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5PSQ-120 Impact of the COVID-19 pandemic on the use of antimicrobials in primary and hospital care COVID-19大流行对基层和医院护理中使用抗微生物药物的影响
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.426
I. Oterino Moreira, BM Escudero Vilaplana, G. Silva Riádigos, CM Meseguer Barros, G. Picazo Sanchiz, L. Jamart Sanchez, S. Sanz Márquez, M. Pérez Encinas
Background and importanceThe characteristics of the patient who requires health care are different between primary care (PC) and hospital care (HC). The COVID-19 pandemic has impacted on public access to health services. Therefore, prescribing patterns and consumption of antimicrobials in both contexts could have changed.Aim and objectivesTo assess the impact of the COVID-19 pandemic on antimicrobial consumption in PC and HC.Material and methodsDescriptive cross-sectional study that evaluated the antimicrobial consumption (ATC J01) in adult patients 1 year before (March 2019–February 2020) and 1 year after (March 2020–February 2021) the arrival of the COVID-19 pandemic.Antimicrobial consumption rates were expressed in defined daily doses per 1000 inhabitants-day (DID). In PC we included the reference population of our area and in HC the number of patients discharged. The impact was assessed by the difference in DID between both periods and care settings.Data on antimicrobial prescribing in PC were obtained from a public database with anonymised data on the total number of items of each drug prescribed. Hospital data were obtained from the clinical unit of pharmacy.ResultsBetween March 2020 and February 2021 antimicrobial consumption decreased –36.0% (7.3 vs 11.4 DID) in PC and increased +37.5 (16.5 vs 12.0 DID) in HC, both compared to the same period of the previous year.The most prescribed antimicrobials in PC before the COVID-19 pandemic were amoxicillin, amoxicillin/clavulanate, doxycycline, azithromycin, ciprofloxacin, and between March 2020 and February 2021 these were amoxicillin/clavulanate, amoxicillin, doxycycline, ciprofloxacin and azithromycin.The most prescribed antimicrobial used in HC before the COVID-19 pandemic were amoxicillin/clavulanate, levofloxacin, piperacillin/tazobactam, ceftriaxone and ciprofloxacin, and between March 2020 and February 2021 these were amoxicillin/clavulanate, ceftriaxone, azithromycin, piperacillin/tazobactam and meropenem.Comparing the COVID period with the previous year, in PC the antimicrobial that most decreased in consumption was phenoxymethylpenicillin (–66.59%). Amoxicillin decreased by –52.13%, clarithromycin (–50.60%), moxifloxacin (–45.98%), levofloxacin (–44.42%), amoxicillin/clavulanate (–35.55%) and azithromycin (–29.05%). For HC the antimicrobial that most increased in consumption was azithromycin (+721.42%), followed by amoxicillin (+602.0%), ceftriaxone (+184.34%), vancomycin (+116.9%) and amikacin (+88.79%). Meropenem DID increased by +52.94%.Conclusion and relevanceThe COVID-19 pandemic has impacted on the increase in antimicrobial use in HC along with a proportional decrease in PC.Antimicrobial prescription patterns in PC remain stable. The increase in amoxicillin/clavulanate over amoxicillin may be related to non-contact patient care (telemedicine).In HC, antimicrobial stewardship strategies can help return the consumption of broad-spectrum antibiotics to acceptable levels.References a
背景与重要性初级保健(PC)和医院保健(HC)患者需要卫生保健的特点不同。COVID-19大流行影响了公众获得卫生服务的机会。因此,在这两种情况下,抗菌素的处方模式和消费可能已经改变。目的和目的评估COVID-19大流行对PC和HC抗菌药物消费的影响。材料和方法描述性横断面研究,评估COVID-19大流行到来前1年(2019年3月- 2020年2月)和后1年(2020年3月- 2021年2月)成人患者的抗菌药物消耗量(ATC J01)。抗菌药物消费率以每1000名居民每天的限定日剂量(DID)表示。在PC中,我们纳入了本地区的参考人群,在HC中纳入了出院患者的数量。通过两个时期和护理环境之间的DID差异来评估其影响。PC的抗菌药物处方数据来自一个公共数据库,该数据库包含每种药物处方的总项目数的匿名数据。医院数据来自药学临床单位。结果2020年3月至2021年2月,与上年同期相比,PC的抗菌药物消费量下降了-36.0%(7.3比11.4 DID), HC的抗菌药物消费量增加了+37.5(16.5比12.0 DID)。在COVID-19大流行之前,PC中处方最多的抗菌药是阿莫西林、阿莫西林/克拉维酸盐、多西环素、阿奇霉素、环丙沙星,在2020年3月至2021年2月期间,处方最多的抗菌药是阿莫西林/克拉维酸盐、阿莫西林、多西环素、环丙沙星和阿奇霉素。在COVID-19大流行之前,HC中使用最多的处方抗微生物药物是阿莫西林/克拉维酸盐、左氧氟沙星、哌拉西林/他唑巴坦、头孢曲松和环丙沙星,在2020年3月至2021年2月期间,这些药物是阿莫西林/克拉维酸盐、头孢曲松、阿奇霉素、哌拉西林/他唑巴坦和美罗培南。与前一年相比,PC中用量下降最多的抗菌药物是苯氧苄青霉素(-66.59%)。阿莫西林(-52.13%)、克拉霉素(-50.60%)、莫西沙星(-45.98%)、左氧氟沙星(-44.42%)、阿莫西林/克拉维酸(-35.55%)、阿奇霉素(-29.05%)下降。HC类抗菌药物用量增加最多的是阿奇霉素(+721.42%),其次是阿莫西林(+602.0%)、头孢曲松(+184.34%)、万古霉素(+116.9%)和阿米卡星(+88.79%)。美罗培南DID增加+52.94%。结论及相关性2019冠状病毒病(COVID-19)大流行影响了丙型肝炎患者抗菌药物使用的增加,同时影响了丙型肝炎患者PC的比例下降。PC的抗菌处方模式保持稳定。阿莫西林/克拉维酸比阿莫西林增加可能与非接触患者护理(远程医疗)有关。在HC中,抗菌药物管理战略可帮助将广谱抗生素的消费恢复到可接受的水平。参考文献和/或致谢利益冲突无利益冲突
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引用次数: 0
5PSQ-119 A descriptive, retrospective analysis of high-dose intravenous vitamin C administration in critically ill COVID-19 patients 5PSQ-119: COVID-19危重症患者大剂量静脉注射维生素C的描述性回顾性分析
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.425
C. Şanlıoğlu, B. Sitter, I. Lagoja, W. Oczenski
Background and importanceProinflammatory cytokines seem to have an influence on the course and severity of a COVID-19 infection. The use of high-dose vitamin C (HDVC) represents a possible adjunctive therapy approach for the treatment of critically ill COVID-19 patients owing to its immune-modulating, anti-inflammatory and antioxidant properties.Aim and objectivesTo determine the impact of adjunctive HDVC therapy on inflammatory markers such as interleukin-6 (IL-6).Material and methodsSetting: A descriptive, retrospective analysis with critically ill COVID-19 patients admitted to the intermediate care unit (IMCU) and intensive care unit (ICU) in a public hospital.Adult ICU-hospitalised patients with COVID-19 were included with those who were to receive, besides the standard of care, either: HDVC (treatment group with 7.5 g/day VC up to 10 days)Low-dose VC (LDVC with 1g/day VC up to 10 days)No additional VC (control group).All data were obtained from the patients’ medical records from November to December 2020 and from March to May 2021.ResultsData were collected from 83 critically ill patients with confirmed COVID-19 infection. 40 patients were administered HDVC, 24 patients received LDVC and 19 patients did not receive any VC.The mean age of the patients in the treatment group was 57.3 years, in the LDVC group 62.1 years and in the control group 55.8 years. The average IMCU and ICU length of stay was 17.4 days for patients in the HDVC-group, 21.4 days in the LDVC-group and 21.5 days in the control group. 68% from the HDVC group survived and were discharged from hospital. In the LDVC group 58% survived and in the control group 42%. Lower levels of IL-6 in the HDVC-group as compared with the LDVC-group and control group were detected.Conclusion and relevanceOur findings have demonstrated that the use of HDVC can lead to a clinical benefit due to decreased levels of IL-6. Additional investigations should be encouraged in order to further characterise adjunctive HDVC treatment in COVID-19 infection. Unlike some previous studies, our results have shown no detrimental effects of HDVC on glomerular filtration rate and serum creatinine levels.References and/or acknowledgementsConflict of interestNo conflict of interest
背景和重要性促炎细胞因子似乎对COVID-19感染的病程和严重程度有影响。由于其免疫调节、抗炎和抗氧化特性,使用高剂量维生素C (HDVC)可能是治疗COVID-19危重患者的一种辅助治疗方法。目的和目的探讨辅助治疗对炎症标志物如白细胞介素-6 (IL-6)的影响。材料与方法背景:对某公立医院中级监护病房(IMCU)和重症监护病房(ICU)收治的COVID-19危重患者进行描述性回顾性分析。在重症监护病房住院的COVID-19成人患者包括接受标准护理的患者:HDVC(治疗组,7.5 g/天VC,持续10天)低剂量VC (LDVC, 1g/天VC,持续10天)无额外VC(对照组)。所有数据均来自2020年11月至12月和2021年3月至5月的患者病历。结果收集了83例确诊COVID-19感染的危重患者的数据。40例患者接受了HDVC治疗,24例患者接受了LDVC治疗,19例患者未接受任何VC治疗。治疗组患者平均年龄57.3岁,低密度脂蛋白组患者平均年龄62.1岁,对照组患者平均年龄55.8岁。hdvc组患者IMCU和ICU的平均住院时间分别为17.4天、21.4天和21.5天。HDVC组68%存活并出院。LDVC组58%存活,对照组42%存活。检测到hdl - c组IL-6水平低于ldl - c组和对照组。结论和相关性:我们的研究结果表明,由于IL-6水平的降低,使用HDVC可导致临床获益。应鼓励开展更多调查,以进一步确定COVID-19感染中辅助hdl治疗的特征。与之前的一些研究不同,我们的结果显示hdl对肾小球滤过率和血清肌酐水平没有不利影响。参考文献和/或致谢利益冲突无利益冲突
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引用次数: 0
5PSQ-105 Insulin perfusion in neonatology: which one is the safest? 新生儿胰岛素灌注:哪一种最安全?
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.423
M. Aguar Carrascosa, Á. S. García, I. Lara Cantón, A. García Robles, A. Cruz Sánchez, J. P. Poveda Andrés, A. Pinilla González, A. Illana
Figure. Pareto diagram. MATERIALS AND METHODS: experimental study to determinate which variable most influences the concentration and dose of insulin administrated. 24 experimental infusions were made, using combinations of different variables: additive (albumin yes/no), solvent (NaCl 0,9%/D5%) operator (1/2), pre-conditioning (yes/no), purge (yes/no), concentration (0.05-0.1 UI/mL), infusion rate (0.3-0.7mL/h) and infusion duration (1h/24h).
数字帕累托图。材料与方法:通过实验研究确定哪些变量对胰岛素的浓度和剂量影响最大。采用添加剂(白蛋白是/否)、溶剂(NaCl 0,9%/D5%)、操作符(1/2)、预处理(是/否)、吹扫(是/否)、浓度(0.05 ~ 0.1 UI/mL)、滴注速率(0.3 ~ 0.7mL/h)、滴注时间(1h/24h)等不同变量组合进行24次实验输注。
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引用次数: 0
4CPS-073 Desensitisation to ibrutinib in a patient with serious late reaction: a case report 严重晚期反应患者对伊鲁替尼脱敏1例报告
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.389
R. Tamayo Bermejo, L. Yunquera Romero, M. Nieto Guindo, I. Muñoz Castillo
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引用次数: 0
4CPS-272 Integration of the hospital pharmacist into a multidisciplinary dysphagia screening team in an intermediate and long-stay hospital 4CPS-272将医院药师纳入中长住院医院多学科吞咽困难筛查团队
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.416
A. Viney, M. Pereda Molina, AC Llamas Vallejo, IM Sánchez Pérez, MB Pereda Hernández, EV Sedamanos Saca, V. García Bordalás, J. P. Pérez Moreno, V. Contreras Rivera, M. Calero Martínez
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引用次数: 0
4CPS-265 Chronic complex palliative paediatric patient at-home care unit: pharmacotherapeutic profile and analysis of sialorrhea treatment 慢性复杂姑息治疗儿科患者家庭护理单元:药物治疗概况和唾液治疗分析
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.415
T. Rovira, M. de Castro Julve, T. Gili Bigatà, G. Gómez Llanes, Y. Campos García, G. Molas Ferrer, B. López García, M. Gómez-Valent
{"title":"4CPS-265 Chronic complex palliative paediatric patient at-home care unit: pharmacotherapeutic profile and analysis of sialorrhea treatment","authors":"T. Rovira, M. de Castro Julve, T. Gili Bigatà, G. Gómez Llanes, Y. Campos García, G. Molas Ferrer, B. López García, M. Gómez-Valent","doi":"10.1136/ejhpharm-2022-eahp.415","DOIUrl":"https://doi.org/10.1136/ejhpharm-2022-eahp.415","url":null,"abstract":"","PeriodicalId":393937,"journal":{"name":"Section 7: Post Congress additions","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123768630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2SPD-022 Relevance of universal kit composition and economic value of non-used medical devices 非使用医疗器械通用试剂盒组成与经济价值的相关性
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.378
A. Bayen, A. Nourddine, L. Zarayby, S. Derfoufi
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引用次数: 0
1ISG-009 Implementation and evaluation of telepharmacy during the COVID-19 pandemic in an academic medical city: paving the way for telepharmacy 1ISG-009新型冠状病毒病疫情下学术医疗城市远程药学实施与评价:为远程药学的发展铺平道路
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.375
A. Alasseri, M. Manna
1ISG-009 Figure 1ResultsThe Pharmacy Department has the capacity to switch all outpatient prescriptions to be requested through the online portal and a total of 14 618 medication shipments were home delivered from 15 March to 10 June 2020. 14 618 medication shipments were delivered out of 25 520 online requests submitted;the difference between the number of delivered prescriptions and received requests was due to repeated submissions by patients or because the refill due date did not arrive.WhatsApp Business has been initiated for direct communication between patients and pharmacists. A total of 10 030 inpatient pharmacy and outpatient pharmacy orders were verified through remote access. 1ISG-009 Table 1Parameter Online refill March 2020 3340 April 2020 9413 May 2020 4990 10 June 2020 7777 Total number of requests during 2019 488 Total number of requests in 2020 25 520 Total shipped 15 March to 10 June 2020 14 618 WhatsApp sent message 14 633 WhatsApp received message 26 613 Orders verified by remote access (outpatient) 4650 Orders verified by remote access (inpatient) 5380 Conclusion and relevanceIn conclusion, the implementation of telepharmacy via the utilisation of medication home delivery services, remote access, and modification of the previous workflow was associated with promising outcomes in terms of efficient, high-quality pharmaceutical care delivery while avoiding medication distribution disturbances as well as containing the spread of the pandemic among staff and patients, thus ensuring their safety during this crisis.References and/or acknowledgementsConflict of interestNo conflict of interest
图1结果药房具备通过在线门户切换所有门诊处方的能力,从2020年3月15日至6月10日,共送出14 618批药品。在提交的25 520份在线请求中,交付了14 618批药品;交付的处方数量与收到的请求数量之间的差异是由于患者反复提交或补药到期日未到。开通了WhatsApp Business,方便患者与药剂师直接沟通。通过远程访问,共核实住院药房和门诊药房订单10030张。表1参数在线补码2020年3月3340 2020年4月9413 2020年5月4990 2020年6月10日7777 2019年请求总数488 2020年请求总数25 520总发货量2020年3月15日至6月10日14 618 WhatsApp发送消息14 633 WhatsApp收到消息26 613远程访问验证订单(门诊)4650远程访问验证订单(住院)5380结论与相关性通过利用药物上门递送服务、远程访问和修改以前的工作流程来实施远程药房,在提供高效、高质量的药物服务方面取得了可喜的成果,同时避免了药物分发的干扰,并遏制了流行病在工作人员和患者中的传播,从而确保了他们在这场危机期间的安全。参考文献和/或致谢利益冲突无利益冲突
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引用次数: 0
6ER-006 Paracetamol versus ibuprofen for treatment of persistent ductus arteriosus closure in preterm infants: IBUPAR-Trial 对乙酰氨基酚与布洛芬治疗早产儿持续性动脉导管关闭:ibupar试验
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.430
A. García Robles, Mdm Serrano Martin, MJ Párraga, E. Guerrero Hurtado, P. Polo Montanero, J. P. Poveda Andrés, M. Aguar Carrascosa, A. Gimeno Navarro
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引用次数: 0
5PSQ-101 Medication errors in unit-dose drug distribution system: quality control 5PSQ-101单位剂量配药系统用药差错:质量控制
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.422
Z. Rodríguez Fernández, S. Llamas Lorenzana, P. González Pérez, X. Casás Fernández, A. Vélez Blanco, C. De Castro Avedillo, JC Sáez Hortelano, R. Varela Fernández, E. Martínez Álvarez, N. Álvarez Núñez, JJ Ortiz de Urbina González
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引用次数: 0
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Section 7: Post Congress additions
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