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Relationship between Sleep Disturbance and Polypharmacy among Hospitalized Elderly 住院老年人睡眠障碍与多种药物的关系
Pub Date : 2019-10-01 DOI: 10.21608/ejgg.2019.139022
Sara A. Hamza, Heba G Saber, Nesma AM Hassan
Background Aging induces many changes in sleep architecture, many studies suggests that older adults are particularly vulnerable (1) . Although changes in sleep architecture are to be expected with increasing age, age itself does not result in disturbed sleep. But it is the ability to sleep that decreases with age, which may be due to other associated factors with aging (2) . Sleep disturbance is common in older adults because aging is associated with an increasing prevalence of multiple morbidities and polypharmacy (3) . Medication use is another factor that may increase risk for sleep disturbances in older adults. Polypharmacy may also contribute to heightened risk for sleep disturbance in older adults (3) . Polypharmacy is associated with adverse outcomes including mortality, falls, adverse drug reactions, increased length of stay in hospital and readmission to hospital soon after discharge (4) . The risk of adverse effects and harm increases with increasing numbers of medications (5) . The use of multiple drugs more than 5 drugs is defined by many authors as polypharmacy (6) . Polypharmacy is really common as age-related morbidities increase, putting the elderly at risk for drug-drug and drugdisease interactions (7) .
衰老会引起睡眠结构的许多变化,许多研究表明老年人尤其容易发生这种变化(1)。虽然随着年龄的增长,睡眠结构会发生变化,但年龄本身并不会导致睡眠紊乱。但睡眠能力随着年龄的增长而下降,这可能是由于其他与衰老相关的因素(2)。睡眠障碍在老年人中很常见,因为衰老与多种疾病和多种药物的患病率增加有关(3)。药物使用是另一个可能增加老年人睡眠障碍风险的因素。多种药物也可能增加老年人睡眠障碍的风险(3)。多种用药与不良后果相关,包括死亡率、跌倒、药物不良反应、住院时间延长和出院后不久再次住院(4)。不良反应和危害的风险随着药物数量的增加而增加(5)。使用5种以上的多种药物被许多作者定义为多药(polypharmacy)(6)。随着年龄相关发病率的增加,多重用药确实很常见,这使老年人面临药物-药物和药物-疾病相互作用的风险(7)。
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引用次数: 3
Ezzat Hegazy: an Eminent Father of Social Gerontology in The Arabic World Ezzat Hegazy:阿拉伯世界杰出的社会老年学之父
Pub Date : 2019-10-01 DOI: 10.21608/ejgg.2019.136555
A. Mohammedin, S. Rohaiem
Educational and scientific foundation: ---------------------------------------He enjoyed the highly esteemed Egyptian education in the pre-1952 revolution era. During this period the Egyptian nation was investing many resources in education. One quote by Taha Hussain (1889-1973) the famous Egyptian academic, writer, social reformer and then Minister of Education: "Education is like water and air, essential for life"(2) ii .
教育和科学基础:---------------------------------------在1952年革命前,他享受着备受推崇的埃及教育。在此期间,埃及国家在教育方面投入了大量资源。引用埃及著名学者、作家、社会改革家、前教育部长塔哈·侯赛因(1889-1973)的话:“教育就像水和空气,是生命所必需的。”
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引用次数: 0
Dysnatremia in hospitalized elderly patients 住院老年患者钠血症
Pub Date : 2019-10-01 DOI: 10.21608/EJGG.2019.139408
Abeer H. M. Matter
Dysnatremia is the most common electrolyte disorder in hospitalized patients; it encompasses hyponatremic and hypernatremic conditions. It is a common finding at Intensive Care Unit (ICU) admission [1-3]. Up to one third of critically ill patients have dysnatremia at ICU admission [2]. Another one-third of critically ill patients will develop an ICU-acquired dysnatremia during ICU stay [4,5]. Prevalence of dysnatremia at ICU admission, however, varies greatly according to the chosen definition [1,2,6,7]. Hyponatremia is a pathologic condition defined as a serum sodium < 135 mmol/L. It is the most common electrolyte disorder in hospitalized patients. Up to 40% of the overall population of hospitalized patients has a hyponatremia at admission [8]. Presence of severe hyponatremia on hospital admission has been demonstrated to be independently associated with an increased risk for ICU admission and poor prognosis [9]. Hyponatremia may be due to chronic organ dysfunctions (that is heart failure or liver dysfunction) but also to diuretic use, syndrome of inappropriate antidiuretic hormone (ADH) secretion, adrenal insufficiency, and cerebral or renal salt wasting syndromes [10,11]. Hypernatremia is defined as a serum sodium > 145 mmol/L. It is generally related to water losses with increase of plasma osmolality. Serum sodium is the main cation of extracellular fluid and plays a key role in serum osmolarity. It is less frequent than hyponatremia [10] with a reported in-hospital prevalence of up to 7.7% [2]. Since thirst and free access to water are the most important mechanisms that prevent hypernatremia, critically ill patients and older patients are at high risk for this disorder [4,11]. Only 2.5% patients have been found to develop moderate to severe hypernatremia in the general in-hospital population of patients. Higher prevalence has been Abstract Background: Dysnatremia is the most common elect roly te disorder in hospi tal ized pat ients ; i t encompasses hyponatremic and hypernat remic condi t ions . Dysnatremia is also a common f inding at In tensive Care Uni t admission. Abnormal serum sodium concentrat ions are known to adversely af fect physiologic funct ion and an increasing evidence suggests that dysnatremia may be associated wi th adverse outcome.
钠血症是住院患者中最常见的电解质紊乱;它包括低钠血症和高钠血症。这是重症监护病房(ICU)入院时常见的发现[1-3]。高达三分之一的危重患者在ICU入院时出现血钠异常[2]。另有三分之一的危重患者在ICU住院期间会出现ICU获得性钠血症[4,5]。然而,根据所选择的定义,ICU入院时钠血症的患病率差异很大[1,2,6,7]。低钠血症是一种病理状态,定义为血清钠< 135 mmol/L。这是住院患者中最常见的电解质紊乱。高达40%的住院患者在入院时出现低钠血症[8]。入院时出现严重低钠血症已被证明与ICU入院风险增加和预后不良独立相关[9]。低钠血症可能是由于慢性器官功能障碍(如心力衰竭或肝功能障碍),但也与利尿剂使用、抗利尿激素(ADH)分泌不当综合征、肾上腺功能不全以及脑或肾盐消耗综合征有关[10,11]。高钠血症定义为血清钠> 145 mmol/L。它通常与血浆渗透压增加引起的水分流失有关。血清钠是细胞外液的主要阳离子,在血清渗透压中起关键作用。它的发生率低于低钠血症[10],据报道住院患病率高达7.7%[2]。由于口渴和自由饮水是预防高钠血症的最重要机制,危重患者和老年患者是高钠血症的高危人群[4,11]。在一般住院患者中,仅发现2.5%的患者出现中度至重度高钠血症。摘要背景:钠血症是住院患者中最常见的疾病;它包括低钠血症和高钠血症。钠血症也是重症监护病房入院时的常见发现。已知血清钠浓度异常会对生理功能产生不利影响,越来越多的证据表明钠血症可能与不良后果有关。
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引用次数: 0
Dysnatremia in hospitalized elderly patients 住院老年患者钠血症
Pub Date : 2019-09-29 DOI: 10.21608/ejgg.2019.16461.1019
Abeer mohamed matter
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引用次数: 0
The Effect of Chronic Diseases on Functional Status measured by the Care Dependency Scale in a Sample of Community-dwelling Elderly Egyptians 慢性疾病对功能状态的影响通过护理依赖量表测量在社区居住的埃及老年人样本
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30901
M ElbeheryH, S MohammedinA, A AbdelgawadM, M EbeidS, M FaridT, S SweedH
AbstractBackground: The increasing number of elderly population has made it more important to focus on elderly function and independent living. Chronic diseases represent a major threat to elderly independence and the Care Dependency Scale is considered a comprehensive tool for assessment of functional status in elderlyAim: To study the effect of chronic diseases on functional independence in elderly using the Care Dependency Scale Methods: One-hundred twenty seven community-dwelling elderly Egyptians were enrolled in the study. Cases were selected by convenient sampling regarding age, sex, governorate, religion, educational level, socioeconomic status, marital status and working status. This was based on data supplied by the Egyptian Central Agency for Public Mobilization and Statistics (CAPMAS) report of 2013 supplied to the National Center for Social and Criminological Research (NCSCR)Results: In the current study sample, visual impairment, hypertension and DM were the most prevalent chronic diseases with a prevalence of 53.5, 44.1, 31.5 respectively. While cerebrovascular accidents were the least prevalent recording 4.7% of the study sample. Insomnia, chronic kidney diseases (CKD), heart failure and previous hospitalization were significantly related to lower CDS scores in the current study. The mean CDS in our study sample was 74.9Conclusions: Insomnia, CKD, heart failure and previous hospitalization are related to higher rates of care dependency in elderly Egyptians.
【摘要】背景:随着老年人口数量的不断增加,关注老年功能和独立生活变得更加重要。慢性疾病是老年人独立性的主要威胁,护理依赖量表被认为是评估老年人功能状态的综合工具。目的:利用护理依赖量表研究慢性病对老年人功能独立性的影响方法:127名居住在社区的埃及老年人参加了这项研究。按年龄、性别、所属省份、宗教信仰、文化程度、社会经济状况、婚姻状况、工作状况等进行方便抽样。这是基于埃及中央公共动员和统计机构(CAPMAS)向国家社会和犯罪学研究中心(NCSCR)提供的2013年报告提供的数据。结果:在目前的研究样本中,视力障碍、高血压和糖尿病是最普遍的慢性病,患病率分别为53.5、44.1和31.5。而脑血管事故发生率最低,仅占研究样本的4.7%。在本研究中,失眠、慢性肾脏疾病(CKD)、心力衰竭和既往住院与较低的CDS评分显著相关。我们研究样本的平均CDS为74.9。结论:失眠、CKD、心力衰竭和既往住院与埃及老年人较高的护理依赖率有关。
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引用次数: 0
Defining Cut-off Scores for MMSE in an Educated and Illiterate Arabic Speaking Egyptian Elderly Population 定义受过教育和不识字的阿拉伯语埃及老年人口MMSE的分界点
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30899
N. Elkholy, Tawfik M, Ebeid S, Hamza A, Madkor E
AbstractBackground: Dementia prevalence is increasing, becoming a public health problem in geriatric population requiring early diagnosis. The MMSE is the most commonly used screening method in the diagnosis and assessment of dementia severity in clinical and research fields; however cut off points in Egyptian population with its different levels of education are not clear.Aim: To review MMSE cut-off values adjusted for schooling in an Arabic speaking sample of Egyptian elderly.Methods: The study was conducted on 159 male and female community-dwelling participants aged ≥ 60 years, cut-off points were determined according to DSM-IV criteria for dementia after defining the participants according to their level of education.Results: Overall the sample, the cut-off score of MMSE for diagnosing dementia was 23 points (sensitivity=95%, specificity= 73.83%). For participants with > 9 years education cut off point was ≤ 22 (sensitivity=94%, specificity=70.2%) while for those with for participants ≤ 9 years education cut off point was ≤ 21 (sensitivity= 91%, specificity=33.3%).Conclusions: New cut off points for MMSE became now available for both educated and low educated geriatric people. The new cut-off scores are ≤ 22 for subjects > 9 years education and ≤ 21 for illiterate subjects and those with <9 years education.
【摘要】背景:老年痴呆患病率日益上升,已成为老年人群中需要早期诊断的公共卫生问题。MMSE是临床和研究领域中诊断和评估痴呆严重程度最常用的筛查方法;然而,不同教育水平的埃及人口的分界点并不清楚。目的:回顾在讲阿拉伯语的埃及老年人样本中调整学校教育的MMSE截止值。方法:对159名年龄≥60岁的社区居民进行研究,根据受教育程度对参与者进行定义后,根据DSM-IV痴呆标准确定分界点。结果:总体而言,MMSE诊断痴呆的截止评分为23分(敏感性为95%,特异性为73.83%)。受教育程度> 9年的受试者截断点≤22(灵敏度=94%,特异性=70.2%),受教育程度≤9年的受试者截断点≤21(灵敏度= 91%,特异性=33.3%)。结论:受教育程度和受教育程度较低的老年人现在都可以获得MMSE的新分界点。新的分数线为:教育程度> 9年的分数线为≤22分,文盲和教育程度<9年的分数线为≤21分。
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引用次数: 9
Non adherence to Antihypertensive medications among hypertensive elderly patients in outpatient geriatric clinic 老年门诊高血压患者抗高血压药物依从性不高
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30888
S. Hamza, R. E. Akkad, E. Abdelrahman, Sherief A. Abd elghany
AbstractBackground: Hypertension is an important public health challenge worldwide. Non-adherence to antihypertensive treatment is a big obstacle in blood pressure control and predispose to disease progression to complications.Aim: to determine adherence to antihypertensive medications among elderly patients, and to elicit factors associated with poor adherence among elderly hypertensive.Methods: A cross sectional study was done on 160 elderly hypertensive patients gathered from el Demerdash outpatient clinic, Ain Shams university hospital, Cairo, Egypt. The Hill bone scale was used to assess adherence to antihypertensive drugs.Results: According to Hill Bone Scale for assessment of adherence to anti-hypertensive medications the prevalence was 62.7% of the studied cases were non adherent to medications, while 37.3% were adherent to their antihypertensive medications.The findings of this study show that the significant factors that influence antihypertensive treatment adherence are sociodemographic factors such as Age marital status, education, income, occupation ,health-related factors, patients’ knowledge about hypertension and antihypertensive medication adherence.Conclusions: Advocacy of adherence to antihypertensive drugs should be inculcated in each and every hypertensive patient along with regular and uninterrupted drug supply and high quality health care service in all health care organizations where health education and counseling gets the highest priority
摘要背景:高血压是世界范围内重大的公共卫生挑战。不坚持抗高血压治疗是血压控制的一大障碍,容易导致疾病进展到并发症。目的:了解老年高血压患者抗高血压药物的依从性,并探讨老年高血压患者依从性差的相关因素。方法:对来自埃及开罗艾因沙姆斯大学医院el Demerdash门诊的160例老年高血压患者进行横断面研究。采用Hill骨量表评估抗高血压药物的依从性。结果:采用Hill Bone量表对降压药物依从性进行评估,62.7%的患者不坚持服药,37.3%的患者坚持服药。本研究结果显示,影响降压治疗依从性的显著因素是年龄、婚姻状况、受教育程度、收入、职业等社会人口因素、与健康相关的因素、患者的高血压知识和降压药物依从性。结论:各卫生保健机构应在每一位高血压患者中倡导坚持降压药物治疗,定期不间断地提供药物,提供优质的卫生保健服务,并将健康教育和咨询放在首位
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引用次数: 4
Sarcopenia and Risk of Falls in Patients with Chronic Kidney Disease, a Meet of Three Geriatric Giants 慢性肾脏疾病患者的肌肉减少症和跌倒的风险,三个老年巨人的会面
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30889
S. Aly, H. Tawfik, W. Bichari, M. El-Sadany, M. H. E. Banouby
AbstractBackground: Sarcopenia is devastating health problem in geriatric population in general and in patients with chronic kidney disease in particular.Aim: to assess the risk of falls in chronic kidney disease patients with sarcopenia.Methods: : A case control study was conducted, including 80 male and female elderly population aged 60 years old and above, at different stages of CKD including patients on hemodialysis, who were admitted to Ain Shams University Hospitals. They were divided into 41 cases and 39 controls according to the presence or absence of sarcopenia. History was taken, calf circumference was measured and blood sample was withdrawn for measuring creatinine level, parathyroid hormone and hemoglobin level. Risk of falls was assessed using gait speed and timed up and go test.Results: participants with sarcopenia had higher risk of falls, lower muscle mass, hand grip strength, gait speed and calf circumference. Calf circumference was associated with low gait speed, greater time in timed up and go test in chronic kidney disease participants with sarcopenia. Anemia was associated with low gait speed and hyperparathyroidism with higher score in timed up and go test.Conclusions: chronic kidney disease patients with sarcopenia have higher risk of falls. Calf circumference, anemia, and hyperparathyroidism are associated with higher risk of falls in these patients.
摘要背景:骨骼肌减少症是一种危害老年人健康的疾病,尤其是慢性肾脏疾病患者。目的:评估慢性肾脏病伴肌少症患者发生跌倒的风险。方法:对在艾因沙姆斯大学附属医院住院的60岁及以上不同阶段CKD患者,包括血液透析患者,男女80例进行病例对照研究。根据有无肌少症分为41例和39例对照。记录病史,测量小腿围,抽血测定肌酐水平、甲状旁腺激素水平和血红蛋白水平。通过步态速度和计时测试来评估跌倒的风险。结果:患有肌肉减少症的参与者摔倒的风险更高,肌肉质量、手握力、步态速度和小腿围都更低。在患有肌肉减少症的慢性肾脏病参与者中,小腿围与步态速度慢、时间较长有关。贫血与慢速步态和甲状旁腺功能亢进相关,且在计时起走测试中得分较高。结论:慢性肾病合并肌肉减少症患者有较高的跌倒风险。这些患者的小腿围、贫血和甲状旁腺功能亢进与较高的跌倒风险相关。
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引用次数: 3
Evaluation of MPI as a prognostic tool among the hospitalized elderly patients at Ain-Shams University hospital 在Ain-Shams大学医院住院老年患者中MPI作为预后工具的评价
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30887
M. Azzam, S. Ebeid, S. Said
AbstractBackground: There is a steady progression in the number of the elderly population, with increase burden of their own problems; one of these problems is hospitalization with its drawbacks. This emerge the importance of developing prognostic tools which predict the outcome of the hospitalized elderly patient, one of these tools is MPI.Aim: To investigate whether the MPI is an effective predictor of intra-hospital functional decline, longer length of hospital stay and intra-hospital mortality after admission to Ain shams university hospital medical wardsMethods: One hundred and sixty elderly were enrolled in the study, they were recruited from Ain Shams University Hospital, the following was done for them after taking consent, Comprehensive Geriatric Assessment, applying MPI toolResults: showed significant relationship between MPI with polypharmacy, cohabitational status, number of drugs, comprehensive geriatric tools, simple basic laboratory data including hemoglobin levels, hematocrit and sodium levels. Age , sex, and cause of admission was found to irrelevant to functional decline and length of hospital stay and multidimensional prognostic index score. Depression and cognitive impairment were closely associated with higher MPI scores, prolonged length of hospital stay and increased incidence of mortality and finally Multidimensional prognostic index was found to be highly related to the outcome of hospitalized elderly patients.Conclusions: Multidimensional prognostic index showed excellent specificity and sensitivity as a prognostic index among hospitalized elderly patients. So its study on larger size of participants is recommended
摘要背景:我国老年人口数量稳步增长,伴随着自身负担加重的问题;其中一个问题是住院治疗及其弊端。这表明开发预测住院老年患者预后的工具的重要性,这些工具之一是MPI。目的:探讨MPI是否能有效预测艾因沙姆斯大学医院病房入院后的院内功能下降、住院时间延长和院内死亡率。方法:从艾因沙姆斯大学医院招募160名老年人,在征得同意、综合老年病学评估、应用MPI工具后对他们进行以下研究。MPI与多种用药、同居状态、药物数量、综合老年医学工具、简单的基础实验室数据(血红蛋白水平、红细胞压积和钠水平)有显著相关。发现年龄、性别和入院原因与功能衰退、住院时间和多维预后指数评分无关。抑郁和认知功能障碍与MPI评分升高、住院时间延长和死亡率升高密切相关,多维预后指数与住院老年患者预后高度相关。结论:多维预后指标作为老年住院患者的预后指标具有良好的特异性和敏感性。因此建议其研究对象规模较大
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引用次数: 0
Prevalence of Sarcopenia among Hospitalized Elderly Patients 老年住院患者肌肉减少症的患病率
Pub Date : 2019-03-01 DOI: 10.21608/EJGG.2019.30890
Sanad T, Ali H, Alsadany A, El Banouby H
AbstractBackground: Sarcopenia is a common clinical condition among elderly population. Sarcopenia is characterized by progressive generalized loss of skeletal muscle mass and strength with an increased risk of adverse outcomes as physical disability, poor quality of life, and death.Aim: To evaluate prevalence of sarcopenia in hospitalized elderly patients.Methods: A cross sectional study, included 127 elderly participants, men and women, 60 years old and above, who were admitted to geriatric department in Ain Shams University Hospital (El-Demerdash). Sarcopenia was defined according to EWGSOP criteria (European Working Groups on Sarcopenia in Older People) as low skeletal mass with either low hand grip strength or slow gait speed. Muscle mass was measured by bioelectrical impedance analysis (BIA).Results: Sarcopenia was found in 31% of all the study participants. Prevalence of sarcopenia was 47% among men and 14% among women. Sarcopenic participants had more functional decline and poor nutritional status. Malnutrition was present in 80% of sarcopenic men and 77% of sarcopenic women. Sarcopenia was associated with an increased risk of fall that was 90% among men and 88.9% among women. Elderly with sarcopenia had lower serum total protein and albumin levels.Conclusions: Sarcopenia is highly prevalent among elderly Egyptian hospitalized patients. It is a hidden, although common, medical condition among elderly that can compromise their health, functional ability, and quality of life.
摘要背景:肌肉减少症是老年人常见的临床疾病。骨骼肌减少症的特征是骨骼肌质量和力量的进行性全身性丧失,伴有身体残疾、生活质量差和死亡等不良后果的风险增加。目的:了解老年住院患者肌肉减少症的患病率。方法:采用横断面研究方法,纳入艾因沙姆斯大学医院老年科收治的127例老年患者,男女均有,年龄60岁及以上。骨骼肌减少症根据EWGSOP标准(欧洲老年人骨骼肌减少症工作组)定义为低骨量,手部握力低或步态速度慢。采用生物电阻抗分析法(BIA)测定肌肉质量。结果:31%的研究参与者出现了肌肉减少症。肌肉减少症的患病率在男性中为47%,在女性中为14%。肌肉减少的参与者有更多的功能下降和营养状况不佳。80%的肌肉减少症男性和77%的肌肉减少症女性存在营养不良。肌肉减少症与跌倒风险增加有关,男性为90%,女性为88.9%。老年肌肉减少症患者血清总蛋白和白蛋白水平较低。结论:肌肉减少症在埃及老年住院患者中非常普遍。这是一种在老年人中常见的隐性疾病,会损害他们的健康、功能能力和生活质量。
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引用次数: 0
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The Egyptian Journal of Geriatrics and Gerontology
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