Therapeutic Advances in Gastrointestinal Endoscopy最新文献

Benign gastric outlet obstruction (bGOO) presents a significant therapeutic challenge, with etiologies ranging from peptic strictures to complex postsurgical or inflammatory conditions. While surgery has historically offered durable outcomes, its morbidity in frail populations underscores the need for effective, less invasive alternatives. This review critically examines the current literature up to April 2025 on surgical, endoscopic, and endoscopic ultrasound-guided interventions for bGOO, evaluating technical success, clinical outcomes, recurrence rates, and adverse events. Endoscopic balloon dilation shows excellent efficacy in simple peptic strictures but has limited efficacy in anatomically complex cases. Fully covered self-expandable metal stents can provide temporary relief but are associated with significant migration risk. Among emerging techniques, endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) stands out by combining the anatomical efficacy of surgery with the minimal invasiveness of endoscopy. Recent studies report technical and clinical success rates exceeding 95%, with lower recurrence and complication rates compared to traditional approaches. Comparative data increasingly support EUS-GJ as the preferred option in refractory or high-risk patients. Tailoring treatment strategies based on etiology, anatomical complexity, and patient condition is essential. EUS-GJ is redefining the therapeutic landscape of bGOO, offering a minimally invasive and durable alternative to surgery in carefully selected cases.

Gastrointestinal (GI) endoscopy and visceral surgery have been tightly merging to change GI disease diagnosis and the course of treatment. In addition to facilitating minimally invasive therapeutic procedures and improving postoperative outcomes, this synergistic strategy increases diagnostic precision. Recent technical advancements, such as high-definition endoscopic imaging, robotic-assisted surgery, and artificial intelligence integration, have refined patient care. The historical development, current therapeutic application, interdisciplinary collaborations, and potential future directions of integrating endoscopy and visceral surgery are covered in this review. It also discusses the difficulties in putting advanced approaches into clinical practice, including the need for specialized training and ethical issues. It is important to fully realize how endoscopic and surgical cooperation could translate into GI healthcare.

Background: Colorectal cancer (CRC) screening programmes commonly use the Faecal immunochemical test (FIT) followed by colonoscopy. When colonoscopy is not feasible, computed tomography colonography (CTC) serves as an alternative. However, CTC has limitations, such as lower sensitivity for smaller polyps and radiation exposure. Colon capsule endoscopy (CCE) is a non-invasive alternative that may improve polyp detection in FIT-positive individuals.

Objectives: To evaluate the feasibility of CCE in FIT-positive participants from the Dutch CRC screening programme who are unable or unwilling to undergo colonoscopy.

Design: Prospective multicentre, interventional study.

Methods: FIT-positive participants ingested the PillCam^® Colon 2 capsule. Colonoscopy was recommended if polyp(s) ⩾6 or suspected malignancy were detected. The primary outcome was the per-patient polyp detection rate (PDR) for polyps ⩾6 mm.

Results: Of 169 FIT-positive participants unable to undergo colonoscopy, 54.4% were ineligible for CCE due to contraindications. CCE was performed in 13 participants, with a completion rate of 69.2% and adequate bowel preparation in 38.5. A total of 54 polyps were detected, 46.3% of which were ⩾6 mm. The per-patient detection rate for polyps ⩾6 mm was 76.9%. In 84.6% of cases, follow-up colonoscopy was advised. CCE findings matched colonoscopy in 66.7% of cases; in the remaining 33.3%, polyps were found to be < 6 mm during colonoscopy. One participant was diagnosed with a pT4bN0M0 adenocarcinoma after CCE revealed a tumorous obstruction.

Conclusion: Despite a high per-patient PDR, this study indicates that CCE is less suitable for FIT-positive individuals unable or unwilling to undergo colonoscopy due to high comorbidity and frequent contraindications. Inadequate bowel preparation, likely due to reduced gastrointestinal motility, further limited feasibility. Given the elevated risk of advanced neoplasia in this population, many still required follow-up colonoscopy. Therefore, CCE may be better suited for lower-risk populations with fewer procedural limitations.

Trial registration: Overview of Medical Research in the Netherlands, NL-OMON55511.

The diagnostic procedure of gastrointestinal endoscopy serves essential functions in handling gastrointestinal disorders. Classic endoscopic approaches encounter multiple problems because they depend on human operators and yield ambiguous results during lesion detection. The development of artificial intelligence systems has risen as an efficient technology to enhance diagnosis precision and procedural efficiency during endoscopic procedures. The objective of this review is to assess how artificial intelligence (AI) technology influences gastrointestinal (GI) endoscopic procedures for both lesion identification and classification, and malignant polyp identification, as well as clinical intervention operations. The research investigates obstacles that exist alongside AI implementation problems in clinical gastroenterological practices and determines forthcoming guidelines. A thorough literature survey was conducted through accessing databases, including PubMed alongside Scopus as well as ScienceDirect, Elsevier, and Springer. Studies after 2019 were evaluated for the AI performance in GI endoscopic examination. The use of AI in endoscopic visual examinations boosts both the diagnostic accuracy of esophagogastroduodenoscopy and colonoscopy lesions and exceeds traditional analysis methods. AI technology enhances predictions of malignant polyp status, which helps doctors make treatment decisions while lowering the number of unnecessary biopsies. Several obstacles, including technical boundaries and biased data, and regulatory obstacles, together with clinical implementation obstacles, still continue to exist. The advancement of artificial intelligence through GI endoscopy has led to an improvement of diagnostic outcomes and treatment efficiency alongside better clinical choice capabilities. AI will implement its complete role in routine clinical practice, but needs research about current challenges and regulatory adjustments, and technological improvements to boost patient outcomes.

Background: Malignant bowel obstruction (MBO) is a frequent and debilitating complication in advanced abdominal cancers, particularly ovarian, colorectal, and gastric malignancies associated with peritoneal carcinomatosis. Surgery is often not feasible, and conventional decompression carries substantial morbidity. Endoscopic ultrasound-guided enterocolostomy (EUS-EC) with lumen-apposing metal stents (LAMS) has emerged as a minimally invasive alternative, but the evidence remains limited.

Objectives: To systematically evaluate the feasibility, safety, and clinical outcomes of EUS-EC with LAMS for the palliation of MBO.

Design: Systematic review and meta-analysis.

Methods: A comprehensive literature search was performed across PubMed, Embase, Cochrane Library, and Web of Science from database inception through August 2025. Studies were eligible for inclusion if they involved patients with MBO undergoing EUS-EC using LAMS. Statistical analysis was performed using a random-effects model with Hartung-Knapp adjustments. Primary outcomes were technical success (defined as successful stent deployment) and clinical success (defined as relief of obstruction and restoration of bowel function).

Results: Twenty-three studies (78 patients) were included. Pooled technical and clinical success rates were 96.1% and 88.4%, respectively. The mean hospital stay was 10.6 days, and oral intake resumed after a mean of 3.1 days. Mean post-procedure survival was 91 days, consistent with the advanced disease stage of most included patients. Adverse events were uncommon: diarrhea (6.4%), perforation (3.8%), bleeding (2.5%), and aspiration (1.2%). Stent misdeployment occurred in one cohort (26.6%), but all cases were managed endoscopically without major sequelae. Among 33 deaths reported, most (78.8%) were due to disease progression, with only 6.1% procedure-related.

Conclusion: EUS-EC with LAMS demonstrates high technical and clinical success, rapid symptom relief, and low procedure-related morbidity, supporting its potential as an emerging palliative option for carefully selected patients with MBO. Evidence remains limited to small retrospective cohorts and case reports, highlighting the need for prospective comparative trials with patient-centered outcomes.

Background: Insulinomas are the most common functional pancreatic neuroendocrine tumors (pNETs). Minimally invasive approaches like endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and ethanol ablation (EUS-EA) are emerging treatment options for small insulinomas (<2 cm).

Objectives: To assess the safety, efficacy, and long-term outcomes of EUS-RFA and EUS-EA in treating small pancreatic insulinomas.

Design: A retrospective, single-center study of nine patients diagnosed with insulinomas and treated with EUS ablation methods.

Methods: Nine lesions (mean size 11 mm; range: 6-19 mm) were treated with EUS-RFA (n = 7) or EUS-EA (n = 2). EUS-RFA procedures had a mean ablation time of 31 s (range: 17-69 s), while EUS-EA used a mean ethanol volume of 1.4 ml and 0.5 ml for respective patients. All patients were followed up radiologically with CT and/or EUS for a median of 25 months (range: 6-46 months).

Results: All patients had immediate hypoglycemia relief after a single treatment. The median clinical follow-up was 40 months (range: 22-60 months), with all patients remaining asymptomatic. Complete radiologic regression was observed in six patients. Two patients had minor adverse events; no severe complications occurred.

Conclusion: EUS-guided ablation (RFA or EA) is a safe and effective treatment for small pancreatic insulinomas, providing symptom relief and radiologic regression. Further studies are needed to evaluate long-term efficacy and recurrence rates.

Background and aims: Endoscopic assessment of the regular arrangement of collecting venules (RAC) is a simple and reliable tool for predicting the absence of Helicobacter pylori (H. pylori) infection in the stomach, particularly in Asian populations. While initial studies in Western countries have yielded similar findings, RAC assessment has not yet been widely adopted in these settings. This study aims to evaluate the diagnostic accuracy of RAC in determining H. pylori status in a non-Asian population.

Methods: This prospective, multicenter study was conducted in 12 hospitals across non-Asian countries. Patients with no history of H. pylori infection or eradication were included, regardless of proton pump inhibitor (PPI) use. All participants underwent high-definition upper endoscopy without magnification or virtual chromoendoscopy. Endoscopists were trained using a 20-image test to identify the RAC pattern. H. pylori status was determined by histology and/or immunohistochemistry.

Results: A total of 648 patients were included, with an H. pylori infection prevalence of 34.7%. The RAC+ pattern was observed in 31.5% of patients, with no significant differences between those receiving PPI treatment and those who were not (p = 0.55). Absence of pathological endoscopic findings was significantly associated with a RAC+ pattern (p = 0.01). The sensitivity and negative predictive value (NPV) of RAC+ for ruling out H. pylori infection were 0.97 (95% CI: 0.94-0.99), reaching 1.00 when discordant images were reviewed by a blinded expert endoscopist. No significant differences in sensitivity or NPV were found between PPI users and non-users, or between regions with high and low H. pylori prevalence.

Conclusion: The presence of the RAC pattern along the minor gastric curvature, as assessed with white-light endoscopy, accurately identifies patients without H. pylori infection in non-Asian countries, regardless of PPI use.

Background: Primary small intestinal lymphoma (PSIL) is a rare malignancy with heterogeneous clinical and pathological features, making accurate diagnosis challenging.

Objectives: To investigate the clinical value of double-balloon enteroscopy (DBE) combined with endoscopic ultrasonography (EUS) in the diagnosis of small intestinal lymphoma.

Design: Retrospective cohort study.

Methods: We retrospectively reviewed 21 patients with pathologically confirmed PSIL who underwent both DBE and EUS at the Department of Small Intestinal Endoscopy, The Sixth Affiliated Hospital of Sun Yat-sen University, between September 2022 and May 2025. Clinical data were collected and analyzed in combination with pathological findings.

Results: A total of 21 patients were included (12 males, 9 females; median age of 52 years, range 31-87 years. Subtypes of B-cell lymphomas included diffuse large B-cell lymphoma (n = 5), follicular lymphoma (n = 3), and mucosa-associated lymphoid tissue lymphoma (n = 6). T-cell lymphomas included peripheral T-cell lymphoma (n = 7). Endoscopic findings were classified into five categories (1): hypertrophic type (2), exophytic tumor type (3), follicular/polypoid type (4), ulcerative type, and (5) diffusion type. EUS classification included superficial spreading (38.1%, 8/21), diffuse infiltrative (42.9%, 9/21), and nodular (19.0%, 4/21).

Conclusion: DBE combined with EUS provides complementary morphological and structural information for the diagnosis of PSIL, improving clinical recognition and subtype characterization. Future multicenter studies with larger cohorts are warranted to validate these findings and establish standardized diagnostic protocols.