Communicative and Integrative Biology最新文献

It is generally assumed that verbal communication can articulate concepts like 'fact' and 'truth' accurately. However, language is fundamentally inaccurate and ambiguous and it is not possible to express exact propositions accurately in an ambiguous medium. Whether truth exists or not, language cannot express it in any exact way. A major problem for verbal communication is that words are fundamentally differently interpreted by the sender and the receiver. In addition, intrapersonal verbal communication - the voice in our head - is a useless extension to the thought process and results in misunderstanding our own thoughts. The evolvement of language has had a profound impact on human life. Most consequential has been that it allowed people to question the old human rules of behavior - the pre-language way of living. As language could not accurately express the old rules, they lost their authority and disappeared. A long period without any rules of how to live together must have followed, probably accompanied by complete chaos. Later, new rules were devised in language, but the new rules were also questioned and had to be enforced by punishment. Language changed the peaceful human way of living under the old rules into violent and aggressive forms of living under punitive control. Religion then tried to incorporate the old rules into the harsh verbal world. The rules were expressed in language through parables: imaginary beings - the gods - who possessed the power of the old rules, but who could be related to through their human appearance and behavior.

Alzheimer's disease (AD) is a common brain disease associated with cognitive impairment and dementia. donepezil, an acetylcholinesterase (AChE) inhibitor drug as a commercial AD drug represents a non-cost-effective treatment with the toxic effects reported. As the prevalence of AD increases, the development of effective therapeutic treatments is urgently required. Laminaria digitata is a brown seaweed claimed to be able to prevent and treat neurodegenerative diseases. Therefore, this study measured and compared the binding affinity and toxicity of seven common phytoconstituents in Laminaria digitata against acetylcholinesterase (AChE) with those of donepezil using a molecular docking approach. The binding free energy values of donepezil, dieckol, eckol, fucodiphlorethol G, 7-Phloroecol, laminaran, alginic acid, and fucoidan with acetylcholinesterase (AChE) were -12.3, -13.5, -10.5, -8,7, -9.7, -8.0, -10.3, and -7.4 kcal/mol. All ligands constantly interacted with the AChE amino acid residues, namely Tyr124. Dieckol, with the strongest and most stable interaction, is classified as class IV toxicity, with an LD50 value of 866 mg/kg. It has aryl hydrocarbon receptor (AhR) and mitochondrial membrane potential (MMP) toxicity at certain doses. Theoretically, based on Lipinski's rule, dieckol is likely to have poor absorption and permeation properties; therefore, several considerations during the drug discovery process are needed.

Soybean (Glycine max) is the most important plant protein source, and Fall Armyworm (FAW, Spodoptera frugiperda) is considered a major pest. This study aimed to examine the impact of FAW feeding on soybean accessions that vary in their water use efficiency (WUE) traits, by examining FAW growth and life history parameters along with plant growth response to pest damage. Soybean accessions were grown in a greenhouse and exposed to FAW larval feeding for 48 h at three different soybean growth stages: V3, R3, and R6. The growth and development of the FAW and soybeans were monitored. Results showed that faster wilting soybean accessions grow taller and have more leaves than slower wilting accessions, but yield was higher in slower wilting soybean accessions. FAW experienced the highest mortality on mid-stage (R3) soybean plants, but they gained the least mass on early stage (V3) soybean plants. These results can assist in better understanding plant insect-interactions at different life stages in both soybean and FAW with implications for management.

Glycolysis is a metabolic pathway that directly generates adenosine triphosphate (ATP), provides metabolic intermediates for anabolism, and supports mitochondrial oxidative phosphorylation. This review addresses recent advances in our understanding of the functions of neuronal glycolysis during the development of neuronal morphogenesis, focusing on the emergent concept that neuronal glycolysis serves local subcellular bioenergetic roles in maintaining neuronal function. The current evidence indicates that glycolysis is subcellularly targeted to specific organelles and molecular machinery to locally supply bioenergetic support for defined subcellular mechanisms underlying neuronal morphogenesis (i.e. axon extension, axon retraction and axonal transport). Thus, the concept of glycolysis as a "housekeeping" mechanism in neurons would benefit revision and future work aim to further define its subcellular functions at varied developmental stages.

In this hypothesis, I discuss how laughter from physical play could have evolved to being induced via visual or even verbal stimuli, and serves as a signal to highlight incongruity that could potentially pose a threat to survival. I suggest how laughter's induction could have negated the need for physical contact in play, evolving from its use in tickling, to tickle-misses, and to taunting, and I discuss how the application of deep learning neural networks trained on images of spectra of a variety of laughter types from a variety of individuals or even species, could be used to determine such evolutionary pathways via the use of latent space exploration.

I summarize my recent theorizing on orientation and navigation across life. Organisms use navigational servomechanisms working with oscillators to get to goals. Navigational servomechanisms track errors from the best direction of travel and initiate action to correct the error. They work with endogenously generated action patterns, oscillations produced by oscillators, to adjust the course of travel. The theme applies to all scales of life from micrometers to thousands of kilometers. Servomechanisms and oscillators also characterize some other domains of cognition.

The feelings of knowing - fundamental interoceptive patterns (FoK-FIP) theory is both a theory of the mind and a unification theory. It includes cosmological and cellular frameworks. The cellular frameworks occur through the cosmological frameworks. This framework within a framework approach allows the connection between physics and consciousness to be envisioned in new ways, expanding current understanding and definitions. The cosmological frameworks refer to the astrophysics and theoretical physics constructs (e.g., string theory) that, without the use of mathematical language, conceptually expand the theory. In contrast, the cellular frameworks are the constructs represented by living organism models with DNA. In this way, the FoK-FIP theory represents an efficient framework for understanding consciousness and its phenomena. The transdisciplinary modeling of the FoK-FIP theory creates contextual bridging between classical theory and quantum theory as well as a broad range of empirical research so that biology and information connect, creating new avenues for disease diagnosis, intervention, and prevention. This article intends to render the FoK-FIP theory more robust and accessible for practical application by introducing the FoK-FIP system, which includes figures to promote clarity. Further, the theory aims to stimulate reasoning that challenges current notions about 'life' and the concept of 'self.' Through this process, the theory might contribute to the transdisciplinary collaboration needed to address some of the world's complex issues. It is suggested that a significant contributor to the current complex matters in the world is the lack of understanding of how things are and how they appear.

Neo-Darwinism conceptualizes evolution as the continuous succession of predominately random genetic variations disciplined by natural selection. In that frame, the primary interaction between cells and the virome is relegated to host-parasite dynamics governed by selective influences. Cognition-Based Evolution regards biological and evolutionary development as a reciprocating cognition-based informational interactome for the protection of self-referential cells. To sustain cellular homeorhesis, cognitive cells collaborate to assess the validity of ambiguous biological information. That collective interaction involves coordinate measurement, communication, and active deployment of resources as Natural Cellular Engineering. These coordinated activities drive multicellularity, biological development, and evolutionary change. The virome participates as the vital intercessory among the cellular domains to ensure their shared permanent perpetuation. The interactions between the virome and the cellular domains represent active virocellular cross-communications for the continual exchange of resources. Modular genetic transfers between viruses and cells carry bioactive potentials. Those exchanges are deployed as nonrandom flexible tools among the domains in their continuous confrontation with environmental stresses. This alternative framework fundamentally shifts our perspective on viral-cellular interactions, strengthening established principles of viral symbiogenesis. Pathogenesis can now be properly appraised as one expression of a range of outcomes between cells and viruses within a larger conceptual framework of Natural Viral Engineering as a co-engineering participant with cells. It is proposed that Natural Viral Engineering should be viewed as a co-existent facet of Natural Cellular Engineering within Cognition-Based Evolution.

Anti-sigma factor antagonists SpoIIAA and RsbV from Bacillus subtilis are the archetypes for single-domain STAS proteins in bacteria. The structures and mechanisms of these proteins along with their cognate anti-sigma factors have been well studied. SpoIIAA and RsbV utilize a partner-switching mechanism to regulate gene expression through protein-protein interactions to control the activity of their downstream anti-sigma factor partners. The Vibrio fischeri STAS domain protein SypA is also proposed to employ a partner-switching mechanism with its partner SypE, a serine kinase/phosphatase that controls SypA's phosphorylation state. However, this regulation appears opposite to the canonical pathway, with SypA being the more downstream component rather than SypE. Here we explore the commonalities and differences between SypA and the canonical single-domain STAS proteins SpoIIAA and RsbV. We use a combination of AlphaFold 2 structure predictions and computational modeling to investigate the SypA-SypE binding interface. We then test a subset of our predictions in V.fischeri by generating and expressing SypA variants. Our findings suggest that, while SypA shares many sequence and structural traits with anti-sigma factor antagonist STAS domain proteins, there are significant differences that may account for SypA's distinct regulatory output.

Fundamental tensions exist between formal-logical approaches and cognitive approaches to linguistic meaning. The divergence arises from the fundamental differences in nature and form between formal/mathematical structures of natural language meaning and their cognitive representations. While the former are abstract and logical categories of representations, the latter are ultimately embodied and grounded in sensory-motor systems of the brain. This article aims to motivate a unifying theory/formalism of linguistic meaning from a general biologically integrative perspective in the context of current theorizing in linguistics, neurobiology and cognitive sciences on human language meaning within which two divergent approaches for the mathematical and cognitive aspects of linguistic meaning exist. The tensions can be somewhat neutralized if formal-mathematical structures and cognitive representations of natural language meaning can be shown to have representational duality and unity in brain dynamics. This work shows a broad outline of one, if not the only one, path toward this vision.