K. Matsuura, Wenqian Li, Kuan-Hung Chen, Y. Asano, K. Naruse, Chao-Min Cheng
{"title":"Paper-based diagnostic devices for estimating human sperm motility","authors":"K. Matsuura, Wenqian Li, Kuan-Hung Chen, Y. Asano, K. Naruse, Chao-Min Cheng","doi":"10.11239/JSMBE.52.O-551","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-551","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73670319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Near-infrared spectroscopic measurement of fat in the myocardial optical phantom","authors":"Takuma Hibi, K. Yasumoto, E. Ogawa, T. Arai","doi":"10.11239/jsmbe.52.O-454","DOIUrl":"https://doi.org/10.11239/jsmbe.52.O-454","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81063688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular structure of matrices solubilized with HCl from decellularized liver and the production of albumin from hepatocytes cultured on the matrices","authors":"Shintaro Nakamura, Souta Nishimura, H. Ijima","doi":"10.11239/JSMBE.52.O-194","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-194","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73932945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Zulaziz, N. Himeno, H. Miyazaki, D. Saitoh, A. Azhim, Y. Morimoto
In order to simultaneously monitor neutrophil migration in vivo during inflammation, we developed a novel animal model for subcutaneous soft tissue infection using transgenic mouse bearing fluorescence-positive neutrophils and bioluminescent methicillin-resistant Staphylococcus aureus (MRSA). Methods: Eight to nine-week-old male lys-EGFP C57BL/6 were anesthetized (50 mg/kg pentobarbital sodium, ip) and 1.0 ×107 CFU of bioluminescent MRSA (Xen31, PerkinElmer) were subcutaneously injected. Control group was injected with PBS while the treatment group was given Arbekacin (25 mg/kg) intravenously via tail vein. For the evaluation of MRSA activity and neutrophil accumulation, an in vivo imaging system (LAS-4000, GE) was performed. Results: Both groups displayed similar pattern with significant drop in MRSA bioluminescence and neutrophil fluorescence peaked on day 1. However, bacterial infection completely resolved in treatment group by day 6 with gradual decline in neutrophil fluorescence. Conclusions: This animal model could be a competent method for assessment of subcutaneous soft tissue infections.
{"title":"A Novel Animal Model for Monitoring Bacterial Infection and Neutrophil Activity","authors":"N. Zulaziz, N. Himeno, H. Miyazaki, D. Saitoh, A. Azhim, Y. Morimoto","doi":"10.11239/JSMBE.52.O-285","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-285","url":null,"abstract":"In order to simultaneously monitor neutrophil migration in vivo during inflammation, we developed a novel animal model for subcutaneous soft tissue infection using transgenic mouse bearing fluorescence-positive neutrophils and bioluminescent methicillin-resistant Staphylococcus aureus (MRSA). \u0000Methods: Eight to nine-week-old male lys-EGFP C57BL/6 were anesthetized (50 mg/kg pentobarbital sodium, ip) and 1.0 ×107 CFU of bioluminescent MRSA (Xen31, PerkinElmer) were subcutaneously injected. Control group was injected with PBS while the treatment group was given Arbekacin (25 mg/kg) intravenously via tail vein. For the evaluation of MRSA activity and neutrophil accumulation, an in vivo imaging system (LAS-4000, GE) was performed. \u0000Results: Both groups displayed similar pattern with significant drop in MRSA bioluminescence and neutrophil fluorescence peaked on day 1. However, bacterial infection completely resolved in treatment group by day 6 with gradual decline in neutrophil fluorescence. \u0000Conclusions: This animal model could be a competent method for assessment of subcutaneous soft tissue infections.","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86396610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaodong Zhu, K. Iwasaki, J. Arai, T. Oba, H. Tokutake, M. Umezu
{"title":"Construction on finite element analysis method of coronary stent in cyclical bending-load environment simulated bending motion of coronary artery","authors":"Xiaodong Zhu, K. Iwasaki, J. Arai, T. Oba, H. Tokutake, M. Umezu","doi":"10.11239/JSMBE.52.O-106","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-106","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79803678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Miura, Eiko Takasaki, D. Yamashige, Yasunori Taira, A. Yamada, Y. Tsuboko, K. Sano, Y. Shiraishi, T. Yambe
{"title":"Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine","authors":"H. Miura, Eiko Takasaki, D. Yamashige, Yasunori Taira, A. Yamada, Y. Tsuboko, K. Sano, Y. Shiraishi, T. Yambe","doi":"10.11239/JSMBE.52.SY-25","DOIUrl":"https://doi.org/10.11239/JSMBE.52.SY-25","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82594355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of scattering suppression technique for optical trasillumination image using equation for beam wave propagation","authors":"Hiroyuki Tanaka, T. Namita, Y. Kato, K. Shimizu","doi":"10.11239/JSMBE.52.O-141","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-141","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83219702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We studied the drug delivery methodology on a vascular wall with a heating to improve drug delivery performance. This drug delivery has been used for hyperplasia suppression such as the drug eluting stent. We aim thermal denature of vascular collagen might lengthen drug penetration depth to the media because of collagen structure change. The drug concentration and penetration depth in vascular were measured by a fluorescent microscope after 15 s of immersing vascular pieces in heated 3.5 re was set to 50-70 and 37 for control. The drug concentration and penetration depth increased with the heating temperature increasing. The drug concentration was 10-10 times higher than the control. The penetration depth was 2-9 times deeper than the control. We found possibility of drug delivery performance improvement by the means of thermal denatured collagen in the vascular wall.
{"title":"Study of drug delivery to vascular wall with a heating ex vivo","authors":"Machiko Shinozuka, N. Shimazaki, T. Arai","doi":"10.11239/JSMBE.52.O-72","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-72","url":null,"abstract":"We studied the drug delivery methodology on a vascular wall with a heating to improve drug delivery performance. This drug delivery has been used for hyperplasia suppression such as the drug eluting stent. We aim thermal denature of vascular collagen might lengthen drug penetration depth to the media because of collagen structure change. The drug concentration and penetration depth in vascular were measured by a fluorescent microscope after 15 s of immersing vascular pieces in heated 3.5 re was set to 50-70 and 37 for control. The drug concentration and penetration depth increased with the heating temperature increasing. The drug concentration was 10-10 times higher than the control. The penetration depth was 2-9 times deeper than the control. We found possibility of drug delivery performance improvement by the means of thermal denatured collagen in the vascular wall.","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76620492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Katayama, Yuuki Noguchi, M. Kaneko, Y. Miyagi, K. Iramina
{"title":"Evaluation of DBS treatment against Parkinson's disease by the motion analysis of the pronospination of forearms","authors":"Y. Katayama, Yuuki Noguchi, M. Kaneko, Y. Miyagi, K. Iramina","doi":"10.11239/JSMBE.52.O-45","DOIUrl":"https://doi.org/10.11239/JSMBE.52.O-45","url":null,"abstract":"","PeriodicalId":39233,"journal":{"name":"Transactions of Japanese Society for Medical and Biological Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74096487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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