Pub Date : 2024-01-01Epub Date: 2024-07-03DOI: 10.1080/17469899.2024.2368801
Brenna S Hefley, Arsalan A Ali, Pradipta Bhattacharya, Jesper Hjortdal, Maria K Walker, Dimitrios Karamichos
Introduction: Keratoconus (KC) is the most prevalent corneal ectasia in the world and its pathogenesis is influenced by both ocular and systemic factors. This review explores the multifaceted associations between keratoconus and systemic health conditions, ocular characteristics, and various other environmental/exogenous factors, aiming to illuminate how these relationships influence the pathophysiology of the disease.
Areas covered: This review will summarize the fundamental attributes of KC, review and discuss the systemic and ocular association of KC including molecular biomarkers, and provide an organized overview of the parallel alterations occurring within various biological pathways in KC.
Expert opinion: Despite the substantial volume of research on keratoconus, the precise etiology of the disease remains elusive. Further studies are necessary to deepen our understanding of this intricate disorder and improve its management.
{"title":"Systemic and Ocular Associations of Keratoconus.","authors":"Brenna S Hefley, Arsalan A Ali, Pradipta Bhattacharya, Jesper Hjortdal, Maria K Walker, Dimitrios Karamichos","doi":"10.1080/17469899.2024.2368801","DOIUrl":"10.1080/17469899.2024.2368801","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoconus (KC) is the most prevalent corneal ectasia in the world and its pathogenesis is influenced by both ocular and systemic factors. This review explores the multifaceted associations between keratoconus and systemic health conditions, ocular characteristics, and various other environmental/exogenous factors, aiming to illuminate how these relationships influence the pathophysiology of the disease.</p><p><strong>Areas covered: </strong>This review will summarize the fundamental attributes of KC, review and discuss the systemic and ocular association of KC including molecular biomarkers, and provide an organized overview of the parallel alterations occurring within various biological pathways in KC.</p><p><strong>Expert opinion: </strong>Despite the substantial volume of research on keratoconus, the precise etiology of the disease remains elusive. Further studies are necessary to deepen our understanding of this intricate disorder and improve its management.</p>","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"19 5","pages":"379-391"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-06-19DOI: 10.1080/17469899.2024.2365736
Nazlee Zebardast, Janey L Wiggs
{"title":"How Genome-Wide Association Studies Transform Care for Patients at Risk of Glaucoma.","authors":"Nazlee Zebardast, Janey L Wiggs","doi":"10.1080/17469899.2024.2365736","DOIUrl":"10.1080/17469899.2024.2365736","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"19 4","pages":"243-246"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-26DOI: 10.1080/17469899.2023.2296884
A. Elgenidy, Aya Hesham, Mostafa Atef, Ahmed Awad, Abdullah Emad, Omar Alomari, Ramez M. Odat, Andrew G Lee
{"title":"Spaceflight associated neuro-ocular syndrome (SANS): a systematic review, implications for the sans case definition","authors":"A. Elgenidy, Aya Hesham, Mostafa Atef, Ahmed Awad, Abdullah Emad, Omar Alomari, Ramez M. Odat, Andrew G Lee","doi":"10.1080/17469899.2023.2296884","DOIUrl":"https://doi.org/10.1080/17469899.2023.2296884","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"14 20","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-20DOI: 10.1080/17469899.2023.2296895
Leopoldo Rubinato, Enrico Redolfi de Zan, Valentina Sarao, Daniele Veritti, P. Lanzetta
{"title":"Stem cell therapy in retinal diseases: current evidence","authors":"Leopoldo Rubinato, Enrico Redolfi de Zan, Valentina Sarao, Daniele Veritti, P. Lanzetta","doi":"10.1080/17469899.2023.2296895","DOIUrl":"https://doi.org/10.1080/17469899.2023.2296895","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"47 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139169450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-16DOI: 10.1080/17469899.2023.2296882
Muawyah Al Bdour, Dima Abu Nasrieh, Farah Al Omari, Walid Mahafzah, Darwish Badran, Abdul Hakeem AL-Obaidy, S. A. Alryalat
{"title":"Morphometric analysis of orbital CT scan in a Jordanian sample","authors":"Muawyah Al Bdour, Dima Abu Nasrieh, Farah Al Omari, Walid Mahafzah, Darwish Badran, Abdul Hakeem AL-Obaidy, S. A. Alryalat","doi":"10.1080/17469899.2023.2296882","DOIUrl":"https://doi.org/10.1080/17469899.2023.2296882","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"58 41","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: High temperatures can trigger cellular oxidative stress and disrupt spermatogenesis, potentially leading to male infertility. We investigated the effects of retinoic acid (RA), chitosan nanoparticles (CHNPs), and retinoic acid loaded with chitosan nanoparticles (RACHNPs) on spermatogenesis in mice induced by scrotal hyperthermia (Hyp).
Methods: Thirty mice (weighing 25 to 30 g) were divided into five experimental groups of six mice each. The groups were as follows: control, Hyp induced by a water bath (43 °C for 30 minutes/day for 5 weeks), Hyp+RA (2 mg/kg/day), Hyp+CHNPs (2 mg/kg/72 hours), and Hyp+RACHNPs (4 mg/kg/72 hours). The mice were treated for 35 days. After the experimental treatments, the animals were euthanized. Sperm samples were collected for analysis of sperm parameters, and blood serum was isolated for testosterone measurement. Testis samples were also collected for histopathology assessment, reactive oxygen species (ROS) evaluation, and RNA extraction, which was done to compare the expression levels of the bax, bcl2, p53, Fas, and FasL genes among groups. Additionally, immunohistochemical staining was performed.
Results: Treatment with RACHNPs significantly increased stereological parameters such as testicular volume, seminiferous tubule length, and testicular cell count. Additionally, it increased testosterone concentration and improved sperm parameters. We observed significant decreases in ROS production and caspase-3 immunostaining in the RACHNP group. Moreover, the expression levels of bax, p53, Fas, and FasL significantly decreased in the groups treated with RACHNPs and RA.
Conclusion: RACHNPs can be considered a potent antioxidative and antiapoptotic agent for therapeutic strategies in reproductive and regenerative medicine.
{"title":"Retinoic acid loaded with chitosan nanoparticles improves spermatogenesis in scrotal hyperthermia in mice.","authors":"Fatemeh Mazini, Mohammad-Amin Abdollahifar, Hassan Niknejad, Asma Manzari-Tavakoli, Mohsen Zhaleh, Reza Asadi-Golshan, Ali Ghanbari","doi":"10.5653/cerm.2023.06149","DOIUrl":"10.5653/cerm.2023.06149","url":null,"abstract":"<p><strong>Objective: </strong>High temperatures can trigger cellular oxidative stress and disrupt spermatogenesis, potentially leading to male infertility. We investigated the effects of retinoic acid (RA), chitosan nanoparticles (CHNPs), and retinoic acid loaded with chitosan nanoparticles (RACHNPs) on spermatogenesis in mice induced by scrotal hyperthermia (Hyp).</p><p><strong>Methods: </strong>Thirty mice (weighing 25 to 30 g) were divided into five experimental groups of six mice each. The groups were as follows: control, Hyp induced by a water bath (43 °C for 30 minutes/day for 5 weeks), Hyp+RA (2 mg/kg/day), Hyp+CHNPs (2 mg/kg/72 hours), and Hyp+RACHNPs (4 mg/kg/72 hours). The mice were treated for 35 days. After the experimental treatments, the animals were euthanized. Sperm samples were collected for analysis of sperm parameters, and blood serum was isolated for testosterone measurement. Testis samples were also collected for histopathology assessment, reactive oxygen species (ROS) evaluation, and RNA extraction, which was done to compare the expression levels of the bax, bcl2, p53, Fas, and FasL genes among groups. Additionally, immunohistochemical staining was performed.</p><p><strong>Results: </strong>Treatment with RACHNPs significantly increased stereological parameters such as testicular volume, seminiferous tubule length, and testicular cell count. Additionally, it increased testosterone concentration and improved sperm parameters. We observed significant decreases in ROS production and caspase-3 immunostaining in the RACHNP group. Moreover, the expression levels of bax, p53, Fas, and FasL significantly decreased in the groups treated with RACHNPs and RA.</p><p><strong>Conclusion: </strong>RACHNPs can be considered a potent antioxidative and antiapoptotic agent for therapeutic strategies in reproductive and regenerative medicine.</p>","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"11 1","pages":"230-243"},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82036522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-29DOI: 10.1080/17469899.2023.2279178
J. Gomez Marin, Alejandra de la Torre, Mónica Vargas-Montes
{"title":"Immunopathogenesis of ocular toxoplasmosis and implications for treatment","authors":"J. Gomez Marin, Alejandra de la Torre, Mónica Vargas-Montes","doi":"10.1080/17469899.2023.2279178","DOIUrl":"https://doi.org/10.1080/17469899.2023.2279178","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"113 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139211688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-23DOI: 10.1080/17469899.2023.2287178
Cynthia Owsley, Thomas A. Swain, Deepayan Kar, C. Curcio
{"title":"Rod mediated dark adaptation, a functional test for early and intermediate AMD outcomes","authors":"Cynthia Owsley, Thomas A. Swain, Deepayan Kar, C. Curcio","doi":"10.1080/17469899.2023.2287178","DOIUrl":"https://doi.org/10.1080/17469899.2023.2287178","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1080/17469899.2023.2286607
Majid Khan, Olawale E. Akinyemi, Maliha Masud, Mathew J. Thomas, Nicholas Martin, A. Khanani
{"title":"Targeting the complement system in geographic atrophy: mechanisms and therapeutics","authors":"Majid Khan, Olawale E. Akinyemi, Maliha Masud, Mathew J. Thomas, Nicholas Martin, A. Khanani","doi":"10.1080/17469899.2023.2286607","DOIUrl":"https://doi.org/10.1080/17469899.2023.2286607","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"5 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1080/17469899.2023.2284313
S. Shivaji
{"title":"Examining correlation between ocular microbiome and ocular diseases including keratitis","authors":"S. Shivaji","doi":"10.1080/17469899.2023.2284313","DOIUrl":"https://doi.org/10.1080/17469899.2023.2284313","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"48 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号