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Journal of the American Society of Cytopathology最新文献

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Cytology-histology correlation of atypical glandular cells on cervical Papanicolaou tests: A study of 628 cases 宫颈涂片检查中非典型腺细胞的细胞学-组织学相关性:对 628 个病例的研究
Q2 Medicine Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.05.002

Introduction

The finding of atypical glandular cells (AGC) on Papanicolaou test is becoming more important as the incidence of squamous intraepithelial lesions decreases in recent decades. Therefore, the interpretation and follow-up of patients with AGC are particularly important. The aim of our study was to assess the histologic findings and clinical correlations in patients with AGC identified on Papanicolaou test.

Materials and methods

A total of 714 patients with AGC identified on cervical Papanicolaou tests were studied for their clinicopathologic features, such as follow-up histology and patient age. We investigated the histologic follow-up results for each individual subcategories of AGC and their correlation with patients’ age.

Results

Most of the glandular cell abnormalities (80.0%) in the study group were classified as “atypical glandular cells, not otherwise specified (NOS)”. About 28.9% of patients’ follow-up histology showed malignant or precancerous lesions. The mean age of patients with malignant or precancerous lesions was significantly higher than that of patients with benign or non-precancerous lesions. The malignant histologies included 52 cases of endometrial cancers and 31 cases of cervical carcinomas. The second most common subcategory was “atypical glandular cells, favor neoplastic” (5.0%), while “atypical endocervical cells, favor neoplastic” constituted about 2.7% of cases in our study. The average age of patients with “atypical glandular cells, favor neoplastic” was significantly higher than that of patients with “atypical endocervical cells, favor neoplastic”. The follow-up histology of about 82.1% of “atypical glandular cells, favor neoplastic” showed endometrial (73.9%) or cervical malignancies (26.1%). The follow-up histology of about 70.6% of “atypical endocervical cells, favor neoplastic” showed endometrial (50.0%) or cervical cancers (50.0%). Other glandular abnormalities included 25 of 714 cases of “atypical endometrial cells” (3.5%) and 6 of 714 cases of “atypical endocervical cells” (0.8%).

Conclusion

Based on our data, we have observed significantly more endometrial malignancies in both “atypical glandular cells, NOS” and “atypical glandular cells, favor neoplastic” subcategories and even some in “atypical endocervical cells, favor neoplastic” category. This predominance of endometrial malignancies is also associated with patients’ age and tumor types.

导言:近几十年来,随着鳞状上皮内病变发病率的降低,巴氏涂片检查发现非典型腺细胞(AGC)变得越来越重要。因此,对 AGC 患者的解释和随访尤为重要。我们的研究旨在评估宫颈巴氏涂片检查发现的 AGC 患者的组织学结果和临床相关性。材料和方法我们共研究了 714 例宫颈巴氏涂片检查发现的 AGC 患者的临床病理学特征,如随访组织学和患者年龄。结果研究组中大多数腺细胞异常(80.0%)被归类为 "非典型腺细胞,未另作说明(NOS)"。约 28.9% 的患者的随访组织学检查结果显示为恶性或癌前病变。恶性或癌前病变患者的平均年龄明显高于良性或非癌前病变患者。恶性病变包括 52 例子宫内膜癌和 31 例宫颈癌。第二大常见亚类是 "非典型腺细胞,倾向于肿瘤性"(5.0%),而 "非典型宫颈内膜细胞,倾向于肿瘤性 "在我们的研究中约占 2.7%。非典型腺细胞,倾向于肿瘤性 "患者的平均年龄明显高于 "非典型宫颈内膜细胞,倾向于肿瘤性 "患者。约 82.1%的 "非典型腺细胞,倾向于肿瘤性 "患者的随访组织学结果显示为子宫内膜恶性肿瘤(73.9%)或宫颈恶性肿瘤(26.1%)。约 70.6%的 "非典型宫颈内膜细胞,倾向于肿瘤性 "的随访组织学结果显示为子宫内膜癌(50.0%)或宫颈癌(50.0%)。其他腺体异常包括 714 例 "非典型子宫内膜细胞 "中的 25 例(3.5%)和 714 例 "非典型宫颈内膜细胞 "中的 6 例(0.8%)。结论根据我们的数据,我们观察到 "非典型腺体细胞,NOS "和 "非典型腺体细胞,倾向于肿瘤性 "亚类中的子宫内膜恶性肿瘤明显较多,甚至在 "非典型宫颈内膜细胞,倾向于肿瘤性 "类别中也有一些。子宫内膜恶性肿瘤占多数还与患者的年龄和肿瘤类型有关。
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期刊
Journal of the American Society of Cytopathology
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