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Towards Automatic Generation of Patient-Specific Knee Models 面向患者特异性膝关节模型的自动生成
Pub Date : 1900-01-01 DOI: 10.29007/5r88
E. Elyasi, M. Bucki, Boubaker Asaadi, D. Elizondo, A. Perrier
The objective of the current paper is to present a pipeline designed to reduce the pre-processing time required to build subject-specific finite element knee models and facilitate their clinical integration. The pipeline involves development and validation of an atlas model of the knee joint and features of the TwInsight software suit that use novel methodologies such as: 1) deep learning for automatic segmentation of the bones from computed tomography scans, 2) automatic generation of finite element meshes with hexahedral elements, and 3) anatomical inference algorithm to adapt the atlas model to the morphology of a subject and result in the subject’s personalized biomechanical model.
本论文的目的是提出一种管道,旨在减少建立特定主题的有限元膝关节模型所需的预处理时间,并促进其临床整合。该流程涉及膝关节图谱模型的开发和验证,以及使用新方法的TwInsight软件套装的功能,例如:1)深度学习用于从计算机断层扫描中自动分割骨骼,2)自动生成具有六面体元素的有限元网格,以及3)解剖推理算法,使图谱模型适应受试者的形态,并产生受试者的个性化生物力学模型。
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引用次数: 0
Tibial and femoral bones segmentation on CT-scans: a deep learning approach ct扫描胫骨和股骨分割:一种深度学习方法
Pub Date : 1900-01-01 DOI: 10.29007/6jqc
Ludivine Maintier, Ehouarn Maguet, A. Clavé, E. Stindel, V. Burdin, G. Dardenne
Custom implants in Total Knee Arthroplasty (TKA) could improve prosthesis’ durability and patient’s comfort, but designing such personalized implants requires a simplified and thus automatic workflow to be easily integrated in the clinical routine. A good knowledge of the shape of the patient's femur and tibia is necessary to design it, but segmentation is still today a key issue. We present here an automatic segmentation approach of the three joints of the lower limb: hip, knee and ankle, using convolutional neural networks (CNNs) on successive transverse views from CT images. Our three 2D CNNs are built on the U-net model, and their specialization each on one joint allowed us to achieve promising results presented here. This could be integrated in a TKA planning software allowing the automatic design of TKA custom implants.
全膝关节置换术(TKA)中的定制假体可以提高假体的耐用性和患者的舒适度,但设计这种个性化的假体需要一个简化的自动化工作流程,以便于与临床常规相结合。对患者股骨和胫骨的形状有很好的了解是设计它的必要条件,但分割仍然是当今的一个关键问题。本文提出了一种自动分割下肢三个关节的方法:髋关节、膝关节和踝关节,使用卷积神经网络(cnn)对CT图像的连续横向视图进行分割。我们的三个二维cnn是建立在U-net模型上的,它们在一个关节上的专门化使我们获得了这里展示的有希望的结果。这可以集成在TKA规划软件中,允许TKA定制植入物的自动设计。
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引用次数: 0
Ability to Achieve Mediolateral Gap Balance with Instrumented Navigated Total Knee Arthroplasty – A Review of the First 150 Cases 有器械导航的全膝关节置换术实现内外侧间隙平衡的能力——前150例的回顾
Pub Date : 1900-01-01 DOI: 10.29007/d37h
L. Angibaud, A. Jung, C. Hamad, Wen Fan, M. Davis, Brian J Zirgibel, Jake Deister, J. Huddleston
Appropriate management of the soft tissue envelope at the time of the surgery is critical to the long- term success of total knee arthroplasty (TKA). In this regard, thiscomputer-assisted orthopedic surgery (a force-controlled intraarticular distractor. The first 150 cases performed by 16 surgeons were reported without any exclusions, and for each of these cases, the final mediolateral (ML) laxity was compared to the predicted ML laxity. The average signed ML laxity was well aligned with a neutral differential throughout the full arc of motion and ranged from -0.05mm at 35° of flexion to 0.37mm at 85° of flexion. The signed ML laxity curves tend to be surgeon specific. The average unsigned ML laxity was linear throughout the full arc motion and ranged from 1.14mm at 85° of flexion to 1.27mmat 30° of flexion.the targeted ML gap balance when using afeaturingDespite data from all the users (not only design surgeons) involved with this pilotrelease were considered and the learning curve cases were not excluded, it was observed a high abilitystudy evaluated the ability to achieveCAOS) systemto achieve the targeted ML laxity using the proposed method.
手术时对软组织包膜的适当处理是全膝关节置换术(TKA)长期成功的关键。在这方面,这种计算机辅助骨科手术(力控制关节内牵引器)。由16位外科医生进行的前150例报告没有任何排除,并且对于每个病例,最终的中外侧(ML)松弛与预测的ML松弛进行比较。在整个运动弧度中,平均签名ML松弛度与中性差对齐良好,范围从35°屈曲时的-0.05mm到85°屈曲时的0.37mm。有符号的ML松弛曲线往往是外科医生特有的。在整个弧形运动中,平均无符号ML松弛度呈线性,范围从85°屈曲时的1.14mm到30°屈曲时的1.27mm。尽管考虑了参与该试验发布的所有用户(不仅仅是设计外科医生)的数据,并且不排除学习曲线案例,但观察到一项高能力研究评估了使用所提出的方法实现ecos系统的目标ML松弛的能力。
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引用次数: 0
Preoperative planning in shoulder arthroplasty: what about the soft tissue? 肩关节置换术的术前计划:软组织怎么办?
Pub Date : 1900-01-01 DOI: 10.29007/x1n7
J. Werthel, F. Boux de Casson, Cédric Manelli, J. Chaoui, G. Walch, V. Burdin
The primary objective of this study was to obtain a reliable method of automatic segmentation of shoulder muscles. The secondary objective of this study was to define a new computed tomography (CT)-based quantitative 3-dimensional (3D) measure of muscle loss (3DML) based on the rationale of the 2-dimensional (2D) qualitative Goutallier score. 102 CT scans were manually segmented and an algorithm of automated segmentation of the muscles was created. The volume of muscle fibers without intramuscular fat was then calculated for each rotator cuff muscle and normalized to the patient's scapular volume to account for the effect of body size (NVfibers). 3D muscle mass (3DMM) was calculated by dividing the NVfibers value of a given muscle by the mean expected volume in healthy shoulders. 3D muscle loss (3DML) was defined as 1 - (3DMM). Automated segmentation of the muscles was possible with a mean Dice of 0.904 ± 0.01 for the deltoid, 0.887 ± 0.014 for the infraspinatus (ISP), 0.892 ± 0.008 for the subscapularis (SSC), 0.885 for the supraspinatus (SSP) and 0.796 ± 0.006 for the teres minor (TM). The mean values of 3DFI and 3DML were 0.9% and 5.3% for Goutallier 0, 2.9% and 25.6% for Goutallier 1, 11.4% and 49.5% for Goutallier 2, 20.7% and 59.7% for Goutallier 3, and 29.3% and 70.2% for Goutallier 4, respectively. 3DML measurements obtained automatically incorporate both atrophy and fatty infiltration, thus they could become a very reliable index for assessing shoulder muscle function which could help in the decision process in shoulder surgery
本研究的主要目的是获得一种可靠的肩部肌肉自动分割方法。本研究的次要目的是在二维定性Goutallier评分的基础上,定义一种新的基于计算机断层扫描(CT)的定量三维(3D)肌肉损失(3DML)测量方法。对102个CT扫描图像进行了手工分割,并创建了一种自动分割肌肉的算法。然后计算每个肩袖肌不含肌内脂肪的肌纤维体积,并将其归一化为患者的肩胛骨体积,以考虑体型(NVfibers)的影响。通过将给定肌肉的NVfibers值除以健康肩部的平均预期体积,计算出3D肌肉质量(3DMM)。3D肌肉损失(3DML)定义为1 - (3DMM)。三角肌的平均分割概率为0.904±0.01,冈下肌(ISP)为0.887±0.014,肩胛下肌(SSC)为0.892±0.008,冈上肌(SSP)为0.885,小圆肌(TM)为0.796±0.006。Goutallier 0的3DFI和3DML平均值分别为0.9%和5.3%,Goutallier 1的2.9%和25.6%,Goutallier 2的11.4%和49.5%,Goutallier 3的20.7%和59.7%,Goutallier 4的29.3%和70.2%。获得的3DML测量值自动包含萎缩和脂肪浸润,因此它们可以成为评估肩部肌肉功能的非常可靠的指标,有助于肩部手术的决策过程
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引用次数: 0
Computer and Robotic Assisted Orthopaedic Knee Arthroplasty Surgery: Did CAOS technologies have an impact on the mainstream principles and concepts in the orthopaedic knee forum? A case study on alignment and balancing for TKA. 计算机和机器人辅助骨科膝关节成形术:CAOS技术对骨科膝关节论坛的主流原则和概念有影响吗?TKA的对准与平衡案例研究。
Pub Date : 1900-01-01 DOI: 10.29007/h7k4
D. Wallace, F. Mahmood, A. Deakin, P. Riches, K. Deep, J. Baines, F. Picard
Computer technology is ubiquitous and relied upon in virtually all professional activities. Confounding this is orthopaedic surgery where less than 5% of surgeons are using computer-assisted technologies routinely. However, the impact of Computer Assisted Orthopaedic Surgery (CAOS) may go beyond adoption in theatre.We searched pubmed for all knee arthroplasty papers concerning knee alignment and balancing between 1976 and 2016, dividing the results into those related to CAOS and those not. Results were grouped by technology.Between 2001 and 2008, the number of publications regarding knee navigation multiplied by 20 mainly focused on this topic of alignment and balancing, with alignment papers paralleled between navigation and non-navigation until 2010. After 2010, when navigation publications decline the number of articles related to the knee alignment and balancing without navigation increased granting the value of assessing accurately intraoperative kinematic data to improve Total Knee Arthroplasty (TKA) outcomes. From 2008, patient specific instrumentation (PSI) publications greatly increase, but navigation decreases, while robotic publications rise from 2014.CAOS surgery publications on the search topic of alignment and balancing increased greatly between 2001 and 2018 which may suggest the impact of CAOS technology on this important knee orthopaedic forum segment.
计算机技术无处不在,几乎在所有的专业活动中都离不开它。令人困惑的是,在骨科手术中,只有不到5%的外科医生常规使用计算机辅助技术。然而,计算机辅助骨科手术(CAOS)的影响可能超出了在剧院的采用。我们检索了1976年至2016年间有关膝关节对齐和平衡的所有膝关节置换术论文,并将结果分为与CAOS相关的和与CAOS无关的。结果按技术分组。在2001年至2008年期间,关于膝关节导航的出版物数量增加了20,主要集中在对齐和平衡这一主题上,直到2010年,导航和非导航之间的对齐论文并行。2010年后,当导航出版物减少时,与无导航的膝关节对齐和平衡相关的文章数量增加,赋予准确评估术中运动学数据以改善全膝关节置换术(TKA)结果的价值。从2008年开始,患者专用仪器(PSI)的出版物大幅增加,但导航减少,而机器人出版物从2014年开始上升。2001年至2018年间,CAOS外科出版物中关于对齐和平衡的搜索主题大幅增加,这可能表明CAOS技术对这一重要的膝关节骨科论坛领域产生了影响。
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引用次数: 0
Computer and Robotic Assisted Orthopaedic Knee Arthroplasty Surgery Who drives innovations? 计算机和机器人辅助骨科膝关节成形术谁在推动创新?
Pub Date : 1900-01-01 DOI: 10.29007/xn1l
D. Wallace, F. Mahmood, A. Deakin, P. Riches, K. Deep, J. Baines, F. Picard
Computer assisted and Robotic technology in orthopaedic surgery is still not commonplace compared to un-assisted, conventional orthopaedic surgery. We analysed the relationship between patents and publications trend and question whether we could recognise a pattern which would confirm industry-driven innovation in orthopaedic surgery.Following the same methodology used by Dalton et al. in 2016, we searched pubmed for publications between 1980 and 2018 concerning unicompartmental, patient specific instrumentation, navigation and robotic knee arthroplasty, and patents registered under the “knee arthroplasty” or “knee replacement” label over the same period. Data was plotted using 4 point moving averages.Between 2004 and 2008, the number of publications regarding navigation multiplied by 20 following the number of patents registered during the same period. From 2008 onwards, the number of navigation publications declined while Patient Specific Instrumentation (PSI) publications increased also following patent investments from orthopaedic companies. Finally, robotic publications grew significantly pulled by massive patent registrations after 2012.It seems that the industry has finally found a lucrative economical model after many years of trial and errors and sustained driving innovations.
与无辅助的传统骨科手术相比,计算机辅助和机器人技术在骨科手术中的应用仍不普遍。我们分析了专利和出版物趋势之间的关系,并质疑我们是否能够识别出一种模式,这种模式将确认骨科手术行业驱动的创新。按照Dalton等人在2016年使用的相同方法,我们检索了1980年至2018年间关于单室、患者特定器械、导航和机器人膝关节置换术的出版物,以及同期在“膝关节置换术”或“膝关节置换”标签下注册的专利。数据采用4点移动平均线绘制。在2004年至2008年期间,与导航相关的出版物数量增加了20倍,同期的专利注册数量也增加了20倍。从2008年开始,导航出版物的数量下降,而患者专用仪器(PSI)出版物也随着骨科公司的专利投资而增加。最后,2012年之后,机器人出版物在大量专利注册的拉动下显著增长。经过多年的试错和持续的创新,这个行业似乎终于找到了一个有利可图的经济模式。
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引用次数: 0
Development of a Portable Upper Limb Muscle Dynamometer for Assessment of Neuromuscular Injury Patients 用于评估神经肌肉损伤患者的便携式上肢肌肉测功仪的研制
Pub Date : 1900-01-01 DOI: 10.29007/k9ms
Colin Day, Erik Bedard, Yassine El Alaoui, Mark Hwang, Michael Berger, J. Giles
IntroductionPatient recovery from neuromuscular injuries that cause upper limb dysfunction is commonly assessed via manual methods. Manual muscle testing is subjective, time consuming and requires extensive training. Existing dynamometers are more objective, but they are prohibitively expensive and impractically large, making them inaccessible to most clinics and patients with disabilities. Our aim is to develop a table-top upper limb muscle dynamometer that provides standard positioning, ease of use and portability while giving clinicians consistent and reliable quantitative data on a patient’s isotonic and isometric muscle power and strength, respectively.MethodsThe device consists of a lever arm, a brushless DC motor, a load sensor and an ergonomic cuff. It outputs analog data via standard BNC connectors. The device can be intuitively controlled by the operator to test various upper limb joints and motions. Isometric measurement repeatability was assessed by recording the maximal voluntary contractions of 18 healthy participants over three trials.ResultsThe repeatability across 3 trials was 2.70±2.27 Nm (95th percentile: 6.74 Nm) for elbow flexion, and 2.83±2.13 Nm (95th percentile: 5.65 Nm) for elbow extension.ConclusionsThe dynamometer demonstrates a marked improvement in repeatability relative to manual muscle testing. Its small footprint and low cost can make it an easily accessible, standardized testing tool that requires little training to use. Future research and development will focus on using field-oriented control to measure isotonic muscle power in addition to isometric strength.
神经肌肉损伤导致上肢功能障碍的患者恢复情况通常通过手工方法评估。手动肌肉测试是主观的,耗时的,需要大量的训练。现有的测力计更为客观,但它们价格昂贵,体积庞大,使大多数诊所和残疾患者无法使用。我们的目标是开发一种桌面上肢肌肉测力仪,提供标准定位,易于使用和便携性,同时为临床医生提供一致和可靠的定量数据,分别关于患者的等张和等张肌肉力量和力量。方法该装置由杠杆臂、无刷直流电机、负载传感器和人体工程学袖口组成。它通过标准BNC连接器输出模拟数据。操作者可以直观地控制设备,测试上肢的各种关节和动作。通过记录18名健康参与者在三个试验中的最大自愿收缩来评估等长测量的可重复性。结果3个试验的重复性肘关节屈曲为2.70±2.27 Nm(95百分位数:6.74 Nm),肘关节伸直为2.83±2.13 Nm(95百分位数:5.65 Nm)。结论与人工肌肉测试相比,该测功机在重复性上有显著提高。它占地面积小,成本低,可以使它成为一种易于使用的标准化测试工具,几乎不需要培训就可以使用。未来的研究和发展将集中在使用场定向控制来测量等张力肌肉力量。
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引用次数: 0
Cloud-Based Three-Dimensional Pattern Analysis and Classification of Proximal Humeral Fractures – A Feasibility Study 基于云的肱骨近端骨折三维模式分析和分类-可行性研究
Pub Date : 1900-01-01 DOI: 10.29007/bprl
D. Baumann, Ariane Gerber Popp, Markus Degen, D. Brodbeck, F. Coigny, T. Suter, E. Schkommodau
For the complex clinical issue of treatment decision for proximal humeral fractures, dedicated software based on three-dimensional (3D) computer tomography (CT) models would potentially allow for a more accurate fracture classification and help to plan the surgical strategy needed to reduce the fracture in the operating theatre. The aim of this study was to elaborate the feasibility of implementation of such software using state-of-the-art cloud technology to enable access to its functionalities in a distributed manner. Feasibility was studied by implementation of a prototype application, which was tested in a usability study with five biomedical engineers.Implementation of a cloud-based solution was feasible using state-of-the-art technology under application of a specific software architectural approach allowing to distribute computational load between client and server. Mean System Usability Scale (SUS) Score for the developed application was determined to be 63 (StDev 20.4). These results can be interpreted as a medium low usability with high standard deviation of the measured SUS score. We conclude that more test subjects should be included in future studies and the developed application should be evaluated with a representative user group such as orthopaedic shoulder surgeons in a clinical setting.
对于肱骨近端骨折治疗决策的复杂临床问题,基于三维(3D)计算机断层扫描(CT)模型的专用软件可能允许更准确的骨折分类,并有助于计划手术策略,以减少手术室中的骨折。本研究的目的是详细说明使用最先进的云技术实现这种软件的可行性,以便以分布式方式访问其功能。通过实现一个原型应用程序来研究可行性,该应用程序在五名生物医学工程师的可用性研究中进行了测试。基于云的解决方案的实现是可行的,使用最先进的技术,并应用特定的软件体系结构方法,允许在客户机和服务器之间分配计算负载。开发的应用程序的平均系统可用性量表(SUS)得分确定为63 (StDev 20.4)。这些结果可以解释为中等低的可用性与测量的SUS分数的高标准偏差。我们的结论是,在未来的研究中应该纳入更多的测试对象,并且应该在临床环境中与具有代表性的用户群体(如骨科肩关节外科医生)一起评估开发的应用程序。
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引用次数: 1
Comparison of a Novel Joint Distraction Radiology Protocol in Total Knee Arthroplasty Planning with Navigated Joint Gaps 导航关节间隙全膝关节置换术中新型关节牵张放射学方案的比较
Pub Date : 1900-01-01 DOI: 10.29007/j6kh
David W. Liu, Ishaan Jagota, J. Twiggs, B. Miles
Native extension and flexion joint gaps are primarily measured intraoperatively using devices such as navigation systems or tensioners, but there are advantages to being able to pre-operatively plan to such gaps. This study aims to validate the ability of a novel distracted joint gap radiology protocol to measure pre-operative extension andflexion joint gaps. A retrospective study comprised of 42 knees was performed. Patient imaging was obtained and used to perform segmentation, landmarking and 3D-to-2D registration. The pre-operative medial and lateral joint gaps were determined in extension and flexion. Intraoperatively, a range of motion analysis was conducted using the Brainlab Knee 3 navigation system to measure the joint gaps in extension and flexion.In extension, both medial and lateral pre-operative radiological and intraoperative navigated gaps displayed moderate and statistically significant correlations (r=0.45; p=0.003 for medial and r=0.4; p=0.01 for lateral). In flexion, only the medial radiological and navigated joint gaps correlated (r=0.54, p<0.001), with a not statistically significant trend for the lateral flexion joint gaps.The moderate and statistically significant correlations between these joint gaps to those measured intraoperatively suggests they are reflective of on the table experience with patients. Although further work is required to understand if differences are attributable to variability in the radiological or intra-operative assessments, the pre- operative analysis technique described in this study provides the opportunity to develop a more holistic pre-operative surgical plan which considers the state of both hard and soft tissue within the joint.
原生伸展和屈曲关节间隙主要是术中使用导航系统或张力器等设备测量的,但是能够在手术前计划这些间隙是有好处的。本研究旨在验证一种新的分散关节间隙放射学方案的能力,以测量术前伸展和屈曲关节间隙。对42个膝关节进行回顾性研究。获得患者图像并用于进行分割,标记和3d到2d注册。术前确定关节内侧和外侧间隙的伸缩。术中,使用Brainlab Knee 3导航系统进行运动范围分析,测量关节伸展和屈曲间隙。此外,手术前放射学和术中导航间隙的内侧和外侧显示出中度和统计学上显著的相关性(r=0.45;内侧组P =0.003, r=0.4;侧边P =0.01)。在屈曲中,只有内侧关节间隙和导航关节间隙相关(r=0.54, p<0.001),而外侧屈曲关节间隙无统计学意义。这些关节间隙与术中测量的关节间隙之间存在适度且统计学上显著的相关性,这表明它们反映了患者在手术台上的经验。虽然需要进一步的工作来了解差异是否归因于放射学或术中评估的差异,但本研究中描述的术前分析技术为制定更全面的术前手术计划提供了机会,该计划考虑了关节内硬组织和软组织的状态。
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引用次数: 0
Improved Mediolateral Gap Balance Achievement with Instrumented Navigated Total Knee Arthroplasty Compared to Conventional Instrumentation 与传统器械相比,器械导航全膝关节置换术改善了内外侧间隙平衡的实现
Pub Date : 1900-01-01 DOI: 10.29007/4lwm
L. Angibaud, Wen Fan, Florian Kerveillant, P. Dubard, Marine Torrollion, M. Rueff, A. Sah, J. Huddleston
Total knee replacement (TKA) represents a well-established reconstructive procedure for end-stage knee joint disorders with the balancing of soft-tissue envelope throughout the full arc of motion as a newly emerging possibility. This cadaveric study evaluated the ability to achieve targeted mediolateral (ML) gap balance throughout the arc of motion using conventional mechanical instrumentation versus a computer-assisted orthopaedic surgery (CAOS) system featuring an intraarticular distractor while considering surgeon experience level. For the CAOS system, an intraarticular distractor applied a quasi- constant distraction force to the joint (instrumented) while the conventional system involved conventional spacers. Regardless of experience level, the instrumented TKAs were associated with a significantly lower ML gap differential than the conventional TKAs. In contrast, regardless of the type of instrumentation, there were no significant differences between the junior and senior surgeon mean gaps. Historically, soft tissue balancing during TKA has been reported as an art rather than a science. In this regard, the addition of dedicated technology to characterize the soft-tissue envelope during TKA has the potential to provide an augmented perspective to the surgeon and can be particularly beneficial for junior surgeons. The present study established that the usage of instrumented CAOS led to significantly lower ML gap differences than conventional instrumentation.
全膝关节置换术(TKA)代表了终末期膝关节疾病的一种完善的重建程序,在整个运动弧度中平衡软组织包膜是一种新出现的可能性。本尸体研究评估了在考虑外科医生经验水平的情况下,使用传统机械器械与具有关节内牵引器的计算机辅助骨科手术(CAOS)系统在整个运动弧线中实现目标中外侧(ML)间隙平衡的能力。对于CAOS系统,关节内牵张器对关节(固定)施加准恒定的牵张力,而传统系统涉及传统的间隔器。无论经验水平如何,与传统tka相比,仪器tka与ML间隙差异显著降低。相比之下,无论内固定类型如何,初级和高级外科医生的平均间隙没有显著差异。历史上,TKA期间的软组织平衡被认为是一门艺术而不是一门科学。在这方面,在TKA期间加入专门的技术来表征软组织包膜,有可能为外科医生提供一个增强的视角,对初级外科医生特别有益。本研究证实,与传统仪器相比,使用仪器化CAOS可显著降低ML间隙差异。
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引用次数: 0
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