首页 > 最新文献

Journal of the University of Malaya Medical Centre最新文献

英文 中文
CURRENT APPROACHES IN MANAGING DENTAL ANXIETY: A NARRATIVE VIEW 当前的方法在管理牙科焦虑:叙述的观点
Q4 Medicine Pub Date : 2020-12-08 DOI: 10.22452/JUMMEC.VOL23NO2.9
Ting Jing Kweh, Ghee Seong Lim
Introduction: Dental anxiety is a common problem faced by dental practitioners worldwide. Generally, the management of dental anxiety can be classified as pharmacological and non-pharmacological approaches, in multiple studies and reports available on this subject.Aims and objectives: This paper will provide a general overview of the pharmacological and nonpharmacological strategies in the management of dental anxiety, supported by dental literature. This would help dental practitioners understand the benefits and limitations of the different methods of treating their anxious patients.Methodology: This is a narrative review and a summary of the different approaches and methods available in the management of dental anxiety. Relevant articles were searched from the online databases of PubMed, ScienceDirect, and Google Scholar, and the keywords used to identify the papers were ‘Dental Anxiety’, ‘Pharmacological’, and ‘Non-pharmacological’.Conclusion: Appropriate management of dental anxiety is crucial to ensure a successful dental procedure. The choice of the anxiety management must be based on the complete understanding of the particular patient, identifying the source of anxiety, and working hand-in-hand with the patient for better oral health care.
牙科焦虑是全球牙科从业者面临的共同问题。一般来说,牙科焦虑的管理可以分为药物和非药物的方法,在多个研究和报告中,这一主题。目的和目的:本文将提供牙科焦虑症管理的药理学和非药理学策略的总体概述,并得到牙科文献的支持。这将有助于牙科医生了解治疗焦虑患者的不同方法的好处和局限性。方法:这是一个叙述性的回顾和不同的途径和方法的总结,可用于牙科焦虑的管理。从PubMed、ScienceDirect和b谷歌Scholar的在线数据库中检索相关文章,用于识别论文的关键词为“Dental Anxiety”、“pharmacology”和“non - pharmacics”。结论:妥善处理牙科焦虑是确保牙科手术成功的关键。焦虑管理的选择必须基于对特定患者的全面了解,确定焦虑的来源,并与患者共同努力,以获得更好的口腔保健。
{"title":"CURRENT APPROACHES IN MANAGING DENTAL ANXIETY: A NARRATIVE VIEW","authors":"Ting Jing Kweh, Ghee Seong Lim","doi":"10.22452/JUMMEC.VOL23NO2.9","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.9","url":null,"abstract":"Introduction: Dental anxiety is a common problem faced by dental practitioners worldwide. Generally, the management of dental anxiety can be classified as pharmacological and non-pharmacological approaches, in multiple studies and reports available on this subject.Aims and objectives: This paper will provide a general overview of the pharmacological and nonpharmacological strategies in the management of dental anxiety, supported by dental literature. This would help dental practitioners understand the benefits and limitations of the different methods of treating their anxious patients.Methodology: This is a narrative review and a summary of the different approaches and methods available in the management of dental anxiety. Relevant articles were searched from the online databases of PubMed, ScienceDirect, and Google Scholar, and the keywords used to identify the papers were ‘Dental Anxiety’, ‘Pharmacological’, and ‘Non-pharmacological’.Conclusion: Appropriate management of dental anxiety is crucial to ensure a successful dental procedure. The choice of the anxiety management must be based on the complete understanding of the particular patient, identifying the source of anxiety, and working hand-in-hand with the patient for better oral health care.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47187885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ETHICS, PROFESSIONALISM AND LEGAL EDUCATION IN MALAYSIAN UNDERGRADUATE DENTISTRY: A REFLECTION ON THE CURRENT REQUIREMENTS 马来西亚牙科专业本科生的伦理、专业与法律教育&对现行要求的思考
Q4 Medicine Pub Date : 2020-12-08 DOI: 10.22452/JUMMEC.VOL23NO2.10
Usharani Balasingam, L. Seong, C. Yeng
The undergraduate dental degree in Malaysia is regulated by the Malaysian Dental Council (MDC) (Standard of Undergraduate Competencies), Code of Professional Conduct of the Malaysian Dental Council, the Malaysian Qualification Framework 2.0 and the Malaysian Quality Agency (MQA) quality assurance documents. These primary documents emphasize the importance of professional ethics and law in dentistry as will be further detailed and discussed later. This study reflects on the need to integrate ethics, professionalism and law with sufficient coverage in terms of content and emphasis in the dental undergraduate curriculum. Literature and benchmarking practices are reviewed for a deeper reflection of the current needs in a professional dental ethics and law education course. The present study is primarily focused on regulatory requirements, legal cases and comparative literature to serve as a reference on how professional ethics and law courses may be conducted. As an incidental measure, a reflection as to how the course of study of professional ethics is delivered in a local university is considered in a selected local university’s undergraduate dental curriculum. The findings indicate that ethics professionalism and dental law is not given sufficient emphasis as it is included as one of the minor components within another overcrowded subject and the coverage of what is taught is limited in context. This paper is an invitation to all dental schools to review and reflect whether, given the emphasis on professional ethics, legal and regulatory compliance in the regulatory documents, it is adequately reflected in their dental curriculum. In this regard, some benchmarking references are done to suggest what such a course should cover, for consideration of the dental schools.
马来西亚的本科牙科学位受马来西亚牙科委员会(MDC)(本科生能力标准)、马来西亚牙科委员会职业行为准则、马来西亚资格框架2.0和马来西亚质量局(MQA)质量保证文件的监管。这些主要文件强调了职业道德和法律在牙科中的重要性,稍后将进一步详细介绍和讨论。这项研究反映了在牙科本科生课程中,在内容和重点方面,需要将伦理、专业精神和法律充分结合起来。对文献和基准实践进行了审查,以更深入地反映牙科职业道德和法律教育课程的当前需求。本研究主要侧重于监管要求、法律案例和比较文献,以作为如何开展职业道德和法律课程的参考。作为一项附带措施,在选定的当地大学牙科本科生课程中,考虑了如何在当地大学开设职业道德学习课程。调查结果表明,职业道德和牙科法没有得到足够的重视,因为它被列为另一门过于拥挤的学科的次要组成部分之一,而且所教授的内容在上下文中受到限制。鉴于监管文件中强调职业道德、法律和监管合规性,本文邀请所有牙科学校审查并反思其牙科课程是否充分反映了这一点。在这方面,我们做了一些基准参考,以建议这门课程应该涵盖什么,供牙科学校考虑。
{"title":"ETHICS, PROFESSIONALISM AND LEGAL EDUCATION IN MALAYSIAN UNDERGRADUATE DENTISTRY: A REFLECTION ON THE CURRENT REQUIREMENTS","authors":"Usharani Balasingam, L. Seong, C. Yeng","doi":"10.22452/JUMMEC.VOL23NO2.10","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.10","url":null,"abstract":"The undergraduate dental degree in Malaysia is regulated by the Malaysian Dental Council (MDC) (Standard of Undergraduate Competencies), Code of Professional Conduct of the Malaysian Dental Council, the Malaysian Qualification Framework 2.0 and the Malaysian Quality Agency (MQA) quality assurance documents. These primary documents emphasize the importance of professional ethics and law in dentistry as will be further detailed and discussed later. This study reflects on the need to integrate ethics, professionalism and law with sufficient coverage in terms of content and emphasis in the dental undergraduate curriculum. Literature and benchmarking practices are reviewed for a deeper reflection of the current needs in a professional dental ethics and law education course. The present study is primarily focused on regulatory requirements, legal cases and comparative literature to serve as a reference on how professional ethics and law courses may be conducted. As an incidental measure, a reflection as to how the course of study of professional ethics is delivered in a local university is considered in a selected local university’s undergraduate dental curriculum. The findings indicate that ethics professionalism and dental law is not given sufficient emphasis as it is included as one of the minor components within another overcrowded subject and the coverage of what is taught is limited in context. This paper is an invitation to all dental schools to review and reflect whether, given the emphasis on professional ethics, legal and regulatory compliance in the regulatory documents, it is adequately reflected in their dental curriculum. In this regard, some benchmarking references are done to suggest what such a course should cover, for consideration of the dental schools.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41597586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANALYSES OF THE EFFECTIVENESS OF MOVEMENT CONTROL ORDER (MCO) IN REDUCING THE COVID-19 CONFIRMED CASES IN MALAYSIA 行动管制令在减少马来西亚新冠肺炎确诊病例中的效果分析
Q4 Medicine Pub Date : 2020-12-05 DOI: 10.22452/JUMMEC.SP2020NO1.4
Nicholas Pang Tze Ping, A. Kamu, Mohd Amiruddin Mohd Kassim, Ho Chong Mun
The COVID-19 pandemic resulted in 5 consecutive Movement Control Orders (MCOs) in Malaysia in an attempt to flatten the epidemiological curve, with a reduction of cases. This study aims to use statistical analysis to assess whether the decisive public health interventions in the MCO were efficacious. Three statistical tests were employed: Mann-Kendall trend analysis; one way between groups ANOVA; and Pearson correlation test. Results demonstrated significant differences between the second block, MCO 3-5, compared to MCO 1-2. Johor and Selangor states experienced significant increase in early MCO, whereas Sarawak and Selangor states experienced significant decrease by MCO 3-5. The northern border states of Kedah, Perlis and Kelantan, had caseloads stabilised to zero by MCO 4/MCO 5. This study demonstrates that the MCO was effective within the target of twice the two-week incubation period of COVID-19, with cases from community transmission and importation through the air and southern land borders. Selangor and Sarawak had higher cases in early MCO due to situational factors. In conclusion, MCO has been efficacious, with different states attaining different levels of case reduction due to individualised reasons.
新冠肺炎大流行导致马来西亚连续5次发布行动控制令(MCO),试图使流行病学曲线变平,病例减少。本研究旨在使用统计分析来评估MCO中决定性的公共卫生干预措施是否有效。采用了三种统计检验:Mann-Kendall趋势分析;组间单向方差分析;Pearson相关检验。结果显示,与MCO1-2相比,第二块MCO3-5之间存在显著差异。柔佛州和雪兰莪州的早期MCO显著增加,而砂拉越州和雪兰莪州的MCO显著减少3-5。北部边境州吉打州、佩里斯州和吉兰丹州的案件数量在MCO 4/MCO 5中稳定为零。这项研究表明,MCO在新冠肺炎两周潜伏期的目标范围内是有效的,病例来自社区传播和通过空中和南部陆地边界输入。由于环境因素,雪兰莪州和砂拉越州早期MCO的病例较多。总之,MCO是有效的,不同的状态由于个人原因获得了不同程度的病例减少。
{"title":"ANALYSES OF THE EFFECTIVENESS OF MOVEMENT CONTROL ORDER (MCO) IN REDUCING THE COVID-19 CONFIRMED CASES IN MALAYSIA","authors":"Nicholas Pang Tze Ping, A. Kamu, Mohd Amiruddin Mohd Kassim, Ho Chong Mun","doi":"10.22452/JUMMEC.SP2020NO1.4","DOIUrl":"https://doi.org/10.22452/JUMMEC.SP2020NO1.4","url":null,"abstract":"The COVID-19 pandemic resulted in 5 consecutive Movement Control Orders (MCOs) in Malaysia in an attempt to flatten the epidemiological curve, with a reduction of cases. This study aims to use statistical analysis to assess whether the decisive public health interventions in the MCO were efficacious. Three statistical tests were employed: Mann-Kendall trend analysis; one way between groups ANOVA; and Pearson correlation test. Results demonstrated significant differences between the second block, MCO 3-5, compared to MCO 1-2. Johor and Selangor states experienced significant increase in early MCO, whereas Sarawak and Selangor states experienced significant decrease by MCO 3-5. The northern border states of Kedah, Perlis and Kelantan, had caseloads stabilised to zero by MCO 4/MCO 5. This study demonstrates that the MCO was effective within the target of twice the two-week incubation period of COVID-19, with cases from community transmission and importation through the air and southern land borders. Selangor and Sarawak had higher cases in early MCO due to situational factors. In conclusion, MCO has been efficacious, with different states attaining different levels of case reduction due to individualised reasons.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43087410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
HIGHER EDUCATION IN ARMED CONFLICT REGION OF SOUTHERN THAILAND: ASSOCIATION BETWEEN H.M KING BHUMIBOL ADULYADEJ’S SUFFICIENCY ECONOMY PHILOSOPHY AND RESILIENCE 泰国南部武装冲突地区的高等教育:普密蓬·阿杜德国王的充足经济哲学与恢复力之间的关系
Q4 Medicine Pub Date : 2020-11-12 DOI: 10.22452/JUMMEC.VOL23NO2.8
Chonnakarn Jatchavala, Arnont Vittayanont
Background: This research aimed to examine the association between resilience and lifestyle in line with H.M. King Bhumibol Aduyadej’s sufficiency economy philosophy (SEP) among university students studying in restive insurgent areas of Southern Thailand. Methods: Data were collected on a single occasion between 8 August 2018 and 8 October 2018, at Prince of Songkla University, Pattani campus, located in the restive areas of Southern Thailand. A total of 443 university students were assessed using the 20-item Thai Resilience Quotient screening test, and 35-item questionnaire for lifestyle following H.M. King Bhumibol Aduyadej’s SEP. Data were analyzed by using R software package for descriptive analysis, Chi-square and logistic regression. Results: Of the 443 university students who participated in the survey, most participants were Thai, female and Muslim (94.1%, 80.3% and 75.5%, respectively). Most of them perceived that they lived sufficiently, following H.M. King Bhumibol Aduyadej’s SEP, together with normal or higher than normal level of resilience (67.9% and 64.8%, respectively). The association between resillience in total to perception of lifestyle, in line with H.M. King Bhumibol Aduyadej’s SEP , was statistically significant. Resilience was categorized by domains of emotional stability, willpower and coping skill (all p-values<0.001). Sufficient living according to the late king’s SEP was found to be 3.42 times higher than in students who lived non sufficiently (95%CI=2.24, 5.22). Conclusion: Resilience and self-perceived lifestyle according to H.M. King Bhumibol Aduyadej’s SEP were found to have a statistically significant association among university students who studied in restive insurgent areas of South Thailand.
背景:本研究旨在考察泰国南部动乱地区大学生的心理弹性与生活方式之间的关系,这些大学生符合普密蓬·阿杜德国王的充足经济哲学(SEP)。方法:数据于2018年8月8日至2018年10月8日在位于泰国南部动荡地区的宋卡王子大学Pattani校区一次性收集。采用20项泰式弹性商筛选测验和35项普密蓬国王SEP生活方式问卷对443名大学生进行评估,数据采用R软件包进行描述性分析、卡方分析和logistic回归。结果:443名参与调查的大学生中,泰国人、女性和穆斯林占比最高(分别为94.1%、80.3%和75.5%)。他们中的大多数人认为他们的生活足够,遵循国王普密蓬·阿杜德(H.M. King Bhumibol Aduyadej)的SEP,以及正常或高于正常水平的弹性(分别为67.9%和64.8%)。总体复原力与生活方式感知之间的关联,与普密蓬·阿杜德国王的SEP一致,具有统计学意义。弹性以情绪稳定性、意志力和应对技能为分类域(p值均<0.001)。根据已故国王的SEP,生活充足的学生比生活不充足的学生高3.42倍(95%CI=2.24, 5.22)。结论:在泰国南部动乱地区学习的大学生中,泰国国王普密蓬·阿杜德的心理弹性和自我感知的生活方式具有显著的统计学意义。
{"title":"HIGHER EDUCATION IN ARMED CONFLICT REGION OF SOUTHERN THAILAND: ASSOCIATION BETWEEN H.M KING BHUMIBOL ADULYADEJ’S SUFFICIENCY ECONOMY PHILOSOPHY AND RESILIENCE","authors":"Chonnakarn Jatchavala, Arnont Vittayanont","doi":"10.22452/JUMMEC.VOL23NO2.8","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.8","url":null,"abstract":"Background: This research aimed to examine the association between resilience and lifestyle in line with H.M. King Bhumibol Aduyadej’s sufficiency economy philosophy (SEP) among university students studying in restive insurgent areas of Southern Thailand. \u0000Methods: Data were collected on a single occasion between 8 August 2018 and 8 October 2018, at Prince of Songkla University, Pattani campus, located in the restive areas of Southern Thailand. A total of 443 university students were assessed using the 20-item Thai Resilience Quotient screening test, and 35-item questionnaire for lifestyle following H.M. King Bhumibol Aduyadej’s SEP. Data were analyzed by using R software package for descriptive analysis, Chi-square and logistic regression. \u0000Results: Of the 443 university students who participated in the survey, most participants were Thai, female and Muslim (94.1%, 80.3% and 75.5%, respectively). Most of them perceived that they lived sufficiently, following H.M. King Bhumibol Aduyadej’s SEP, together with normal or higher than normal level of resilience (67.9% and 64.8%, respectively). The association between resillience in total to perception of lifestyle, in line with H.M. King Bhumibol Aduyadej’s SEP , was statistically significant. Resilience was categorized by domains of emotional stability, willpower and coping skill (all p-values<0.001). Sufficient living according to the late king’s SEP was found to be 3.42 times higher than in students who lived non sufficiently (95%CI=2.24, 5.22). \u0000Conclusion: Resilience and self-perceived lifestyle according to H.M. King Bhumibol Aduyadej’s SEP were found to have a statistically significant association among university students who studied in restive insurgent areas of South Thailand.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47620096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
PATHOGENESIS OF ATHEROSCLEROSIS AND ALPHA LIPOIC ACID AS A POTENTIAL THERAPEUTIC AGENT AGAINST ATHEROSCLEROSIS - A REVIEW 动脉粥样硬化的发病机制及α -硫辛酸作为动脉粥样硬化潜在治疗剂的研究进展
Q4 Medicine Pub Date : 2020-09-04 DOI: 10.22452/JUMMEC.VOL23NO2.7
V. N. Ahmad, Z. Amom, I. M. Amin, N. B. Ruslan, N. Zain, M. Rahim
Studies have found the association between hypercholesterolemia with oxidative stress and atherogenesis. Atherosclerosis has become one of the leading causes of mortality among industrial countries due to abnormal cholesterol metabolism, inflammation of arterial wall and build-up of atherosclerotic plaque. This disease has been recently linked with alpha lipoic acid (ALA), a mitochondrial compound with antioxidative effects in water- and fat-soluble mediums, in both oxidized and reduced forms: lipoic acid (LA) and dihydrolipoic acid (DHLA), respectively. This article provides a comprehensive review of the development and progression of atherosclerosis and the roles and regulations of ALA as a potent antioxidant against atherosclerosis.
研究发现高胆固醇血症与氧化应激和动脉粥样硬化形成之间存在联系。由于胆固醇代谢异常、动脉壁炎症和动脉粥样硬化斑块的形成,动脉粥样硬化已成为工业国家死亡的主要原因之一。这种疾病最近与α-硫辛酸(ALA)有关,后者是一种线粒体化合物,在水溶性和脂溶性介质中具有抗氧化作用,有氧化形式和还原形式:硫辛酸(LA)和二氢硫辛酸(DHLA)。本文全面综述了动脉粥样硬化的发展和进展,以及ALA作为一种有效的抗动脉粥样硬化抗氧化剂的作用和调节。
{"title":"PATHOGENESIS OF ATHEROSCLEROSIS AND ALPHA LIPOIC ACID AS A POTENTIAL THERAPEUTIC AGENT AGAINST ATHEROSCLEROSIS - A REVIEW","authors":"V. N. Ahmad, Z. Amom, I. M. Amin, N. B. Ruslan, N. Zain, M. Rahim","doi":"10.22452/JUMMEC.VOL23NO2.7","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.7","url":null,"abstract":"Studies have found the association between hypercholesterolemia with oxidative stress and atherogenesis. Atherosclerosis has become one of the leading causes of mortality among industrial countries due to abnormal cholesterol metabolism, inflammation of arterial wall and build-up of atherosclerotic plaque. This disease has been recently linked with alpha lipoic acid (ALA), a mitochondrial compound with antioxidative effects in water- and fat-soluble mediums, in both oxidized and reduced forms: lipoic acid (LA) and dihydrolipoic acid (DHLA), respectively. This article provides a comprehensive review of the development and progression of atherosclerosis and the roles and regulations of ALA as a potent antioxidant against atherosclerosis.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2020-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49124676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DIETARY PHYTOCHEMICALS ON ELIMINATION OF CANCER STEM CELLS THROUGH TARGETING ITS QUIESCENCE AND SURVIVAL MECHANISMS 膳食植物化学物质通过靶向其静止和存活机制消除癌症干细胞
Q4 Medicine Pub Date : 2020-08-27 DOI: 10.22452/JUMMEC.VOL23NO2.6
S. Lee, Chu Xin Ng
According to tradition, plants and herbs are potential cures for numerous illnesses. In recent decades, they have gained worldwide recognition as critical sources of new drugs, especially for cancer, and the focus on medicinal plant research has increased tremendously. Currently, research scientists attribute the occurrence of post-chemotherapy tumour exacerbation to the presence of cancer stem cells hidden in the bulk of the malignant tumour, forming a rare subpopulation that plays a major role in tumour re-initiation, progression and recurrence. There is increasing evidence of cancer stem cells in a wide array of tumours, and these cells could be the crucial target for future chemotherapy approaches. This review of the major plant-based phytochemicals with documented antagonistic activities against cancer stem cells, their molecular targets and the mechanisms involved, may serve as a guide for developing from the existing natural agents, more effective, and broader spectrum anti-cancer stem cell compounds with the potential for clinical application.
根据传统,植物和草药有可能治愈许多疾病。近几十年来,它们已成为全球公认的新药,特别是抗癌新药的重要来源,药用植物研究的重点也大大增加。目前,研究人员将化疗后肿瘤恶化的发生归因于隐藏在大部分恶性肿瘤中的癌症干细胞的存在,形成了一个罕见的亚群,在肿瘤的重新启动、进展和复发中起着重要作用。越来越多的证据表明,癌症干细胞存在于多种肿瘤中,这些细胞可能成为未来化疗方法的关键目标。本文综述了具有抗癌活性的主要植物化学物质及其分子靶点和作用机制,为从现有的天然药物中开发出更有效、谱更广、具有临床应用潜力的抗癌干细胞化合物提供指导。
{"title":"DIETARY PHYTOCHEMICALS ON ELIMINATION OF CANCER STEM CELLS THROUGH TARGETING ITS QUIESCENCE AND SURVIVAL MECHANISMS","authors":"S. Lee, Chu Xin Ng","doi":"10.22452/JUMMEC.VOL23NO2.6","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.6","url":null,"abstract":"According to tradition, plants and herbs are potential cures for numerous illnesses. In recent decades, they have gained worldwide recognition as critical sources of new drugs, especially for cancer, and the focus on medicinal plant research has increased tremendously. Currently, research scientists attribute the occurrence of post-chemotherapy tumour exacerbation to the presence of cancer stem cells hidden in the bulk of the malignant tumour, forming a rare subpopulation that plays a major role in tumour re-initiation, progression and recurrence. There is increasing evidence of cancer stem cells in a wide array of tumours, and these cells could be the crucial target for future chemotherapy approaches. This review of the major plant-based phytochemicals with documented antagonistic activities against cancer stem cells, their molecular targets and the mechanisms involved, may serve as a guide for developing from the existing natural agents, more effective, and broader spectrum anti-cancer stem cell compounds with the potential for clinical application.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"25-41"},"PeriodicalIF":0.0,"publicationDate":"2020-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44054189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STILLBIRTH DUE TO UNRECOGNIZED CARDIAC ANOMALY: A FORENSIC AUTOPSY CASE REPORT 未识别的心脏异常导致的死产:一例法医尸检报告
Q4 Medicine Pub Date : 2020-08-27 DOI: 10.22452/JUMMEC.VOL23NO2.5
G. Selvaraja, N. B. Ibrahim, M. Singh
Congenital heart disease (CHD) is the result of a complicated interplay between genetic and non-genetic, or “environmental,” factors acting on the foetus and one of those environmental factors is maternal hyperglycemia. Maternal diabetes has teratogenic effects on the evolution of the foetal cardiovascular system; as a consequence, cardiovascular malformations are the most common anomalies in infants of diabetic mothers with transposition of the great arteries, tricuspid atresia and truncus arteriosus being some of the common cardiac malformations encountered. Thus, it is important to perform a detailed heart examination at autopsy of perinatal deaths in order to ascertain related anomalies. We present a case of stillbirth in a woman with Type 1 Diabetes mellitus on insulin therapy who claims she was unaware about her pregnancy.
先天性心脏病(CHD)是作用于胎儿的遗传和非遗传或“环境”因素之间复杂相互作用的结果,其中一个环境因素是母体高血糖。母体糖尿病对胎儿心血管系统的发育有致畸作用;因此,心血管畸形是糖尿病母亲婴儿最常见的畸形,大动脉转位、三尖瓣闭锁和动脉干是常见的心脏畸形之一。因此,重要的是在围产期死亡的尸检中进行详细的心脏检查,以确定相关的异常情况。我们报告了一例1型糖尿病妇女在接受胰岛素治疗时死产的病例,她声称自己不知道自己怀孕了。
{"title":"STILLBIRTH DUE TO UNRECOGNIZED CARDIAC ANOMALY: A FORENSIC AUTOPSY CASE REPORT","authors":"G. Selvaraja, N. B. Ibrahim, M. Singh","doi":"10.22452/JUMMEC.VOL23NO2.5","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.5","url":null,"abstract":"Congenital heart disease (CHD) is the result of a complicated interplay between genetic and non-genetic, or “environmental,” factors acting on the foetus and one of those environmental factors is maternal hyperglycemia. Maternal diabetes has teratogenic effects on the evolution of the foetal cardiovascular system; as a consequence, cardiovascular malformations are the most common anomalies in infants of diabetic mothers with transposition of the great arteries, tricuspid atresia and truncus arteriosus being some of the common cardiac malformations encountered. Thus, it is important to perform a detailed heart examination at autopsy of perinatal deaths in order to ascertain related anomalies. We present a case of stillbirth in a woman with Type 1 Diabetes mellitus on insulin therapy who claims she was unaware about her pregnancy.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"22-24"},"PeriodicalIF":0.0,"publicationDate":"2020-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49517393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE STUDY OF BROKEN HEARTS: A PRAGMATIC CASE REPORT ON TAKOTSUBO CARDIOMYOPATHY IN MALAYSIA 心碎的研究:马来西亚takotsubo心肌病的实用病例报告
Q4 Medicine Pub Date : 2020-08-12 DOI: 10.22452/JUMMEC.VOL23NO2.2
Syeda Humayra, Abd. Rahim Mohamad, A. Ghapar, L. Mohamed
The Takotsubo syndrome is an acquired, non-ischemic stress-induced cardiomyopathy popularly known as the ‘broken heart syndrome’. It is an acute left ventricular dysfunction presenting mostly in older women after an intensely stressful event. The exact pathophysiology remains elusive. The term came into existence in the early 1990s in Japan, where the distinctive change in the shape of the left ventricle with apical ballooning during systole, resembled the Takotsubo, an octopus pot used bythe Japanese fisherman. From a rare underrecognized syndrome, it has been increasingly recognised as a form of acute cardiac failure. Clinical diagnosis of the syndrome may be unidentified due to its similarity with the acute coronary syndrome, but without the narrowing of coronary vessels in angiographic imaging. There is a substantial elevation of the cardiac biomarkers, troponin and the natriuretic peptides which helps in differentiating the Takotsubo syndrome from myocardial infarction. A case report of a 59-year old Malaysian lady with typical, recurrent episodes of the Takotsubo syndrome is presented.
Takotsubo综合征是一种获得性、非缺血性应激诱导的心肌病,通常被称为“心碎综合征”。这是一种急性左心室功能障碍,主要发生在老年女性的强烈压力事件后。确切的病理生理学仍然难以捉摸。这个词于20世纪90年代初在日本出现,在日本,左心室形状的独特变化伴随着收缩期心尖气球的膨胀,类似于日本渔民使用的章鱼锅Takotsubo。从一种罕见的被低估的综合征,它越来越被认为是急性心力衰竭的一种形式。该综合征的临床诊断可能无法确定,因为它与急性冠状动脉综合征相似,但在血管造影成像中没有冠状动脉狭窄。心脏生物标志物、肌钙蛋白和钠尿肽显著升高,有助于区分Takotsubo综合征和心肌梗死。本文报告一位59岁的马来西亚妇女,她患有典型的复发性Takotsubo综合征。
{"title":"THE STUDY OF BROKEN HEARTS: A PRAGMATIC CASE REPORT ON TAKOTSUBO CARDIOMYOPATHY IN MALAYSIA","authors":"Syeda Humayra, Abd. Rahim Mohamad, A. Ghapar, L. Mohamed","doi":"10.22452/JUMMEC.VOL23NO2.2","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.2","url":null,"abstract":"The Takotsubo syndrome is an acquired, non-ischemic stress-induced cardiomyopathy popularly known as the ‘broken heart syndrome’. It is an acute left ventricular dysfunction presenting mostly in older women after an intensely stressful event. The exact pathophysiology remains elusive. The term came into existence in the early 1990s in Japan, where the distinctive change in the shape of the left ventricle with apical ballooning during systole, resembled the Takotsubo, an octopus pot used bythe Japanese fisherman. From a rare underrecognized syndrome, it has been increasingly recognised as a form of acute cardiac failure. Clinical diagnosis of the syndrome may be unidentified due to its similarity with the acute coronary syndrome, but without the narrowing of coronary vessels in angiographic imaging. There is a substantial elevation of the cardiac biomarkers, troponin and the natriuretic peptides which helps in differentiating the Takotsubo syndrome from myocardial infarction. A case report of a 59-year old Malaysian lady with typical, recurrent episodes of the Takotsubo syndrome is presented.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"2020-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41837227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RELATIONSHIP OF ISOKINETIC LEG STRENGTH AND 2 KM TIME TRIAL ON STATIONARY ROWING ERGOMETER AMONG MALAYSIAN MALE NATIONAL ROWERS 马来西亚男子国家赛艇运动员等速腿部力量与固定式赛艇2公里计时赛的关系
Q4 Medicine Pub Date : 2020-08-07 DOI: 10.22452/JUMMEC.VOL23NO2.4
Amirah Zahiran, M. Ong, S. Shaharudin
Background: Strength of leg musculature is crucial to generate propulsive force during rowing. The purpose of this study was to determine the relationship of isokinetic dominant leg strength and 2 km time trial on stationary rowing ergometer among male national rowers. Methods: Seventeen male national rowers were recruited for the study. Their hip and knee isokinetic strength were determined in the sagittal plane at 60°/s angular velocity. The relationship between the hip and knee strength, and 2 km time trial performance were evaluated using Pearson correlation. Results: The national rowers completed the 2 km time trial duration in 7.20±0.39 minutes. The hamstring to quadriceps ratio (H:Q) was significantly correlated to 2 km time trial performance (r=-0.491, p=0.045). No other significant relationships between hip and knee isokinetic strength and 2 km time trial performance were observed. Conclusion: Increased isokinetic knee strength ratio (H:Q) may enhance 2 km time trial performance among male national rowers. Other isokinetic variables of hip and knee isokinetic strength were not significantly related to 2 km time trial.
背景:在划船过程中,腿部肌肉组织的力量是产生推进力的关键。摘要本研究旨在探讨国家男子赛艇运动员等速优势腿力量与固定式赛艇2公里计时赛的关系。方法:招募17名男性国家赛艇运动员进行研究。在矢状面以60°/s的角速度测定髋关节和膝关节的等速强度。采用Pearson相关法评估髋关节和膝关节力量与2公里计时赛成绩之间的关系。结果:全国赛艇运动员以7.20±0.39分钟完成2公里计时赛。腿筋与股四头肌之比(H:Q)与2公里计时赛成绩显著相关(r=-0.491, p=0.045)。髋关节和膝关节等动强度与2公里计时赛成绩之间没有其他显著关系。结论:提高等速膝关节力量比(H:Q)可提高男子国家赛艇运动员2公里计时赛成绩。髋关节和膝关节等速力量的其他等速变量与2公里计时赛无显著相关。
{"title":"RELATIONSHIP OF ISOKINETIC LEG STRENGTH AND 2 KM TIME TRIAL ON STATIONARY ROWING ERGOMETER AMONG MALAYSIAN MALE NATIONAL ROWERS","authors":"Amirah Zahiran, M. Ong, S. Shaharudin","doi":"10.22452/JUMMEC.VOL23NO2.4","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.4","url":null,"abstract":"Background: Strength of leg musculature is crucial to generate propulsive force during rowing. The purpose of this study was to determine the relationship of isokinetic dominant leg strength and 2 km time trial on stationary rowing ergometer among male national rowers. \u0000Methods: Seventeen male national rowers were recruited for the study. Their hip and knee isokinetic strength were determined in the sagittal plane at 60°/s angular velocity. The relationship between the hip and knee strength, and 2 km time trial performance were evaluated using Pearson correlation. \u0000Results: The national rowers completed the 2 km time trial duration in 7.20±0.39 minutes. The hamstring to quadriceps ratio (H:Q) was significantly correlated to 2 km time trial performance (r=-0.491, p=0.045). No other significant relationships between hip and knee isokinetic strength and 2 km time trial performance were observed. \u0000Conclusion: Increased isokinetic knee strength ratio (H:Q) may enhance 2 km time trial performance among male national rowers. Other isokinetic variables of hip and knee isokinetic strength were not significantly related to 2 km time trial.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42887268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SELF-PERCEIVED ORTHODONTIC NEED, INFORMATIONSEEKING BEHAVIOUR AND KNOWLEDGE ON ORTHODONTIC TREATMENT AMONG YOUNG MALAYSIAN ADULTS 马来西亚年轻人的自我认知正畸需求、信息寻求行为和正畸治疗知识
Q4 Medicine Pub Date : 2020-07-01 DOI: 10.22452/JUMMEC.VOL23NO2.3
Dewi Mayang Sari Kamarozaman, Y. Kamarudin, Tengku Norbanee Tengku Hamzah, N. Nor
Objective: This study aimed to assess self-perceived aesthetics and orthodontic need, information-seeking behaviours and knowledge on orthodontic treatment among young adults in Malaysia. Methods: A cross-sectional study was conducted among 933 polytechnic students in Malaysia using a selfadministered questionnaire. The Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN) was used to assess self-perceived orthodontic need. Respondents were also asked about their intention to seek orthodontic treatment. Those showing intention were further asked about their reason(s) for seeking treatment, their information-seeking behaviours, and knowledge on orthodontic treatment. Data was analysed using SPSS. Results: The overall response rate was 93.2% with the mean age of 20.43 (SD±1.07). Although most of the respondents rated themselves under the no treatment need category of the AC-IOTN scale, 61.9% reported intention to seek orthodontic treatment. The main reason for seeking treatment was to improve dental function (45.3%) and aesthetics (40.1%). Most claimed to look for information prior to orthodontic treatment, either using online or offline platforms. Many relied on friends (83.3%) as a source of information and more than half used online sources including social media and websites. A minority demonstrated lack of knowledge in terms of appropriate places to receive treatment (2.2%) and qualification of orthodontic practitioners (37.7%). Conclusions: The majority of young Malaysian adults have high intention to seek orthodontic treatment regardless of their perceived need. A minority had lack of knowledge about qualified orthodontic providers and places to receive treatment. Majority reported positive attitudes towards information-seeking behaviour prior to seeking orthodontic treatment.
目的:本研究旨在评估马来西亚年轻人对正畸治疗的自我审美和正畸需求、信息寻求行为和知识。方法:采用自填问卷对933名马来西亚理工学院学生进行横断面研究。采用正畸治疗需求指数(IOTN)的审美成分(AC)评估自我感知的正畸需求。受访者还被问及他们寻求正畸治疗的意图。那些表示有意向的人进一步被问及他们寻求治疗的原因、他们的信息寻求行为和对正畸治疗的了解。数据采用SPSS进行分析。结果:总有效率为93.2%,平均年龄20.43岁(SD±1.07)。虽然大多数受访者认为自己属于AC-IOTN量表的无治疗需要类别,但61.9%的受访者表示有意寻求正畸治疗。寻求治疗的主要原因是改善牙功能(45.3%)和美观(40.1%)。大多数人声称在正畸治疗前会通过在线或线下平台查找信息。许多人(83.3%)依赖朋友作为信息来源,超过一半的人使用包括社交媒体和网站在内的在线资源。少数人表示缺乏适当的治疗地点(2.2%)和正畸医生资格(37.7%)方面的知识。结论:大多数马来西亚年轻成年人有很高的意愿寻求正畸治疗,无论他们的感知需求。少数人对合格的正畸提供者和接受治疗的地点缺乏了解。大多数报告在寻求正畸治疗之前对信息寻求行为持积极态度。
{"title":"SELF-PERCEIVED ORTHODONTIC NEED, INFORMATIONSEEKING BEHAVIOUR AND KNOWLEDGE ON ORTHODONTIC TREATMENT AMONG YOUNG MALAYSIAN ADULTS","authors":"Dewi Mayang Sari Kamarozaman, Y. Kamarudin, Tengku Norbanee Tengku Hamzah, N. Nor","doi":"10.22452/JUMMEC.VOL23NO2.3","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL23NO2.3","url":null,"abstract":"Objective: This study aimed to assess self-perceived aesthetics and orthodontic need, information-seeking behaviours and knowledge on orthodontic treatment among young adults in Malaysia. \u0000Methods: A cross-sectional study was conducted among 933 polytechnic students in Malaysia using a selfadministered questionnaire. The Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN) was used to assess self-perceived orthodontic need. Respondents were also asked about their intention to seek orthodontic treatment. Those showing intention were further asked about their reason(s) for seeking treatment, their information-seeking behaviours, and knowledge on orthodontic treatment. Data was analysed using SPSS. \u0000Results: The overall response rate was 93.2% with the mean age of 20.43 (SD±1.07). Although most of the respondents rated themselves under the no treatment need category of the AC-IOTN scale, 61.9% reported intention to seek orthodontic treatment. The main reason for seeking treatment was to improve dental function (45.3%) and aesthetics (40.1%). Most claimed to look for information prior to orthodontic treatment, either using online or offline platforms. Many relied on friends (83.3%) as a source of information and more than half used online sources including social media and websites. A minority demonstrated lack of knowledge in terms of appropriate places to receive treatment (2.2%) and qualification of orthodontic practitioners (37.7%). \u0000Conclusions: The majority of young Malaysian adults have high intention to seek orthodontic treatment regardless of their perceived need. A minority had lack of knowledge about qualified orthodontic providers and places to receive treatment. Majority reported positive attitudes towards information-seeking behaviour prior to seeking orthodontic treatment.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"23 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45374664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Journal of the University of Malaya Medical Centre
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1