Aim was to show the duration of chest pain in patients with Angina pectoris (AP) and acute coronary syndrome (ACS) prior to reporting to the ambulance as well as the patients' self management of the pain. Materials and methods. The study was done between 1st August 2014th and 1st October 2018th in the infirmary of EMS in Belgrade. The study involved 161 patients, out of 9437 patients in total, who were treated by one doctor and with confirmed or suspected diagnosis of an ACS or AP. Results. Patients with AP most commonly waited between 2-24 hours, while the patients with ACS waited <1h from the pain onset until contacting EMS. Most patients with MI (17) as well as with AP (79) did not take any kind of therapy, while some patients administered one or more drugs in order to relieve the pain. In patients with AP, the drugs of choice were antihypertensive medications (17.42%) and in MI patients Nitroglycerin and analgesics (31.03%). All patients previously diagnosed with MI and AP have self-administered Nitroglycerin in 12.42% of cases. Conclusion. Patients with AP wait longer when having chest pain before calling EMS from patients with ACS, but their self-administered drugs of choice were antihypertensive medications. Nitroglycerine as the first appropriate drug of choice is used less and in most cases patients even do not have it readily available.
{"title":"Chest pain and prehospital delay","authors":"M. Stevanovic, S. Živanović","doi":"10.5937/mckg55-26065","DOIUrl":"https://doi.org/10.5937/mckg55-26065","url":null,"abstract":"Aim was to show the duration of chest pain in patients with Angina pectoris (AP) and acute coronary syndrome (ACS) prior to reporting to the ambulance as well as the patients' self management of the pain. Materials and methods. The study was done between 1st August 2014th and 1st October 2018th in the infirmary of EMS in Belgrade. The study involved 161 patients, out of 9437 patients in total, who were treated by one doctor and with confirmed or suspected diagnosis of an ACS or AP. Results. Patients with AP most commonly waited between 2-24 hours, while the patients with ACS waited <1h from the pain onset until contacting EMS. Most patients with MI (17) as well as with AP (79) did not take any kind of therapy, while some patients administered one or more drugs in order to relieve the pain. In patients with AP, the drugs of choice were antihypertensive medications (17.42%) and in MI patients Nitroglycerin and analgesics (31.03%). All patients previously diagnosed with MI and AP have self-administered Nitroglycerin in 12.42% of cases. Conclusion. Patients with AP wait longer when having chest pain before calling EMS from patients with ACS, but their self-administered drugs of choice were antihypertensive medications. Nitroglycerine as the first appropriate drug of choice is used less and in most cases patients even do not have it readily available.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir Nikolić, Nikola Subotić, Jovana Subotić, L. Marković-Denić
Objective. Determination of the correlations between the search for key terms related to the COVID-19 pandemic and the course of the epidemic in Serbia. Methods. A survey was conducted as a cross-sectional study, in November 2020. The research was conducted through the Google Trends website. This open-access platform is based on automatic data collection to estimate the percentage of searches for relevant keywords of interest. The data collected were anonymous and were divided by days, months, years, and geographical regions. Results. The study included 32 key terms related to the COVID-19 pandemic. There was a statistically significant positive correlation with the number of registered cases per day for the terms: "coronavirus", "corona", "covid-19", "covid", " COVID", "virus", "corona symptoms", "loss of smell", "loss of taste", "loss of smell and taste", "loss of sense of smell", "loss of sense of taste", "pneumonia", " COVID infirmary", "infirmary", " COVID test", "corona test", "PCR", "serology ", "antibodies ", "corona antibodies", "vaccine ", "corona vaccine". Conclusion. The shown correlation between the search for appropriate terms related to the COVID-19 pandemic and the course of the epidemic in Serbia can significantly help in predicting the course of the COVID-19 epidemic. In the future, we should work on developing predictive models and software tools based on these resources, not only for COVID-19, but also for other diseases, which would monitor Internet searches in real-time, all with the aim of adequate and timely organization of public health activities.
{"title":"Google trends as an aid in predicting the course of the COVID-19 epidemic in Serbia","authors":"Vladimir Nikolić, Nikola Subotić, Jovana Subotić, L. Marković-Denić","doi":"10.5937/mckg55-32609","DOIUrl":"https://doi.org/10.5937/mckg55-32609","url":null,"abstract":"Objective. Determination of the correlations between the search for key terms related to the COVID-19 pandemic and the course of the epidemic in Serbia. Methods. A survey was conducted as a cross-sectional study, in November 2020. The research was conducted through the Google Trends website. This open-access platform is based on automatic data collection to estimate the percentage of searches for relevant keywords of interest. The data collected were anonymous and were divided by days, months, years, and geographical regions. Results. The study included 32 key terms related to the COVID-19 pandemic. There was a statistically significant positive correlation with the number of registered cases per day for the terms: \"coronavirus\", \"corona\", \"covid-19\", \"covid\", \" COVID\", \"virus\", \"corona symptoms\", \"loss of smell\", \"loss of taste\", \"loss of smell and taste\", \"loss of sense of smell\", \"loss of sense of taste\", \"pneumonia\", \" COVID infirmary\", \"infirmary\", \" COVID test\", \"corona test\", \"PCR\", \"serology \", \"antibodies \", \"corona antibodies\", \"vaccine \", \"corona vaccine\". Conclusion. The shown correlation between the search for appropriate terms related to the COVID-19 pandemic and the course of the epidemic in Serbia can significantly help in predicting the course of the COVID-19 epidemic. In the future, we should work on developing predictive models and software tools based on these resources, not only for COVID-19, but also for other diseases, which would monitor Internet searches in real-time, all with the aim of adequate and timely organization of public health activities.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivan Stojadinovic, J. Milosevic, Srđan Vlajović, Z. Jovanović, N. Prodanović, Dušan Todorović
About 2/3 of malignant tumors develop metastases. The skeletal system is the third most common site of metastases, of which the spine takes the first place in terms of prevalence. Skeletal metastases can occur in all types of malignant tumors, and the breast is one of the most common localizations. Treatment of vertebral fractures can be non-operative and operative. Although numerous studies have shown the benefits of both non-operative and operative treatments, depending on the situation, several of them have recommended a surgical approach as a better way to preserve the patient's mobility. The patient contacted a spinal surgeon due to back pain when she was diagnosed with a pathological fracture of the 7th cervical and 12th thoracic vertebrae. Both fractures were operatively treated, in two time intervals. Given the advances in the treatment of malignant diseases, more people with spinal metastases live today than ever before in history. Patients with unstable pathological fractures are treated surgically, while patients who have stable fractures without dislocations can be treated only with chemotherapy and radiotherapy. The presentation of this patient showed how pathologically unstable vertebral fractures were treated on several levels. Operational approaches were as different as operational techniques. After the surgical treatment and an early rehabilitation, there was a significant improvement in the clinical picture and quality of life of the patient.
{"title":"Spinal stabilization of pathological fractures in metastatic disease in distant segments: A case report","authors":"Ivan Stojadinovic, J. Milosevic, Srđan Vlajović, Z. Jovanović, N. Prodanović, Dušan Todorović","doi":"10.5937/mckg55-31873","DOIUrl":"https://doi.org/10.5937/mckg55-31873","url":null,"abstract":"About 2/3 of malignant tumors develop metastases. The skeletal system is the third most common site of metastases, of which the spine takes the first place in terms of prevalence. Skeletal metastases can occur in all types of malignant tumors, and the breast is one of the most common localizations. Treatment of vertebral fractures can be non-operative and operative. Although numerous studies have shown the benefits of both non-operative and operative treatments, depending on the situation, several of them have recommended a surgical approach as a better way to preserve the patient's mobility. The patient contacted a spinal surgeon due to back pain when she was diagnosed with a pathological fracture of the 7th cervical and 12th thoracic vertebrae. Both fractures were operatively treated, in two time intervals. Given the advances in the treatment of malignant diseases, more people with spinal metastases live today than ever before in history. Patients with unstable pathological fractures are treated surgically, while patients who have stable fractures without dislocations can be treated only with chemotherapy and radiotherapy. The presentation of this patient showed how pathologically unstable vertebral fractures were treated on several levels. Operational approaches were as different as operational techniques. After the surgical treatment and an early rehabilitation, there was a significant improvement in the clinical picture and quality of life of the patient.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dysphagia is a swallowing disorder that is characterized by difficulty to swallow and to control saliva as well as by feeding difficulties. Dysphagia is a common symptom of laryngeal cancer, or a consequence of surgical treatment as well as radiotherapy and chemotherapy of this neoplasma. The patients after laryngectomy are at risk of developing malnutrition, and aspiration pneumonia. Removal of anatomical structures and reorganization of remaining tissues has a significant impact on the physiology of swallowing. For most patients, safe swallowing is the main feature of a positive treatment outcome. Swallowing therapy is important before, during and after treatment of larynx cancer. The aim of this paper is to explore a correlation between swallowing disorders and laryngeal cancer treatment, and to understand the anatomical and physiological bases of dysphagia treatment.
{"title":"Swallowing disorders during and after the treatment of larynx cancer","authors":"Mirna Zelić, Mirjana Petrović-Lazić, Dusko Pavlovic","doi":"10.5937/mckg55-31139","DOIUrl":"https://doi.org/10.5937/mckg55-31139","url":null,"abstract":"Dysphagia is a swallowing disorder that is characterized by difficulty to swallow and to control saliva as well as by feeding difficulties. Dysphagia is a common symptom of laryngeal cancer, or a consequence of surgical treatment as well as radiotherapy and chemotherapy of this neoplasma. The patients after laryngectomy are at risk of developing malnutrition, and aspiration pneumonia. Removal of anatomical structures and reorganization of remaining tissues has a significant impact on the physiology of swallowing. For most patients, safe swallowing is the main feature of a positive treatment outcome. Swallowing therapy is important before, during and after treatment of larynx cancer. The aim of this paper is to explore a correlation between swallowing disorders and laryngeal cancer treatment, and to understand the anatomical and physiological bases of dysphagia treatment.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evgeniy Fisher, A. Urakov, Milena D Svetova, Darya O Suntsova, Ilnur I Yagudin
It has been shown that the new coronavirus infection is life-threatening for patients not because of the COVID-19 virus, but because of the complications it causes. The most dangerous complication of this disease is the airway obstruction syndrome, which occurs with atypical pneumonia. Blockage of the airways occurs due to the accumulation of excessively large amounts of mucus and pus in them and swelling of the lung tissue, so ventilation of the lungs with air becomes almost impossible. The sad outcome of respiratory obstruction is hypoxia and hypoxic brain damage. Under these conditions, extracorporeal membrane oxygenation remains the only known way to increase blood oxygenation. However, in 2021, it was shown that intra-pulmonary administration of a warm alkaline solution of hydrogen peroxide immediately turns mucus and pus into oxygen foam and increases blood oxygen saturation. The proposed technology is a new variant of emergency blood oxygenation in severe suffocation caused by blockage of the respiratory tract with mucus, pus and blood.
{"title":"Covid-19: Intrapulmonary alkaline hydrogen peroxide can immediately increase blood oxygenation","authors":"Evgeniy Fisher, A. Urakov, Milena D Svetova, Darya O Suntsova, Ilnur I Yagudin","doi":"10.5937/mckg55-35424","DOIUrl":"https://doi.org/10.5937/mckg55-35424","url":null,"abstract":"It has been shown that the new coronavirus infection is life-threatening for patients not because of the COVID-19 virus, but because of the complications it causes. The most dangerous complication of this disease is the airway obstruction syndrome, which occurs with atypical pneumonia. Blockage of the airways occurs due to the accumulation of excessively large amounts of mucus and pus in them and swelling of the lung tissue, so ventilation of the lungs with air becomes almost impossible. The sad outcome of respiratory obstruction is hypoxia and hypoxic brain damage. Under these conditions, extracorporeal membrane oxygenation remains the only known way to increase blood oxygenation. However, in 2021, it was shown that intra-pulmonary administration of a warm alkaline solution of hydrogen peroxide immediately turns mucus and pus into oxygen foam and increases blood oxygen saturation. The proposed technology is a new variant of emergency blood oxygenation in severe suffocation caused by blockage of the respiratory tract with mucus, pus and blood.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarcoidosis is a multiorgan, granulomatous disease of unknown etiology. The diagnosis is determined based on clinical and radiographic findings of hilar and or mediastinal lymphadenopathy with or without focal lesions in the lung parenchyma. It is confirmed according to pathohistological findings of a non-caseous granuloma on biopsied lymph nodes or lung parenchyma obtained by standard bronchoscopy. VATS procedures are used when it is impossible to confirm the disease using standard diagnostic methods. Mainly, it is applied in the case of sudden worsening of conditions. The application of VATS is particularly justified because of a more straightforward approach to the target tissue of the mediastinum. This study aimed to determine the efficacy of the VATS procedure in diagnosing sarcoidosis-affected hilar and mediastinal lymph nodes. We presented a case of a 67-year-old patient with radiographic findings of hilar and mediastinal lymphadenopathy and focal lesions in the lung parenchyma. The patient unsuccessfully underwent multiple bronchological examinations. The pathohistological conclusion is not convincing for an accurate diagnosis of sarcoid lymphadenopathy. Due to disease progression and the appearance of bilateral pleural effusion with focal lesions on the lung parenchyma, the VATS procedure obtained lymph nodes, and lung parenchyma confirmed the diagnosis of sarcoidosis. Four months after the diagnosis and treatment with systemic corticosteroids, we observed significant radiological regression. In conclusion, VATS is an efficient and safe auxiliary diagnostic procedure in sarcoid hilar and mediastinal lymphadenopathy.
{"title":"Video-assisted thoracoscopic surgery (VATS) in sarcoidosis involving hilus and mediastinal lymphadenopathy","authors":"Ivana Meta-Jevtović, Miroslav S. Tomovic","doi":"10.5937/mckg55-31905","DOIUrl":"https://doi.org/10.5937/mckg55-31905","url":null,"abstract":"Sarcoidosis is a multiorgan, granulomatous disease of unknown etiology. The diagnosis is determined based on clinical and radiographic findings of hilar and or mediastinal lymphadenopathy with or without focal lesions in the lung parenchyma. It is confirmed according to pathohistological findings of a non-caseous granuloma on biopsied lymph nodes or lung parenchyma obtained by standard bronchoscopy. VATS procedures are used when it is impossible to confirm the disease using standard diagnostic methods. Mainly, it is applied in the case of sudden worsening of conditions. The application of VATS is particularly justified because of a more straightforward approach to the target tissue of the mediastinum. This study aimed to determine the efficacy of the VATS procedure in diagnosing sarcoidosis-affected hilar and mediastinal lymph nodes. We presented a case of a 67-year-old patient with radiographic findings of hilar and mediastinal lymphadenopathy and focal lesions in the lung parenchyma. The patient unsuccessfully underwent multiple bronchological examinations. The pathohistological conclusion is not convincing for an accurate diagnosis of sarcoid lymphadenopathy. Due to disease progression and the appearance of bilateral pleural effusion with focal lesions on the lung parenchyma, the VATS procedure obtained lymph nodes, and lung parenchyma confirmed the diagnosis of sarcoidosis. Four months after the diagnosis and treatment with systemic corticosteroids, we observed significant radiological regression. In conclusion, VATS is an efficient and safe auxiliary diagnostic procedure in sarcoid hilar and mediastinal lymphadenopathy.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Zorenko, G. Gubina-Vakulyck, O. Pavlova, T. Gorbach, E. Shchegelskaya, E. Omelchenko
Objective. The aim of this study was to assess the vascular endothelium morphofunctional state of the brain microcirculatory bed in rats with nitrite-induced Alzheimer's type dementia on the background of stem cells administration. Methods. 14 days after the experiment's end, the endothelin-1, VEGF-A, eNOS, von Willebrand factor were determined in blood serum by the enzyme immunoassay and photometric methods in rats with a model of nitrite-induced dementia (14 and 28 days of sodium nitrite intraperitoneal introduction) with and without mesenchymal stem cells (MSCs) administration. The brain slices were stained according to the Einarson's method and immunohistochemically by staging the reaction with antibodies to VEGF. Results. With an increase in the sodium nitrite administration period, the degree of damage of brain capillaries and neurons increased, dystrophy of "surviving" neurons developed and ability to produce VEGF decreased. After 14 days of "regeneration period" in groups without MSCs administration, further stimulation of VEGF production by endotheliocytes, cortex and hippocampus neurons of varying degrees was observed. In groups where stem cells were introduced, the number of capillaries increased, with endothelial hyperplasia in some cases. Conclusion. In animals with nitrite-induced dementia, dose-dependent damage to the endothelium of the capillary bed is noted. From the first day damage the vascular regeneration can be proved by VEGF expression. The stem cells administration more effectively stimulates capillary regeneration, as evidenced by a noticeable increase of the number of brain capillaries.
{"title":"Dynamics of indicators of the endothelium morphofunctional state of the brain microcirculatory bed vessels in rats with nitrite-induced Alzheimer's type dementia on the background of mesenchymal stem cell administration","authors":"Y. Zorenko, G. Gubina-Vakulyck, O. Pavlova, T. Gorbach, E. Shchegelskaya, E. Omelchenko","doi":"10.5937/mckg55-31775","DOIUrl":"https://doi.org/10.5937/mckg55-31775","url":null,"abstract":"Objective. The aim of this study was to assess the vascular endothelium morphofunctional state of the brain microcirculatory bed in rats with nitrite-induced Alzheimer's type dementia on the background of stem cells administration. Methods. 14 days after the experiment's end, the endothelin-1, VEGF-A, eNOS, von Willebrand factor were determined in blood serum by the enzyme immunoassay and photometric methods in rats with a model of nitrite-induced dementia (14 and 28 days of sodium nitrite intraperitoneal introduction) with and without mesenchymal stem cells (MSCs) administration. The brain slices were stained according to the Einarson's method and immunohistochemically by staging the reaction with antibodies to VEGF. Results. With an increase in the sodium nitrite administration period, the degree of damage of brain capillaries and neurons increased, dystrophy of \"surviving\" neurons developed and ability to produce VEGF decreased. After 14 days of \"regeneration period\" in groups without MSCs administration, further stimulation of VEGF production by endotheliocytes, cortex and hippocampus neurons of varying degrees was observed. In groups where stem cells were introduced, the number of capillaries increased, with endothelial hyperplasia in some cases. Conclusion. In animals with nitrite-induced dementia, dose-dependent damage to the endothelium of the capillary bed is noted. From the first day damage the vascular regeneration can be proved by VEGF expression. The stem cells administration more effectively stimulates capillary regeneration, as evidenced by a noticeable increase of the number of brain capillaries.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Increased concentrations of vitamin B12 are the result of excessive intake of this vitamin, increased release of vitamins from hepatic depots, or elevated concentrations of transcobalamin resulting from the increased production or reduced decomposition of this molecule. The most common diseases that lead to B12 hypervitaminosis are malignancies and solid tumours. As a result of elevated concentrations, acnes emerge or exacerbate the already existing acneiform changes. Rosacea fulminant, allergic, and other anaphylactic reactions may also develop. The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health. In a study conducted by Deneuvil and associates, the elevated B12 vitamin levels were observed in 12% of respondents. In the study by Carmel and associates, 14% of the respondents had high cobalanemia. The results of other studies show that the prevalence of high cobalanemia is 13%, while very high cobalanemia is registered in 7% of cases. In the multicentric BDOSE study, the incidence of high serum cobalamin was 18%. The increased concentrations of cobalamin are most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common. As a result of B12 hypervitaminosis, acnes emerge or exacerbation of the pre-existing acneiform changes may occur. In addition to acne, other dermatological diseases (Rosacea fulminant, dermatitis) may develop as a result of hypervitaminosis, followed by allergic and anaphylactic reactions.
{"title":"Hypervitaminosis B12","authors":"Marko Koprivica, J. Bjelanović","doi":"10.5937/mckg55-33665","DOIUrl":"https://doi.org/10.5937/mckg55-33665","url":null,"abstract":"Increased concentrations of vitamin B12 are the result of excessive intake of this vitamin, increased release of vitamins from hepatic depots, or elevated concentrations of transcobalamin resulting from the increased production or reduced decomposition of this molecule. The most common diseases that lead to B12 hypervitaminosis are malignancies and solid tumours. As a result of elevated concentrations, acnes emerge or exacerbate the already existing acneiform changes. Rosacea fulminant, allergic, and other anaphylactic reactions may also develop. The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health. In a study conducted by Deneuvil and associates, the elevated B12 vitamin levels were observed in 12% of respondents. In the study by Carmel and associates, 14% of the respondents had high cobalanemia. The results of other studies show that the prevalence of high cobalanemia is 13%, while very high cobalanemia is registered in 7% of cases. In the multicentric BDOSE study, the incidence of high serum cobalamin was 18%. The increased concentrations of cobalamin are most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common. As a result of B12 hypervitaminosis, acnes emerge or exacerbation of the pre-existing acneiform changes may occur. In addition to acne, other dermatological diseases (Rosacea fulminant, dermatitis) may develop as a result of hypervitaminosis, followed by allergic and anaphylactic reactions.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Velickovic, Sofija Sekulić-Marković, Aleksandar Acović, Snežana Radovanović, T. Kanjevac
Objective. Enamel hypoplasia is a quantitative disorder of enamel deposition during the secretory phase and is characterised by a deficiency of the enamel, while hypomineralization is a qualitative disorder caused by incomplete mineralization and maturation of the enamel, followed by the porosity of the solid dental tissues and the opalescent tooth colour. Clinically, hypoplasia is a risk for caries, tooth sensitivity, erosion, and affects the aesthetic appearance of a patient with a psychological connotation. The aim of the paper is to present the case report, the possibility of preventive measures and restorative treatments with minimally invasive requirements in these patients. Methods. At the Faculty of Medical Sciences, University of Kragujevac, in March 2018, a thirteen-year-old boy was diagnosed with isolated hypoplastic enamel defects on teeth 24, 25, 26, 33 and 34. Results. Enamel hypoplasia was diagnosed by anamnesis, clinical and radiological examination. Preventive measures and conservative interventions were used to prevent progressive abrasion and early tooth loss due to caries and its complications. Conclusion. Early diagnosis, timely preventive methods and minimally invasive restorative treatment can correct anomalies and prevent possible complications.
{"title":"Non-invasive treatment of multiple enamel hypoplasia: A case report","authors":"M. Velickovic, Sofija Sekulić-Marković, Aleksandar Acović, Snežana Radovanović, T. Kanjevac","doi":"10.5937/mckg55-25392","DOIUrl":"https://doi.org/10.5937/mckg55-25392","url":null,"abstract":"Objective. Enamel hypoplasia is a quantitative disorder of enamel deposition during the secretory phase and is characterised by a deficiency of the enamel, while hypomineralization is a qualitative disorder caused by incomplete mineralization and maturation of the enamel, followed by the porosity of the solid dental tissues and the opalescent tooth colour. Clinically, hypoplasia is a risk for caries, tooth sensitivity, erosion, and affects the aesthetic appearance of a patient with a psychological connotation. The aim of the paper is to present the case report, the possibility of preventive measures and restorative treatments with minimally invasive requirements in these patients. Methods. At the Faculty of Medical Sciences, University of Kragujevac, in March 2018, a thirteen-year-old boy was diagnosed with isolated hypoplastic enamel defects on teeth 24, 25, 26, 33 and 34. Results. Enamel hypoplasia was diagnosed by anamnesis, clinical and radiological examination. Preventive measures and conservative interventions were used to prevent progressive abrasion and early tooth loss due to caries and its complications. Conclusion. Early diagnosis, timely preventive methods and minimally invasive restorative treatment can correct anomalies and prevent possible complications.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dragan B. Sekulic, A. Tomić, D. Milasinovic, D. Nikolić, D. Paunovic, Uros M. Miladinovic, Igor Sekulic, Maja Savić-Sekulić, B. Milev
Objective. Femoropopliteal bypass is indicated in the advanced stage of peripheral arterial occlusive disease. The indications for surgical treatment are determined on the basis of a clinical exam, "ankle-brachial index" and angiographic findings. Using the finite element analysis method, three-dimensional models can be made based on angiography, and these models can be used to measure different physical quantities and calculate the value of the "ankle-brachial index". The aim of this paper is to show the hemodynamics of arteries by using the finite element analysis method based on preoperative and postoperative angiography, as well as physical quantities that can be measured in this way. Methods. This case shows the hemodynamics of femoropopliteal bypass in the preoperative and postoperative models. The models obtained by finite element analysis show: pressure, shear stress, velocities, and streamlines. The pressure, i.e. the "ankle-brachial index", was compared with the values measured on the patient, while the other three values were compared preoperatively and postoperatively. Results. Postoperatively, higher values of pressure and "ankle-brachial index" were measured on the patient and on the models. Wall shear stress and velocity values were reduced in postoperative models. The streamlines showed a dominant anterior tibial artery. Conclusion. The values of physical quantities measured on patient and on the models obtained by the finite element analysis method correlate significantly. Some physical quantities could indicate the "weak points" of a particular model.
{"title":"Haemodynamics of femoropopliteal bypass surgery using finite element analysis method","authors":"Dragan B. Sekulic, A. Tomić, D. Milasinovic, D. Nikolić, D. Paunovic, Uros M. Miladinovic, Igor Sekulic, Maja Savić-Sekulić, B. Milev","doi":"10.5937/mckg55-31632","DOIUrl":"https://doi.org/10.5937/mckg55-31632","url":null,"abstract":"Objective. Femoropopliteal bypass is indicated in the advanced stage of peripheral arterial occlusive disease. The indications for surgical treatment are determined on the basis of a clinical exam, \"ankle-brachial index\" and angiographic findings. Using the finite element analysis method, three-dimensional models can be made based on angiography, and these models can be used to measure different physical quantities and calculate the value of the \"ankle-brachial index\". The aim of this paper is to show the hemodynamics of arteries by using the finite element analysis method based on preoperative and postoperative angiography, as well as physical quantities that can be measured in this way. Methods. This case shows the hemodynamics of femoropopliteal bypass in the preoperative and postoperative models. The models obtained by finite element analysis show: pressure, shear stress, velocities, and streamlines. The pressure, i.e. the \"ankle-brachial index\", was compared with the values measured on the patient, while the other three values were compared preoperatively and postoperatively. Results. Postoperatively, higher values of pressure and \"ankle-brachial index\" were measured on the patient and on the models. Wall shear stress and velocity values were reduced in postoperative models. The streamlines showed a dominant anterior tibial artery. Conclusion. The values of physical quantities measured on patient and on the models obtained by the finite element analysis method correlate significantly. Some physical quantities could indicate the \"weak points\" of a particular model.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70986140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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