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Spinal cord injury: pathophysiology and principles of management 脊髓损伤:病理生理学和处理原则
Q4 Medicine Pub Date : 2024-08-26 DOI: 10.1016/j.mporth.2024.07.002
Simon B Roberts, Athanasios I Tsirikos
Spinal cord injury (SCI) is a catastrophic neurological condition resulting in increased physical dependency, medical comorbidity, psychological distress and economic burden. New SCI affects 250,000–500,000 individuals globally each year. The pathophysiological mechanisms following SCI are incompletely understood, and the management of patients following SCI is challenging. Understanding the evolution of pathophysiological changes following SCI is fundamental to delivering and developing appropriate management strategies. Timely interventions following acute SCI can prevent secondary neurological deterioration and improve potential for neurological recovery. A bespoke, multidisciplinary and holistic approach to the management and rehabilitation of SCI patients can optimize physical and mental wellbeing and maximize patient's neurological recovery and functional capabilities. Current therapeutic options following SCI are limited and do not overcome the debilitating effects of SCI. Current knowledge of the pathophysiological mechanism following SCI, management strategies and novel therapies for adult and paediatric SCI patients are reviewed.
脊髓损伤(SCI)是一种灾难性的神经系统疾病,会增加身体依赖性、医疗并发症、心理困扰和经济负担。全球每年新增脊髓损伤患者达 25 万至 50 万人。人们对 SCI 后的病理生理机制尚不完全了解,对 SCI 患者的管理也极具挑战性。了解 SCI 后病理生理变化的演变是提供和制定适当管理策略的基础。急性 SCI 后及时干预可防止继发性神经功能恶化,并提高神经功能恢复的可能性。为 SCI 患者量身定制的多学科综合管理和康复方法可以优化患者的身心健康,最大限度地提高患者的神经康复和功能能力。目前对 SCI 患者的治疗方案有限,无法克服 SCI 造成的衰弱影响。本文回顾了目前对 SCI 后的病理生理机制、成人和儿童 SCI 患者的管理策略和新型疗法的了解。
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引用次数: 0
Biomechanics of the spine and the implications for spinal injuries 脊柱的生物力学及其对脊柱损伤的影响
Q4 Medicine Pub Date : 2024-08-26 DOI: 10.1016/j.mporth.2024.07.001
Simon B Roberts, Athanasios I Tsirikos
Biomechanics is the application of principles of engineering and computers to biological problems. Clinical biomechanics of the spine is the understanding of normal and pathological functions of the human vertebral column in response to mechanical insult, which may include traumatic, degenerative, pathological, or slowly applied loads to the spine. Spinal biomechanics involves the regional features of the vertebrae, intervertebral discs, ligaments, facet joints and muscles. The role of these structures individually and in concert in relation to spinal injuries is discussed. Regional spinal biomechanics, maintenance of spinal stability and assessment of spinal instability following injury are described. Finally, the biomechanical principles, individual structural components, mechanisms of injury and principles specific to the adult and paediatric spine are reviewed.
生物力学是将工程学和计算机原理应用于生物问题的学科。脊柱临床生物力学是了解人体椎体在受到机械损伤时的正常和病理功能,这些损伤可能包括创伤、退行性病变、病理或缓慢施加于脊柱的负荷。脊柱生物力学涉及椎骨、椎间盘、韧带、面关节和肌肉的区域特征。本文讨论了这些结构在脊柱损伤中的单独和协同作用。介绍区域脊柱生物力学、脊柱稳定性的维持和损伤后脊柱不稳定性的评估。最后,回顾了成人和儿童脊柱的生物力学原理、单个结构成分、损伤机制和特定原理。
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引用次数: 0
Answers to the CME questions on The Elbow 关于肘部的继续医学教育问题解答
Q4 Medicine Pub Date : 2024-08-24 DOI: 10.1016/j.mporth.2024.07.012
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引用次数: 0
CME questions on Spinal Trauma 关于脊柱创伤的继续医学教育问题
Q4 Medicine Pub Date : 2024-08-24 DOI: 10.1016/j.mporth.2024.07.011
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引用次数: 0
Revision total elbow arthroplasty: a primer for exam candidates 翻修型全肘关节置换术:考生入门指南
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.007
Alistair Ian Eyre-Brook, Lawrence Majkowski, Margo Dirckx, Amjid Ali, Simon Booker

Total elbow arthroplasty (TEA) has a relatively high revision rate compared to conventional joint arthroplasties (4–7% at 5 years). The cause for revision is most commonly implant loosening. A thorough work-up with history, examination, bloods, radiographs and joint tissue or fluid samples are all required to rule out peri-prosthetic infection. Patient factors and soft tissue management must be considered before revising a TEA to ensure the best outcome and longevity of the revised implant. Surgical strategies for TEA revision include single or two-stage revision, bearing exchange, bone windows and strut grafts.

与传统的关节置换术相比,全肘关节置换术(TEA)的翻修率相对较高(5年翻修率为4%-7%)。翻修的原因最常见的是假体松动。要排除假体周围感染,就必须进行全面的检查,包括病史、检查、血液、X光片和关节组织或液体样本。在对 TEA 进行翻修前,必须考虑患者因素和软组织管理,以确保翻修后的种植体达到最佳效果并延长使用寿命。TEA翻修的手术策略包括单阶段或双阶段翻修、轴承交换、骨窗和支柱移植。
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引用次数: 0
Answers to the CME questions on Principles of Orthopaedics 骨科原理》继续医学教育问题解答
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.008
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引用次数: 0
Distal biceps pathology: an evidence-based approach 肱二头肌远端病理学:循证方法
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.002
Leanne Dupley, Adam Watts

Distal biceps tendons are a potential source of anterior elbow pain, with pathology ranging from tendinopathy to degenerative ruptures and acute traumatic ruptures. In some instances, non-surgical management is appropriate, but the majority of acute ruptures should be managed surgically for superior outcomes. This article will discuss distal biceps pathology, the relevant surgical anatomy, fixation and approach options and the potential complications following repair and reconstruction.

肱二头肌远端肌腱是肘关节前部疼痛的潜在来源,其病理变化包括肌腱病变、退行性断裂和急性创伤性断裂。在某些情况下,非手术治疗是合适的,但大多数急性断裂应通过手术治疗,以获得更好的疗效。本文将讨论肱二头肌远端病理、相关手术解剖、固定和方法选择以及修复和重建后的潜在并发症。
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引用次数: 0
Lateral elbow pain in adults: a review of the less common causes 成人肘外侧疼痛:不常见原因综述
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.004
Blair Tweedie, Sam Vollans

Lateral elbow pain and tennis elbow have been considered almost synonymous, in that historically all patients with lateral elbow pain were assumed to have tennis elbow. With the evolution of diagnostic imaging, elbow arthroscopy and further understanding of the pathological processes, alongside analysis of failed tennis elbow treatment, a whole host of possible differential diagnoses that might cause lateral elbow pain became recognized. In addition to tendinopathies (tennis and golfers elbow), these include intraarticular mechanical issues (radiocapitellar plica and snapping annular ligament), elbow instability, nerve compression syndromes, osteochondral defects and degenerative joint disease (radiocapitellar joint arthritis). Accurate clinical assessment and diagnosis is key, alongside selective use of investigations that can confirm or refute diagnoses and guide ongoing management. This article serves to provide an overview of the history, examination findings, investigations and management options for lateral elbow pain. Whilst we will cover the whole scope of possible diagnoses responsible for lateral elbow pain, we will not be considering in detail those covered in other articles in this issue (tennis elbow, osteochondritis dissecans, elbow instability). The focus of this article will be to elaborate on the tips and tricks within the clinical assessment, and how to properly assess the lateral side of the elbow. We will mention the rarer conditions encountered (posterior interosseous nerve entrapment, synovial plica syndrome and snapping annular ligament) and discuss the reconstructive ladder for lateral sided degenerative joint disease.

肘外侧疼痛和网球肘几乎是同义词,历史上所有肘外侧疼痛的患者都被认为患有网球肘。随着影像诊断技术、肘关节镜技术的发展和对病理过程的进一步了解,以及对网球肘治疗失败的分析,人们认识到了可能导致肘外侧疼痛的一系列鉴别诊断。除肌腱病(网球肘和高尔夫球肘)外,还包括关节内机械问题(桡侧髌骨骨板和环状韧带断裂)、肘关节不稳定、神经压迫综合征、骨软骨缺损和退行性关节疾病(桡侧髌关节关节炎)。准确的临床评估和诊断是关键所在,同时有选择性地使用可确诊或反驳诊断并指导持续治疗的检查方法。本文旨在概述肘外侧疼痛的病史、检查结果、检查和治疗方案。虽然我们将涵盖肘外侧疼痛的所有可能诊断,但不会详细讨论本期其他文章中涉及的诊断(网球肘、骨软骨炎、肘关节不稳定)。本文将重点阐述临床评估的技巧和诀窍,以及如何正确评估肘外侧。我们还将提到较罕见的情况(后骨间神经卡压、滑膜板综合征和环韧带断裂),并讨论外侧退行性关节疾病的重建阶梯。
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引用次数: 0
Elbow instability 肘关节不稳定
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.005
Siddharth Virani, Joideep Phadnis

The elbow joint consists of the ulnohumeral joint, radiocapitellar joint and the proximal radio-ulnar joint. The osseous anatomy, static ligamentous restraints and dynamic stabilizers all contribute to maintain elbow stability. Elbow instability is a commonly encountered condition in clinical practice. There are several ways to classify elbow instability. Instability can be classified as simple or complex based on presence of an associated fracture, it could be classified based on mechanism of injury or it could be classified in a temporal fashion as acute or chronic. It is critical to understand injury patterns that can be treated non-operatively with physiotherapy and mobilization and the ones that need surgery. Surgical management of elbow instability could involve a combination of interventions addressing various ligaments like the lateral ulnar collateral ligament and medial collateral ligament; osseous structures including the radial head, coronoid and proximal ulna based on the mechanism and extent of injury. Adjunctive and salvage procedures may be necessary in delayed presentations or severe injuries. These include application of an internal joint stabilizer, external fixator, internal bracing of the ligament and bone grafting of the coronoid. The goal of treatment of instability is to provide an elbow that is stable and amenable to early active mobilization.

肘关节由尺肱关节、桡髌关节和近端桡尺关节组成。骨性解剖结构、静态韧带约束和动态稳定器都有助于保持肘关节的稳定性。肘关节不稳定是临床实践中经常遇到的情况。肘关节不稳定有几种分类方法。根据是否存在相关骨折,可将不稳定性分为简单和复杂两种;根据受伤机制,可将不稳定性分为急性和慢性两种;根据时间,可将不稳定性分为急性和慢性两种。关键是要了解哪些损伤模式可以通过理疗和活动进行非手术治疗,哪些需要手术治疗。肘关节不稳的手术治疗可根据损伤的机制和程度,采取多种干预措施,包括治疗各种韧带(如尺侧副韧带和内侧副韧带)、骨结构(包括桡骨头、冠状骨和尺骨近端)。对于延迟出现或严重受伤的情况,可能需要进行辅助和挽救手术。这些方法包括应用关节内稳定器、外固定器、韧带内支撑和冠状面植骨术。治疗不稳定的目标是使肘关节保持稳定,并能尽早积极活动。
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引用次数: 0
Compressive neuropathies of the elbow 肘部压迫性神经病
Q4 Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mporth.2024.05.003
Angus T McMillan, Gráinne Bourke

The major peripheral nerves supplying motor and sensory function to the forearm and hand traverse the elbow joint. The complex anatomical relationships of these nerves to the joint and its surrounding musculotendinous structures creates a series of sites where these nerves are vulnerable to compression. Compression syndromes result in distressing constellations of pain, paraesthesia, weakness and loss of coordinated motor function. This article discusses the anatomy and pathophysiology of compressive neuropathies around the elbow joint, their presentation, how they are investigated and diagnosed, and the available management options.

为前臂和手部提供运动和感觉功能的主要外周神经穿过肘关节。这些神经与关节及其周围肌肉腱膜结构之间复杂的解剖关系造成了一系列神经容易受到压迫的部位。压迫综合征会导致令人痛苦的疼痛、麻痹、虚弱和协调运动功能丧失。本文将讨论肘关节周围压迫性神经病变的解剖学和病理生理学、表现形式、检查和诊断方法以及可用的治疗方案。
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Orthopaedics and Trauma
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