平有关，但尚不清楚慢性炎症是否也会导致糖尿病相关的肾脏衰退。“长期以来，我们一直在寻求在糖尿病中，TNF受体表明肾脏衰退的风险
{"title":"In Diabetes, TNF Receptors Indicate Risk for Renal Decline","authors":"Janelle Weaver","doi":"10.1097/01.NEP.0000413135.11861.94","DOIUrl":"https://doi.org/10.1097/01.NEP.0000413135.11861.94","url":null,"abstract":"Blood levels of two receptors that bind to tumor necrosis factoralpha (TNF ) strongly predict early and late stages of kidney function decline in patients with type 1 and type 2 diabetes, reported two studies published online ahead of print by the Journal of the American Society of Nephrology. Type 1 diabetes patients with the highest concentrations of tumor necrosis factor receptor 2 (TNFR2) had a 60% 12-year cumulative incidence of chronic kidney disease (CKD) Stage 3 or higher, while the 12-year cumulative incidence of end-stage renal disease (ESRD) was 54% for type 2 diabetes patients with the highest concentrations of tumor necrosis factor receptor 1 (TNFR1). “Before, nobody considered that these markers are useful for diagnostic purposes, and now it looks like they are the best,” said lead investigator Andrzej S. Krolewski, MD, PhD, Head of the Section on Genetics and Epidemiology at the Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School. “You can just measure their levels and predict what will happen within six to 12 years in the future. None of the other markers is able to do this.” While previous studies showed that the risk of developing diabetes is linked to levels of proinfl ammatory cytokines, such as TNF , it was not known whether chronic infl ammation also contributes to diabetes-related kidney decline. “We have been on a long quest for In Diabetes, TNF Receptors Indicate Risk for Renal Decline","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129240712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-02-01DOI: 10.1097/01.NEP.0000413138.34732.4C
F. Lowry
{"title":"Blood Pressure Target Need Not Go So Low, Observational Data Says","authors":"F. Lowry","doi":"10.1097/01.NEP.0000413138.34732.4C","DOIUrl":"https://doi.org/10.1097/01.NEP.0000413138.34732.4C","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131592400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-02-01DOI: 10.1097/01.NEP.0000413142.44141.FF
M. Coleman
{"title":"College Social Media Campaign Boosts Organ Donor Registration","authors":"M. Coleman","doi":"10.1097/01.NEP.0000413142.44141.FF","DOIUrl":"https://doi.org/10.1097/01.NEP.0000413142.44141.FF","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133965065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.1097/01.NEP.0000411042.02533.99
L. Szczech
{"title":"Immunosuppressive Drug Coverage Would Pay for Itself","authors":"L. Szczech","doi":"10.1097/01.NEP.0000411042.02533.99","DOIUrl":"https://doi.org/10.1097/01.NEP.0000411042.02533.99","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128647902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.1097/01.NEP.0000411047.17780.EC
F. Lowry
{"title":"Kidneys from Healthy Living Donors Older than 70 Benefit Recipients","authors":"F. Lowry","doi":"10.1097/01.NEP.0000411047.17780.EC","DOIUrl":"https://doi.org/10.1097/01.NEP.0000411047.17780.EC","url":null,"abstract":"","PeriodicalId":380758,"journal":{"name":"Nephrology Times","volume":"273 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114008610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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