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The prevalence of low anterior resection syndrome in rectal cancer patients who underwent surgical treatment in Isfahan City Hospital during 2012-2018 2012-2018年在伊斯法罕市医院接受手术治疗的直肠癌患者中低位前切除术综合征的患病率
Q4 Medicine Pub Date : 2020-09-23 DOI: 10.5937/MCKG54-24636
B. Sanei, Mohammad Ghasemi Fard, M. Kolahduzan
Objective. We aimed to determine the relative frequency of low anterior resection syndrome (LARS) in patients with rectal cancers who underwent surgical treatment in Isfahan. Methods. We evaluated all patients who were referred to the surgery clinic of Saint Al-Zahra hospital in Isfahan within six years. If LARS was identified, according to the LARS score tool, the frequency of resection complications, factors affecting the LARS, morbidity, and mortality, the frequency distribution of defecation, stool consistency, and rate of significant improvement was evaluated. Results. Fifty-two patients were evaluated. The prevalence of LARS was 78.8%. Postoperative fecal and gas incontinence, clustering, fecal frequency, and fecal urgency in LARS patients were significantly higher than in patients without LARS (P<0.05). There was no significant difference between the two groups in terms of factors affecting the LARS (p<0.05). In most of the patients with LARS, the defecation frequency was more than seven times a week (82.1%), and they mostly had liquid stool (61.5%). 95.5% of the patients with LARS showed significant improvement, which was mostly after 7-11 months (38.5). There was a significant difference between the frequency distribution of defecation, stool consistency, and significant improvement status in patients with and without LARS. Conclusion. LARS occurs commonly among patients undergoing LAR with TME and it is associated with more resection complications. Patients with LARS have significantly higher frequency of defecation per week and liquid stools and mostly achieve significant improvements. Other factors might not be significantly different between patients with or without LARS.
目标。我们的目的是确定在伊斯法罕接受手术治疗的直肠癌患者低前切除术综合征(LARS)的相对频率。方法。我们对六年内转诊到伊斯法罕圣扎赫拉医院外科诊所的所有患者进行了评估。如果确定了LARS,根据LARS评分工具,评估切除并发症的频率、影响LARS的因素、发病率和死亡率、排便频率分布、大便一致性和显著改善率。结果。对52例患者进行了评估。LARS患病率为78.8%。LARS患者术后大便和气体失禁、聚类、大便频率和大便急迫性均显著高于无LARS患者(P<0.05)。两组间影响LARS的因素比较差异无统计学意义(p<0.05)。大多数LARS患者排便次数≥7次/周(82.1%),多为液体便(61.5%)。95.5%的LARS患者有明显改善,主要发生在7-11个月(38.5%)。LARS患者与非LARS患者的排便频率分布、大便一致性及明显改善情况存在显著差异。结论。LARS常见于接受LAR合并TME的患者,并且与更多的切除术并发症相关。LARS患者每周排便频率和液体便明显增高,多数患者均有显著改善。其他因素在有或没有LARS的患者之间可能没有显著差异。
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引用次数: 0
Assessment of the influence of expanded hemodialysis on the rate of removal of middle molecular weight uremic toxins 扩大血液透析对中分子量尿毒症毒素脱除率影响的评价
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-30496
M. Nenadović, A. Nikolic, M. Kostović, Branislava Drašković, M. Jovanovic, T. Nikolić, D. Petrovic
Objective. The aim of this study was to examine the effect of expanded hemodialysis on the degree of b2-microglobulin removal. Methods. Sixteen patients treated with extended MCO hemodialysis were examined. The main parameter for assessing the efficiency of removal of uremic toxins of middle molecular weight is the concentration of b2-microglobulin in the serum before and after a single session of extended MCO hemodialysis. The following were used for statistical analysis: Kolmogorov-Smirnov test, Student's T test for bound samples and Wilcoxon test. Results. Extended MCO hemodialysis effectively removes uremic toxins of middle molecular weight. The reduction index of b2-microglobulin during a single session of extended MCO hemodialysis is 70.60 ± 5.88%. The average loss of albumin during a single session of extended MCO hemodialysis is 1.88 ± 1.02 g/4h, and the index of albumin reduction is 4.94 ± 2.49%. Conclusion. Extended MCO hemodialysis effectively removes b2-microglobulin. The b2-microglobulin reduction index is ~ 71% and the albumin loss is less than 4.0 g/4h. This dialysis modality prevents the development of amyloidosis, atherosclerosis and atherosclerotic cardiovascular diseases in the population of patients treated with regular hemodialysis.
目标。本研究的目的是检查扩大血液透析对b2微球蛋白去除程度的影响。方法。对16例延长MCO血液透析患者进行了检查。评估中等分子量尿毒症毒素清除效率的主要参数是在单次延长MCO血液透析前后血清中b2微球蛋白的浓度。采用Kolmogorov-Smirnov检验、Student’s T检验和Wilcoxon检验进行统计分析。结果。延长MCO血液透析可有效去除中等分子量的尿毒症毒素。延长MCO单次血液透析期间b2微球蛋白降低指数为70.60±5.88%。延长MCO血液透析单次平均白蛋白损失为1.88±1.02 g/4h,白蛋白降低指数为4.94±2.49%。结论。延长MCO血液透析有效去除b2微球蛋白。b2-微球蛋白减少指数为~ 71%,白蛋白损失小于4.0 g/4h。这种透析方式可以防止淀粉样变性、动脉粥样硬化和动脉粥样硬化性心血管疾病在接受常规血液透析治疗的人群中的发展。
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引用次数: 3
Profile of linguistic and cognitive deficits in persons with a semantic variant of a primary progressive aphasia 原发性进行性失语症语义变体患者的语言和认知缺陷概况
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-27796
Lana Jerkić, Dusko Pavlovic, M. Vuković, J. Todorović, Mirna Zelić
Primary progressive aphasia (PPA) includes a group of neurodegenerative disorders that are characterized by progressive deterioration of language functions, while other cognitive functions, at least at the onset of the disease, are relatively spared. There are three basic subtypes of PPA: the nonfluent progressive aphasia (nvPPA), the semantic variant of a primary progressive aphasia (svPPA), and the logopenic progressive aphasia (lvPPA). The semantic variant of a PPA can also be found in the literature under the term of semantic dementia. It is clinically manifested by progressive deterioration of semantic knowledge, fluent aphasia, impaired naming and comprehension, prosopagnosia and surface dyslexia and dysgraphia (in languages with irregular orthography). As the disease progresses, other cognitive changes can be observed. The main cause of the disorder is progressive bilateral atrophy of the anterior temporal lobes, which is more manifested in the left hemisphere. The literature is modest in terms of the use of specific treatment methods in the rehabilitation of these patients. Since speech and language disorders are the most conspicuous symptom, at least at the beginning of the disease, the role of speech therapists in the assessment and restitution of speechlanguage and communication skills is also indisputable.
原发性进行性失语症(PPA)包括一组以语言功能进行性恶化为特征的神经退行性疾病,而其他认知功能,至少在疾病发作时,相对完好。PPA有三种基本亚型:非流利进行性失语症(nvPPA)、原发性进行性失语症的语义变体(svPPA)和语素缺失进行性失语症(lvPPA)。PPA的语义变体也可以在文献中找到语义痴呆的术语。临床表现为语义知识的进行性恶化,流利的失语,命名和理解障碍,面孔失认症和表面阅读障碍和书写障碍(不规则拼写的语言)。随着疾病的进展,可以观察到其他认知变化。这种疾病的主要原因是进行性双侧颞叶萎缩,主要表现在左半球。文献在这些患者的康复中使用特定的治疗方法方面是适度的。由于言语和语言障碍是最明显的症状,至少在疾病开始时是如此,言语治疗师在评估和恢复言语和沟通技能方面的作用也是无可争辩的。
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引用次数: 0
The influence of nutrition and lifestyles on bone health in patients with schizophrenia and depression 营养和生活方式对精神分裂症合并抑郁症患者骨骼健康的影响
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/mckg54-28437
B. Bajić, S. Ristić, Marija Palibrk, A. Arnaut, S. Curcic, K. Taušanović
Objective. The aim of this paper is to investigate the influence of nutrition and pattern behaviors on bone health in people with mental health disorders. Methods. A cross-sectional study has been conducted at the Clinic for Psychiatry of the Clinical Center of Kragujevac and at the Department of Neuropsychiatry of the Specialist-Consultative Service of Health Care Center Kragujevac. The survey included 46 patients from the age of 22 to 81, both genders, with schizophrenia as a diagnosis for mental disorders and depression determined by a psychiatrist. Quantitative testing of calcium, magnesium, phosphorus, sodium and potassium has been performed by standard biochemical methods. Vitamin D has been determined by high performance/pressure liquid chromatography i.e. by a liquid chromatography under high pressure. Results. In the whole group of patients tested, 58.7% of patients were physically active and the patients with schizophrenia (p = 0.026) were less physically active. Out of the total number, 67% of patients eat irregularly and this habit is more present in patients with schizophrenia (p = 0.003). In terms of the presence of certain nutrients, fish is more represented in the nutrition of people suffering from depression. Three patients (6.5%) reported osteoporosis in their medical history, one of whom had a spontaneous fracture. In the anamneses (6.5%) of the patients stated that their parents had had spontaneous bone fractures. Low values of 25 (OH) D in the serum were present in both study groups. Conclusion. Unhealthy lifestyles, low level of Vitamin D found in people who have mental health disorders represent risk factors for the reduced bone mass. The results of our research indicate the need for timely identification of potential risk factors and improvement of prevention in order to raise awareness of the importance of healthy lifestyles and behavior modification.
目标。本文旨在探讨营养和行为模式对精神健康障碍患者骨骼健康的影响。方法。在克拉古耶瓦茨临床中心的精神病学诊所和克拉古耶瓦茨保健中心专家咨询服务处的神经精神科进行了一项横断面研究。该调查包括46名患者,年龄在22岁至81岁之间,男女皆有,精神科医生诊断精神分裂症为精神障碍和抑郁症。用标准的生化方法对钙、镁、磷、钠、钾进行了定量检测。维生素D的测定采用高效液相色谱法,即高压液相色谱法。结果。在整个测试组中,58.7%的患者有身体活动,精神分裂症患者的身体活动较少(p = 0.026)。在总数中,67%的患者饮食不规律,这种习惯在精神分裂症患者中更为普遍(p = 0.003)。就某些营养素的存在而言,鱼类在抑郁症患者的营养中更具代表性。3例(6.5%)患者有骨质疏松病史,其中1例有自发性骨折。在调查中,有6.5%的患者表示他们的父母曾发生过自发性骨折。两组患者血清中25 (OH) D含量均较低。结论。不健康的生活方式、精神疾病患者体内维生素D含量低是导致骨量减少的危险因素。我们的研究结果表明,需要及时识别潜在的危险因素并改善预防措施,以提高人们对健康生活方式和行为改变重要性的认识。
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引用次数: 0
Anxiety in healthcare workers during the COVID-19 pandemic COVID-19大流行期间医护人员的焦虑
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/mckg54-27871
M. Lazarević
Objective. At the time of a pandemic, anxiety is a common occurrence in those persons who are exposed to direct contact with the patients or the possibility of the same. The aim of the study was to determine the degree of anxiety among medical workers employed in the city of Loznica and suburban municipalities, at the time of the COVID-19 pandemic. Methods. Anxiety in 120 adult health workers (36 males, 84 females, 25-65 years old) at the time of the pandemic was assessed based on the value of Beck Anxiety Inventory for determining the degree of anxiety, which was sent electronically to all respondents in the days of the epidemic increase and peak in the number of patients infected with COVID-19 virus. The results. The analysis of the results yielded a mean value of the Beck Anxiety Inventory for the assessment of fear and anxiety of 6.82 (standard deviation, 7.49, range 0-39), which is a state of anxiety without clinical significance. There were no statistically significant differences of the mean Beck Anxiety Inventory values between study subgroups based on subjects' gender (p=0.32), age (p=0.96) and education (p=0.06) categories. Conclusion. The paper presents the emotional reaction of health workers in the city of Loznica and suburban municipalities during the COVID-19 pandemic. It was determined that the anxiety reaction is not present in a significant form, and the most common psychosomatic reactions that occur at the peak of a pandemic are presented.
目标。在大流行期间,与患者直接接触或有可能与患者直接接触的人通常会感到焦虑。该研究的目的是确定在2019冠状病毒病大流行期间,洛兹尼察市和郊区市政当局雇用的医务工作者的焦虑程度。方法。根据用于确定焦虑程度的贝克焦虑量表(Beck Anxiety Inventory)的值,对大流行时120名成年卫生工作者(36名男性,84名女性,25-65岁)的焦虑进行了评估,该量表在疫情增加和感染COVID-19病毒的患者人数高峰期以电子方式发送给所有受访者。结果。分析结果显示,贝克焦虑量表对恐惧和焦虑的评估均值为6.82(标准差为7.49,范围0-39),属于无临床意义的焦虑状态。不同性别(p=0.32)、年龄(p=0.96)、教育程度(p=0.06)分组的贝克焦虑量表均值差异无统计学意义。结论。本文介绍了在2019冠状病毒病大流行期间,洛兹尼察市和郊区城市卫生工作者的情绪反应。经确定,焦虑反应不以显著形式存在,并呈现了在大流行高峰期发生的最常见的心身反应。
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引用次数: 3
Local guidelines for drug treatment of patients with COVID-19 当地COVID-19患者药物治疗指南
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/mckg54-29760
S. Janković, K. Pavlović, V. Vukićević, J. Gavrilović, M. Folic, Predrag Čanović, R. Marjanovic, S. Mojsilović, Nebojša Stevanović, N. Rošić
Objective. Until now, there have been no guidelines for the use of drugs in patients with COVID 19 in the Republic of Serbia that have been authorized and published in the professional or scientific literature, or on the official websites of the Ministry of Health or healthcare institutions. The aim of this paper is to present a local guideline for the use of drugs in patients with COVID 19 and the process of its development and adoption. Methods. The guideline proposal was prepared by a working group based on the results of a systematic research of the medical literature, and quality control of found publications from the category "clinical practice guidelines". The proposal of the working group was considered and adopted at the sessions of the Drug / Therapeutics Committee and the Quality Assurance Committee of the University Clinical Centre Kragujevac. Results. The guideline's recommendations are based on the type of patient, and all have the same degree of recommendation and the same quality of evidence on which they are based. Patient types are formed according to the severity of the disease and the need for respiratory support, as well as according to the risk of secondary bacterial infection. Conclusion. The local guideline to the use of drugs in patients with COVID 19 was developed and adopted in a short period of time, primarily due to the need for its urgent use. A revision of this guide is planned after 6 months from the moment of adoption.
目标。到目前为止,塞尔维亚共和国还没有在专业或科学文献、卫生部或医疗机构的官方网站上授权和发布的针对COVID - 19患者的药物使用指南。本文的目的是为COVID - 19患者提供一份当地的药物使用指南及其开发和采用的过程。方法。指南提案是由一个工作组根据对医学文献的系统研究和对“临床实践指南”类别中发现的出版物的质量控制的结果编写的。药物/治疗委员会和克拉古耶瓦茨大学临床中心质量保证委员会的会议审议并通过了工作组的建议。结果。指南的建议是基于患者的类型,所有的建议都具有相同的推荐程度和相同的证据质量。根据疾病的严重程度和呼吸支持的需要,以及继发性细菌感染的风险,形成患者类型。结论。在短时间内制定并通过了当地的新冠肺炎患者用药指南,主要是由于急需使用。本指南计划在通过之日起6个月后进行修订。
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引用次数: 2
Analysis of tiazofurin-induced DNA damage in human whole blood cells using an in vitro comet assay 用体外彗星试验分析噻唑呋喃诱导的人全血细胞DNA损伤
Q4 Medicine Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-28798
Dijana Topalović, L. Živković, Ninoslav Đelić, V. Bajic, B. Spremo-Potparević
Objective. Inosine 5'-monophosphate dehydrogenase (IMPDH) activity in cancer cells is increased. Tiazofurin selectively inhibits the activity of IMPDH, and it has been granted for the treatment of different cancers and new viral diseases. Its widespread use was limited because exposure to tiazofurin under certain circumstances was found to have a higher frequency of severe non-hematologic toxicity. Therefore, the objective of this study was to examine genotoxic action and inducement of DNA damage of tiazofurin using the comet assay. Methods. The ability of tiazofurin to induce DNA damage was evaluated using single-cell gel electrophoresis (SCGE) technique/comet assay. Human whole blood cells were exposed to three final concentrations of tiazofurin (1µM/mL, 2 µM/mL, and 5 µM/mL) for 30 min in vitro. Results. Our results indicate that tiazofurin produced a significant level of DNA damage on whole blood cells after 30 min of exposure vs. control. All tested concentrations were significantly comet-forming, in a concentration-dependent manner. Conclusion. Our investigation on the tiazofurin-treated cells and their relationship to the formation of DNA damage demonstrated that the genotoxic effect was induced after exposure to tiazofurin under described conditions.
目标。肌苷5′-单磷酸脱氢酶(IMPDH)在癌细胞中的活性增加。噻唑呋喃选择性地抑制IMPDH的活性,它已被批准用于治疗不同的癌症和新的病毒性疾病。它的广泛使用受到限制,因为发现在某些情况下接触噻唑呋喃发生严重非血液学毒性的频率更高。因此,本研究的目的是利用彗星试验来检测噻唑呋喃的基因毒性作用和诱导DNA损伤。方法。采用单细胞凝胶电泳(SCGE)技术/彗星法评价噻唑呋林诱导DNA损伤的能力。将人全血细胞体外暴露于三种最终浓度(1 μ M/mL、2 μ M/mL和5 μ M/mL)的噻唑呋林中30分钟。结果。我们的研究结果表明,与对照组相比,噻唑呋喃暴露30分钟后对全血细胞产生了显著水平的DNA损伤。所有测试的浓度都以浓度依赖的方式显著形成彗星。结论。我们对tiazofurin处理的细胞及其与DNA损伤形成的关系的研究表明,在上述条件下暴露于tiazofurin后可诱导遗传毒性效应。
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引用次数: 0
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Medicinski Casopis
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