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The Role of Radiologic Technology in Enforcing Diagnosis of Covid-19 Disease: Case Report at RSPAW Salatiga 放射学技术在加强Covid-19疾病诊断中的作用:萨拉蒂加RSPAW病例报告
Pub Date : 2020-10-31 DOI: 10.24246/IJPNA.V5I3.76-79
L. Lestari
Coronavirus has become a world pandemic since WHO announced it in March 2020. This study aims to report on the role of radiologic technology in helping to diagnose the Covid-19 disease handled by RSPAW Salatiga. The research method chosen was descriptive-analytic case reports. The results of the study explained that radiologic technology of chest X-Ray was able to provide an image of Covid-19 with 89% sensitivity, namely the discovery of reticulonodular, ground-glass opacity (GGO), crazy paving, consolidation, location in the periphery of the lung, and the inferior lobe of the lung.
自世卫组织于2020年3月宣布冠状病毒以来,冠状病毒已成为一种世界大流行。本研究旨在报告放射学技术在帮助诊断RSPAW Salatiga处理的Covid-19疾病中的作用。选择的研究方法是描述性分析案例报告。研究结果说明,胸部x线放射学技术能够以89%的灵敏度提供新冠肺炎的图像,即发现网状结节,磨玻璃影(GGO),疯狂铺路,实变,位于肺周围和肺下叶。
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引用次数: 0
GAMMA RADIATION ANALYSIS ON IN VIVO/ IN VITRO TESTING FACILITY BORON NEUTRON CAPTURE THERAPY 体内/体外试验装置硼中子俘获治疗的伽玛辐射分析
Pub Date : 2020-10-31 DOI: 10.24246/IJPNA.V5I3.80-86
Gabriel Simanjuntak
BNCT is the latest method in nuclear technology that combines chemotherapy and radiotherapy. Therapy that uses ionizing radiation must pay attention to the safety of patients, radiation workers and the environment. Therefore, shielding is needed for radiation protection, especially gamma radiation. A refining for the shielding and the testing had been done to know the limitation for the use of testing facility in vivo / in vitro that meets the NPD/Dose Constraint limitation from PSTA BATAN with parameter shielding radiation outcome, shielding geometry, and energy value Kartini Reactor. The highest measurement result reaches 4.8 mSv/j with 100kW energy. By considering the measurement result with the NPD/Dose Constraint limitation from PSTA BATAN for Kartini Reactor operation, the activity of testing facility in vivo/in vitro can be done 46 times in a year. Keywords  : BNCT, Shielding, Gamma Radiation.  
BNCT是结合化疗和放疗的最新核技术方法。使用电离辐射的治疗必须注意患者、放射工作人员和环境的安全。因此,辐射防护,特别是伽马辐射防护需要屏蔽。对屏蔽和测试进行了改进,以了解体内/体外测试设备的使用限制,该限制符合PSTA BATAN的NPD/剂量限制,参数屏蔽辐射结果,屏蔽几何形状和能量值Kartini反应器。当能量为100kW时,最高测量结果达到4.8 mSv/j。考虑到PSTA BATAN对Kartini反应器运行的NPD/Dose Constraint限制的测量结果,一年可以进行46次体内/体外测试设施的活动。关键词:BNCT,屏蔽,伽马辐射。
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引用次数: 0
Distribution of Water Phantom BNCT Cyclotron based Using PHITS 基于PHITS的水影BNCT回旋加速器分布
Pub Date : 2019-08-14 DOI: 10.24246/ijpna.v4i1.1-7
S. Maimanah, S. Susilo, Y. Sardjono
This research purpose is to estimate the dose distribution of BNCT in water phantom. Some common methods in the treatment of cancer such as brakhiterapi, surgery, chemotherapy, and radiotherapy still have the risk of damaging healthy tissue around cancer cells. BNCT is a selectively-designed technique by targeting high-loaded LET particles to tumors at the cellular level. BNCT proves to be a powerful method of killing cancer without damaging normal tissue. The source of the neutron used from the cyclotron dose in water phantom with the size of 30 cm x 30 cm x 30 cm was calculated using PHITS program. The result from the simulation is that boron water panthom has a dosimetri higher than phantom water without boron.
本研究的目的是估计BNCT在水影中的剂量分布。一些常见的治疗癌症的方法,如brakhiterapi、手术、化疗和放疗,仍然有损害癌细胞周围健康组织的风险。BNCT是一种选择性设计的技术,通过在细胞水平上将高负载LET颗粒靶向肿瘤。事实证明,BNCT是一种在不损害正常组织的情况下杀死癌症的有效方法。利用PHITS程序计算了30 cm × 30 cm × 30 cm水幻影中回旋加速器剂量所使用的中子源。模拟结果表明,含硼水的辐射剂量比无硼水的辐射剂量高。
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引用次数: 0
In Vivo Total Dose Analysis in Mice for BNCT Trial TRIGA Kartini Research Reactor Based Using PHITS 基于PHITS的TRIGA Kartini研究反应器中BNCT试验小鼠体内总剂量分析
Pub Date : 2019-08-14 DOI: 10.24246/ijpna.v4i1.27-32
Ramadhan Valiant Gill S Balle
Boron neutron capture therapy (BNCT) is an effective radiotherapy modality to kill cancer. BNCT can selectively kill cancer cells without damaging the healthy tissue around it by using alpha particle and lithium ion from the reaction of 10B(n,α)7Li. These particles have a track of more or less 5 to 9 μm which is the same as the cell diameter. In order to support the development of BNCT in Indonesia an in vivo simulation is performed in a simple mouse geometry containing a 4T1 breast cancer characteristic treated with BNCT using PHITS program. The Neutron source that was used in this simulation was based on TRIGA Kartini Research Reactor. The boron compound concentration in the tumor was varied from 20 ppm up to 90 ppm, and then the total dose was calculated in the mice. Total dose that the tumor received was 0.0161, 0.0168, 0.0175, 0.0182, 0.0185, 0.0188, 0.019, and 0.0191 Gy-Eq/s, respectively and the irradiation time to reach 50 Gy was 51, 50, 48, 46, 45, 45, 44, 44, 40 minutes respectively. This shows that the higher the concentration of boron compound in the tumor the higher the dose that mice received and irradiation time was decreased with the increase of the boron compound concentration.
硼中子俘获治疗(BNCT)是一种有效的杀伤肿瘤的放射治疗方式。BNCT利用α粒子与10B(n,α)7Li反应产生的锂离子,在不损伤周围健康组织的情况下选择性杀伤癌细胞。这些颗粒的轨迹大致为5至9 μm,与细胞直径相同。为了支持BNCT在印度尼西亚的发展,在一个简单的小鼠几何结构中进行了体内模拟,其中包含使用PHITS程序的BNCT治疗的4T1乳腺癌特征。在这个模拟中使用的中子源是基于TRIGA Kartini研究反应堆。硼化合物在肿瘤中的浓度从20 ppm到90 ppm不等,然后计算小鼠的总剂量。肿瘤接受的总剂量分别为0.0161、0.0168、0.0175、0.0182、0.0185、0.0188、0.019、0.0191 Gy- eq /s,达到50 Gy的照射时间分别为51、50、48、46、45、45、44、44、40分钟。由此可见,肿瘤中硼化合物浓度越高,小鼠接受的剂量越大,照射时间随硼化合物浓度的增加而缩短。
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引用次数: 1
Neutron Chareacterization of BNCT Water Phantom Based on 30 MeV Cyclotron Using PHITS Computational Code 基于PHITS计算代码的30 MeV回旋加速器BNCT水影中子表征
Pub Date : 2019-08-14 DOI: 10.24246/ijpna.v4i1.22-26
O. D. Rahayuningsih, S. Susilo, Y. Sardjono
Cancer is the second leading cause of death globally and was responsible for 8,8 million deaths in 2015. Approximately 70% of deaths from cancer occur in low- and middle-income countries. The war on cancer has been fought with three tools – surgery (cut), radiation therapy (burn) including radiotherapy and bracytherapy, and also chemotherapy (poison). Cancer therapy has increased life expectancy of patients but each treatment modality has its own effects, complications and toxicity. Moreover we have found a new effective method to fight cancer, that is, Boron Neutron Capture Therapy (BNCT). Boron Neutron Capture Therapy (BNCT) has for many decades been advocated as an innovative form of radiotherapy that, in principle, has the potential to be the ideal form of treatment for many types of cancers. This research’s aim is the characterising neutron of BNCT water phantom based on 30 MeV cyclotron using PHITS computational code. The result from the simulation is that thickness of the water phantom, related to flux neutron.
癌症是全球第二大死因,2015年造成880万人死亡。大约70%的癌症死亡发生在低收入和中等收入国家。与癌症的战争用了三种工具——手术(割伤),放射治疗(烧伤),包括放射治疗和近距离放疗,还有化疗(中毒)。癌症治疗提高了患者的预期寿命,但每种治疗方式都有自己的效果、并发症和毒性。此外,我们还发现了一种新的有效的抗癌方法,即硼中子俘获疗法(BNCT)。几十年来,硼中子俘获疗法(BNCT)一直被认为是一种创新的放射治疗形式,原则上,它有可能成为许多类型癌症的理想治疗形式。本研究的目的是利用PHITS计算代码对30 MeV回旋加速器的BNCT水影的中子进行表征。模拟结果表明,水模的厚度与中子通量有关。
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引用次数: 0
Dose Analysis in Boron Neutron-capture Cancer Therapy (BNCT) Neutron Generator Based for Breast Cancer 基于乳腺癌硼中子俘获癌治疗(BNCT)中子发生器的剂量分析
Pub Date : 2019-08-14 DOI: 10.24246/ijpna.v4i1.8-11
rawi pramusinta, Rosilatul Zailani, Y. Sardjono
The purpose of this study is to know the concentration of boron and irradiation times which optimizes the treatment of breast cancer using the BNCT method. This research was conducted by using MCNPX simulation which outputs are flux neutron, neutron scattering dose and gamma dose. The neutron source used is the BSA D-D Neutron generator model. The independent variable of this research is the boron concentration injected into the cancer. The dependent variable is the total dose rate and irradiation time which determines the effectiveness of  BNCT therapy. The controlled variables are the output of the neutron flux, dose and gamma neutron scattering dose. The results showed that in the range of 70-150 µg/g, the dose rate received by cancer increases with increasing the concentration of boron-10. If the dose rate is increased, the irradiation time interval will be faster. The Boron dose of 70 μg/g and the dose rate of irradiation 0.00293603 Gy/sec needs an irradiation time of 409.43 minutes; the boron dose of 90 µg/g and the dose rate of irradiation 0.00241049 Gy/sec needs an irradiation time of 345.71 minutes; the boron dose of 110 µg/g and the dose rate of irradiation 0.00271236 Gy/sec needs an irradiation time of 307.24 minutes; the boron dose of 130 µg/g and the dose rate of irradiation 0.00303389 Gy/sec needs an irradiation time of 274.67 minutes; and the boron dose 150 µg/g and the dose rate of irradiation 0.00334565 Gy/sec needs an irradiation time of 249.08 minutes. The Optimum concentration of boron is 150 µg/g with irradiation time of 249.08 minutes.
本研究的目的是了解硼的浓度和照射次数,从而优化BNCT治疗乳腺癌的方法。本研究采用MCNPX模拟,输出通量中子、中子散射剂量和伽马剂量。使用的中子源是BSA D-D中子发生器模型。这项研究的独立变量是注入癌细胞的硼浓度。因变量是总剂量率和照射时间,它们决定了BNCT治疗的有效性。控制变量是中子通量、剂量和中子散射剂量的输出。结果表明,在70 ~ 150µg/g范围内,随着硼-10浓度的增加,肿瘤接受的剂量率增大。如果剂量率增加,照射时间间隔会变快。硼的剂量为70 μg/g,辐照剂量率为0.00293603 Gy/sec,辐照时间为409.43 min;硼的剂量为90µg/g,辐照剂量率为0.00241049 Gy/sec,辐照时间为345.71 min;硼剂量为110µg/g,辐照剂量率为0.00271236 Gy/sec,辐照时间为307.24 min;硼剂量为130µg/g,辐照剂量率为0.00303389 Gy/sec,辐照时间为274.67 min;硼剂量为150µg/g,辐照剂量率为0.00334565 Gy/sec,辐照时间为249.08 min。硼的最佳浓度为150µg/g,辐照时间为249.08 min。
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引用次数: 0
FACTORS AFFECTING INFANT MORTALITY RATE IN KARANGASEM, BALI 影响巴厘岛karangasem婴儿死亡率的因素
Pub Date : 2019-08-14 DOI: 10.24246/IJPNA.V4I1.12-15
N. L. P. Suciptawati, M. Asih, Kartika Sari, I. Srinadi
The purpose of this study was to determine the factors that influence the infant mortality rate in Karangasem, Bali. The method used in this research is the Log Linier model. In the Log linear model analyze relationship pattern among group of categorical variables which include an association of two or more variables, either simultaneously or partially. A Patterned relationship between variables can be seen from the interaction between variables. Log linear analysis does not distinguish between explanatory variables and response variables. The population in this study was all babies born in Karangasem in 2015 that is as many as 7,895 babies with live birth status and as many as 7,835 babies and 60 infants died. As a sample, 100 babies were taken, of which 60 were live and 40 died. The results show that infant mortality is affected by infant weight, how old the mother during childbirth, and interaction between birth spacing and infant weight  
本研究的目的是确定影响巴厘岛Karangasem婴儿死亡率的因素。本研究采用的方法是对数线性模型。在对数线性模型中,分析包含两个或多个变量同时或部分关联的一组分类变量之间的关系模式。从变量之间的相互作用可以看出变量之间的模式化关系。对数线性分析不区分解释变量和响应变量。这项研究中的人口是2015年在Karangasem出生的所有婴儿,即多达7895名活产婴儿,多达7835名婴儿和60名婴儿死亡。研究人员选取了100名婴儿作为样本,其中60名存活,40名死亡。结果表明,婴儿死亡率受婴儿体重、分娩时母亲年龄以及生育间隔与婴儿体重的相互作用的影响
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引用次数: 0
Neutron Characterization of BNCT Water Phantom Based on Kartini Research Reactor Using PHITS 基于Kartini研究堆的BNCT水影的PHITS中子表征
Pub Date : 2019-08-14 DOI: 10.24246/ijpna.v4i1.16-21
Vika Hutaria, S. Susilo, Y. Sardjono
Boron Neutron Capture Therapy (BNCT) is a therapy that utilizes the interaction of thermal neutrons with a boron-10 core that produces alpha particles and lithium nuclei. The result of this boron reaction has high linear energy transfer (LET).  BNCT has an advantage over other radiation therapy in that it has a high selectivity level. This research was run using PHITS simulation to find out the value of neutron flux spread over a water phantom. The conclusion of the research is the distribution of neutron flux in the water phantom without boron is higher the the distribution of neutron flux in the water phantom containing boron
硼中子俘获疗法(BNCT)是一种利用热中子与硼-10核心相互作用产生α粒子和锂核的疗法。硼反应的结果具有较高的线性能量转移(LET)。BNCT与其他放射治疗相比有优势,因为它具有高选择性。本研究利用PHITS模拟计算了水模体上的中子通量值。研究结果表明,无硼水模中的中子通量分布高于含硼水模中的中子通量分布
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引用次数: 0
DESIGN AND MANUFACTURING DEVICE MOBILITY LOAD MOTION SHIELDING PARAFFIN RADIATION PROTECTION SYSTEM FACILITY TEST IN VITRO IN VIVO 设计制造装置移动负荷运动屏蔽石蜡辐射防护系统装置体外体内试验
Pub Date : 2019-06-30 DOI: 10.24246/IJPNA.V4I2.66-70
W. Widarto
Practical work at PSTA-BATAN to find paraffin design and the design of mobile devices with Monte Carlo N Particle (MCNP) software. The method used is to determine the paraffin design and calculate the volume of paraffin. The resulting intact writing that modeled with the MCNP. Shielding is required to absorb the leaking radiation until the 20 mSv / year Dose Limit Value for radiation workers is met. The material used is paraffin. Calculation is done by using MCNPX calculation facility with tariff of 10,42 μSv / hour. The paraffin design criteria are built on recommendations from Indonesian Journal of Physics and Nuclear Applications Volume 1, Number 1, February 2016. Some of the above-standard methods are overcome with the protection aspects of distance and radiation time. Paraffin used is made of hydrocarbons suitable for strengthening shielding structures and for absorbing gamma radiation.  
在PSTA-BATAN的实际工作中,使用蒙特卡罗N粒子(MCNP)软件进行石蜡设计和移动设备设计。所采用的方法是测定石蜡设计和计算石蜡体积。用MCNP建模得到的完整的文字。需要屏蔽以吸收泄漏的辐射,直到达到辐射工作人员的20毫西弗/年剂量限值。所用的材料是石蜡。计算采用MCNPX计算工具,电费为10.42 μSv / h。石蜡设计标准是根据2016年2月《印度尼西亚物理与核应用杂志》第1卷第1期的建议建立的。一些以上标准的方法克服了防护距离和辐射时间的问题。使用的石蜡是由适于加强屏蔽结构和吸收伽马辐射的碳氢化合物制成的。
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引用次数: 0
MEASUREMENT OF YTTRIUM-90 BIODISTRIBUTION IN SELECTIVE INTERNAL RADIATION THERAPY (SIRT) 选择性内放射治疗中钇-90生物分布的测定(sirt)
Pub Date : 2019-06-30 DOI: 10.24246/IJPNA.V4I2.45-57
S. G. Pinasti
Measurement of radionuclides biodistribution in post-radioembolization 90Y SIRT is a part of treatment evaluation, in which the assessment of biodistribution is used to evaluate the possible extrahepatic presence and the absorbed dose estimation for the tumor cells, healthy liver cells, and critical organs. As the dose-response analysis is performed based on this evaluation, the biodistribution measurement coming from post-imaging modality has a crucial role in achieving these goals. The two devices, Single Photon Emission Tomography (SPECT) and Positron Emission Tomography are discussed in some aspects, including the quality of quantitative images, performance characteristics, and absorbed dose considerations.
90Y SIRT放射栓塞后放射性核素生物分布测量是治疗评估的一部分,生物分布评估用于评估肿瘤细胞、健康肝细胞和关键器官可能存在的肝外存在和吸收剂量估计。由于剂量-反应分析是基于这种评估进行的,因此来自成像后模式的生物分布测量在实现这些目标方面具有至关重要的作用。讨论了单光子发射层析成像(SPECT)和正电子发射层析成像(Positron Emission Tomography)这两种器件,包括定量图像的质量、性能特点和吸收剂量的考虑。
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引用次数: 1
期刊
Indonesian Journal of Physics and Nuclear Applications
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