Steve Balsis, Jack Mancuso, Gemma S Krautzel, Alexandra Foote, Crystal DiMauro, Mark S Eskander
Background: A recent advance in spine surgery instrumentation is the awl-tipped screw, which allows for a reduction in the number of steps during a procedure. This innovation has the potential to decrease surgical time and affect overall efficiency. The purpose of the present study was to determine whether the use of awl-tipped pedicle screws reduces surgical time and blood loss compared with the use of conventional pedicle screws.
Methods: Using a retrospective records review, 410 patients who underwent open posterior lumbar spinal fusion surgery were analyzed. We compared 205 cases that used awl-tipped screws to 205 matched controls that used conventional pedicle screws that required tapping. The awl-tipped screw and control groups were matched for instrumented spine levels fused and were equivalent regarding other patient characteristics.
Results: Surgeries with awl-tipped pedicle screws took less time (mean [SD] = 94.35 [24.09] minutes) than surgeries with conventional screws that required tapping (mean [SD] = 111.11 [33.00] minutes; t408 = 5.87, P < 0.001). The amount of blood loss did not differ significantly between the 2 groups but trended in the expected direction.
Conclusion: Clinicians who use pedicle screws in their practice should consider utilizing awl-tipped screws rather than traditional ones, as the reduced surgical time they can provide may translate into benefits for patients.
背景:最近脊柱外科器械的一项进展是锥头螺钉,它可以减少手术过程中的步骤数。这项创新有可能减少手术时间并影响整体效率。本研究的目的是确定锥头椎弓根螺钉的使用是否比传统椎弓根螺钉减少手术时间和出血量。方法:对410例后路腰椎融合术患者进行回顾性分析。我们比较了205例使用锥头螺钉的病例和205例使用常规椎弓根螺钉需要攻丝的对照组。锥头螺钉组和对照组在融合的椎体水平上匹配,在其他患者特征上相同。结果:锥头椎弓根螺钉的手术时间(mean [SD] = 94.35 [24.09] min)少于常规螺钉的手术时间(mean [SD] = 111.11 [33.00] min; t 408 = 5.87, P < 0.001)。两组间失血量无显著差异,但呈预期趋势。结论:临床医生在实践中使用椎弓根螺钉时应考虑使用锥头螺钉而不是传统螺钉,因为锥头螺钉可以减少手术时间,从而为患者带来好处。
{"title":"Use of Awl-Tipped Pedicle Screws Reduces Surgical Time.","authors":"Steve Balsis, Jack Mancuso, Gemma S Krautzel, Alexandra Foote, Crystal DiMauro, Mark S Eskander","doi":"10.14444/8842","DOIUrl":"https://doi.org/10.14444/8842","url":null,"abstract":"<p><strong>Background: </strong>A recent advance in spine surgery instrumentation is the awl-tipped screw, which allows for a reduction in the number of steps during a procedure. This innovation has the potential to decrease surgical time and affect overall efficiency. The purpose of the present study was to determine whether the use of awl-tipped pedicle screws reduces surgical time and blood loss compared with the use of conventional pedicle screws.</p><p><strong>Methods: </strong>Using a retrospective records review, 410 patients who underwent open posterior lumbar spinal fusion surgery were analyzed. We compared 205 cases that used awl-tipped screws to 205 matched controls that used conventional pedicle screws that required tapping. The awl-tipped screw and control groups were matched for instrumented spine levels fused and were equivalent regarding other patient characteristics.</p><p><strong>Results: </strong>Surgeries with awl-tipped pedicle screws took less time (mean [SD] = 94.35 [24.09] minutes) than surgeries with conventional screws that required tapping (mean [SD] = 111.11 [33.00] minutes; <i>t</i> <sub>408</sub> = 5.87, <i>P</i> < 0.001). The amount of blood loss did not differ significantly between the 2 groups but trended in the expected direction.</p><p><strong>Conclusion: </strong>Clinicians who use pedicle screws in their practice should consider utilizing awl-tipped screws rather than traditional ones, as the reduced surgical time they can provide may translate into benefits for patients.</p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanjay Konakondla, Albert Telfeian, Raymond Gardocki, Jian Shen
Background: Thoracic disc herniations (TDHs) are rare, comprising <1% of all disc herniations, but when symptomatic can cause severe neurological dysfunction. Traditional open and mini-open approaches allow for ventral canal decompression but are associated with high morbidity, including pulmonary complications, chest tube placement, and frequent need for fusion. Full-endoscopic thoracic discectomy has emerged as an ultra-minimally invasive alternative with reduced complications and faster recovery, but its application to midline or calcified thoracic discs remains technically demanding.
Case presentation: We report the case of a 54-year-old man with progressive chest wall pain and lower-extremity hyperreflexia who was found to have a T6 to T7 central disc herniation with mild calcification and spinal cord signal change. The patient underwent an outpatient right-sided full-endoscopic transforaminal discectomy. Complete decompression was achieved without spinal cord retraction or manipulation. The patient had complete resolution of his preoperative pain and was discharged home within 2 hours.
Discussion: Compared with open thoracic discectomy, endoscopic approaches significantly lower complication rates, blood loss, hospital stay, and cost while preserving motion segments. Our case highlights strategies for addressing technically challenging central TDHs, including lateralized access, controlled bony resection, and angled instrumentation. These methods align with growing evidence demonstrating the safety and efficacy of endoscopy in thoracic pathology, though the technique requires advanced endoscopic expertise and careful patient selection.
Conclusion: Full-endoscopic transforaminal discectomy provides a safe, effective, and minimally invasive option for central TDHs in selected cases. With proper planning and advanced technical execution, endoscopic surgery can achieve decompression comparable to open surgery while minimizing morbidity and expediting recovery.
{"title":"Full-Endoscopic Transforaminal Approach With Partial Pediculectomy for a Central Thoracic Disc Herniation: Technical Note and Literature Review.","authors":"Sanjay Konakondla, Albert Telfeian, Raymond Gardocki, Jian Shen","doi":"10.14444/8839","DOIUrl":"https://doi.org/10.14444/8839","url":null,"abstract":"<p><strong>Background: </strong>Thoracic disc herniations (TDHs) are rare, comprising <1% of all disc herniations, but when symptomatic can cause severe neurological dysfunction. Traditional open and mini-open approaches allow for ventral canal decompression but are associated with high morbidity, including pulmonary complications, chest tube placement, and frequent need for fusion. Full-endoscopic thoracic discectomy has emerged as an ultra-minimally invasive alternative with reduced complications and faster recovery, but its application to midline or calcified thoracic discs remains technically demanding.</p><p><strong>Case presentation: </strong>We report the case of a 54-year-old man with progressive chest wall pain and lower-extremity hyperreflexia who was found to have a T6 to T7 central disc herniation with mild calcification and spinal cord signal change. The patient underwent an outpatient right-sided full-endoscopic transforaminal discectomy. Complete decompression was achieved without spinal cord retraction or manipulation. The patient had complete resolution of his preoperative pain and was discharged home within 2 hours.</p><p><strong>Discussion: </strong>Compared with open thoracic discectomy, endoscopic approaches significantly lower complication rates, blood loss, hospital stay, and cost while preserving motion segments. Our case highlights strategies for addressing technically challenging central TDHs, including lateralized access, controlled bony resection, and angled instrumentation. These methods align with growing evidence demonstrating the safety and efficacy of endoscopy in thoracic pathology, though the technique requires advanced endoscopic expertise and careful patient selection.</p><p><strong>Conclusion: </strong>Full-endoscopic transforaminal discectomy provides a safe, effective, and minimally invasive option for central TDHs in selected cases. With proper planning and advanced technical execution, endoscopic surgery can achieve decompression comparable to open surgery while minimizing morbidity and expediting recovery.</p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Casal Grau, Patrick S Barhouse, Rohaid Ali, José Luis Tomé Delgado, Francisco Javier Sanchez Benitez de Soto, Christian Schroeder, Albert E Telfeian
Background: Lateral lumbar interbody fusion is a widely used technique to address degenerative lumbar conditions but can be associated with injury to the psoas, lumbar plexus, and abdominal wall owing to retractor usage. We describe a minimally invasive endoscopic lateral lumbar interbody fusion (ELLIF) procedure that aims to reduce these complications by avoiding prolonged muscle retraction, preparing the disc space under direct endoscopic vision, and shortening the surgical time.
Methods: Between 2019 and 2024, 35 patients underwent ELLIF at a single center. Discectomy, endplate preparation, and iliac crest harvest were done via a working-channel endoscope without expandable retractors. Neurophysiological monitoring was used to minimize nerve injury. Outcomes included complications, visual analog scale scores for pain, and Oswestry Disability Index (ODI).
Results: Of the 35 patients (mean age 60 years), 26 had preoperative radicular pain and 9 had neurological deficits. Six minor complications occurred in 4 patients (11.4%), all managed conservatively without permanent deficits. No patients developed new radiculopathy or paresis, and there were no infections or reoperations. ODI improved by 57% at 1 month and by 88% at 1 year (both P < 0.001). By the 3-year follow-up in 9 patients, ODI scores remained near normal, and visual analog scale was reduced by 93% from baseline.
Clinical relevance: We present a minimally invasive, ELLIF, and decompression technique that provides patients with minimal complications and excellent functional recovery.
Conclusion: ELLIF offers a safe, minimally invasive alternative for patients with lumbar degenerative disease. This technique minimizes direct retraction on the psoas and lumbar plexus, resulting in a low complication rate and substantial functional recovery at short- and medium-term follow-up.
{"title":"Prone Endoscopic Lateral Lumbar Interbody Fusion: Operative Technique and Functional Outcomes in 35 Patients.","authors":"Ricardo Casal Grau, Patrick S Barhouse, Rohaid Ali, José Luis Tomé Delgado, Francisco Javier Sanchez Benitez de Soto, Christian Schroeder, Albert E Telfeian","doi":"10.14444/8840","DOIUrl":"https://doi.org/10.14444/8840","url":null,"abstract":"<p><strong>Background: </strong>Lateral lumbar interbody fusion is a widely used technique to address degenerative lumbar conditions but can be associated with injury to the psoas, lumbar plexus, and abdominal wall owing to retractor usage. We describe a minimally invasive endoscopic lateral lumbar interbody fusion (ELLIF) procedure that aims to reduce these complications by avoiding prolonged muscle retraction, preparing the disc space under direct endoscopic vision, and shortening the surgical time.</p><p><strong>Methods: </strong>Between 2019 and 2024, 35 patients underwent ELLIF at a single center. Discectomy, endplate preparation, and iliac crest harvest were done via a working-channel endoscope without expandable retractors. Neurophysiological monitoring was used to minimize nerve injury. Outcomes included complications, visual analog scale scores for pain, and Oswestry Disability Index (ODI).</p><p><strong>Results: </strong>Of the 35 patients (mean age 60 years), 26 had preoperative radicular pain and 9 had neurological deficits. Six minor complications occurred in 4 patients (11.4%), all managed conservatively without permanent deficits. No patients developed new radiculopathy or paresis, and there were no infections or reoperations. ODI improved by 57% at 1 month and by 88% at 1 year (both <i>P</i> < 0.001). By the 3-year follow-up in 9 patients, ODI scores remained near normal, and visual analog scale was reduced by 93% from baseline.</p><p><strong>Clinical relevance: </strong>We present a minimally invasive, ELLIF, and decompression technique that provides patients with minimal complications and excellent functional recovery.</p><p><strong>Conclusion: </strong>ELLIF offers a safe, minimally invasive alternative for patients with lumbar degenerative disease. This technique minimizes direct retraction on the psoas and lumbar plexus, resulting in a low complication rate and substantial functional recovery at short- and medium-term follow-up.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diego T Soto Rubio, César Carballo Cuello, Kiana J Yeganeh, Schahin Salmanian, Bryan Clampitt, Samantha Schimmel, Molly Monsour, Mohammadmahdi Sabahi, Dana Saleh, Mohsen Rostami, Jay I Kumar, Mark Greenberg, Puya Alikhani
<p><strong>Background: </strong>Osteotomies are fundamental for correcting adult spinal deformity (ASD). This study sought to compare the effectiveness of anterior column realignment (ACR), pedicle subtraction osteotomy (PSO), intradiscal osteotomy (IDO), and Ponte osteotomies in achieving spinopelvic correction, clinical outcomes, and complications.</p><p><strong>Methods: </strong>A retrospective analysis of 146 patients who underwent posterior fusions for ASD correction between 2016 and 2022 was conducted. Patients with ≥1 year of follow-up were included. Patients were grouped according to the osteotomies with the most significant impact on sagittal alignment change: IDO, PSO, ACR, or Ponte. Spinopelvic parameters-including pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), lumbar lordosis (LL), PI-LL mismatch, and sagittal vertical axis (SVA)-and their changes from pre- to postoperative images were compared. Surgical and clinical variables were collected, including mechanical complications (proximal junctional kyphosis, proximal junctional failure, different types of hardware failure, estimated blood loss, packed red blood cell transfusions, and length of stay). Clinical status was measured with the Oswestry Disability Index. Revision-free survival time was analyzed using Kaplan-Meier curves, with patients followed from index surgery until revision or last follow-up, and differences between osteotomy types were assessed.</p><p><strong>Results: </strong>A total of 146 patients underwent ASD correction with IDO (<i>n</i> = 23), PSO (<i>n</i> = 21), ACR (<i>n</i> = 32), or Ponte (<i>n</i> = 70) osteotomies. Groups were comparable in age, body mass index, preoperative disability, and most spinopelvic parameters. PSO achieved the greatest sagittal correction (ΔLL = 29.7° ± 19.1°, ΔPI-LL mismatch = -24.75 ± 14.52, ΔSVA = -74.6 ± 51.6), IDO and ACR produced intermediate corrections, and Ponte produced the least. Estimated blood loss and packed red blood cell units transfused were lower in ACR and Ponte groups, corresponding to shorter instrumented constructs. Proximal junctional kyphosis occurred most frequently in ACR (31.3%) and Ponte (21.7%) groups, while the IDO group had the lowest rate (8.7%). Hardware complications were common but similar across groups, with screw pullout more frequent in ACR. Kaplan-Meier analysis of revision-free survival up to 50 months showed no significant differences among groups (Log-rank, <i>P</i> = 0.478), with the earliest reoperations occurring in the Ponte group, followed by the ACR and PSO groups.</p><p><strong>Conclusions: </strong>PSO achieved the greatest sagittal correction, while IDO and ACR provided intermediate correction. Although not statistically significant, IDO showed a numerically higher revision-free survival, with the earlier reoperations observed in Ponte, followed by ACR and PSO. These findings suggest a trend toward greater durability with IDO, highlighting the importance of osteotomy se
{"title":"Optimizing Spinal Realignment: A Comparative Analysis of Correction and Complications of Osteotomy Techniques in Adult Spinal Deformity.","authors":"Diego T Soto Rubio, César Carballo Cuello, Kiana J Yeganeh, Schahin Salmanian, Bryan Clampitt, Samantha Schimmel, Molly Monsour, Mohammadmahdi Sabahi, Dana Saleh, Mohsen Rostami, Jay I Kumar, Mark Greenberg, Puya Alikhani","doi":"10.14444/8810","DOIUrl":"10.14444/8810","url":null,"abstract":"<p><strong>Background: </strong>Osteotomies are fundamental for correcting adult spinal deformity (ASD). This study sought to compare the effectiveness of anterior column realignment (ACR), pedicle subtraction osteotomy (PSO), intradiscal osteotomy (IDO), and Ponte osteotomies in achieving spinopelvic correction, clinical outcomes, and complications.</p><p><strong>Methods: </strong>A retrospective analysis of 146 patients who underwent posterior fusions for ASD correction between 2016 and 2022 was conducted. Patients with ≥1 year of follow-up were included. Patients were grouped according to the osteotomies with the most significant impact on sagittal alignment change: IDO, PSO, ACR, or Ponte. Spinopelvic parameters-including pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), lumbar lordosis (LL), PI-LL mismatch, and sagittal vertical axis (SVA)-and their changes from pre- to postoperative images were compared. Surgical and clinical variables were collected, including mechanical complications (proximal junctional kyphosis, proximal junctional failure, different types of hardware failure, estimated blood loss, packed red blood cell transfusions, and length of stay). Clinical status was measured with the Oswestry Disability Index. Revision-free survival time was analyzed using Kaplan-Meier curves, with patients followed from index surgery until revision or last follow-up, and differences between osteotomy types were assessed.</p><p><strong>Results: </strong>A total of 146 patients underwent ASD correction with IDO (<i>n</i> = 23), PSO (<i>n</i> = 21), ACR (<i>n</i> = 32), or Ponte (<i>n</i> = 70) osteotomies. Groups were comparable in age, body mass index, preoperative disability, and most spinopelvic parameters. PSO achieved the greatest sagittal correction (ΔLL = 29.7° ± 19.1°, ΔPI-LL mismatch = -24.75 ± 14.52, ΔSVA = -74.6 ± 51.6), IDO and ACR produced intermediate corrections, and Ponte produced the least. Estimated blood loss and packed red blood cell units transfused were lower in ACR and Ponte groups, corresponding to shorter instrumented constructs. Proximal junctional kyphosis occurred most frequently in ACR (31.3%) and Ponte (21.7%) groups, while the IDO group had the lowest rate (8.7%). Hardware complications were common but similar across groups, with screw pullout more frequent in ACR. Kaplan-Meier analysis of revision-free survival up to 50 months showed no significant differences among groups (Log-rank, <i>P</i> = 0.478), with the earliest reoperations occurring in the Ponte group, followed by the ACR and PSO groups.</p><p><strong>Conclusions: </strong>PSO achieved the greatest sagittal correction, while IDO and ACR provided intermediate correction. Although not statistically significant, IDO showed a numerically higher revision-free survival, with the earlier reoperations observed in Ponte, followed by ACR and PSO. These findings suggest a trend toward greater durability with IDO, highlighting the importance of osteotomy se","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"794-805"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael J Pompliano, Ali Bagheri, Christopher B Colwell, Camille R Nosewicz, Ethan P Deller, Bahar Shahidi, David C Sing, James D Bruffey, Hani Malone, Gregory M Mundis, Robert K Eastlack
Background: SPECT-CT highlights metabolic activity within skeletal structures, including degenerative arthropathies and other potentially pain-producing abnormalities.
Objectives: Investigate the effectiveness of single-photon emission computed tomography (SPECT-CT) in identifying pain generators and assess its role in clinical and surgical decision-making and planning.
Methods: Prospective study of 110 patients presenting with neck and back pain. SPECT-CT was ordered to identify pain generators and/or guide surgical planning. Pre- and post-SPECT-CT surveys were obtained to assess pain generator identification and subsequent changes to treatment recommendations.
Results: SPECT-CT demonstrated increased uptake in areas corresponding to clinical symptoms in 78.1% of patients. This increased diagnostic specificity reduced the number of diagnostic possibilities per patient and led to a changed diagnosis in 68.1% of patients and a changed treatment plan in 62.7%. The nonoperative group was more likely to have specific, identified targets for injections after SPECT-CT. In 57.7% of surgical candidates, the surgical plan was altered, with 11 patients (42.3%) receiving surgical treatment recommendations involving fewer surgical levels and 4 (15.3%) involving more surgical levels.
Conclusions: SPECT-CT appears to be a valuable diagnostic tool in assessing neck and back pain. It may help identify pain generators and limit the need for further diagnostic workup. It was impactful in guiding treatment strategies and potentially improved surgical planning by specifically targeting the affected areas. Further research is needed to validate these findings and establish clinical guidelines for their use in patients with neck and back pain.
{"title":"What Is the Impact of Single-Photon Emission Computed Tomography on the Management of Degenerative Cervical and Lumbar Spine Disease? A Single-Institution Study.","authors":"Michael J Pompliano, Ali Bagheri, Christopher B Colwell, Camille R Nosewicz, Ethan P Deller, Bahar Shahidi, David C Sing, James D Bruffey, Hani Malone, Gregory M Mundis, Robert K Eastlack","doi":"10.14444/8819","DOIUrl":"10.14444/8819","url":null,"abstract":"<p><strong>Background: </strong>SPECT-CT highlights metabolic activity within skeletal structures, including degenerative arthropathies and other potentially pain-producing abnormalities.</p><p><strong>Objectives: </strong>Investigate the effectiveness of single-photon emission computed tomography (SPECT-CT) in identifying pain generators and assess its role in clinical and surgical decision-making and planning.</p><p><strong>Methods: </strong>Prospective study of 110 patients presenting with neck and back pain. SPECT-CT was ordered to identify pain generators and/or guide surgical planning. Pre- and post-SPECT-CT surveys were obtained to assess pain generator identification and subsequent changes to treatment recommendations.</p><p><strong>Results: </strong>SPECT-CT demonstrated increased uptake in areas corresponding to clinical symptoms in 78.1% of patients. This increased diagnostic specificity reduced the number of diagnostic possibilities per patient and led to a changed diagnosis in 68.1% of patients and a changed treatment plan in 62.7%. The nonoperative group was more likely to have specific, identified targets for injections after SPECT-CT. In 57.7% of surgical candidates, the surgical plan was altered, with 11 patients (42.3%) receiving surgical treatment recommendations involving fewer surgical levels and 4 (15.3%) involving more surgical levels.</p><p><strong>Conclusions: </strong>SPECT-CT appears to be a valuable diagnostic tool in assessing neck and back pain. It may help identify pain generators and limit the need for further diagnostic workup. It was impactful in guiding treatment strategies and potentially improved surgical planning by specifically targeting the affected areas. Further research is needed to validate these findings and establish clinical guidelines for their use in patients with neck and back pain.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"645-651"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jared D Ament, Amir Vokshoor, Jack Petros, Tina Zabehi, Armen Khachatryan, Matthew Scott-Young, J Alex Sielatycki, Rick C Sasso, Jason M Cuéllar, Jack Zigler, Richard D Guyer, Scott Blumenthal, Todd Lanman
Background: Artificial disc replacement (ADR) has become an evidence-based alternative to traditional fusion surgery. Current guidelines for safe return-to-activity (RTA) levels following surgery have yet to be determined. This Modified Delphi study aimed to establish expert-sourced consensus for safe and optimized RTA recommendations following cervical disc arthroplasty.
Methods: Ten expert spine surgeons with an average of 15 years of surgical experience participated in a 3-round Modified Delphi Method. The first round presented experts with 11 clinical cases and 19 multiple-choice questions regarding recommendations for patient RTA following surgery for 1-, 2-, or 3-level arthroplasty. First-round responses were analyzed and presented in second-round surveys to the experts, who repeated 19 multiple-choice questions. The third round presented consensus recommendation statements derived from the second round for the final assessment of the expert agreement.
Results: Experts agreed on 19 of 22 (86.4%) postarthroplasty RTA recommendations. Eight recommendations achieved unanimous agreement; the most robust consensus (95%-100% agreement) included recommendations that patients may return to basic activities such as walking, social activities, sedentary work, air travel, and sexual activity within 2 weeks of arthroplasty surgery and that arthroplasty patients will have a shorter recovery, resuming normal activities sooner than fusion patients. Experts agreed that patients may return to light and heavy physical activity (strong consensus) earlier for 2- and 3-level ADR compared to hybrid constructs. Experts also agreed that ADR patients can resume light physical activity at 4 to 6 weeks and engage in intense conditioning and sport-specific training at 6 weeks. However, a weaker consensus was achieved for returning to physically demanding work at 4 to 6 weeks and high-intensity physical activity/sports at 6 weeks, indicating that individual patient factors and the specific nature of the activity should be considered.
Conclusion: This study provides the first consensus-based recommendations for RTA following cervical disc arthroplasty.
{"title":"Return to Activity for On- and Off-Label Cervical Arthroplasty Patients: A Multicentered Expert Panel Recommendation.","authors":"Jared D Ament, Amir Vokshoor, Jack Petros, Tina Zabehi, Armen Khachatryan, Matthew Scott-Young, J Alex Sielatycki, Rick C Sasso, Jason M Cuéllar, Jack Zigler, Richard D Guyer, Scott Blumenthal, Todd Lanman","doi":"10.14444/8834","DOIUrl":"10.14444/8834","url":null,"abstract":"<p><strong>Background: </strong>Artificial disc replacement (ADR) has become an evidence-based alternative to traditional fusion surgery. Current guidelines for safe return-to-activity (RTA) levels following surgery have yet to be determined. This Modified Delphi study aimed to establish expert-sourced consensus for safe and optimized RTA recommendations following cervical disc arthroplasty.</p><p><strong>Methods: </strong>Ten expert spine surgeons with an average of 15 years of surgical experience participated in a 3-round Modified Delphi Method. The first round presented experts with 11 clinical cases and 19 multiple-choice questions regarding recommendations for patient RTA following surgery for 1-, 2-, or 3-level arthroplasty. First-round responses were analyzed and presented in second-round surveys to the experts, who repeated 19 multiple-choice questions. The third round presented consensus recommendation statements derived from the second round for the final assessment of the expert agreement.</p><p><strong>Results: </strong>Experts agreed on 19 of 22 (86.4%) postarthroplasty RTA recommendations. Eight recommendations achieved unanimous agreement; the most robust consensus (95%-100% agreement) included recommendations that patients may return to basic activities such as walking, social activities, sedentary work, air travel, and sexual activity within 2 weeks of arthroplasty surgery and that arthroplasty patients will have a shorter recovery, resuming normal activities sooner than fusion patients. Experts agreed that patients may return to light and heavy physical activity (strong consensus) earlier for 2- and 3-level ADR compared to hybrid constructs. Experts also agreed that ADR patients can resume light physical activity at 4 to 6 weeks and engage in intense conditioning and sport-specific training at 6 weeks. However, a weaker consensus was achieved for returning to physically demanding work at 4 to 6 weeks and high-intensity physical activity/sports at 6 weeks, indicating that individual patient factors and the specific nature of the activity should be considered.</p><p><strong>Conclusion: </strong>This study provides the first consensus-based recommendations for RTA following cervical disc arthroplasty.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"806-813"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: To describe a staged surgical protocol combining halo-pelvic traction (HPT) and posterior spinal fusion (PSF) for severe scoliosis in a patient with osteogenesis imperfecta (OI) type IV and to evaluate its outcomes. Given the paucity of population-level data on spinal orthoses in OI, this report highlights a tailored surgical approach for this high-risk population.
Case presentation and management: A 16-year-old girl with OI type IV and progressive scoliosis underwent a 2-stage correction: (1) preoperative HPT for 3 months to reduce coronal deformity and optimize spinal alignment, followed by (2) PSF with all-pedicle-screw instrumentation. The staged protocol achieved successful deformity correction without neurological or implant-related complications. All pedicle screws were safely placed despite osteopenic bone. At follow-up, radiographic outcomes were maintained, and the patient reported improved posture and function. Minor surgical differences and literature review are highlighted for multimodal management.
Conclusion: Progressive scoliosis in patients with OI can be effectively managed through structured, phased therapeutic programs, with the combined approach of HPT and PSF representing a significant surgical intervention strategy.
Clinical relevance: The clinical significance of this approach lies in transforming the management of a challenging rare disease-progressive scoliosis in osteogenesis imperfecta-from an empirical endeavor into a structured, systematic clinical pathway, while providing a validated technical combination for its most critical surgical intervention.
{"title":"Surgical Strategies of Staged Spinal Traction-Fusion for Severe Scoliosis in Osteogenesis Imperfecta Type IV: A Case Report and Literature Review.","authors":"Chunyan Shen, Sheng Lu, Tiannan Zou, Yayu Zhao, Wen Lei, Hongran Ge, Weichao Li","doi":"10.14444/8835","DOIUrl":"10.14444/8835","url":null,"abstract":"<p><strong>Background: </strong>To describe a staged surgical protocol combining halo-pelvic traction (HPT) and posterior spinal fusion (PSF) for severe scoliosis in a patient with osteogenesis imperfecta (OI) type IV and to evaluate its outcomes. Given the paucity of population-level data on spinal orthoses in OI, this report highlights a tailored surgical approach for this high-risk population.</p><p><strong>Case presentation and management: </strong>A 16-year-old girl with OI type IV and progressive scoliosis underwent a 2-stage correction: (1) preoperative HPT for 3 months to reduce coronal deformity and optimize spinal alignment, followed by (2) PSF with all-pedicle-screw instrumentation. The staged protocol achieved successful deformity correction without neurological or implant-related complications. All pedicle screws were safely placed despite osteopenic bone. At follow-up, radiographic outcomes were maintained, and the patient reported improved posture and function. Minor surgical differences and literature review are highlighted for multimodal management.</p><p><strong>Conclusion: </strong>Progressive scoliosis in patients with OI can be effectively managed through structured, phased therapeutic programs, with the combined approach of HPT and PSF representing a significant surgical intervention strategy.</p><p><strong>Clinical relevance: </strong>The clinical significance of this approach lies in transforming the management of a challenging rare disease-progressive scoliosis in osteogenesis imperfecta-from an empirical endeavor into a structured, systematic clinical pathway, while providing a validated technical combination for its most critical surgical intervention.</p><p><strong>Level of evidence: 5: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":"19 6","pages":"751-759"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf T Hantouly, Sathish Muthu, Jawad Derbas, Mohd Ishaq Alamlih, Jad Lawand, Sameh Abolfotouh, Omar Alnori
Background: This systematic overview investigates prior systematic reviews exploring vertebral body tethering (VBT) in managing adolescent idiopathic scoliosis (AIS). The aim is to assess the quality of literature, present the current best evidence, and formulate recommendations.
Methods: We independently conducted duplicate electronic searches in Embase, Medline, Scopus, and Web of Science until 19 August 2023, for systematic reviews on VBT for AIS. Methodological quality was assessed using Oxford Levels of Evidence, Assessment of Multiple Systematic Reviews (AMSTAR) scoring, and AMSTAR 2 grading. The Jadad decision algorithm was utilized to identify the study with the highest quality, representing the current best evidence for recommendations.
Results: Ten systematic reviews meeting eligibility criteria were included. AMSTAR scores ranged from 4 to 10 (mean: 6.8), indicating varied methodological quality. Most studies had critically low reliability in result summaries per AMSTAR 2 grades. The current best evidence (level IV) suggests VBT as an effective surgical approach for scoliosis, with 73.9% achieving clinical success. However, 15.8% required unplanned reoperations, and 52.2% experienced complications, with a 22% tether failure rate. Thus, patient discussions should address the high reoperation and complication rates associated with this procedure.
Conclusion: The quality of evidence on VBT for AIS is critically low. Despite the systematic overview and identifying the best evidence in the literature, high-quality recommendations for practice could not be generated. Future studies with extended follow-up periods are imperative to comprehend VBT's utility in AIS management.
Clinical relevance: Evidence around the use of VBT for AIS is critically low, hence usage of VBT must be considered with caution in AIS.
Level of evidence: 4:
背景:本系统综述调查了先前关于椎体栓系术(VBT)治疗青少年特发性脊柱侧凸(AIS)的系统综述。目的是评估文献的质量,提出当前最佳证据,并制定建议。方法:我们独立地在Embase、Medline、Scopus和Web of Science中进行重复电子检索,直到2023年8月19日,对AIS的VBT进行系统评价。采用牛津证据水平、多系统评价评估(AMSTAR)评分和AMSTAR 2评分对方法学质量进行评估。使用Jadad决策算法来识别具有最高质量的研究,代表当前推荐的最佳证据。结果:纳入10项符合入选标准的系统评价。AMSTAR评分范围从4到10(平均:6.8),表明不同的方法质量。大多数研究在每个AMSTAR 2等级的结果总结中具有极低的可靠性。目前最好的证据(IV级)表明VBT是治疗脊柱侧凸的有效手术入路,73.9%的临床成功率。然而,15.8%的患者需要计划外的再手术,52.2%的患者出现并发症,22%的患者系索失败率。因此,患者应讨论与该手术相关的高再手术率和并发症发生率。结论:VBT治疗AIS的证据质量极低。尽管进行了系统的概述并确定了文献中的最佳证据,但仍无法产生高质量的实践建议。为了了解VBT在AIS管理中的应用,未来的研究需要延长随访期。临床相关性:关于使用VBT治疗AIS的证据非常少,因此在AIS中使用VBT必须谨慎考虑。证据等级:4;
{"title":"Vertebral Body Tethering for Adolescent Idiopathic Scoliosis: Quality of Evidence and Recommendations From a Systematic Overview of Systematic Reviews in Literature.","authors":"Ashraf T Hantouly, Sathish Muthu, Jawad Derbas, Mohd Ishaq Alamlih, Jad Lawand, Sameh Abolfotouh, Omar Alnori","doi":"10.14444/8822","DOIUrl":"10.14444/8822","url":null,"abstract":"<p><strong>Background: </strong>This systematic overview investigates prior systematic reviews exploring vertebral body tethering (VBT) in managing adolescent idiopathic scoliosis (AIS). The aim is to assess the quality of literature, present the current best evidence, and formulate recommendations.</p><p><strong>Methods: </strong>We independently conducted duplicate electronic searches in Embase, Medline, Scopus, and Web of Science until 19 August 2023, for systematic reviews on VBT for AIS. Methodological quality was assessed using Oxford Levels of Evidence, Assessment of Multiple Systematic Reviews (AMSTAR) scoring, and AMSTAR 2 grading. The Jadad decision algorithm was utilized to identify the study with the highest quality, representing the current best evidence for recommendations.</p><p><strong>Results: </strong>Ten systematic reviews meeting eligibility criteria were included. AMSTAR scores ranged from 4 to 10 (mean: 6.8), indicating varied methodological quality. Most studies had critically low reliability in result summaries per AMSTAR 2 grades. The current best evidence (level IV) suggests VBT as an effective surgical approach for scoliosis, with 73.9% achieving clinical success. However, 15.8% required unplanned reoperations, and 52.2% experienced complications, with a 22% tether failure rate. Thus, patient discussions should address the high reoperation and complication rates associated with this procedure.</p><p><strong>Conclusion: </strong>The quality of evidence on VBT for AIS is critically low. Despite the systematic overview and identifying the best evidence in the literature, high-quality recommendations for practice could not be generated. Future studies with extended follow-up periods are imperative to comprehend VBT's utility in AIS management.</p><p><strong>Clinical relevance: </strong>Evidence around the use of VBT for AIS is critically low, hence usage of VBT must be considered with caution in AIS.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"670-682"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kai-Uwe Lewandrowski, Morgan P Lorio, Oscar L Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A Yuan, Alexander R Vaccaro
Spine surgery is a highly skill-dependent specialty, where the surgeon's expertise plays a critical role in determining patient outcomes. Despite the traditional emphasis on randomized controlled trials and meta-analyses as the gold standard for clinical research, these methodologies may fall short in accounting for the variability in surgeon proficiency, which significantly influences success rates in spine surgery. This perspective article examines the limitations of relying solely on randomized controlled trials and meta-analyses in skill-driven fields such as spine surgery and argues for a broader research paradigm that incorporates the role of surgical skill and experience. Alternative methodologies, such as observational studies, surgeon-led outcome tracking, and surgical registries, are proposed to better capture the real-world complexities of spine surgery. This perspective article emphasizes the importance of structured training programs, continuous professional development, and proficiency-based education models in improving surgical outcomes. A call to action is made for policymakers, professional organizations, and academic institutions to shift the focus of spine surgery research toward integrating surgeon expertise alongside traditional evidence-based approaches, ultimately fostering innovation and improving patient care.
{"title":"Surgeon Skill Level, Experience, and Impact on Patient Outcomes: Rethinking Research Paradigms in Spine Surgery.","authors":"Kai-Uwe Lewandrowski, Morgan P Lorio, Oscar L Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A Yuan, Alexander R Vaccaro","doi":"10.14444/8787","DOIUrl":"10.14444/8787","url":null,"abstract":"<p><p>Spine surgery is a highly skill-dependent specialty, where the surgeon's expertise plays a critical role in determining patient outcomes. Despite the traditional emphasis on randomized controlled trials and meta-analyses as the gold standard for clinical research, these methodologies may fall short in accounting for the variability in surgeon proficiency, which significantly influences success rates in spine surgery. This perspective article examines the limitations of relying solely on randomized controlled trials and meta-analyses in skill-driven fields such as spine surgery and argues for a broader research paradigm that incorporates the role of surgical skill and experience. Alternative methodologies, such as observational studies, surgeon-led outcome tracking, and surgical registries, are proposed to better capture the real-world complexities of spine surgery. This perspective article emphasizes the importance of structured training programs, continuous professional development, and proficiency-based education models in improving surgical outcomes. A call to action is made for policymakers, professional organizations, and academic institutions to shift the focus of spine surgery research toward integrating surgeon expertise alongside traditional evidence-based approaches, ultimately fostering innovation and improving patient care.</p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"683-689"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James S Harrop, Puya Alikhani
Objective: Including conditions like obesity, diabetes, hypertension, and dyslipidemia, metabolic syndrome disrupts metabolic homeostasis and impairs recovery, increasing the risk of surgical complications. This study evaluates the impact of metabolic syndrome on spine surgery outcomes, addressing inconsistencies in the existing literature.
Methods: Four databases were searched until December 2024 for studies comparing the postoperative complication rates of spine surgeries between patients with and without metabolic syndrome. Following deduplication, 2 authors independently reviewed the studies. For each included study, demographics and incidence rates of postoperative complications were extracted separately by 2 authors. Data analysis was performed using R.
Results: After deduplication, 115 studies were evaluated for inclusion in our study. Following the review of full texts, 11 studies were included. No significant differences were found between patients with and without metabolic syndrome in terms of mortality and nonhome discharge, pulmonary thromboendarterectomy, pneumonia, and sepsis (P > 0.05). However, metabolic syndrome was associated with a significantly increased risk of 30-day readmission (RR: 1.5, 95% CI: 1.2-1.8), reoperation (RR: 1.3, 95% CI: 1.1-1.6), cardiac complications (RR: 1.7, 95% CI: 1.5-2.1), respiratory complications (RR: 1.68, 95% CI: 1.17-2.40), cerebrovascular complications (RR: 2.0, 95% CI: 1.4-2.9), renal complications (RR: 4.48, 95% CI: 2.58-7.80), urinary complications (RR: 1.45, 95% CI: 1.41-1.48), venous thromboembolism (RR: 1.3, 95% CI: 1.1-1.6), and wound complications (RR: 1.6, 95% CI: 1.3-1.9).
Conclusions: Metabolic syndrome might significantly increase the risk of some postoperative complications in spine surgery patients. These findings highlight the need for personalized preoperative planning and management strategies to mitigate surgery risks.
Clinical relevance: Identifying and optimizing metabolic syndrome components before surgery may improve patient outcomes and reduce complication rates.
{"title":"Metabolic Syndrome as a Risk Factor for Postoperative Complication in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis of More Than 3 Million Cases.","authors":"Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James S Harrop, Puya Alikhani","doi":"10.14444/8813","DOIUrl":"10.14444/8813","url":null,"abstract":"<p><strong>Objective: </strong>Including conditions like obesity, diabetes, hypertension, and dyslipidemia, metabolic syndrome disrupts metabolic homeostasis and impairs recovery, increasing the risk of surgical complications. This study evaluates the impact of metabolic syndrome on spine surgery outcomes, addressing inconsistencies in the existing literature.</p><p><strong>Methods: </strong>Four databases were searched until December 2024 for studies comparing the postoperative complication rates of spine surgeries between patients with and without metabolic syndrome. Following deduplication, 2 authors independently reviewed the studies. For each included study, demographics and incidence rates of postoperative complications were extracted separately by 2 authors. Data analysis was performed using R.</p><p><strong>Results: </strong>After deduplication, 115 studies were evaluated for inclusion in our study. Following the review of full texts, 11 studies were included. No significant differences were found between patients with and without metabolic syndrome in terms of mortality and nonhome discharge, pulmonary thromboendarterectomy, pneumonia, and sepsis (<i>P</i> > 0.05). However, metabolic syndrome was associated with a significantly increased risk of 30-day readmission (RR: 1.5, 95% CI: 1.2-1.8), reoperation (RR: 1.3, 95% CI: 1.1-1.6), cardiac complications (RR: 1.7, 95% CI: 1.5-2.1), respiratory complications (RR: 1.68, 95% CI: 1.17-2.40), cerebrovascular complications (RR: 2.0, 95% CI: 1.4-2.9), renal complications (RR: 4.48, 95% CI: 2.58-7.80), urinary complications (RR: 1.45, 95% CI: 1.41-1.48), venous thromboembolism (RR: 1.3, 95% CI: 1.1-1.6), and wound complications (RR: 1.6, 95% CI: 1.3-1.9).</p><p><strong>Conclusions: </strong>Metabolic syndrome might significantly increase the risk of some postoperative complications in spine surgery patients. These findings highlight the need for personalized preoperative planning and management strategies to mitigate surgery risks.</p><p><strong>Clinical relevance: </strong>Identifying and optimizing metabolic syndrome components before surgery may improve patient outcomes and reduce complication rates.</p><p><strong>Level of evidence: 2: </strong></p>","PeriodicalId":38486,"journal":{"name":"International Journal of Spine Surgery","volume":" ","pages":"783-793"},"PeriodicalIF":1.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}