Yasemin Kayabasi, B. Bahar, Guner Dede, A. Abyad, Lesley Pocock
Background: There may be a significant relationship between smoking and fasting plasma glucose (FPG) in the human body. Method: Consecutive daily smokers at least for a period of six months and age and sex-matched non-smokers were included into the study. Cases with regular alcohol consumption (one drink a day) and patients with inflammatory, infectious, or devastating disorders including eating disorders, malignancies, acute or chronic renal failure, cirrhosis, chronic obstructive pulmonary disease, hyper- or hypothyroidism, or heart failure were excluded from the study. Results: The study included 150 smokers (99 males) and 162 non-smokers. The mean age of smokers was 45.9 years, and 66.0% of them were male. Although the mean body weight, body mass index, systolic and diastolic blood pressures, and hematocrit values were similar in both groups, FPG value was lower in the smokers (101.9 versus 111.9 mg/dL, p<0.01), significantly. Similarly, high density lipoproteins (HDL) value was lower in the smokers (41.1 versus 44.0 mg/dL, p<0.05), again. On the other hand, triglycerides (163.3 versus 151.8 mg/dL, p<0.05), low density lipoproteins (LDL) (126.1 versus 117.4 mg/dL, p<0.05), erythrocyte sedimentation rate (ESR) (10.8 versus 9.4 mm/h, p<0.05), and C-reactive protein (CRP) (2.5 versus 2.1 mg/L, p<0.05) values were all higher in the smokers, significantly. Conclusion: Smoking causes a low-grade systemic inflammation on vascular endothelium terminating with an accelerated atherosclerosis-induced end-organ insufficiencies all over the body. FPG and HDL may be negative whereas triglycerides, LDL, ESR, and CRP positive acute phase reactants indicating the inflammatory effects of smoking in the human body.
背景:吸烟与人体空腹血糖(FPG)之间可能存在显著关系。方法:连续每天吸烟至少6个月，年龄和性别匹配的非吸烟者被纳入研究。经常饮酒(每天喝一杯)的病例和患有炎性、传染性或破坏性疾病(包括饮食失调、恶性肿瘤、急性或慢性肾功能衰竭、肝硬化、慢性阻塞性肺病、甲状腺功能亢进或功能减退或心力衰竭)的患者被排除在研究之外。结果:该研究包括150名吸烟者(99名男性)和162名不吸烟者。吸烟者平均年龄为45.9岁，男性占66.0%。尽管两组的平均体重、体重指数、收缩压和舒张压以及红细胞压积值相似，但吸烟者的FPG值明显较低(101.9 mg/dL vs 111.9 mg/dL, p<0.01)。同样，吸烟者的高密度脂蛋白(HDL)值也较低(41.1 mg/dL比44.0 mg/dL, p<0.05)。另一方面，吸烟者的甘油三酯(163.3 vs 151.8 mg/dL, p<0.05)、低密度脂蛋白(LDL) (126.1 vs 117.4 mg/dL, p<0.05)、红细胞沉降率(ESR) (10.8 vs 9.4 mm/h, p<0.05)和c反应蛋白(CRP) (2.5 vs 2.1 mg/L, p<0.05)值均显著升高。结论:吸烟引起血管内皮低度全身性炎症，最终导致全身动脉粥样硬化引起的终末器官功能不全加速。FPG和HDL可能呈阴性，而甘油三酯、LDL、ESR和CRP急性期反应物可能呈阳性，这表明吸烟对人体的炎症作用。
{"title":"What a Lower Value of Fasting Plasma Glucose in Smokers","authors":"Yasemin Kayabasi, B. Bahar, Guner Dede, A. Abyad, Lesley Pocock","doi":"10.58489/2836-2217/011","DOIUrl":"https://doi.org/10.58489/2836-2217/011","url":null,"abstract":"Background: There may be a significant relationship between smoking and fasting plasma glucose (FPG) in the human body. Method: Consecutive daily smokers at least for a period of six months and age and sex-matched non-smokers were included into the study. Cases with regular alcohol consumption (one drink a day) and patients with inflammatory, infectious, or devastating disorders including eating disorders, malignancies, acute or chronic renal failure, cirrhosis, chronic obstructive pulmonary disease, hyper- or hypothyroidism, or heart failure were excluded from the study. Results: The study included 150 smokers (99 males) and 162 non-smokers. The mean age of smokers was 45.9 years, and 66.0% of them were male. Although the mean body weight, body mass index, systolic and diastolic blood pressures, and hematocrit values were similar in both groups, FPG value was lower in the smokers (101.9 versus 111.9 mg/dL, p<0.01), significantly. Similarly, high density lipoproteins (HDL) value was lower in the smokers (41.1 versus 44.0 mg/dL, p<0.05), again. On the other hand, triglycerides (163.3 versus 151.8 mg/dL, p<0.05), low density lipoproteins (LDL) (126.1 versus 117.4 mg/dL, p<0.05), erythrocyte sedimentation rate (ESR) (10.8 versus 9.4 mm/h, p<0.05), and C-reactive protein (CRP) (2.5 versus 2.1 mg/L, p<0.05) values were all higher in the smokers, significantly. Conclusion: Smoking causes a low-grade systemic inflammation on vascular endothelium terminating with an accelerated atherosclerosis-induced end-organ insufficiencies all over the body. FPG and HDL may be negative whereas triglycerides, LDL, ESR, and CRP positive acute phase reactants indicating the inflammatory effects of smoking in the human body.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126938454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trauma is the emotional and physical harm of people from situations that develop suddenly and that they cannot resist. After the trauma,the person becomesmore prone to many psychological disorders and has tangible consequences such as decreased productivity, loss of job and loss of physical well-being. EMDR is one of the most effective methods used intrauma treatment. EMDR is a therapy method with proven effectiveness in cases of sexual abuse as well as in many types of trauma. However, EMDR applications are not available for Capgras Syndrome. In this study, it was shown that the symptoms of X, who developed Capgras Syndromeafter sexual abuse, were reduced after EMDR treatment in addition to drug treatment. X also had doubts about his sexual orientation and it was determined that these doubts disappeared after the application.
{"title":"EMDR Intervention in the Treatment of Capgras Syndrome Case Report","authors":"","doi":"10.58489/2836-2217/012","DOIUrl":"https://doi.org/10.58489/2836-2217/012","url":null,"abstract":"Trauma is the emotional and physical harm of people from situations that develop suddenly and that they cannot resist. After the trauma,the person becomesmore prone to many psychological disorders and has tangible consequences such as decreased productivity, loss of job and loss of physical well-being. EMDR is one of the most effective methods used intrauma treatment. EMDR is a therapy method with proven effectiveness in cases of sexual abuse as well as in many types of trauma. However, EMDR applications are not available for Capgras Syndrome. In this study, it was shown that the symptoms of X, who developed Capgras Syndromeafter sexual abuse, were reduced after EMDR treatment in addition to drug treatment. X also had doubts about his sexual orientation and it was determined that these doubts disappeared after the application.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"78 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116769919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plasmacytomas are rare solitary soft tissue tumors that arise from proliferations of malignant transformed monoclonal plasma cells and can be diagnosed through biopsy and histopathologic examination. These lesions are closely associated with multiple myelomas, which should be ruled out in all these cases by necessary laboratory and radiographic examinations. A 41yrs old female came to surgery department with a complaint of slow-growing painless mass of 1.0 x0.5 x0.5cm at angle of the mandible. A diagnosis of solitary plasmacytoma was made on the basis of clinical, radiographic, and histopathological findings. Early diagnosis of plasmacytomas is of great importance. Radiotherapy is the common modality of treatment with or without adjuvant chemotherapy. Progression to plasma cell lesion is possible; thus, close follow-up of the patient is essential after the completion of the therapeutic procedure.
{"title":"Intra Oral Plasma Cell Neoplasm: A Case Report","authors":"Sidra Ghayas, N. Zaib, F. Meraj","doi":"10.58489/2836-2217/010","DOIUrl":"https://doi.org/10.58489/2836-2217/010","url":null,"abstract":"Plasmacytomas are rare solitary soft tissue tumors that arise from proliferations of malignant transformed monoclonal plasma cells and can be diagnosed through biopsy and histopathologic examination. These lesions are closely associated with multiple myelomas, which should be ruled out in all these cases by necessary laboratory and radiographic examinations. A 41yrs old female came to surgery department with a complaint of slow-growing painless mass of 1.0 x0.5 x0.5cm at angle of the mandible. A diagnosis of solitary plasmacytoma was made on the basis of clinical, radiographic, and histopathological findings. Early diagnosis of plasmacytomas is of great importance. Radiotherapy is the common modality of treatment with or without adjuvant chemotherapy. Progression to plasma cell lesion is possible; thus, close follow-up of the patient is essential after the completion of the therapeutic procedure.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124777067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mamadou Alpha Balde, A. Babahabib, M. Elhassani, J. Kouach
Homocysteine (Hct) is a substance produced in the metabolism of methionine that can be found in our daily diet. Mutation of the methylenetetrahydrofolate reductase (MTHFR) gene, especially in women with low folate intake. Hyperhomocysteinemia (HHct) can be caused by several factors, such as lack of folic acid, vitamin B6 and B12 deficiency, hypothyroidism, medications, genetic abnormalities, aging and kidney dysfunction. Increased homocysteine in peripheral blood can lead to vascular disease, coronary artery dysfunction, atherosclerotic changes, and embolic disease. Thus, upstream of the trophoblastic plugs, any increase in the thrombogenic power of pregnant women will lead to the formation of a clot and the termination of pregnancy. Recent studies have reported that hyperhomocysteinemia is associated with numerous pregnancy complications, including abortion disease, preeclampsia, preterm birth, hematoma placentae, fetal growth restriction, and gestational diabetes. To avoid thrombosis, the treatment will therefore be based on anticoagulants, sometimes combined with low-dose aspirin because of the anti-aggregating action of the latter. In this article, we report the case of a patient with a history of abortive disease on hyperhomocysteinemia who carried a pregnancy to term, while recalling the metabolism of homocysteine, its impact on pregnancy, and the interest of supplementation folic acid to prevent complications due to hyperhomocysteinemia.
{"title":"Hyperhomocysteinemia and pregnancy: about a case and literature review","authors":"Mamadou Alpha Balde, A. Babahabib, M. Elhassani, J. Kouach","doi":"10.58489/2836-2217/009","DOIUrl":"https://doi.org/10.58489/2836-2217/009","url":null,"abstract":"Homocysteine (Hct) is a substance produced in the metabolism of methionine that can be found in our daily diet. Mutation of the methylenetetrahydrofolate reductase (MTHFR) gene, especially in women with low folate intake. Hyperhomocysteinemia (HHct) can be caused by several factors, such as lack of folic acid, vitamin B6 and B12 deficiency, hypothyroidism, medications, genetic abnormalities, aging and kidney dysfunction. Increased homocysteine in peripheral blood can lead to vascular disease, coronary artery dysfunction, atherosclerotic changes, and embolic disease. Thus, upstream of the trophoblastic plugs, any increase in the thrombogenic power of pregnant women will lead to the formation of a clot and the termination of pregnancy. Recent studies have reported that hyperhomocysteinemia is associated with numerous pregnancy complications, including abortion disease, preeclampsia, preterm birth, hematoma placentae, fetal growth restriction, and gestational diabetes. To avoid thrombosis, the treatment will therefore be based on anticoagulants, sometimes combined with low-dose aspirin because of the anti-aggregating action of the latter. In this article, we report the case of a patient with a history of abortive disease on hyperhomocysteinemia who carried a pregnancy to term, while recalling the metabolism of homocysteine, its impact on pregnancy, and the interest of supplementation folic acid to prevent complications due to hyperhomocysteinemia.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115366321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Methylene blue color has been utilized around the world effectively with few complications in breast surgery. We display two diverse complications including methylene blue: 1) skin and parenchymal rot when color was infused in a subdermal mold and 2) Mycoplasma infection caused by sullied methylene blue in breast lessening surgery. Methods: We show two cases seen at the College of Arizona amid 2008 and alluded to a breast specialist for administration. We assessed and overseen complications of methylene blue color infused by 2 referring surgeons for different indications. A review of the literature was performed. Results: The primary case could be a 67-year ancient female analyzed with invading ductal carcinoma of the left breast for which she was treated by her beginning specialist with cleared out segmental mastectomy and sentinel hub biopsy. The working specialist infused methylene blue in a subareolar subdermal design (removed from the essential tumor); tragically the understanding endured skin and breast corruption requiring multiple surgical debridements and at last accomplishing delayed primary closure. The moment case may be a 45-year ancient female with invading lobular carcinoma with a history of Mycoplasma disease auxiliary to methylene blue infused for breast lessening surgery. She required numerous debridements and had granulomas disguising as cancer on MRI that perplexed her degree of malady. Conclusion: The utilize of methylene blue color in breast surgery isn't without hazard. In both cases methylene blue was mindful for complications requiring surgical debridement for local wound issues. In each case extreme corruption and disease were show. Methylene blue may cause not as it were noteworthy dismalness, but may moreover deliver cosmetically unsatisfactory results.
{"title":"Complications Emerge in Breast Surgery by using dye methylene blue","authors":"","doi":"10.58489/2836-2217/008","DOIUrl":"https://doi.org/10.58489/2836-2217/008","url":null,"abstract":"Introduction: Methylene blue color has been utilized around the world effectively with few complications in breast surgery. We display two diverse complications including methylene blue: 1) skin and parenchymal rot when color was infused in a subdermal mold and 2) Mycoplasma infection caused by sullied methylene blue in breast lessening surgery. Methods: We show two cases seen at the College of Arizona amid 2008 and alluded to a breast specialist for administration. We assessed and overseen complications of methylene blue color infused by 2 referring surgeons for different indications. A review of the literature was performed. Results: The primary case could be a 67-year ancient female analyzed with invading ductal carcinoma of the left breast for which she was treated by her beginning specialist with cleared out segmental mastectomy and sentinel hub biopsy. The working specialist infused methylene blue in a subareolar subdermal design (removed from the essential tumor); tragically the understanding endured skin and breast corruption requiring multiple surgical debridements and at last accomplishing delayed primary closure. The moment case may be a 45-year ancient female with invading lobular carcinoma with a history of Mycoplasma disease auxiliary to methylene blue infused for breast lessening surgery. She required numerous debridements and had granulomas disguising as cancer on MRI that perplexed her degree of malady. Conclusion: The utilize of methylene blue color in breast surgery isn't without hazard. In both cases methylene blue was mindful for complications requiring surgical debridement for local wound issues. In each case extreme corruption and disease were show. Methylene blue may cause not as it were noteworthy dismalness, but may moreover deliver cosmetically unsatisfactory results.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124217817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A case is reported with a prolonged recovery of parathyroid function after a total thyroidectomy.
本文报告一例甲状腺全切除术后甲状旁腺功能恢复时间较长。
{"title":"Recovery of parathyroid function after total thyroidectomy","authors":"E. Vázquez Quintana","doi":"10.58489/2836-2217/006","DOIUrl":"https://doi.org/10.58489/2836-2217/006","url":null,"abstract":"A case is reported with a prolonged recovery of parathyroid function after a total thyroidectomy.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117107014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kidney cancer is a malignant disease that affects a large number of adults around the world. The kidneys are paired organs, extremely important for the normal functioning of the body. Each person has two kidneys, left and right, located along the spine and below the ribs. The kidneys are the main filters in the human body and perform multiple functions. They are responsible for fluid control, excretion of toxins, mineral salts, production of the hormone erythropoietin which stimulates the production of red blood cells. Each kidney works independently and a person can live with one kidney. When the kidneys are severely damaged, this leads to the need for dialysis. Kidney tumor refers to abnormal tissue growth within the kidney, and can be benign or malignant. This disease affects men more often than women aged 55 to 75 years. The disease develops within one or both kidneys, while in an advanced stage it spreads to the lymph nodes and bloodstream. It is important to know that early diagnosis and effective methods can help treat this type of cancer.
{"title":"A Few Words about Kidney Cancer","authors":"Siniša Franjić","doi":"10.58489/2836-2217/001","DOIUrl":"https://doi.org/10.58489/2836-2217/001","url":null,"abstract":"Kidney cancer is a malignant disease that affects a large number of adults around the world. The kidneys are paired organs, extremely important for the normal functioning of the body. Each person has two kidneys, left and right, located along the spine and below the ribs. The kidneys are the main filters in the human body and perform multiple functions. They are responsible for fluid control, excretion of toxins, mineral salts, production of the hormone erythropoietin which stimulates the production of red blood cells. Each kidney works independently and a person can live with one kidney. When the kidneys are severely damaged, this leads to the need for dialysis. Kidney tumor refers to abnormal tissue growth within the kidney, and can be benign or malignant. This disease affects men more often than women aged 55 to 75 years. The disease develops within one or both kidneys, while in an advanced stage it spreads to the lymph nodes and bloodstream. It is important to know that early diagnosis and effective methods can help treat this type of cancer.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129341087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cow's milk and its derivatives are among the most consumed foods in the world being part of the daily diet of several people. However, its consumption is linked to factors that were associated with neoplastic development, such as IGF-1. IGF-1 acts by stimulating growth effects on most cells of the body via the IGF1R receptor. In this context, this work aimed to investigate studies that correlate these variables: IGF-1, cow's milk, and neoplasias. The results showed that IGF-1 in cow's milk may increase serum IGF-1 levels in humans from milk consumption. Also, we have shown it that some supplements such as choline and casein do not alter the amount of IGF-1, but when the cow undergoes recombinant bovine somatotropin treatment, there is a significant increase in circulating IGF-1. However, further studies are needed to explain the cause-and-effect relationship noted in this study.
{"title":"Correlation of Bovine Dairy Igf-1 And the Neoplasia Development","authors":"D. A. C","doi":"10.58489/2836-2217/004","DOIUrl":"https://doi.org/10.58489/2836-2217/004","url":null,"abstract":"Cow's milk and its derivatives are among the most consumed foods in the world being part of the daily diet of several people. However, its consumption is linked to factors that were associated with neoplastic development, such as IGF-1. IGF-1 acts by stimulating growth effects on most cells of the body via the IGF1R receptor. In this context, this work aimed to investigate studies that correlate these variables: IGF-1, cow's milk, and neoplasias. The results showed that IGF-1 in cow's milk may increase serum IGF-1 levels in humans from milk consumption. Also, we have shown it that some supplements such as choline and casein do not alter the amount of IGF-1, but when the cow undergoes recombinant bovine somatotropin treatment, there is a significant increase in circulating IGF-1. However, further studies are needed to explain the cause-and-effect relationship noted in this study.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127748394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To identify the presence of cognitive sequelae in patients who underwent prolonged orotracheal intubation and who received a speech therapy assessment and rehabilitation during hospitalization due to COVID19. Methods: Participants of the study were 50 individuals, 24 females (43.55%) and 26 males (56.45%), with a mean age of 57.8 years (±14.35), who received treatment at Hospital das Clínicas of the School of Medicine of the University of São Paulo, Brazil (HCFMUSP) due to critical COVID-19. Demographic and clinical data were collected using Addenbrooke's Cognitive Examination - Revised Version (ACE-R) [1]. Results: Results indicated the presence of cognitive deficits in 75% of the participants for all of the tested skills. Conclusion: The results of the present study indicated the presence of cognitive deficits in all of the tested parameters. Future studies should include new analyzes correlating patient severity at hospital admission, demographic data and cognitive abilities.
{"title":"Cognitive Deficits in Patients Who Recovered from Critical Covid-19: Unexpected Results of Follow-Up Patients Running title: Cognitive deficits and COVID-19","authors":"C. R. Furquim de Andrade","doi":"10.58489/2836-2217/003","DOIUrl":"https://doi.org/10.58489/2836-2217/003","url":null,"abstract":"Purpose: To identify the presence of cognitive sequelae in patients who underwent prolonged orotracheal intubation and who received a speech therapy assessment and rehabilitation during hospitalization due to COVID19. Methods: Participants of the study were 50 individuals, 24 females (43.55%) and 26 males (56.45%), with a mean age of 57.8 years (±14.35), who received treatment at Hospital das Clínicas of the School of Medicine of the University of São Paulo, Brazil (HCFMUSP) due to critical COVID-19. Demographic and clinical data were collected using Addenbrooke's Cognitive Examination - Revised Version (ACE-R) [1]. Results: Results indicated the presence of cognitive deficits in 75% of the participants for all of the tested skills. Conclusion: The results of the present study indicated the presence of cognitive deficits in all of the tested parameters. Future studies should include new analyzes correlating patient severity at hospital admission, demographic data and cognitive abilities.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132605053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of medicinal plants has been gaining increasing attention due to antibiotic resistance and the need to promote a healthy environment as well as food safety. Secondary metabolites in Trichilia monadelpha stem bark extract (TMSBE) was analyzed using gas chromatography mass spectrometry (GC/MS) system while proximate analysis of experimental diet was carried out using Near Infra-red Spectrophotometer kit (NIR). 40 growing New Zealand white × Chinchilla crossbred rabbits of 6-7 weeks age (472.6 ± 6.2 g) were used for the experiment. Rabbits were randomly assigned to 4 groups; each treatment was further divided into 5 replicates consisting of 2 rabbits each. Group 1 (G1): Basal diet with no TMSBE, G2: Basal diet plus 3 mL TMSBE per rabbit/day, G3: Basal diet plus 6 mL TMSBE per rabbit/day and G4: Basal diet plus 9 mL TMSBE per rabbit/day. Experimental diet was formulated to meet the nutrient requirement standards for growing rabbits according to Nutritional Research Council standards (1977). GC/MS analysis of TMSBE revealed that it is abundant in coapene (25.40 %) followed by azulene (18.29 %), δ-cadinene (15.39 %), α-cubebene (10.61 %) and α-longipinene (10.11 %) respectively other compounds were less than 5 %. Average weekly weight gain (AWWG), average weekly feed intake (AWFI) and feed conversion ratio (FCR) were significantly (P˂0.05) different among the treatments. AWWG and AWFI follow similar trend and were highest in G3 and G4, intermediate in G2, lowest in G1 (P˂0.05). Better FCR were recorded among rabbits in G4 compared to the other groups (P˂0.05). It was concluded that feeding TMSBE at 9 mL/day improved feed intake and enhance performance in rabbits.
由于抗生素耐药性以及促进健康环境和食品安全的需要，药用植物的使用日益受到关注。采用气相色谱-质谱联用技术(GC/MS)分析毛毛菌茎皮提取物(TMSBE)的次生代谢物，采用近红外分光光度计(NIR)对试验饲料进行近似分析。试验选用6 ~ 7周龄(472.6±6.2 g)的新西兰白×栗杂交兔40只。将家兔随机分为4组;每个处理再分为5个重复，每个重复2只兔。1组(G1):基础饲粮不加TMSBE, G2:基础饲粮加3 mL TMSBE每只兔/天，G3:基础饲粮加6 mL TMSBE每只兔/天，G4:基础饲粮加9 mL TMSBE每只兔/天。试验饲粮按照1977年营养研究委员会标准配制，满足生长兔的营养需求标准。TMSBE的GC/MS分析结果显示，其主要成分为铜红烯(25.40%)，其次为叠氮烯(18.29%)、δ-癸二烯(15.39%)、α-三苯(10.61%)和α-长烯(10.11%)，其余化合物含量均低于5%。各组平均周增重(AWWG)、平均周采食量(AWFI)和饲料系数(FCR)差异显著(P小于0.05)。AWWG和AWFI的变化趋势相似，G3和G4最高，G2居中，G1最低(P小于0.05)。G4组的FCR优于其他各组(P小于0.05)。由此可见，饲粮添加9 mL/d TMSBE可改善家兔采食量，提高生产性能。
{"title":"Efficacy Of Trichilia Monadelpha Stem Bark Extracts on The Growth Performance of Growing Rabbits","authors":"A. J.O","doi":"10.58489/2836-2217/005","DOIUrl":"https://doi.org/10.58489/2836-2217/005","url":null,"abstract":"The use of medicinal plants has been gaining increasing attention due to antibiotic resistance and the need to promote a healthy environment as well as food safety. Secondary metabolites in Trichilia monadelpha stem bark extract (TMSBE) was analyzed using gas chromatography mass spectrometry (GC/MS) system while proximate analysis of experimental diet was carried out using Near Infra-red Spectrophotometer kit (NIR). 40 growing New Zealand white × Chinchilla crossbred rabbits of 6-7 weeks age (472.6 ± 6.2 g) were used for the experiment. Rabbits were randomly assigned to 4 groups; each treatment was further divided into 5 replicates consisting of 2 rabbits each. Group 1 (G1): Basal diet with no TMSBE, G2: Basal diet plus 3 mL TMSBE per rabbit/day, G3: Basal diet plus 6 mL TMSBE per rabbit/day and G4: Basal diet plus 9 mL TMSBE per rabbit/day. Experimental diet was formulated to meet the nutrient requirement standards for growing rabbits according to Nutritional Research Council standards (1977). GC/MS analysis of TMSBE revealed that it is abundant in coapene (25.40 %) followed by azulene (18.29 %), δ-cadinene (15.39 %), α-cubebene (10.61 %) and α-longipinene (10.11 %) respectively other compounds were less than 5 %. Average weekly weight gain (AWWG), average weekly feed intake (AWFI) and feed conversion ratio (FCR) were significantly (P˂0.05) different among the treatments. AWWG and AWFI follow similar trend and were highest in G3 and G4, intermediate in G2, lowest in G1 (P˂0.05). Better FCR were recorded among rabbits in G4 compared to the other groups (P˂0.05). It was concluded that feeding TMSBE at 9 mL/day improved feed intake and enhance performance in rabbits.","PeriodicalId":398973,"journal":{"name":"Clinical Case Reports and Trails","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121153466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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