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[The erosive effect of various drinks, foods, stimulants, medications and mouthwashes on human tooth enamel] 各种饮料、食物、兴奋剂、药物和漱口水对人类牙釉质的侵蚀作用。
Q3 Medicine Pub Date : 2023-07-10 DOI: 10.61872/sdj-2023-07-08-03
Adrian Lussi, Brigitte Megert, R Peter Shellis

Two forms of non-carious dental disorder - ero- sive tooth hard tissue loss and dental erosion - have been increasingly observed in recent years. Dental erosion is the chemical loss of dental hard substances caused by exposure to acids not de- rived from oral bacteria. Mechanical forces from, for example, the tongue, the cheeks or tooth- brushing, increase loss of partly demineralized tooth surfaces and the cumulative loss of dental hard tissue is defined as erosive tooth wear (ETW). Dental hard tissue losses that occur be- cause of very frequent acid exposure, such as through increased vomiting, but without me- chanical stress, are also assigned to tooth erosion. Without prior softening, practically no loss of enamel takes place due to abrasion with the modern Western diet. The present work is a con- tinuation of earlier work. A total of 226 beverag-es, foods, stimulants as well as medicines and mouthwashes were tested for their erosive po- tential on premolars and deciduous molars covered with a human pellicle. The influence of temperature, phosphate and calcium was also investigated in additional experiments. The change in hardness before and after immersion in the respective test substance was measured, and the erosive potential was classified. For each test product, we determined pH and other properties which were possibly related to erosive potential. There were considerable and sometimes surpris- ing differences between the tested products. The addition of phosphate did not influence the ero- sive potential of the liquids, but calcium did. A modified erosion scheme that incorporates these and other new findings is presented.

近年来,人们越来越多地观察到两种形式的非龋齿性疾病--腐蚀性牙齿硬组织脱落和牙齿腐蚀。牙蚀是指牙齿硬组织因暴露于非口腔细菌产生的酸性物质而造成的化学性脱落。来自舌头、脸颊或刷牙等的机械力会增加部分脱矿牙齿表面的损失,牙齿硬组织的累积损失被定义为腐蚀性牙齿磨损(ETW)。由于频繁接触酸性物质(如呕吐次数增加)而造成的牙齿硬组织损失,但没有医学压力,也被归为牙齿侵蚀。在现代西方饮食中,如果没有事先软化,珐琅质几乎不会因磨蚀而脱落。本研究是早期研究的延续。共测试了 226 种饮料、食物、兴奋剂以及药物和漱口水对覆盖有人类绒毛的前臼齿和乳磨牙的侵蚀潜力。此外,还在其他实验中研究了温度、磷酸盐和钙的影响。我们测量了在相应测试物质中浸泡前后硬度的变化,并对侵蚀潜力进行了分类。对于每种测试产品,我们都测定了 pH 值和其他可能与侵蚀潜能有关的特性。测试产品之间的差异很大,有时甚至令人吃惊。磷酸盐的添加并不影响液体的侵蚀潜力,但钙却有影响。本文介绍了一种经过修改的侵蚀方案,其中包含了这些新发现和其他新发现。
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引用次数: 0
[Direct adhesive reconstructions for restoration of posterior teeth with erosive tooth wear]. [用直接粘合剂修复有腐蚀性牙齿磨损的后牙]。
Q3 Medicine Pub Date : 2023-07-10 DOI: 10.61872/sdj-2023-07-08-04
Thomas Attin, Patrick R Schmidlin, Tobias T Tauböck

The restorative treatment of dental hard tissue loss, e.g., due to erosion, and the rehabilitation of the original vertical bite dimension confronts the dentist with problems when implementing the therapy. Traditionally, this therapy is conducted with laboratory-fabricated workpieces made of ceramics which usually require a preparation of the remaining tooth substance and also causes high costs for the patient. Therefore, alternative methods should be considered. This article presents the use of direct adhesive composite restorations as a way of reconstructing a dentition severely altered by erosion. To reconstruct the occlusal surfaces, transfer splints are used that are made on the basis of individual wax-up models. The procedure described is a well-researched and proven method for restoring teeth with erosion-related loss of hard tooth substance. As with all new procedures, there will be a certain learning curve for the practical dentist after which high-quality restorations can be implemented with this technique.

牙科医师在对牙齿硬组织缺损(如因侵蚀造成的缺损)进行修复治疗和恢复原来的垂直咬合尺寸时,会遇到一些问题。传统上,这种治疗方法是使用实验室制造的陶瓷工件,通常需要对剩余的牙齿物质进行制备,这也给患者带来了高昂的费用。因此,应考虑采用其他方法。本文介绍了使用直接粘接复合树脂修复体重建因腐蚀而严重改变的牙体的方法。为了重建咬合面,使用了以单个蜡型为基础制作的转移夹板。所述程序是一种经过充分研究和验证的方法,可用于修复因侵蚀而丧失硬质牙齿物质的牙齿。与所有新程序一样,实际操作的牙医需要经过一定的学习曲线,然后才能使用这种技术进行高质量的修复。
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引用次数: 0
Effects of Calcium and Phosphate on Dissolution of Enamel, Dentin and Hydroxyapatite in Citric Acid. 钙和磷酸盐对珐琅质、牙本质和羟基磷灰石在柠檬酸中溶解的影响
Q3 Medicine Pub Date : 2023-07-10 Epub Date: 2023-03-02 DOI: 10.61872/sdj-2023-07-08-02
R Peter Shellis, Michele E Barbour, David M Parker, Martin Addy, Adrian Lussi

The aim was to evaluate the effect of dissolved calcium and phosphate on dissolution rate of enamel, dentin and compressed hydroxyapatite (HA) in citric acid solution as a function of pH. At pH 2.5, dissolution rate of enamel increased significantly by 6% in 20 mmol/L added calcium but, otherwise, dissolution rates of neither enamel, dentin nor HA were significantly affected by 10 or 20 mmol/L calcium. However, enamel dissolution rate was reduced by > 50 mmol/L calcium. At pH 3.25 and 4.0, 10-20 mmol/L calcium inhibited dissolution of enamel by 29-100% and HA by 65-75% but did not affect dentin dissolution. Phosphate (10 or 20 mmol/L) did not inhibit dissolution of enamel, dentin or HA at any pH, but there were increases in dissolution rate of all three substrates at pH 2.5 and, in one test with dentine (at 20 mmol/L phosphate), at pH 3.25. The results suggest that calcium addition to soft drinks and other acidic products such as medications may reduce erosivity against enamel, provided that pH is not too low; that phosphate would not reduce erosivity against enamel; and that neither calcium nor phosphate at these concentrations would reduce erosivity against dentin.

研究的目的是评估溶解的钙和磷酸盐对柠檬酸溶液中珐琅质、牙本质和压缩羟基磷灰石(HA)的溶解速率的影响。在pH值为2.5时,添加20毫摩尔/升钙时,珐琅质的溶解速率显著增加6%,但除此之外,10或20毫摩尔/升钙对珐琅质、牙本质和HA的溶解速率均无显著影响。然而,当钙含量大于 50 mmol/L 时,珐琅质的溶解速率会降低。在 pH 值为 3.25 和 4.0 时,10-20 毫摩尔/升钙可抑制 29-100% 的珐琅质溶解和 65-75% 的 HA 溶解,但不影响牙本质的溶解。磷酸盐(10 或 20 毫摩尔/升)在任何 pH 值下都不会抑制珐琅质、牙本质或 HA 的溶解,但在 pH 值为 2.5 时,所有三种基质的溶解速率都会增加;在一次牙本质测试中(磷酸盐含量为 20 毫摩尔/升),pH 值为 3.25 时,三种基质的溶解速率也会增加。这些结果表明,在软饮料和其他酸性产品(如药物)中添加钙可能会降低对珐琅质的腐蚀性,前提是 pH 值不能太低;磷酸盐不会降低对珐琅质的腐蚀性;这些浓度的钙或磷酸盐都不会降低对牙本质的腐蚀性。
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引用次数: 0
[Minimally invasive treatment of erosions to regain health, function and aesthetics with indirect restorations]. [微创治疗糜烂,用间接修复体恢复健康、功能和美观]。
Q3 Medicine Pub Date : 2023-07-10 DOI: 10.61872/sdj-2023-07-08-05
Alexis Ioannidis, Lorenzo Fiscalini, Pune Nina Paqué, Andrea Patrizi

This article discusses the treatment of tooth structure loss due to erosion using indirect lithium disilicate ceramic restorations. Minimally invasive approaches, in which the eroded teeth are conservatively prepared and restored with minimally invasive restorations, are recommended. Lithium disilicate ceramics are currently the material of choice for this type of treatment as they can withstand maximum occlusal forces in the posterior region. The restorative process should be guided by diagnostic procedures that define the clinical therapeutic goal at the beginning of treatment. Adhesive cementation with the correct protocol is crucial for full mechanical strength of the restoration. At the end of the treatment, in addition to preventive measures, an overnight protective splint is recommended to ensure long-term clinical stability.

本文讨论了使用间接二硅酸锂陶瓷修复体治疗因腐蚀导致的牙齿结构缺损。建议采用微创方法,即对受侵蚀的牙齿进行保守预备,并用微创修复体进行修复。二硅酸锂陶瓷是目前这类治疗的首选材料,因为它们可以承受后牙区域的最大咬合力。修复过程应该以诊断程序为指导,在治疗开始时确定临床治疗目标。采用正确的方案进行粘接对于充分发挥修复体的机械强度至关重要。在治疗结束时,除了采取预防措施外,还建议使用隔夜保护夹板,以确保长期的临床稳定性。
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引用次数: 0
The erosive effect of various drinks, foods, stimulants, medications and mouthwashes on human tooth enamel. 各种饮料、食物、兴奋剂、药物和漱口水对人类牙釉质的侵蚀作用。
Q3 Medicine Pub Date : 2023-07-10 Epub Date: 2023-03-02 DOI: 10.61872/sdj-2023-07-08-01
Adrian Lussi, Brigitte Megert, R Peter Shellis

Two forms of non-carious dental disorder - erosive tooth hard tissue loss and dental erosion - have been increasingly observed in recent years. Dental erosion is the chemical loss of dental hard substances caused by exposure to acids not derived from oral bacteria. Mechanical forces from, for example, the tongue, the cheeks or toothbrushing, increase loss of partly-demineralized tooth surfaces and the cumulative loss of dental hard tissue is defined as erosive tooth wear (ETW). Dental hard tissue losses which occur because of very frequent acid exposure, such as through increased vomiting, but without mechanical stress, are also assigned to tooth erosion. Without prior softening, practically no loss of enamel takes place due to abrasion with the modern Western diet. The present work is a continuation of earlier work. A total of 226 beverages, food, stimulants as well as medicines and mouthwashes were tested for their erosive potential on premolars and deciduous molars covered with a human pellicle. The influence of temperature, phosphate and calcium was also investigated in additional experiments. The change in hardness before and after immersion in the respective test substance was measured and the erosive potential was classified. For each test product, we determined pH and other properties which were possibly related to erosive potential. There were considerable and sometimes surprising differences between the tested products. The addition of phosphate did not influence the erosive potential of the liquids, but calcium did. A modified erosion scheme is presented, which incorporates these and other new findings.

近年来,人们越来越多地观察到两种形式的非龋齿性疾病--腐蚀性牙齿硬组织脱落和牙齿腐蚀。牙齿腐蚀是指牙齿硬组织因暴露于非口腔细菌产生的酸性物质而造成的化学损失。来自舌头、脸颊或刷牙等的机械力会增加部分脱矿的牙齿表面的损失,牙齿硬组织的累积损失被定义为腐蚀性牙齿磨损(ETW)。由于频繁接触酸(如呕吐增多)而造成的牙齿硬组织损失,但没有机械应力,也被归为牙齿腐蚀。在现代西方饮食习惯下,如果没有事先软化,珐琅质几乎不会因磨损而脱落。本研究是早期研究的延续。共测试了 226 种饮料、食物、兴奋剂以及药物和漱口水对覆盖着人类绒毛的前臼齿和落臼齿的侵蚀潜力。在其他实验中还研究了温度、磷酸盐和钙的影响。我们测量了在相应测试物质中浸泡前后硬度的变化,并对侵蚀潜力进行了分类。我们还测定了每种测试产品的 pH 值和其他可能与侵蚀潜能有关的特性。测试产品之间的差异很大,有时甚至令人吃惊。磷酸盐的添加不会影响液体的侵蚀潜力,但钙却会。我们提出了一个经过修改的侵蚀方案,其中包含了这些新发现和其他新发现。
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引用次数: 0
Clinical guidance for maintaining oral hygiene in patients undergoing chemotherapy or radiation therapy: a scoping review. 化疗或放疗患者保持口腔卫生的临床指导:范围界定综述。
Q3 Medicine Pub Date : 2023-06-12 Epub Date: 2023-02-20 DOI: 10.61872/sdj-2023-06-01
Janine Chan, Filippi Filippi, Cornelia Filippi

The aim of this scoping review was to identify clinical guidance for maintaining oral hygiene in patients undergoing chemotherapy, radiation therapy, or both. Electronic searches were conducted in PubMed, Embase, Cochrane Library, and Google Scholar for articles published between January 2000 and May 2020. Systematic reviews, meta-analyses, clinical trials, case series, and expert consensus reports were considered eligible for inclusion. The SIGN Guideline system was used to evaluate the level evidence and the grade of recommendations. A total of 53 studies met the eligibility criteria. The results showed the presence of recommendation for oral care in three domains: management of oral mucositis, prevention and control of radiation caries, and management of xerostomia. However, most of the included studies had low levels of evidence. The review provides recommendations for healthcare professionals caring for patients undergoing chemotherapy, radiation therapy, or both, but a standard oral care protocol could not be established owing to a paucity of evidence-based data.

本范围综述旨在确定化疗、放疗或两者兼有的患者保持口腔卫生的临床指南。我们在 PubMed、Embase、Cochrane Library 和 Google Scholar 中对 2000 年 1 月至 2020 年 5 月间发表的文章进行了电子检索。系统综述、荟萃分析、临床试验、系列病例和专家共识报告均符合纳入条件。SIGN 指南系统用于评估证据水平和建议等级。共有 53 项研究符合资格标准。结果显示,在口腔粘膜炎的治疗、放射性龋齿的预防和控制以及口腔干燥症的治疗这三个领域存在口腔护理建议。不过,大部分纳入的研究证据水平较低。该综述为医护人员护理化疗、放疗或同时接受这两种治疗的患者提供了建议,但由于缺乏循证数据,无法制定标准的口腔护理方案。
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引用次数: 0
Oral retention and extravasation mucoceles of the minor salivary glands - more common than you might think! 口腔潴留和小唾液腺外渗粘液瘤--比你想象的更常见!
Q3 Medicine Pub Date : 2023-06-12 DOI: 10.61872/sdj-2023-06-02
Michael M Bornstein, Martina Schriber, Thomas Menter

Oral mucoceles are cystic changes in the minor salivary glands caused by traumatic damage to the salivary gland ducts or their obstruction with subsequent salivary congestion. In extravasation mucocele, saliva leaks from the ruptured duct into the surrounding tissue and causes a local inflammatory reaction. Thus, histopathologically, granulation tissue is seen around the salivary fluid, but no epithelial lining.

口腔黏液瘤是小唾液腺的囊性病变,由唾液腺导管外伤损伤或阻塞导致唾液充盈引起。在外渗性黏液囊肿中,唾液从破裂的导管渗入周围组织,引起局部炎症反应。因此,从组织病理学角度看,唾液周围可见肉芽组织,但无上皮衬里。
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引用次数: 0
Efficient cleaning of a macro-structured micro-rough dental implant shoulder with a new coronal vertical groove design: A technical note. 具有新型冠状垂直凹槽设计的宏观结构微粗糙牙种植体肩部的有效清洁:技术说明。
Q3 Medicine Pub Date : 2023-06-09 DOI: 10.61872/sdj-2023-11-01
Tim Brandenberger, Stefan Stübinger, Andrea Gubler, Patrick R Schmidlin, Chun C Liu

This evaluation assessed the influence of a new implant shoulder design on cleanability using a now established in-vitro study model. Eight test (Botticelli, Di Meliora AG, Basel, Switzerland) and eight control implants (T3 Osseotite, ZimVie, Winterthur, Switzerland), were embedded in standardized defects in simulated bone. The implant surfaces were painted to be visually distinguishable and debrided with ultrasonic instruments (US) and an air powder waterjet device (AIR). Uncleaned implants served as positive controls. After the standardized cleaning, the implants were photographed and divided into three zones (upper marginal shoulder zone (A); lower marginal shoulder zone (B); fully threaded sub-shoulder zone (C)), and analyzed with an image processing software. On test implants, AIR was almost 100% efficacious compared to 80-90% with US, in both upper zones (A/B). In control implants, results of both AIR and US were almost 100% in zone A, but only 55-75% in zone B. In both implants, AIR showed statistically significant higher efficacy than US (P<0.05). Within the limitations of the present in-vitro model, a new macro-structured micro-rough dental implant shoulder with a new coronal vertical groove design shows similar cleanability in comparison to a smooth and machined surface.

该评估使用目前建立的体外研究模型评估了新植入物肩部设计对可清洁性的影响。八个测试(Botticelli,Di Meliora AG,巴塞尔,瑞士)和八个对照植入物(T3 Osseotite,ZimVie,Winterthur,瑞士)嵌入模拟骨的标准化缺陷中。植入物表面被涂成可在视觉上区分的颜色,并用超声波仪器(US)和空气粉末水喷射装置(air)进行去毛刺。未清洗的植入物作为阳性对照。在标准化清洁后,对植入物进行拍照,并将其分为三个区域(上边缘肩部区域(A);肩部下边缘区(B);全螺纹亚肩区(C))并用图像处理软件进行分析。在测试植入物中,AIR在两个上部区域(A/B)的有效性几乎为100%,而US的有效性为80-90%。在对照植入物中,AIR和US在A区的疗效几乎为100%,但在B区仅为55-75%
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引用次数: 0
Inflammatory stimulation of osteoblasts and keratinocytes from a SAPHO patient for implant risk evaluation. 对一名 SAPHO 患者的成骨细胞和角质细胞进行炎症刺激,以评估植入风险。
Q3 Medicine Pub Date : 2023-05-15 Epub Date: 2023-01-10 DOI: 10.61872/sdj-2023-05-01
Patrick R Schmidlin, Liza L Ramenzoni

The present report exemplifies a translational method, which could assist the clinical preevaluation of patients at risk before surgical interventions. In this study, a presurgical implant decision in a case of SAPHO (synovitis, acne, palmoplantar pustulosis, hyperostosis, osteitis) is described. Since the etiology of this syndrome is likely to involve genetic, infectious and immunological components, lipopolysaccharides (LPS) may conceptually trigger cytokine production leading to a specific chronic inflammation and immunological host response. This may hamper proper healing or accentuate the destruction of periodontal host tissues. In our approach, we examined the ex vivo cell viability and immune responses of primary osteoblasts and keratinocytes under sterile inflammation induced by P. gingivalis LPS. Keratinocytes and osteoblasts were obtained from biopsies of the keratinized gingiva and alveolar bone tissues of a SAPHO human subject. Enzymatically dissociated cells were thus cultured and incubated to LPS at different concentrations (50ng/ml, 200ng/ml, 500ng/ml and 1μg/ml) for 24 h in order to test inflammatory cytokine response (quantitative real time PCR) and toxicity (cell viability). Healthy primary keratinocytes and osteoblasts were used as control cells. The highest concentration of LPS (1μg/ml) significantly reduced cell viability (p < 0.05). Meanwhile, all tested LPS concentrations similarly enhanced the mRNA expressions of selected inflammatory cytokines (TNFα, IL-6, IL-8, IL-1β and IL-1𝛼) up to ≈3.5-fold, when compared to the healthy cell controls (p < 0.05). This study demonstrated a valuable inflammatory risk evaluation before implant placement, which was successfully performed based on the presented laboratory diagnostic/prognostic approach.Sapho.

本报告是一种转化方法的范例,有助于在手术干预前对高危患者进行临床预评估。本研究描述了一例 SAPHO(滑膜炎、痤疮、掌跖脓疱病、骨质增生、骨炎)患者的术前植入决定。由于该综合征的病因可能涉及遗传、感染和免疫因素,脂多糖(LPS)可能在概念上触发细胞因子的产生,导致特定的慢性炎症和免疫宿主反应。这可能会阻碍正常愈合或加剧牙周宿主组织的破坏。在我们的研究中,我们检测了在牙龈脓毒性噬菌体 LPS 诱导的无菌炎症条件下原代成骨细胞和角质形成细胞的体外细胞活力和免疫反应。角质形成细胞和成骨细胞取自 SAPHO 受试者的角化牙龈和牙槽骨组织活组织切片。将酶解离的细胞进行培养,并与不同浓度(50ng/ml、200ng/ml、500ng/ml 和 1μg/ml )的 LPS 培养 24 小时,以检测炎症细胞因子反应(定量实时 PCR)和毒性(细胞存活率)。健康的原代角质细胞和成骨细胞作为对照细胞。最高浓度的 LPS(1 微克/毫升)明显降低了细胞活力(p < 0.05)。同时,与健康细胞对照组相比,所有测试浓度的 LPS 都同样增强了所选炎症细胞因子(TNFα、IL-6、IL-8、IL-1β 和 IL-1𝛼)的 mRNA 表达,最高可达≈3.5 倍(p < 0.05)。这项研究证明了在种植体植入前进行有价值的炎症风险评估是成功的,它是基于所提出的实验室诊断/预后方法进行的。
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引用次数: 0
Intensive oral hygiene programme for the diagnosis and (pre-)treatment of gingival mucosal redness and swelling 用于诊断和(预)治疗牙龈红肿的强化口腔卫生方案。
Q3 Medicine Pub Date : 2023-05-15 DOI: 10.61872/sdj-2023-05-02
Patrick R Schmidlin, Milena Mendolera

Imposing redness and swelling of the gingiva repeatedly cause uncertainty in the dental practice. Insufficient oral hygiene plays a dominant modifying role here. An intensive oral hygiene protocol as an initial screening procedure can therefore often prevent complex diagnostic or therapeutic steps.

牙龈发红和肿胀屡屡给牙科诊所带来不确定性。在这方面,口腔卫生不足起着主要的调节作用。因此,作为初步筛查程序的强化口腔卫生方案往往可以避免复杂的诊断或治疗步骤。
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引用次数: 0
期刊
Swiss dental journal
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