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4CPS-050 Use of galcanezumab in patients with migraine in a tertiary hospital: health results galcanezumab在三级医院偏头痛患者中的应用:健康结果
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.386
A. Revuelta Amallo, C. Vila Gallego, M. Vara Urruchua, M. Inclan Conde, B. Belio Aguera, M. Alvarez Lavin, M. Alonso Díez, A. Aguirrezábal Arredondo
drugs, presence of analgesia abuse, dosage, of start and end of treatment, reason for end of treatment, number of of monthly migraine headache days (MHD) prior to treatment, and number of MHD after 3 months. All the was obtained the record.
药物,是否存在镇痛药滥用,剂量,治疗开始和结束的时间,治疗结束的原因,治疗前每月偏头痛天数(MHD),以及3个月后的MHD天数。所有这些都得到了记录。
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引用次数: 0
6ER-013 Analysis of patients’ mortality in SARS-CoV-2 infection during the first month of hospital admission 6ER-013 SARS-CoV-2感染患者入院第一个月死亡率分析
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.431
R. Castillejo, J. Cordero, M. Romero-González, A. Martinez-Suarez
Background and importanceAs of December 2019, the world is facing a pandemic caused by the SARS-CoV-2 coronavirus (COVID-19). Symptoms resulting from the infection vary widely, ranging from asymptomatic disease to pneumonia and life-threatening complications.Aim and objectivesThe aim was to study the impact of the active oncohaematological process on the severity and short-medium term mortality of COVID-19 infection.Material and methodsObservational retrospective study, carried out in a Spanish tertiary-level hospital. All patients diagnosed with COVID-19 and hospital admission between March 2020 and June 2021 were included. Variables collected were demographics, comorbidities;situation during hospitalisation (defining severe situation as admission to intensive care unit (ICU) or intubation) and mortality at 14 and 30 days after hospital admission. Data were obtained through the digital medical record and managed by R software (V.4–2021).ResultsWe included 1924 patients in the non-oncological group, 47.5% (915) men with a median age of 67 years and interquartile range (IQR) of 53–77. 128 patients (6.23%) were included in the active oncohaematological group, 58.6% were men (median age 72 (IQR 63–78) years). The most prevalent oncohaematological processes were: lung cancer (16.4%), colorectal (15.6%), bladder (10.9%), breast (10.2%) and prostate (8.59%). Metastases were present in 42.2% of patients. The main comorbidities presented by oncohaematological patients with statistical significance versus non-oncological patients were diabetes mellitus (30.5% vs 19.4%), dyslipidaemia (46.9% vs 32.2%), hypertension (52.3% vs 42.0%), chronic renal failure (18.0% vs 8.73%), chronic obstructive pulmonary disease (22.7% vs 9.94%), obesity (14.1% vs 15.2%) and heart failure (13.3% vs 10.6%). In the oncohaematological group, 44.5% were in a serious condition during their admission. The number who died compared to non-oncohaematological patients was 23.4% versus 13.6% at day 14 and 29.7% versus 18.1% at day 30. The two main neoplasms in the deceased patients were lung cancer (26.3%) and colorectal cancer (21%). Univariate analysis showed a relative risk of 1.72 (1.23–2.4) and 1.64 (1.23–2.17) mortality at 14 and 30 days, respectively, for COVID-19 in patients with active oncohematological processes versus non-oncohematological processes.Conclusion and relevanceThe data reflect a higher mortality at 14 and 30 days due to COVID-19 in the oncohaematological population (72% and 64%, respectively). The oncohaematological population has a higher percentage of comorbidities associated with the total that may also influence this increased risk of mortality.References and/or acknowledgementsConflict of interestNo conflict of interest
背景及重要性截至2019年12月,世界正面临由新冠肺炎(COVID-19)引起的大流行。感染引起的症状差别很大,从无症状疾病到肺炎和危及生命的并发症。目的和目的研究活动性肿瘤血液学过程对COVID-19感染严重程度和中短期死亡率的影响。材料与方法观察性回顾性研究,在西班牙一家三级医院进行。所有在2020年3月至2021年6月期间被诊断为COVID-19并住院的患者都被纳入其中。收集的变量包括人口统计学、合并症、住院期间的情况(将严重情况定义为入住重症监护病房(ICU)或插管)以及入院后14天和30天的死亡率。数据通过数字病历获取,并由R软件(V.4-2021)管理。结果我们纳入了1924例非肿瘤组患者,其中47.5%(915例)为男性,中位年龄为67岁,四分位间距(IQR)为53-77。活动性血液肿瘤组128例(6.23%),58.6%为男性(中位年龄72岁(IQR 63-78)岁)。最常见的肿瘤血液学病变为:肺癌(16.4%)、结直肠癌(15.6%)、膀胱癌(10.9%)、乳腺癌(10.2%)和前列腺癌(8.59%)。42.2%的患者存在转移。与非肿瘤患者相比,血液肿瘤患者出现的主要合并症为糖尿病(30.5% vs 19.4%)、血脂异常(46.9% vs 32.2%)、高血压(52.3% vs 42.0%)、慢性肾功能衰竭(18.0% vs 8.73%)、慢性阻塞性肺疾病(22.7% vs 9.94%)、肥胖(14.1% vs 15.2%)和心力衰竭(13.3% vs 10.6%)。在血液肿瘤组中,44.5%的患者入院时病情严重。与非血液肿瘤患者相比,第14天和第30天的死亡人数分别为23.4%和13.6%和29.7%和18.1%。死亡患者的两种主要肿瘤是肺癌(26.3%)和结直肠癌(21%)。单因素分析显示,活动性血液肿瘤过程患者与非血液肿瘤过程患者在14天和30天死亡的相对风险分别为1.72(1.23-2.4)和1.64(1.23-2.17)。数据显示,在血液肿瘤患者中,COVID-19在14天和30天的死亡率较高(分别为72%和64%)。血液病人群的合并症比例较高,这也可能影响死亡风险的增加。参考文献和/或致谢利益冲突无利益冲突
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引用次数: 0
4CPS-255 Frequency of consumption of complementary and alternative medicine among HIV patients: a multicentre cross-sectional study 艾滋病患者使用补充和替代药物的频率:一项多中心横断面研究
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.412
E. Gonzalez Colominas, M. De Antonio Cuscó, M. Masip Torne, M. Martin, G. Cardona, M. Comas, Mathieu Roch, B. Lopez, FI Torres, A. Retamero, P. Luque
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引用次数: 0
5PSQ-071 Real-world results of effectiveness and security of erenumab and galcanezumab in migraine patients erenumab和galcanezumab在偏头痛患者中的有效性和安全性的实际结果
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.421
A. Gracia Moya, C. Varon Galcera, I. Cardona Pascual, E. Florensa Royo, J. Vidal Otero, G. Vancells Lujan, M. G. Gorgas Torner
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引用次数: 0
4CPS-022 To vaccinate or not to vaccinate: impact of a public health action on vaccine hesitancy 接种或不接种:公共卫生行动对疫苗犹豫的影响
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.380
Y. Dhif, P. Bonnabry, A. Diana
Background and importanceVaccine hesitancy is one of the top 10 threats to global health according to the World Health Organization.1 A part of the Swiss population is hesitant to vaccinate against COVID-19.2Aim and objectivesThe aim of this study was to conduct a public health action with hesitant to vaccination and measure its impact on vaccine hesitancy and on vaccination rate.Material and methodsVaccine hesitancy and barriers to vaccination were measured and identified using a pre-test questionnaire. Only non-vaccinated volunteer participants were included, and they were invited to a 1-hour online session using motivational interviewing techniques, animated by a physician and a pharmacist. Two weeks after the session, they were asked to fill a post-test and 2 months later, their vaccine status was requested. Data collection was conducted from April to August 2021.Results31 adults participated for a total of 11 online sessions (2.8 participants/session). Majority were women (68%, n=21) and aged between 35 and 60 years (71%). 10 (32.3%) were public health professionals and 21 (67.7%) were not. Prior to the study, 54.9% did not consider vaccines safe (19.4% post-study), 87.1% were concerned about vaccine side effects (64.5% post-study) and 51.6% considered vaccines to be effective (83.9% post-study). Before the study, participants were classified as certainly willing to vaccinate (3.2%), probably (9.7%), probably not (35.5%), certainly not (12.9%), do not know/other (38.8%) and the degree of confidence in vaccination was 4.5 ± 2.2 (scale 1–10). After the study, the confidence increased to 6.3 ± 2.4 (+29%). Following the study, 52% (n=14) were effectively vaccinated. Among reasons that motivated to vaccinate: vaccination will help with containing the pandemic (5/14) and benefit-risk ratio is positive for the vaccine (5/14). 48% (n=13) were not vaccinated mainly for the following reasons: doubt about the effectiveness (2/13) and fear of side effects (2/13). Opinion on vaccines was moved mainly by having personal questions answered and feeling not judged for having a different opinion on vaccination.Conclusion and relevanceIn this study we could reduce vaccine hesitancy by increasing the degree of confidence in the vaccine and our action effectively convinced half the participants to get vaccinated.References and/or acknowledgements1. https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-20192. https://sotomo.ch/site/wp-content/uploads/2021/02/6.-SRG-Corona-Monitor.pdfConflict of interestNo conflict of interest
背景和重要性根据世界卫生组织,疫苗犹豫是全球健康的十大威胁之一。1部分瑞士人口对接种covid -19疫苗犹豫不决。2目的和目的本研究的目的是开展一项对疫苗接种犹豫不决的公共卫生行动,并衡量其对疫苗犹豫和疫苗接种率的影响。材料和方法使用测试前问卷对疫苗犹豫和疫苗接种障碍进行测量和确定。只有未接种疫苗的志愿者被包括在内,他们被邀请参加一个1小时的在线会议,使用动机性访谈技术,由医生和药剂师指导。两周后,他们被要求填写后测试,两个月后,他们的疫苗状态被要求。数据收集于2021年4月至8月进行。结果31名成年人参加了11个在线会话(2.8人/会话)。大多数是女性(68%,n=21),年龄在35至60岁之间(71%)。公共卫生专业人员10人(32.3%),非公共卫生专业人员21人(67.7%)。在研究前,54.9%的人认为疫苗不安全(研究后为19.4%),87.1%的人担心疫苗副作用(研究后为64.5%),51.6%的人认为疫苗有效(研究后为83.9%)。在研究开始前,参与者被分类为肯定愿意接种疫苗(3.2%),可能(9.7%),可能不(35.5%),肯定不(12.9%),不知道/其他(38.8%),对接种疫苗的置信度为4.5±2.2(量表1-10)。研究结束后,置信度提高到6.3±2.4(+29%)。研究结束后,52% (n=14)的人有效接种了疫苗。促使人们接种疫苗的原因包括:接种疫苗将有助于遏制大流行(5/14),疫苗的利益风险比为正(5/14)。48% (n=13)未接种疫苗的主要原因是:怀疑有效性(2/13)和担心副作用(2/13)。人们对疫苗的看法主要是通过回答个人问题,而不是因为对疫苗接种有不同的看法而受到评判。结论和相关性在这项研究中,我们可以通过增加对疫苗的信心程度来减少疫苗犹豫,我们的行动有效地说服了一半的参与者接种疫苗。参考文献和/或致谢https://www.who.int/news room/spotlight/ten - - -全球卫生威胁- 20192。没有利益冲突
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引用次数: 0
4CPS-130 Analysis of the different cardioversion strategies in the emergency department in a secondary hospital 4CPS-130某二级医院急诊不同复律策略分析
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.396
R. Rodríguez Mauriz, L. Borràs Trias, N. García Farre, N. Almendros-Abad, N. Rudi Sola
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引用次数: 0
4CPS-032 How to improve the appropriate prescription of anticoagulants during unexpected emergency room admittance to the hospital? A case series report using pharmacy practitioners 如何提高意外急诊入院时抗凝血药物处方的适宜性?使用药房从业人员的病例系列报告
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.384
S. Coenradie, C. Batenburg, M. De Graaf-Van Der Kort, P. Langendijk
Background and importance Serious medication errors can be made during unexpected hospital admittance through the emergency ward. In particular, anticoagulants portray a great risk for patients when proper medication reconciliation is absent.We started using pharmacy practitioners (PPs) to improve this process on the emergency ward. We report here the results of two case series with respect to accuracy in the medication reconciliation on the emergency room (ER) ward. Aim and objectives To investigate if appropriate embedding of PPs in the process of medication reconciliation during unexpected admittance to the hospital could lead to fewer medication errors downstream in other hospital wards. Material and methods A PP was embedded in the ER ward team during office hours (08:00 to 17:00) to perform the medication reconciliation of unexpectedly admitted patients instead of ER physicians. The two case series of admitted patients were chosen in a post-propter design. As a zero measurement, a case series of patients (ZMCS) in a pilot phase was used (October-December 2019). This pilot phase was done to collect data on hospital administration in order to show that PPs could be embedded to do this task. This retrospective dataset consisted of 40 patients, unexpectedly admitted on the ER ward and for whom the ER physicians performed the medication reconciliation. A prospective case series of patients was then performed during the period October-December 2020 under the same conditions and used as the experimental case series (EXCS) to compare with the ZMCS. The number of medication errors in the EXCS divided by the number of medication errors during the ZMCS was our main outcome parameter expressed as a percentage. After ER admittance patients were transmitted to several other specialist wards. Results Our results showed a 40% reduction in medication errors downstream in the specialist wards when the PPs were involved in the medication reconciliation process in the EXCS compared to the medication reconciliation done by ER physicians in the ZMCS. Conclusion and relevance We conclude that PPs can make a valuable contribution to reduce the number of medication errors downstream in the hospital when embedded in the ER ward team.
背景与重要性在急诊病房意外入院时可能发生严重的用药错误。特别是,抗凝剂描绘了一个巨大的风险,当适当的药物调解缺席患者。我们开始使用药房从业人员(PPs)来改进急诊病房的这一流程。我们在这里报告了两个病例系列的结果,关于在急诊室(ER)病房的药物和解的准确性。目的和目的探讨在意外入院患者的用药调解过程中适当嵌入PPs是否可以减少下游医院其他病房的用药错误。材料与方法在办公时间(08:00 - 17:00),在急诊室病房团队中嵌入一名PP,代替急诊室医生对意外入院的患者进行药物调解。住院患者的两个病例系列是在一个后适当的设计中选择的。作为零测量,使用了试点阶段(2019年10月至12月)的病例系列患者(ZMCS)。这个试验阶段的目的是收集有关医院管理的数据,以表明可以嵌入pp来完成这项任务。本回顾性数据集包括40名意外入住急诊室的患者,并由急诊室医生对其进行药物调节。然后在2020年10月至12月期间,在相同的条件下,对患者进行前瞻性病例系列研究,并将其作为实验病例系列(EXCS)与ZMCS进行比较。EXCS中的用药错误数除以ZMCS期间的用药错误数是我们的主要结局参数,以百分比表示。急诊室入院后,病人被转到其他几个专科病房。结果我们的研究结果显示,当PPs参与EXCS的药物调解过程时,与ZMCS的急诊室医生进行的药物调解相比,专科病房下游的药物错误减少了40%。结论与意义我们认为,在急诊病房团队中嵌入PPs可以为减少医院下游的用药错误做出有价值的贡献。
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引用次数: 0
4CPS-025 Adequacy of hepatitis B reactivation prophylaxis in patients treated with rituximab 利妥昔单抗治疗患者乙肝再活化预防的充分性
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.381
I. Patier, N. Herranz-Muñoz, F. Fernandez Fraga, J. Sánchez-Rubio Ferrández, I. García-Bermejo, M. Moreno-García, T. Molina-García
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引用次数: 0
4CPS-126 Real-world persistence with fampridine among multiple sclerosis patients 4CPS-126多发性硬化症患者使用福普定的现实世界持久性
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.394
N. Herranz-Muñoz, J. Sánchez-Rubio Ferrández, L. Martín-Zaragoza, M. Gómez-Bermejo, S. Solís-Cuñado, T. Molina-García
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引用次数: 0
4CPS-164 Durability of oral dual antiretroviral therapy in HIV patients HIV患者口服双重抗逆转录病毒治疗的持久性
Pub Date : 2022-03-01 DOI: 10.1136/ejhpharm-2022-eahp.400
L. Perez Cordon, A. Sánchez Ulayar, S. Marín Rubio, V. Aguilera Jimenez, L. Campins Bernadàs, J. Delgado Rodríguez, M. Bitlloch Obiols, R. Merino Méndez, T. Gurrera Roig, D. López Faixó
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引用次数: 1
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Section 7: Post Congress additions
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