Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.22
M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür
The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.
{"title":"The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma","authors":"M. Çelebi, D. M. Mehel, S. Van, Seda Nur Ci̇han, D. Özdemir, A. Özgür","doi":"10.52142/omujecm.40.1.22","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.22","url":null,"abstract":"The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89604013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.36
Yasin Dalda, Özlem Dalda, D. Baskiran, F. Gönültaş
Breast cancer has become an important health problem affecting especially women and its incidence is increasing. It is treated with a multidisciplinary approach involving medical oncology, radiation oncology and surgical oncology. Surgical removal of the tumor is the most important step in its treatment. General anesthesia used during surgery carries significant risks in patient groups with advanced age and comorbidities. In addition, treatment options such as chemotherapy and radiotherapy other than surgery may have significant side effects in these patient groups. Therefore, surgery plays an important role in the treatment of patients. Surgery with local anesthesia is a suitable alternative to general anesthesia in patients with early stage breast cancer because it carries less risk. Breast cancer was diagnosed in a 64-year-old woman who presented with a mass in the right breast. In the anesthesia examination, she was evaluated as ASA 3 because of her comorbidities and age. We present our patient with high comorbidity and advanced age who underwent curative cancer surgery using only local anesthesia.
{"title":"Curative breast cancer surgery with local anesthesia","authors":"Yasin Dalda, Özlem Dalda, D. Baskiran, F. Gönültaş","doi":"10.52142/omujecm.40.1.36","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.36","url":null,"abstract":"Breast cancer has become an important health problem affecting especially women and its incidence is increasing. It is treated with a multidisciplinary approach involving medical oncology, radiation oncology and surgical oncology. Surgical removal of the tumor is the most important step in its treatment. General anesthesia used during surgery carries significant risks in patient groups with advanced age and comorbidities. In addition, treatment options such as chemotherapy and radiotherapy other than surgery may have significant side effects in these patient groups. Therefore, surgery plays an important role in the treatment of patients. Surgery with local anesthesia is a suitable alternative to general anesthesia in patients with early stage breast cancer because it carries less risk. Breast cancer was diagnosed in a 64-year-old woman who presented with a mass in the right breast. In the anesthesia examination, she was evaluated as ASA 3 because of her comorbidities and age. We present our patient with high comorbidity and advanced age who underwent curative cancer surgery using only local anesthesia.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83683558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our study aimed to examine the childhood traumas and psychiatric symptoms of prisoners and their relationship with crime types. Persons convicted in Elazig Penitentiary Institutions were included in the study. The Demographic and Clinical Evaluation Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Childhood Trauma Questionnaire (CTQ) and Symptom Checklist (SCL-90) were administered to all participants. A total of 370 people were included in the study. For prisoners who have been imprisoned before, CTQ-physical abuse, BAI, SCL-90-somatization, anxiety, and hostility subscale scores were higher than those who entered the prison for the first time (p values: 0.020, 0.003, 0.016, 0.017, 0.047, respectively). Prisoners with a family history of prison entry had higher SCL-90 test all subscale scores, total scores and CTQ physical abuse subscale scores than the group without a family history of prison entry. Those exposed to violence in childhood and those who had attempted suicide before had higher scores on all scales. Those with a history of alcohol and substance use had higher total scores on the CTQ-emotional abuse and sexual abuse scale. According to the type of crime committed, only the CTQ-sexual abuse subscale scores differed. These subscale scores of the prisoners involved in more than one crime were higher than those involved in a single crime (p=0.030). The CTQ-sexual abuse subscale scores of those who were involved in the crime of willful homicide were calculated to be high (p=0.030). It was thought that preventing abuse, violence, and traumas in childhood may be necessary in reducing the tendency to crimes.
{"title":"Relationship between psychiatric symptoms, childhood traumas, and types of crime of convicts in Elazig closed prisons","authors":"Şüheda Kaya, Gulay Tasci, Nulufer Kilic, Bahadır Demir, Filiz Özsoy","doi":"10.52142/omujecm.40.1.20","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.20","url":null,"abstract":"Our study aimed to examine the childhood traumas and psychiatric symptoms of prisoners and their relationship with crime types. Persons convicted in Elazig Penitentiary Institutions were included in the study. The Demographic and Clinical Evaluation Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Childhood Trauma Questionnaire (CTQ) and Symptom Checklist (SCL-90) were administered to all participants. A total of 370 people were included in the study. For prisoners who have been imprisoned before, CTQ-physical abuse, BAI, SCL-90-somatization, anxiety, and hostility subscale scores were higher than those who entered the prison for the first time (p values: 0.020, 0.003, 0.016, 0.017, 0.047, respectively). Prisoners with a family history of prison entry had higher SCL-90 test all subscale scores, total scores and CTQ physical abuse subscale scores than the group without a family history of prison entry. Those exposed to violence in childhood and those who had attempted suicide before had higher scores on all scales. Those with a history of alcohol and substance use had higher total scores on the CTQ-emotional abuse and sexual abuse scale. According to the type of crime committed, only the CTQ-sexual abuse subscale scores differed. These subscale scores of the prisoners involved in more than one crime were higher than those involved in a single crime (p=0.030). The CTQ-sexual abuse subscale scores of those who were involved in the crime of willful homicide were calculated to be high (p=0.030). It was thought that preventing abuse, violence, and traumas in childhood may be necessary in reducing the tendency to crimes.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83743429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar
We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI.
{"title":"Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries","authors":"Ali Gürsoy, Belkız Öngen İpek, A. Sade, K. Atasayan, Ezgi DOĞAN TEKBAŞ, M. E. Sitar","doi":"10.52142/omujecm.40.1.1","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.1","url":null,"abstract":"We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83817923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.29
O. Sönmez, Ayşe İkinci Keleş
Intervertebral disc degeneration is a major health problem of close concern to both young and old. The problem is also growing as the global population ages. Intervertebral disc degeneration is defined as progressive changes affecting the spine as a component of natural aging under the effect of multiple factors (such as smoking, obesity, and incorrect exercise). For a solution to be found, experimental disc degeneration must first be induced, the causes of the disease must be identified, and early diagnostic and therapeutic methods must then be developed. Methods of inducing intervertebral disc degeneration with high applicability in rats were identified from the previous literature. This review discusses four methods of disc degeneration induction. It also discusses how to detect degeneration formation and development times. As a result of the literature review, information about four different and reliable intervertebral disc degeneration methods is presented.
{"title":"Experimental intervertebral disc degeneration models","authors":"O. Sönmez, Ayşe İkinci Keleş","doi":"10.52142/omujecm.40.1.29","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.29","url":null,"abstract":"Intervertebral disc degeneration is a major health problem of close concern to both young and old. The problem is also growing as the global population ages. Intervertebral disc degeneration is defined as progressive changes affecting the spine as a component of natural aging under the effect of multiple factors (such as smoking, obesity, and incorrect exercise). For a solution to be found, experimental disc degeneration must first be induced, the causes of the disease must be identified, and early diagnostic and therapeutic methods must then be developed. Methods of inducing intervertebral disc degeneration with high applicability in rats were identified from the previous literature. This review discusses four methods of disc degeneration induction. It also discusses how to detect degeneration formation and development times. As a result of the literature review, information about four different and reliable intervertebral disc degeneration methods is presented.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88299570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.13
Gamze Türk, M. Bilgili, A. Açan, A. Koç
To evaluate the frequency of lumbosacral transitional vertebrae (LSTV) on MRI in patients with backpain and clinically suspected of sacroiliitis. Sacroiliac MRI of patients who had backpain and were clinically suspicious for sacroiliitis between November 2021-March 2022 were retrospectively analyzed from the hospital database by two different radiologists. LSTV cases were identified and subgrouped according to Castellvi classification. Presence of sacroiliitis, degeneration and /or herniation of cranial segment intervertebral disc, facet joint hypertrophy, coxarthrosis and psoas atrophy were recorded. In cases where radiologists were in conflict, consensus was made. Between November 2021-March 2022, 614 sacroiliac MRIs were obtained and 81 (13%) had LSTV. Fifty-nine patients were female (72.8%). Mean age was 43.4. The most common identified LSTV was type 1a (n=30, 10 right-sided, 20 left-sided). Sacroiliitis was significantly more common in younger patients (p=0.04) and in males (p=0.009). Disc degeneration, disc herniation, facet joint hypertrophy and psoas atrophy increased significantly with age (p=0.007, p=0.001, p=0.002 and p=0.013 respectively). No correlation was found between gender or presence of sacroiliitis and any type of LSTV.LSTV may present with backpain and should be considered in patients where sacroiliitis is clinically suspected. MRI is a useful tool to identify other accompanying pathologies in these cases.
{"title":"Lumbosacral transitional vertebrae: An overlooked cause of back pain on MRI","authors":"Gamze Türk, M. Bilgili, A. Açan, A. Koç","doi":"10.52142/omujecm.40.1.13","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.13","url":null,"abstract":"To evaluate the frequency of lumbosacral transitional vertebrae (LSTV) on MRI in patients with backpain and clinically suspected of sacroiliitis. Sacroiliac MRI of patients who had backpain and were clinically suspicious for sacroiliitis between November 2021-March 2022 were retrospectively analyzed from the hospital database by two different radiologists. LSTV cases were identified and subgrouped according to Castellvi classification. Presence of sacroiliitis, degeneration and /or herniation of cranial segment intervertebral disc, facet joint hypertrophy, coxarthrosis and psoas atrophy were recorded. In cases where radiologists were in conflict, consensus was made. Between November 2021-March 2022, 614 sacroiliac MRIs were obtained and 81 (13%) had LSTV. Fifty-nine patients were female (72.8%). Mean age was 43.4. The most common identified LSTV was type 1a (n=30, 10 right-sided, 20 left-sided). Sacroiliitis was significantly more common in younger patients (p=0.04) and in males (p=0.009). Disc degeneration, disc herniation, facet joint hypertrophy and psoas atrophy increased significantly with age (p=0.007, p=0.001, p=0.002 and p=0.013 respectively). No correlation was found between gender or presence of sacroiliitis and any type of LSTV.LSTV may present with backpain and should be considered in patients where sacroiliitis is clinically suspected. MRI is a useful tool to identify other accompanying pathologies in these cases.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.
{"title":"The effect of chamomile on nausea and vomiting after laparoscopic cholecystectomy: A triple-blind randomized clinical trial","authors":"Soheila BAKHTIARI, Gholamreza KHALILI, Razieh Salimi ZADAK","doi":"10.52142/omujecm.40.1.7","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.7","url":null,"abstract":"The present study aimed to evaluate the effect of Chamomilla Recutita on nausea and vomiting after laparoscopic cholecystectomy. Chamomilla Recutita (L.) fell into either chamomile or placebo groups randomly. The intervention was performed one hour before the operation. The severity of nausea and the frequency of vomiting was measured using a visual analog scale. Both groups were studied in three stages before the operation, after the operation in recovery, and 2 hours after the operation. Data were analyzed using descriptive and analytical statistics (SPSS). The mean severity of nausea increased significantly over time in both groups; however, this increase was significantly slighter in the chamomile group than that in the placebo group. The frequency of preoperative nausea in the chamomile and placebo groups was 6.2% and 25%, respectively, before being discharged from the recovery. Two hours later, in the surgical ward, this frequency was estimated to be 31.2% in the chamomile group and 75% in the placebo group (P <0.05). The frequency of vomiting in the surgical ward was 15.6% and 56.2% in the chamomile and placebo groups, respectively. Thus, this frequency in the chamomile group was significantly lower than in the placebo group (P<0.001). It seems that in laparoscopic surgeries, the use of chamomile drops as a preventive drug reduces postoperative nausea and vomiting.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.30
D. Aygün, Murat Polat
Movement disorders can be defined as the abnormality of the speed and form of body movements. Although movement disorders often occur chronically, they can sometimes develop acutely or sub-acutely, and some can be fatal if not diagnosed and treated early. Here, emergencies in movement disorders are discussed under two main headings as emergencies related to hyperkinetic movement disorders and emergencies related to hypokinetic movement disorders. This review draws attention to the importance of that accurate diagnosis and early treatment can be life-saving in emergencies in movement disorders. It also provides recommendations for diagnosis and therapy.
{"title":"Emergencies in movement disorders","authors":"D. Aygün, Murat Polat","doi":"10.52142/omujecm.40.1.30","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.30","url":null,"abstract":"Movement disorders can be defined as the abnormality of the speed and form of body movements. Although movement disorders often occur chronically, they can sometimes develop acutely or sub-acutely, and some can be fatal if not diagnosed and treated early. Here, emergencies in movement disorders are discussed under two main headings as emergencies related to hyperkinetic movement disorders and emergencies related to hypokinetic movement disorders. This review draws attention to the importance of that accurate diagnosis and early treatment can be life-saving in emergencies in movement disorders. It also provides recommendations for diagnosis and therapy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87414893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.40
H. Akça
SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.
{"title":"SCUBE-1 as a novel predictor of thromboembolic event","authors":"H. Akça","doi":"10.52142/omujecm.40.1.40","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.40","url":null,"abstract":"SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87800122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.52142/omujecm.40.1.10
Esra Çataltepe, Nergiz Ekmen, M. Cindoruk
The aim of this study was to investigate patients diagnosed with inflammatory bowel disease (IBD), the effects of drug groups used in the treatment of inflammatory bowel disease on depression and anxiety. This study was a single-center prospective study involving 94 patients with inflammatory bowel disease, 51 of whom had ulcerative colitis (UC) and 43 had Crohn's disease (CD). Harvey-Bradshaw activity scores for CD and Mayo Clinic activation scores for UC were calculated. Depression and anxiety data were collected with the Beck Depression Inventory and Beck Anxiety Inventory. The mean age for UC and CD were 40.25 ± 14 and 38.9 ± 13.8 years, respectively. There was a positive correlation between disease activation and depression and anxiety levels in both IBD subgroups (p<0.05). All patients included in the study were compared in terms of depression and anxiety levels before and after treatment, and a statistically significant improvement was found with the remission of both ulcerative colitis and Crohn's disease (p<0.001). There was a significant difference in depression and anxiety levels before and after treatment according to treatment options (p<0.001). There is a positive relationship between the disease activation score and the level of depression and anxiety in IBD. Immunosuppressive and immunomodulatory drugs used in the treatment of IBD may also improve the parameters of depression and anxiety in this disease.
{"title":"Comparison of depression and anxiety in inflammatory bowel patients treated with anti-TNF or immune modulators","authors":"Esra Çataltepe, Nergiz Ekmen, M. Cindoruk","doi":"10.52142/omujecm.40.1.10","DOIUrl":"https://doi.org/10.52142/omujecm.40.1.10","url":null,"abstract":"The aim of this study was to investigate patients diagnosed with inflammatory bowel disease (IBD), the effects of drug groups used in the treatment of inflammatory bowel disease on depression and anxiety. This study was a single-center prospective study involving 94 patients with inflammatory bowel disease, 51 of whom had ulcerative colitis (UC) and 43 had Crohn's disease (CD). Harvey-Bradshaw activity scores for CD and Mayo Clinic activation scores for UC were calculated. Depression and anxiety data were collected with the Beck Depression Inventory and Beck Anxiety Inventory. The mean age for UC and CD were 40.25 ± 14 and 38.9 ± 13.8 years, respectively. There was a positive correlation between disease activation and depression and anxiety levels in both IBD subgroups (p<0.05). All patients included in the study were compared in terms of depression and anxiety levels before and after treatment, and a statistically significant improvement was found with the remission of both ulcerative colitis and Crohn's disease (p<0.001). There was a significant difference in depression and anxiety levels before and after treatment according to treatment options (p<0.001). There is a positive relationship between the disease activation score and the level of depression and anxiety in IBD. Immunosuppressive and immunomodulatory drugs used in the treatment of IBD may also improve the parameters of depression and anxiety in this disease.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76172582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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