Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.13
Gamze Türk, M. Bilgili, A. Açan, A. Koç
To evaluate the frequency of lumbosacral transitional vertebrae (LSTV) on MRI in patients with backpain and clinically suspected of sacroiliitis. Sacroiliac MRI of patients who had backpain and were clinically suspicious for sacroiliitis between November 2021-March 2022 were retrospectively analyzed from the hospital database by two different radiologists. LSTV cases were identified and subgrouped according to Castellvi classification. Presence of sacroiliitis, degeneration and /or herniation of cranial segment intervertebral disc, facet joint hypertrophy, coxarthrosis and psoas atrophy were recorded. In cases where radiologists were in conflict, consensus was made. Between November 2021-March 2022, 614 sacroiliac MRIs were obtained and 81 (13%) had LSTV. Fifty-nine patients were female (72.8%). Mean age was 43.4. The most common identified LSTV was type 1a (n=30, 10 right-sided, 20 left-sided). Sacroiliitis was significantly more common in younger patients (p=0.04) and in males (p=0.009). Disc degeneration, disc herniation, facet joint hypertrophy and psoas atrophy increased significantly with age (p=0.007, p=0.001, p=0.002 and p=0.013 respectively). No correlation was found between gender or presence of sacroiliitis and any type of LSTV.LSTV may present with backpain and should be considered in patients where sacroiliitis is clinically suspected. MRI is a useful tool to identify other accompanying pathologies in these cases.
{"title":"Lumbosacral transitional vertebrae: An overlooked cause of back pain on MRI","authors":"Gamze Türk, M. Bilgili, A. Açan, A. Koç","doi":"10.52142/omujecm.40.1.13","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.13","url":null,"abstract":"To evaluate the frequency of lumbosacral transitional vertebrae (LSTV) on MRI in patients with backpain and clinically suspected of sacroiliitis. Sacroiliac MRI of patients who had backpain and were clinically suspicious for sacroiliitis between November 2021-March 2022 were retrospectively analyzed from the hospital database by two different radiologists. LSTV cases were identified and subgrouped according to Castellvi classification. Presence of sacroiliitis, degeneration and /or herniation of cranial segment intervertebral disc, facet joint hypertrophy, coxarthrosis and psoas atrophy were recorded. In cases where radiologists were in conflict, consensus was made. Between November 2021-March 2022, 614 sacroiliac MRIs were obtained and 81 (13%) had LSTV. Fifty-nine patients were female (72.8%). Mean age was 43.4. The most common identified LSTV was type 1a (n=30, 10 right-sided, 20 left-sided). Sacroiliitis was significantly more common in younger patients (p=0.04) and in males (p=0.009). Disc degeneration, disc herniation, facet joint hypertrophy and psoas atrophy increased significantly with age (p=0.007, p=0.001, p=0.002 and p=0.013 respectively). No correlation was found between gender or presence of sacroiliitis and any type of LSTV.LSTV may present with backpain and should be considered in patients where sacroiliitis is clinically suspected. MRI is a useful tool to identify other accompanying pathologies in these cases.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.36
Yasin Dalda, Özlem Dalda, D. Baskiran, F. Gönültaş
Breast cancer has become an important health problem affecting especially women and its incidence is increasing. It is treated with a multidisciplinary approach involving medical oncology, radiation oncology and surgical oncology. Surgical removal of the tumor is the most important step in its treatment. General anesthesia used during surgery carries significant risks in patient groups with advanced age and comorbidities. In addition, treatment options such as chemotherapy and radiotherapy other than surgery may have significant side effects in these patient groups. Therefore, surgery plays an important role in the treatment of patients. Surgery with local anesthesia is a suitable alternative to general anesthesia in patients with early stage breast cancer because it carries less risk. Breast cancer was diagnosed in a 64-year-old woman who presented with a mass in the right breast. In the anesthesia examination, she was evaluated as ASA 3 because of her comorbidities and age. We present our patient with high comorbidity and advanced age who underwent curative cancer surgery using only local anesthesia.
{"title":"Curative breast cancer surgery with local anesthesia","authors":"Yasin Dalda, Özlem Dalda, D. Baskiran, F. Gönültaş","doi":"10.52142/omujecm.40.1.36","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.36","url":null,"abstract":"Breast cancer has become an important health problem affecting especially women and its incidence is increasing. It is treated with a multidisciplinary approach involving medical oncology, radiation oncology and surgical oncology. Surgical removal of the tumor is the most important step in its treatment. General anesthesia used during surgery carries significant risks in patient groups with advanced age and comorbidities. In addition, treatment options such as chemotherapy and radiotherapy other than surgery may have significant side effects in these patient groups. Therefore, surgery plays an important role in the treatment of patients. Surgery with local anesthesia is a suitable alternative to general anesthesia in patients with early stage breast cancer because it carries less risk. Breast cancer was diagnosed in a 64-year-old woman who presented with a mass in the right breast. In the anesthesia examination, she was evaluated as ASA 3 because of her comorbidities and age. We present our patient with high comorbidity and advanced age who underwent curative cancer surgery using only local anesthesia.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83683558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our study aimed to examine the childhood traumas and psychiatric symptoms of prisoners and their relationship with crime types. Persons convicted in Elazig Penitentiary Institutions were included in the study. The Demographic and Clinical Evaluation Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Childhood Trauma Questionnaire (CTQ) and Symptom Checklist (SCL-90) were administered to all participants. A total of 370 people were included in the study. For prisoners who have been imprisoned before, CTQ-physical abuse, BAI, SCL-90-somatization, anxiety, and hostility subscale scores were higher than those who entered the prison for the first time (p values: 0.020, 0.003, 0.016, 0.017, 0.047, respectively). Prisoners with a family history of prison entry had higher SCL-90 test all subscale scores, total scores and CTQ physical abuse subscale scores than the group without a family history of prison entry. Those exposed to violence in childhood and those who had attempted suicide before had higher scores on all scales. Those with a history of alcohol and substance use had higher total scores on the CTQ-emotional abuse and sexual abuse scale. According to the type of crime committed, only the CTQ-sexual abuse subscale scores differed. These subscale scores of the prisoners involved in more than one crime were higher than those involved in a single crime (p=0.030). The CTQ-sexual abuse subscale scores of those who were involved in the crime of willful homicide were calculated to be high (p=0.030). It was thought that preventing abuse, violence, and traumas in childhood may be necessary in reducing the tendency to crimes.
{"title":"Relationship between psychiatric symptoms, childhood traumas, and types of crime of convicts in Elazig closed prisons","authors":"Şüheda Kaya, Gulay Tasci, Nulufer Kilic, Bahadır Demir, Filiz Özsoy","doi":"10.52142/omujecm.40.1.20","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.20","url":null,"abstract":"Our study aimed to examine the childhood traumas and psychiatric symptoms of prisoners and their relationship with crime types. Persons convicted in Elazig Penitentiary Institutions were included in the study. The Demographic and Clinical Evaluation Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Childhood Trauma Questionnaire (CTQ) and Symptom Checklist (SCL-90) were administered to all participants. A total of 370 people were included in the study. For prisoners who have been imprisoned before, CTQ-physical abuse, BAI, SCL-90-somatization, anxiety, and hostility subscale scores were higher than those who entered the prison for the first time (p values: 0.020, 0.003, 0.016, 0.017, 0.047, respectively). Prisoners with a family history of prison entry had higher SCL-90 test all subscale scores, total scores and CTQ physical abuse subscale scores than the group without a family history of prison entry. Those exposed to violence in childhood and those who had attempted suicide before had higher scores on all scales. Those with a history of alcohol and substance use had higher total scores on the CTQ-emotional abuse and sexual abuse scale. According to the type of crime committed, only the CTQ-sexual abuse subscale scores differed. These subscale scores of the prisoners involved in more than one crime were higher than those involved in a single crime (p=0.030). The CTQ-sexual abuse subscale scores of those who were involved in the crime of willful homicide were calculated to be high (p=0.030). It was thought that preventing abuse, violence, and traumas in childhood may be necessary in reducing the tendency to crimes.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83743429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.22
M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür
The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.
{"title":"The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma","authors":"M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür","doi":"10.52142/omujecm.40.1.22","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.22","url":null,"abstract":"The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89604013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.32
M. Yüce
Stem cell-based studies have accelerated to treat various pathologies, particularly neurological, cardiovascular, orthopedic diseases and cancer with the understanding of their therapeutic potential after their discovery. Stem cells have recently aroused great interest as a promising treatment option in the fighting to cancer with extensive study in the fields of cancer biology. Nevertheless, much uncertainty regarding the act of stem cells in cancer development and treatment remains obscure before the clinical use of stem cell investigation. Despite many obstacles, the migration ability of stem cells, the bioactive factors they secrete, and their immune regulatory properties make them advantageous for gene therapy strategies. However, unknowns and a lack of scientific data remain concerning the use of stem cell based therapies. Therefore, more experimental data are needed to confirm the different study results presented by different scientific communities. In this review, we focused on summarizing the available experimental and clinical data on the potential uses of mesenchymal stem cells in cancer therapy.
{"title":"From laboratory studies to clinical applications mesenchymal stem cells in cancer treatment: Translational oncology","authors":"M. Yüce","doi":"10.52142/omujecm.40.1.32","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.32","url":null,"abstract":"Stem cell-based studies have accelerated to treat various pathologies, particularly neurological, cardiovascular, orthopedic diseases and cancer with the understanding of their therapeutic potential after their discovery. Stem cells have recently aroused great interest as a promising treatment option in the fighting to cancer with extensive study in the fields of cancer biology. Nevertheless, much uncertainty regarding the act of stem cells in cancer development and treatment remains obscure before the clinical use of stem cell investigation. Despite many obstacles, the migration ability of stem cells, the bioactive factors they secrete, and their immune regulatory properties make them advantageous for gene therapy strategies. However, unknowns and a lack of scientific data remain concerning the use of stem cell based therapies. Therefore, more experimental data are needed to confirm the different study results presented by different scientific communities. In this review, we focused on summarizing the available experimental and clinical data on the potential uses of mesenchymal stem cells in cancer therapy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76123850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.18
E. Keleş, U. Öztürk, C. Alınca, Damla Yücel, M. Api, K. N. Baydili
We aimed to evaluate the psychosexual impact of being diagnosed with human papillomavirus (HPV). A cross-sectional study was conducted to assess the anxiety and depression levels and sexual functions in women with and without HPV between March and May 2021. Beck anxiety inventory (BAI), the Beck depression inventory (BDI), and the Libido scoring system scales (LSSS) were used as scales. A total of 575 respondents were included; 292 (50.2%) HPV-negative, and 283 (49.8%) HPV-positive, of whom 170 (60,1%) had high risk HPV genotypes 16/18 and 113 (39,9%) had non-16/18 high risk HPV-positive patients. There was no significant association between HPV-negative and HPV-positive patients in terms of sociodemographic characteristics. While 21.6% of the HPV-positive group experienced masturbation, it was 15.1% in the HPV-negative group (p=0.044). While severe depression was 4.9% in HPV-positive women, this rate was 1.4% in HPV-negative women (p=0.002). The present study showed that being diagnosed with HPV made a significant difference in sexual function, except for sexual interest, but increased anxiety and depression scores. Sexual dysfunction following an HPV diagnosis cannot be explained solely by depression and anxiety.
{"title":"Impact of an HPV diagnosis on the psychosexual sphere","authors":"E. Keleş, U. Öztürk, C. Alınca, Damla Yücel, M. Api, K. N. Baydili","doi":"10.52142/omujecm.40.1.18","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.18","url":null,"abstract":"We aimed to evaluate the psychosexual impact of being diagnosed with human papillomavirus (HPV). A cross-sectional study was conducted to assess the anxiety and depression levels and sexual functions in women with and without HPV between March and May 2021. Beck anxiety inventory (BAI), the Beck depression inventory (BDI), and the Libido scoring system scales (LSSS) were used as scales. A total of 575 respondents were included; 292 (50.2%) HPV-negative, and 283 (49.8%) HPV-positive, of whom 170 (60,1%) had high risk HPV genotypes 16/18 and 113 (39,9%) had non-16/18 high risk HPV-positive patients. There was no significant association between HPV-negative and HPV-positive patients in terms of sociodemographic characteristics. While 21.6% of the HPV-positive group experienced masturbation, it was 15.1% in the HPV-negative group (p=0.044). While severe depression was 4.9% in HPV-positive women, this rate was 1.4% in HPV-negative women (p=0.002). The present study showed that being diagnosed with HPV made a significant difference in sexual function, except for sexual interest, but increased anxiety and depression scores. Sexual dysfunction following an HPV diagnosis cannot be explained solely by depression and anxiety.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76678126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar
We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI.
{"title":"Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries","authors":"Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar","doi":"10.52142/omujecm.40.1.1","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.1","url":null,"abstract":"We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83817923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.
{"title":"The effect of chamomile on nausea and vomiting after laparoscopic cholecystectomy: A triple-blind randomized clinical trial","authors":"Soheila BAKHTIARI, Gholamreza KHALILI, Razieh Salimi ZADAK","doi":"10.52142/omujecm.40.1.7","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.7","url":null,"abstract":"The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.30
D. Aygün, Murat Polat
Movement disorders can be defined as the abnormality of the speed and form of body movements. Although movement disorders often occur chronically, they can sometimes develop acutely or sub-acutely, and some can be fatal if not diagnosed and treated early. Here, emergencies in movement disorders are discussed under two main headings as emergencies related to hyperkinetic movement disorders and emergencies related to hypokinetic movement disorders. This review draws attention to the importance of that accurate diagnosis and early treatment can be life-saving in emergencies in movement disorders. It also provides recommendations for diagnosis and therapy.
{"title":"Emergencies in movement disorders","authors":"D. Aygün, Murat Polat","doi":"10.52142/omujecm.40.1.30","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.30","url":null,"abstract":"Movement disorders can be defined as the abnormality of the speed and form of body movements. Although movement disorders often occur chronically, they can sometimes develop acutely or sub-acutely, and some can be fatal if not diagnosed and treated early. Here, emergencies in movement disorders are discussed under two main headings as emergencies related to hyperkinetic movement disorders and emergencies related to hypokinetic movement disorders. This review draws attention to the importance of that accurate diagnosis and early treatment can be life-saving in emergencies in movement disorders. It also provides recommendations for diagnosis and therapy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87414893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.40
H. Akça
SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.
{"title":"SCUBE-1 as a novel predictor of thromboembolic event","authors":"H. Akça","doi":"10.52142/omujecm.40.1.40","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.40","url":null,"abstract":"SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87800122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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