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Treatable movement disorders in children 儿童可治疗的运动障碍
Q3 Medicine Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.003
Gautam P Ambegaonkar
Movement disorders are common in children but can be difficult to assess and diagnose as they are often mistaken for developmental disorders, may occur intermittently/ paroxysmally, and the child or their parents may not be able to describe them accurately. The aetiologies of paediatric movement disorders are significantly different to adults. Whilst many of the early onset paediatric movement disorders have a genetic basis and do not have a cure, there are some movement disorders which have a potentially reversible cause and treatable. This review provides an approach to the common, treatable, movement disorders in children.
运动障碍在儿童中很常见,但很难评估和诊断,因为它们经常被误认为发育障碍,可能间歇性/阵发性地发生,儿童或其父母可能无法准确描述它们。儿童运动障碍的病因与成人有显著不同。虽然许多早期儿童运动障碍有遗传基础,无法治愈,但有一些运动障碍有潜在的可逆原因和可治疗的。这篇综述提供了一种常见的,可治疗的,儿童运动障碍的方法。
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引用次数: 0
Neuroprotection in traumatic brain injury 外伤性脑损伤的神经保护
Q3 Medicine Pub Date : 2025-04-19 DOI: 10.1016/j.paed.2025.04.001
Swathy Subhash, Shruti Agrawal
Traumatic brain injury is the leading cause of trauma-related death and disability in children worldwide. To improve neuro-outcomes after injury, neuroprotective measures are implemented to limit secondary brain injury by providing adequate cerebral perfusion and oxygenation. In this article we review the general supportive and targeted neuroprotective measures that are outlined in the international paediatric guidelines and the physiological basis for these recommendations based on the underlying pathology. We also discuss multimodal neuro-monitoring in the PICU. We aim to provide a practical approach on how to respond to deteriorating patients, and manage complications arising during the course of their treatment.
创伤性脑损伤是全世界儿童创伤相关死亡和残疾的主要原因。为了改善损伤后的神经预后,实施神经保护措施,通过提供足够的脑灌注和氧合来限制继发性脑损伤。在这篇文章中,我们回顾了国际儿科指南中概述的一般支持和有针对性的神经保护措施,以及基于潜在病理的这些建议的生理基础。我们还讨论了PICU中的多模式神经监测。我们的目标是提供一种实用的方法来应对病情恶化的患者,并管理治疗过程中出现的并发症。
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引用次数: 0
Childhood pneumonia: an update in the post-COVID-19 era 儿童肺炎:后covid -19时代的最新情况
Q3 Medicine Pub Date : 2025-04-17 DOI: 10.1016/j.paed.2025.04.005
Shana Irvine, Peter Logan, Michael D Shields, Paddy McCrossan
Community acquired pneumonia is the leading global cause of death in childhood. Whilst COVID-19 infection does not typically cause severe illness in children the subsequent social isolation, along with changes in hygiene practices led to reduced levels of respiratory viruses and bacteria during the pandemic. This caused a significant change in the seasonality of community acquired pneumonia. Viruses are still the most common cause of community acquired pneumonia, however bacteria can cause more severe disease and it can be difficult to distinguish clinically between them. Generally, children with pneumonia can be managed at home with antipyretics, oral hydration and oral antibiotics, however a small subset need admission to hospital. Complications from pneumonia include pleural effusion, empyema, necrotizing pneumonia and pneumatocele. This article aims to direct physicians on the diagnosis and management of community acquired pneumonia and highlight the key changes since the COVID-19 pandemic.
社区获得性肺炎是全球儿童死亡的主要原因。虽然COVID-19感染通常不会在儿童中引起严重疾病,但随后的社会隔离以及卫生习惯的改变导致大流行期间呼吸道病毒和细菌的水平降低。这导致了社区获得性肺炎季节性的显著变化。病毒仍然是社区获得性肺炎的最常见原因,但细菌可引起更严重的疾病,并且在临床上很难区分它们。一般来说,肺炎儿童可在家中通过退烧药、口服水合剂和口服抗生素进行治疗,但一小部分儿童需要住院治疗。肺炎的并发症包括胸腔积液、脓胸、坏死性肺炎和气腹膨出。本文旨在指导医生对社区获得性肺炎的诊断和管理,并强调新冠肺炎大流行以来的主要变化。
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引用次数: 0
Children with tracheostomies in the paediatric intensive care unit 在儿科重症监护室进行气管切开术的儿童
Q3 Medicine Pub Date : 2025-04-17 DOI: 10.1016/j.paed.2025.04.004
Nicola Holt, Will Tremlett
Tracheostomy has a long history, and is a procedure that is carried out in ever growing numbers of children. The main indications for tracheostomy can be divided into airway obstruction, rehabilitation, and long term ventilation. The decision to place a tracheostomy is not trivial, and should be made by the multi-disciplinary team working together with the family, as well as the child where possible. Artificial airways such as a tracheostomy can carry significant risks. The National Tracheostomy Safety Project provides guidelines and resources for their management, which aim to mitigate these risks. Standardization of practices across hospital sites supports this. Appropriate training for all individuals involved in the care of a child with a tracheostomy is essential to minimize the risk of problems.
气管切开术有着悠久的历史,是一项在越来越多的儿童中进行的手术。气管切开术的主要适应症可分为气道阻塞、康复和长期通气。气管切开术的决定不是微不足道的,应该由多学科的团队和家庭一起做出,在可能的情况下,还有孩子。气管切开术等人工气道有很大的风险。国家气管切开术安全项目为其管理提供了指导方针和资源,旨在减轻这些风险。各医院的标准化实践支持这一点。对所有参与气管切开术患儿护理的人员进行适当的培训对于最大限度地减少问题的风险至关重要。
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引用次数: 0
Management of extubation failure on the paediatric intensive care unit 儿科重症监护室拔管失败的处理
Q3 Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.paed.2025.04.003
Deepika Puthucode, Patrick Davies
Extubation failure is common in PICU especially in the current era when patients with multiple complexities can be of a significant challenge. Extubation failure is defined as inability to sustain spontaneous breathing after removal of artificial airway leading to the need for re-intubation within 48 hours of a planned extubation. The pathophysiology of extubation failure can be grouped under four categories: airway, muscular power, respiratory drive, and lung parenchymal pathologies with cardiopulmonary interactions. To achieve success and maintain extubation, it is important to identify risk factors contributing for failure and fix them, wean ventilation using appropriate weaning strategies and by stepwise process, assess readiness and extubate at the optimum time. Repeated extubation failures can also be complications increasing the risk of mortality and length of stay. Causes are diverse with clinical complexity, needing multidisciplinary team approach for a comprehensive management of extubation failure. The paediatric intensivist needs to recognize children at risk of extubation failure, make a comprehensive plan and intervene at the earliest opportunity to prevent further morbidity.
拔管失败在PICU中很常见,特别是在当今时代,当患者具有多种复杂性时,拔管失败可能是一个重大挑战。拔管失败的定义是在取出人工气道后无法维持自主呼吸,导致在计划拔管48小时内需要重新插管。拔管失败的病理生理学可分为四类:气道、肌肉力量、呼吸驱动和肺实质病变与心肺相互作用。为了取得成功并维持拔管,重要的是要识别导致失败的危险因素并加以解决,使用适当的脱机策略并逐步进行脱机,评估准备情况并在最佳时间拔管。反复拔管失败也可能是并发症,增加了死亡风险和住院时间。拔管失败的原因多种多样,临床复杂,需要多学科团队的方法进行综合管理。儿科重症医师需要认识到有拔管失败风险的儿童,制定综合计划并尽早干预,以防止进一步发病。
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引用次数: 0
Approach to the use of rescue medications in children for prolonged epileptic seizures in the community 社区儿童长时间癫痫发作抢救用药的探讨
Q3 Medicine Pub Date : 2025-04-01 DOI: 10.1016/j.paed.2025.01.004
Nermin Alashal, Nahin Hussain
Prolonged seizures including convulsive status epilepticus (CSE) in children are significant problems to manage in the community. Early treatment may shorten episodes and prevent subsequent mortality and long-term morbidity. It is likely that pre-hospital treatment is an important part of the optimal management of CSE as it helps to optimize the management in a hospital setting. Benzodiazepines were successfully used for many years with rectal diazepam was the mainstay of treatment. More recently buccal and intranasal midazolam have taken over its place due to their efficacy and ease of administration. Buccal midazolam is more acceptable to the careers and parents for the drug to be administered through mouth, rather than rectally in a tense and anxious situation. Intranasal midazolam has recently been approved for use in children in the USA. Although rectal paraldehyde is widely used in acute settings in the UK, there is relatively little evidence to support this practice. This short article outlines some of the more important studies that can help to guide clinical decision making and offers some practical advice for health professionals caring for children with seizures who may need rescue medication.
儿童长时间癫痫发作包括惊厥性癫痫持续状态(CSE)是社区需要处理的重大问题。早期治疗可缩短发作时间,防止随后的死亡和长期发病率。院前治疗很可能是CSE优化管理的重要组成部分,因为它有助于优化医院环境中的管理。苯二氮卓类药物已成功使用多年,直肠安定是主要的治疗方法。最近,口腔和鼻内咪达唑仑由于其疗效和易于管理而取代了它的位置。口腔用咪达唑仑比在紧张和焦虑的情况下直肠用咪达唑仑更容易被工作人员和家长接受。鼻内咪达唑仑最近在美国被批准用于儿童。尽管直肠双醛在英国的急性环境中被广泛使用,但支持这种做法的证据相对较少。这篇简短的文章概述了一些更重要的研究,这些研究可以帮助指导临床决策,并为照顾可能需要抢救药物治疗的癫痫患儿的卫生专业人员提供了一些实用的建议。
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引用次数: 0
Glucagon-like peptide-1 (GLP-1) receptor agonists: applications in childhood diabetes and obesity 胰高血糖素样肽-1 (GLP-1)受体激动剂在儿童糖尿病和肥胖症中的应用
Q3 Medicine Pub Date : 2025-04-01 DOI: 10.1016/j.paed.2025.01.003
Kun Hu, Timothy G Barrett
Glucagon-like 1 receptor agonists (GLP-1 RAs) are a class of synthetic incretin analogues that were originally developed to treat hyperglycaemia in adults with type 2 diabetes. Their mechanisms of action include effects on body weight through reducing appetite and slowing gastric emptying and these have been exploited in new indications for weight reduction in obesity. Most recently, convincing evidence has been published for their benefits in obstructive sleep apnoea, renal function in diabetes, and possibly anti-ageing. Studies in children have mainly focussed on childhood type 2 diabetes and obesity, and their efficacy has led to licensing for children from 10 years of age (type 2 diabetes) and 12 years (obesity). Early studies of these agents as add-on therapies in type 1 diabetes showed efficacy but significant risks of hypoglycaemia. This review will discuss the history and development of GLP-1 RAs in the context of the rising prevalence of childhood obesity and type 2 diabetes, the evidence for their effectiveness in children, and potential future applications such as in children with type 1 diabetes.
胰高血糖素样1受体激动剂(GLP-1 RAs)是一类合成肠促胰岛素类似物,最初用于治疗成人2型糖尿病患者的高血糖。它们的作用机制包括通过减少食欲和减缓胃排空来影响体重,这些已被用于肥胖症减肥的新适应症。最近,发表了令人信服的证据,证明它们对阻塞性睡眠呼吸暂停、糖尿病患者的肾功能以及可能的抗衰老有好处。对儿童的研究主要集中在儿童2型糖尿病和肥胖上,其疗效已导致10岁(2型糖尿病)和12岁(肥胖)的儿童获得许可。这些药物作为1型糖尿病附加治疗的早期研究显示出疗效,但存在显著的低血糖风险。本文将讨论GLP-1 RAs在儿童肥胖和2型糖尿病患病率上升的背景下的历史和发展,其在儿童中的有效性的证据,以及潜在的未来应用,如在1型糖尿病儿童中的应用。
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引用次数: 0
Klinefelter syndrome: what every paediatrician needs to know 克氏综合征:每个儿科医生都需要知道的
Q3 Medicine Pub Date : 2025-04-01 DOI: 10.1016/j.paed.2025.01.002
Gary Butler
Klinefelter syndrome (KS) is a common sex chromosome variation around one in 750 live male births. The karyotype is usually 47,XXY. However, three quarters of KS males are never identified. Lifespan is not reduced. There is no specific infant phenotype. Prepubertal growth is generally rapid and children may become taller than the mid-parental height. Adolescent growth is not increased, so extreme tall stature is unusual. Overweight and central obesity occur in some boys from mid-childhood. Infant development is usually within age related ranges, although one third may need speech support and two thirds reading and language support. IQ is within the population range.
Puberty onset is not delayed and testosterone levels increase typically at first but often fail to rise in late puberty and biochemical hypogonadism is diagnosed by a low morning testosterone concentration. Clinical hypogonadism is common with central obesity, gynaecomastia and low muscle development and strength. Testosterone supplementation with transdermal gel or injections may help to improve physical development and functioning. Sperm production is severely reduced resulting in azoospermia in the majority. Fertility counselling is important but assessment not needed until late adolescence when surgical testicular sperm extraction can be performed, with no advantage at younger ages.
Klinefelter综合征(KS)是一种常见的性染色体变异,大约每750个活产男婴中就有一个。核型通常为47,xxy。然而,四分之三的KS男性从未被确认身份。寿命不会减少。没有特定的婴儿表型。青春期前的生长通常很快,孩子可能比父母的中等身高还要高。青春期的生长没有增加,所以身材极高是不寻常的。超重和中心性肥胖发生在一些男孩的童年中期。婴儿的发育通常在年龄相关的范围内,尽管三分之一的婴儿可能需要言语支持,三分之二的婴儿可能需要阅读和语言支持。智商在人口范围内。青春期开始不会延迟,睾酮水平通常在开始时增加,但在青春期后期往往不能上升,生化性腺功能减退可通过早晨睾酮浓度低来诊断。临床性腺功能减退常伴有中枢性肥胖、女性乳房发育、肌肉发育和力量低下。通过透皮凝胶或注射补充睾酮可能有助于改善身体发育和功能。精子产生严重减少,导致大多数无精子症。生育咨询很重要,但直到青春期晚期才需要评估,那时可以进行手术睾丸精子提取,在年轻时没有优势。
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引用次数: 0
Prader Willi syndrome: an update on the multidisciplinary approach Prader Willi综合征:多学科方法的更新
Q3 Medicine Pub Date : 2025-04-01 DOI: 10.1016/j.paed.2025.01.005
Chamidri Randika Naotunna, Angela K Lucas-Herald, Malcolm DC Donaldson , M Guftar Shaikh
Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by hypotonia, hyperphagia, obesity, and a spectrum of cognitive and behavioural issues. Clinical manifestations differ according to the age of presentation and as such a multidisciplinary approach is important across the lifespan to improve outcomes. Often this may be led by paediatric endocrinology but should include input from dietetics, psychology, respiratory, speech and language and others according to clinical need. It is likely these needs will change as the child grows and, as such, the composition of the team should remain flexible. Overall, a comprehensive, multidisciplinary approach encompassing medical, nutritional, behavioural, and educational support is essential for managing individuals with PWS, significantly improving the quality of life and long-term outcomes for affected children and their families.
普瑞德-威利综合征(PWS)是一种罕见的遗传性疾病,其特征是低张力、嗜食、肥胖以及一系列认知和行为问题。临床表现因年龄的不同而不同,因此多学科治疗对于改善预后非常重要。通常,这可能由儿科内分泌学主导,但根据临床需要,应包括营养学、心理学、呼吸学、言语和语言等方面的投入。随着孩子的成长,这些需求很可能会发生变化,因此,团队的组成应该保持灵活。总体而言,综合的多学科方法,包括医疗、营养、行为和教育支持,对于管理PWS患者至关重要,可以显著改善受影响儿童及其家庭的生活质量和长期结果。
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引用次数: 0
Making great occupational therapy referrals: how to get the right help, first time, for children, young people and families 进行出色的职业治疗转诊:如何在第一时间为儿童、年轻人和家庭获得正确的帮助
Q3 Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.paed.2024.12.004
Sally Payne
The demand for children's occupational therapy is rising, but resources and capacity are not following at the same pace. As a result, many children and young people are waiting too long to receive the occupational therapy they need and deserve. This article offers guidance for paediatricians to increase the chances of their referrals being accepted so children and young people can access the help they need, when they need it. The article begins by examining the reasons behind the growing demand, then explains how the universal, targeted, and individualized service model is being used to provide more timely access to occupational therapy expertise. Lastly, it offers guidance to help referrers make great referrals to enable children and young people to access the level and type of occupational therapy they need to fulfil their potential and live full and happy lives.
对儿童职业治疗的需求正在上升,但资源和能力却没有跟上同样的步伐。因此,许多儿童和年轻人等待太久,无法接受他们需要和应得的职业治疗。这篇文章为儿科医生提供了指导,以增加他们的转诊被接受的机会,这样儿童和年轻人就可以在需要的时候获得他们需要的帮助。本文首先分析了需求增长背后的原因,然后解释了如何使用通用的、有针对性的和个性化的服务模式来提供更及时的职业治疗专业知识。最后,它提供了指导,以帮助转介者做出伟大的转介,使儿童和年轻人能够获得他们需要的职业治疗的水平和类型,以实现他们的潜力,过上充实和幸福的生活。
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引用次数: 0
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Paediatrics and Child Health (United Kingdom)
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