Pub Date : 2022-12-29DOI: 10.4274/tji.galenos.2022.70298
Demet GÜR VURAL, Büşra Usta, Muhammet Samet Emre Daştan, Y. Tanrıverdi Çaycı, K. Bilgin, H. Bilek, A. Birinci
Objective: Coronavirus disease-2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome-coronavirus-2 continues across the world. Some patients with COVID-19 develop cytokine storm secondary to virally driven hyper-inflammation. This study aimed to assess the relationship of interleukin-6 (IL-6), procalsitonin (PCT) and C-reactive protein (CRP) levels with the severity of the disease in patients with COVID-19. Materials and Methods: This retrospective study included 63 patients diagnosed with COVID-19 from January 2020 to March 2021. Data on demographic characteristics and clinical characteristics with the levels of IL-6, CRP, and PCT on admission were collected. ROC analysis was performed to determine whether interleukin-6 had a diagnostic value in predicting mortality. IL-6, CRP and procalcitonin values were evaluated by the Spearman correlation analysis. Results: In the ROC analysis performed in terms of predicting mortality, it was observed that IL-6 level predicted mortality at a statistically significant level (area under the curve: 0.708, p=0.004, 95% confidence interval: 0.583-0.833). A value of >358.3 pg/mL for IL-6 showed prognostic significance on mortality. In the Spearman correlation analysis performed between IL-6, CRP and procalcitonin values, a positive correlation was observed between CRP and procalcitonin (r=0.474, p=0.001). Conclusion: The serum levels of IL-6 and CRP can effectively assess disease severity in patients with COVID-19. (English) [ FROM AUTHOR]
{"title":"Evaluation of the Effects of Interleukin-6, C-reactive Protein and Procalcitonin on the Prognosis of the Disease in Patients with COVID-19","authors":"Demet GÜR VURAL, Büşra Usta, Muhammet Samet Emre Daştan, Y. Tanrıverdi Çaycı, K. Bilgin, H. Bilek, A. Birinci","doi":"10.4274/tji.galenos.2022.70298","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.70298","url":null,"abstract":"Objective: Coronavirus disease-2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome-coronavirus-2 continues across the world. Some patients with COVID-19 develop cytokine storm secondary to virally driven hyper-inflammation. This study aimed to assess the relationship of interleukin-6 (IL-6), procalsitonin (PCT) and C-reactive protein (CRP) levels with the severity of the disease in patients with COVID-19. Materials and Methods: This retrospective study included 63 patients diagnosed with COVID-19 from January 2020 to March 2021. Data on demographic characteristics and clinical characteristics with the levels of IL-6, CRP, and PCT on admission were collected. ROC analysis was performed to determine whether interleukin-6 had a diagnostic value in predicting mortality. IL-6, CRP and procalcitonin values were evaluated by the Spearman correlation analysis. Results: In the ROC analysis performed in terms of predicting mortality, it was observed that IL-6 level predicted mortality at a statistically significant level (area under the curve: 0.708, p=0.004, 95% confidence interval: 0.583-0.833). A value of >358.3 pg/mL for IL-6 showed prognostic significance on mortality. In the Spearman correlation analysis performed between IL-6, CRP and procalcitonin values, a positive correlation was observed between CRP and procalcitonin (r=0.474, p=0.001). Conclusion: The serum levels of IL-6 and CRP can effectively assess disease severity in patients with COVID-19. (English) [ FROM AUTHOR]","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82537283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-29DOI: 10.4274/tji.galenos.2022.55264
S. Khatib
The basic concept of vaccination has been based on engendering an adaptive immune response armed with effective immune cells, memory cells, and cytokines. These elements cooperate to mount either a humoral or a cell-mediated response. Coronavirus disease-2019 vaccines, although diversified, adapted the same objective with the previous vaccines prepared since Edward Jenner's work. The spike surface protein (S) and the receptor binding domain constituted the main antigenic determinants for which the binding antibodies as well as the neutralizing antibodies were secreted. The unprecedented use of mRNA vaccines represented an unmatched breakthrough, which paved the road for a new era of vaccine generation. They showed a substantial ability to elicit antibody secretion with a moderate helper T cell response just after inoculation of the first dose. Besides, the adenoviruses-shuttled vaccines were able to engender a spectrum of polyclonal antibodies including neutralizing antibodies apt to drive a multitude of antibodies-mediated functions and activate T cell immune responses. In either case, the antibody titers as well as lymphocytes-mediated responses were significantly intensified. Deciphering the mechanisms of immune response activation by the inoculated vaccines in addition to the elaboration of innate elements involvement should open the door for a better decryption of the induced immune protection and pave the road for the formulation of a more effective vaccine that surmounts the incessant mutational variation of the viral antigenic attributes. (English) [ FROM AUTHOR]
{"title":"The Rationale Behind the Effectiveness of COVID-19 Vaccines and Associated Immunological Mechanisms","authors":"S. Khatib","doi":"10.4274/tji.galenos.2022.55264","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.55264","url":null,"abstract":"The basic concept of vaccination has been based on engendering an adaptive immune response armed with effective immune cells, memory cells, and cytokines. These elements cooperate to mount either a humoral or a cell-mediated response. Coronavirus disease-2019 vaccines, although diversified, adapted the same objective with the previous vaccines prepared since Edward Jenner's work. The spike surface protein (S) and the receptor binding domain constituted the main antigenic determinants for which the binding antibodies as well as the neutralizing antibodies were secreted. The unprecedented use of mRNA vaccines represented an unmatched breakthrough, which paved the road for a new era of vaccine generation. They showed a substantial ability to elicit antibody secretion with a moderate helper T cell response just after inoculation of the first dose. Besides, the adenoviruses-shuttled vaccines were able to engender a spectrum of polyclonal antibodies including neutralizing antibodies apt to drive a multitude of antibodies-mediated functions and activate T cell immune responses. In either case, the antibody titers as well as lymphocytes-mediated responses were significantly intensified. Deciphering the mechanisms of immune response activation by the inoculated vaccines in addition to the elaboration of innate elements involvement should open the door for a better decryption of the induced immune protection and pave the road for the formulation of a more effective vaccine that surmounts the incessant mutational variation of the viral antigenic attributes. (English) [ FROM AUTHOR]","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84609851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-29DOI: 10.4274/tji.galenos.2022.25238
M. Bilgin, Eşe Başbulut, H. S. Baklacioglu, Adem Keskin, Recai Aci
Objective: The effect of severe acute respiratory syndrome-coronavirus-2 (SARS‑CoV‑2) infection on autoimmunity in both disease and post-disease stages has not been fully explained. There is not enough information about the evaluation of autoimmune antibodies in convalescent SARS-CoV-2 patients. This study aimed to investigate the presence and types of autoantibodies in post-illness coronavirus disease-2019 (COVID-19) patients and to compare them with indirect immunofluorescence assay (IIF)-antinuclear antibody (ANA) results before SARS-CoV-2 infection. Materials and Methods: Twenty-four COVID-19 patients with known and reported ANA test results prior to SARS-CoV-2 infection were included in this study. Patients' IIF-ANA, extractable nuclear antigen blot and anti-dsDNA tests were studied three and nine months after SARS-CoV-2 infection. Results: Three months after SARS-CoV-2 infection, 41.66% of patients had a positive IIF-ANA test. When we compared these results with pre-infection ANA results, 3 patients (12.5%) were variable. The first case was chromosomal granular positive before infection and was found to be homogeneous, and cytoplasm was speckled positive after infection. Additionally, Scl-70, DFS70, and anti-dsDNA were found to be positive. We think that lupus symptoms were triggered after COVID-19. The second case had negative ANA before infection, while the ANA was antinuclear membrane positive (2+) three months after infection. Also, anti-RNP/Sm was detected as positive. The third case had negative ANA before infection, and was detected to have speckled weakly positive ANA three months after infection. However, autoantibody positivity was not detected. Conclusion: As a result, these data support the idea that SARS-CoV-2 infection may trigger autoimmunity and be associated with the development of autoantibodies. (English) [ FROM AUTHOR]
{"title":"Could SARS-CoV-2 Trigger the Formation of Antinuclear Antibodies?","authors":"M. Bilgin, Eşe Başbulut, H. S. Baklacioglu, Adem Keskin, Recai Aci","doi":"10.4274/tji.galenos.2022.25238","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.25238","url":null,"abstract":"Objective: The effect of severe acute respiratory syndrome-coronavirus-2 (SARS‑CoV‑2) infection on autoimmunity in both disease and post-disease stages has not been fully explained. There is not enough information about the evaluation of autoimmune antibodies in convalescent SARS-CoV-2 patients. This study aimed to investigate the presence and types of autoantibodies in post-illness coronavirus disease-2019 (COVID-19) patients and to compare them with indirect immunofluorescence assay (IIF)-antinuclear antibody (ANA) results before SARS-CoV-2 infection. Materials and Methods: Twenty-four COVID-19 patients with known and reported ANA test results prior to SARS-CoV-2 infection were included in this study. Patients' IIF-ANA, extractable nuclear antigen blot and anti-dsDNA tests were studied three and nine months after SARS-CoV-2 infection. Results: Three months after SARS-CoV-2 infection, 41.66% of patients had a positive IIF-ANA test. When we compared these results with pre-infection ANA results, 3 patients (12.5%) were variable. The first case was chromosomal granular positive before infection and was found to be homogeneous, and cytoplasm was speckled positive after infection. Additionally, Scl-70, DFS70, and anti-dsDNA were found to be positive. We think that lupus symptoms were triggered after COVID-19. The second case had negative ANA before infection, while the ANA was antinuclear membrane positive (2+) three months after infection. Also, anti-RNP/Sm was detected as positive. The third case had negative ANA before infection, and was detected to have speckled weakly positive ANA three months after infection. However, autoantibody positivity was not detected. Conclusion: As a result, these data support the idea that SARS-CoV-2 infection may trigger autoimmunity and be associated with the development of autoantibodies. (English) [ FROM AUTHOR]","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80120029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.18209
B. Aru, Gizem Gürel, G. Yanikkaya Demirel
{"title":"Mesenchymal Stem Cells: History, Characteristics and an Overview of Their Therapeutic Administration","authors":"B. Aru, Gizem Gürel, G. Yanikkaya Demirel","doi":"10.4274/tji.galenos.2022.18209","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.18209","url":null,"abstract":"","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72538856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.26349
Abubaker H. Ali, A. Zidan
Objective: Coronavirus disease-2019 (COVID-19) is a potentially fatal respiratory disease caused by SARS-CoV-2, which has occurred in a human pandemic. This study aims to assess the responses of IgM and IgG antibodies to the virus after 7-14 days following the onset of illness. Materials and Methods: A total of 95 cases, including 67 patients with COVID-19 (24 male and 43 female) and 28 healthy individuals without COVID-19 as the control group (7 male and 21 female), were selected in the present study. IgM and IgG antibodies for COVID-19 were evaluated using rapid chromatographic immunoassay (RCI). Results: RCI demonstrated that IgM antibody was found as positive in 67 patients (100%) after 7-14 days, whereas IgG antibody was found as positive in 56 patients (83.6%) after 7 days and 67 patients (100%) were positive after 14 days. Conclusion: According to the obtained results, RCI for IgM and IgG antibodies can be used to make a quick and accurate diagnosis of COVID-19 infections (English) [ FROM AUTHOR] Amaç: Koronavirüs hastalığı-2019 (COVID-19), bir insan pandemisi olarak ortaya çıkan, SARS-CoV-2 tarafından bulaşan, potansiyel olarak ölümcül bir solunum yolu hastalığıdır. Bu çalışma, hastalığın başlangıcından 7-14 gün sonra IgM ve IgG antikorlarının virüse karşı oluşan antikorları saptamayı amaçlamaktadır. Gereç ve Yöntem: Bu çalışmada COVID-19'lu 67 hasta (24 erkek ve 43 kadın) ve COVID-19'suz 28 sağlıklı birey (7 erkek ve 21 kadın) içeren kontrol grubu olarak olmak üzere toplam 95 olgu irdelendi. COVID-19 için IgM ve IgG antikorları, hızlı kromatografik immünoassay test (RCI) kullanılarak değerlendirildi. Bulgular: RCI ile 7-14 gün sonra 67 hastada (%100) IgM antikoru pozitif, 7 gün sonra 56 hastada (%83.6), 14 gün sonra 67 hastada (%100) IgG antikor pozitifliği saptandı. Sonuç: Elde edilen sonuçlara göre, RCI, IgM ve IgG antikorlarını değerlendirerek, COVID-19 enfeksiyonun hızlı ve doğru teşhisini sağlamak için kullanılabilir (Turkish) [ FROM AUTHOR] Copyright of Turkish Journal of Immunology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
目的:冠状病毒病-2019 (COVID-19)是由SARS-CoV-2引起的一种可能致命的呼吸道疾病，已在人类大流行中发生。本研究旨在评估发病后7-14天IgM和IgG抗体对病毒的反应。材料与方法:本研究共95例，其中新冠肺炎患者67例(男24例，女43例)，未感染新冠肺炎的健康人28例(男7例，女21例)作为对照组。采用快速免疫层析法(RCI)检测COVID-19的IgM和IgG抗体。结果:RCI显示，7 ~ 14 d后IgM抗体阳性67例(100%)，7 d后IgG抗体阳性56例(83.6%)，14 d后阳性67例(100%)。结论:根据所得结果，IgM和IgG抗体的RCI可用于快速准确诊断COVID-19感染(英文)[FROM AUTHOR] Amaç: koronavir hastalığı-2019 (COVID-19)， bir insan pandemisi olarak ortaya çıkan, SARS-CoV-2 tarafından bula an, potansiyel olarak ölümcül bir solunum yolu hastalığıdır。Bu çalışma, hastalığın başlangıcından 7-14 g n sonra IgM ve IgG antikorlarının vir se kar olu an antikorlarka saptamayyi amaçlamaktadır。Gereç ve Yöntem: Bu çalışmada COVID-19' lu67 hasta (24 erkek ve 43 kadın) ve COVID-19'suz 28 sağlıklı birey (7 erkek ve 21 kadın) 控制组olarak olmak zere toplam 95 olgu irdelendi。COVID-19 - IgM - ve - IgG antikorlari, hızlı kromatografik免疫检测(RCI) kullanılarak değerlendirildi。结果:RCI 7-14 g n sonra 67 hasada (%100) IgM antikoru pozitif, 7 g n sonra 56 hasada (%83.6)， 14 g n sonra 67 hasada (%100) IgG antikor pozitifliği saptandir。Sonuç: Elde edilen sonulara göre, RCI, IgM ve IgG antikorlarını değerlendirerek, COVID-19 enfeksiyonun hızlı ve doğru tehisini sağlamak iin kullanılabilir(土耳其语)[来自作者]版权归土耳其免疫学杂志所有，属于Galenos Yayinevi Tic。有限公司未经版权所有者的明确书面许可，STI及其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有人。)
{"title":"Detection of Antibodies in Patients with COVID-19 by Rapid Chromatographic Immunoassay","authors":"Abubaker H. Ali, A. Zidan","doi":"10.4274/tji.galenos.2022.26349","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.26349","url":null,"abstract":"Objective: Coronavirus disease-2019 (COVID-19) is a potentially fatal respiratory disease caused by SARS-CoV-2, which has occurred in a human pandemic. This study aims to assess the responses of IgM and IgG antibodies to the virus after 7-14 days following the onset of illness. Materials and Methods: A total of 95 cases, including 67 patients with COVID-19 (24 male and 43 female) and 28 healthy individuals without COVID-19 as the control group (7 male and 21 female), were selected in the present study. IgM and IgG antibodies for COVID-19 were evaluated using rapid chromatographic immunoassay (RCI). Results: RCI demonstrated that IgM antibody was found as positive in 67 patients (100%) after 7-14 days, whereas IgG antibody was found as positive in 56 patients (83.6%) after 7 days and 67 patients (100%) were positive after 14 days. Conclusion: According to the obtained results, RCI for IgM and IgG antibodies can be used to make a quick and accurate diagnosis of COVID-19 infections (English) [ FROM AUTHOR] Amaç: Koronavirüs hastalığı-2019 (COVID-19), bir insan pandemisi olarak ortaya çıkan, SARS-CoV-2 tarafından bulaşan, potansiyel olarak ölümcül bir solunum yolu hastalığıdır. Bu çalışma, hastalığın başlangıcından 7-14 gün sonra IgM ve IgG antikorlarının virüse karşı oluşan antikorları saptamayı amaçlamaktadır. Gereç ve Yöntem: Bu çalışmada COVID-19'lu 67 hasta (24 erkek ve 43 kadın) ve COVID-19'suz 28 sağlıklı birey (7 erkek ve 21 kadın) içeren kontrol grubu olarak olmak üzere toplam 95 olgu irdelendi. COVID-19 için IgM ve IgG antikorları, hızlı kromatografik immünoassay test (RCI) kullanılarak değerlendirildi. Bulgular: RCI ile 7-14 gün sonra 67 hastada (%100) IgM antikoru pozitif, 7 gün sonra 56 hastada (%83.6), 14 gün sonra 67 hastada (%100) IgG antikor pozitifliği saptandı. Sonuç: Elde edilen sonuçlara göre, RCI, IgM ve IgG antikorlarını değerlendirerek, COVID-19 enfeksiyonun hızlı ve doğru teşhisini sağlamak için kullanılabilir (Turkish) [ FROM AUTHOR] Copyright of Turkish Journal of Immunology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78245032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.03522
M. Mosadegh, A. Khalkhali, Yasaman Sadeghi, Y. Erfani
{"title":"The Anti-Inflammatory Effects of the Nutrition Bio-Shield (NBS) Supplement Intake on Adjuvant-Induced Rheumatoid Arthritis in Rat","authors":"M. Mosadegh, A. Khalkhali, Yasaman Sadeghi, Y. Erfani","doi":"10.4274/tji.galenos.2022.03522","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.03522","url":null,"abstract":"","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72393851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.08370
Rowen Govender, N. Govender, T. Naicker
{"title":"Does Complement Factor I Correlate with Complement Component 4b in HIV Infected Patients with Preeclampsia?","authors":"Rowen Govender, N. Govender, T. Naicker","doi":"10.4274/tji.galenos.2022.08370","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.08370","url":null,"abstract":"","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75046913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.04796
Nurten Sayın Ekinci, Ş. Darbaş, F. Uçar
{"title":"CXCR5+CD8+ Follicular Cytotoxic T Cell Biology and Its Relationship with Diseases","authors":"Nurten Sayın Ekinci, Ş. Darbaş, F. Uçar","doi":"10.4274/tji.galenos.2022.04796","DOIUrl":"https://doi.org/10.4274/tji.galenos.2022.04796","url":null,"abstract":"","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89971969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.80774
A. Şahin, S. Korkunç, Fatıma Hacer Kurtoğlu, Hilal Taskiran, Betigul Ekmekci, Huseyn Babayev, A. Ekmekci
The severe acute respiratory syndrome coronavirus-2, a coronavirus, is known to cause acute respiratory distress syndrome and a range of non)respiratory effects, particularly in elderly male patients with underlying health conditions such overweight, diabetes, and hypertension. The coronavirus disease-2019 sequelae include multiple organ failure and neurological issues, and these prior health issues are linked to endothelial dysfunction. Although inhalation is the most frequent mode of infection, this virus has also been discovered in neurons, cerebrospinal fluid, the choroid plexus, and meningeal vasculature (English) [ FROM AUTHOR] Bir koronavirüs olan şiddetli akut solunum yolu sendromu koronavirüsü-2’nin, özellikle obezite, diyabet ve hipertansiyon gibi sağlık sorunları olan yaşlı erkek hastalarda akut solunum sıkıntısı sendromuna ve bir dizi solunum dışı sekellere neden olduğu bilinmektedir. Bu sağlık sorunları endotel disfonksiyonla bağlantılıdır ve koronavirüs hastalığı-2019 sekelleri, çoklu organ yetmezliği ve nörolojik sorunları içerir. Solunum birincil enfeksiyon modu olsa da, bu virüs koroid pleksus ve meningeal arterlerin yanı sıra nöronlar ve beyin omurilik sıvısı dahil olmak üzere çeşitli organlarda keşfedilmiştir (Turkish) [ FROM AUTHOR] Copyright of Turkish Journal of Immunology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Pub Date : 2022-08-16DOI: 10.4274/tji.galenos.2022.63935
J. Shah, A. Ammar, Waqar Khan, Rajesh Kumar, F. Ali, Shahid Ahmed, Mehwish Zehra, J. Sial, T. Saghir, Z. Rehman
Objective: This study aimed to assess the changes in the perceptions and practices during the coronavirus disease-2019 (COVID-19) era before and after vaccination and antibodies titer among the healthcare workers (HCWs) at a tertiary care cardiac center. Materials and Methods: This descriptive study included HCWs working at a tertiary care cardiac center in Karachi, Pakistan. A predefined structured questionnaire was used to assess the sense of security, practice, and perception of the HCWs before vaccination, after vaccination, and after knowing the antibodies titer. Results: Out of 151 HCWs, 70.2% (106) were male, and a majority, 65.6% (99), were ≤35 years old with an overall mean age of 34.92 ± 7.64 years. Nearly half of the individuals, (n=74;49%), were doctors, 10 individuals (6.6%) were non-clinical staff, and reaming were nursing staff. The mean day since COVID-19 vaccination was 89.6 ± 40.07 before COVID-19 infection. Antibodies titer levels were >250 U/mL in 108 cases (71.5%) and ≤100 U/mL in 18 cases (11.8%). A significant increase in perception score was observed after serology with a mean of 61.04 ± 25.23 vs 53.86 ± 28.96;(p=0.008) compared to the post-vaccination perception score. A significant declining trend has been witnessed in mean practice scores, with a pre-vaccination mean of 69.93 ± 27.12, post-vaccination mean of 59.47 ± 30.61 (p<0.001). And post-serology mean of 55.1 ± 27.1 (p<0.001). Conclusion: An increase in the sense of security and leniency in adherence to personal protective measures has been observed among HCWs after vaccination and after knowing the antibodies titer (English) [ FROM AUTHOR] Amaç: Bu çalışmada, üçüncü basamak bir kalp merkezindeki sağlık çalışanları arasında koronavirüs hastalığı-2019 (COVID-19) döneminde aşılama öncesi ve sonrası algı ve uygulamalardaki değişikliklerinin ve antikor titrelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Bu tanımlayıcı çalışma, Pakistan, Karaçi’deki üçüncü basamak bir kalp merkezindeki sağlık çalışanlarını içermektedir. Sağlık çalışanlarının aşılamadan önce, aşılamadan sonra ve antikor titresini öğrendikten sonra güvenlik hissi, uygulama ve algılarını değerlendirmek için önceden tanımlanmış yapılandırılmış bir anket kullanılmıştır. Bulgular: Yüz elli bir sağlık çalışanının %70.2 (n=106) erkek ve katılımcıların çoğunluğu, %65.6 (n=99) 35 yaşında ya da daha geç yaştaydı ve ortalama yaş 34.92 ± 7.64 yıl olarak saptandı. Neredeyse yarısı, (n=74;%49) hekim ve %6.6 (n=10) klinik dışı personel, geri kalan kişiler hasta bakım personeli görevindeydi. Önceki COVID-19 enfeksiyonu, doğası gereği 10 kişide (%6.6) ciddi, 1 kişide (%0.7) kritik olmak üzere 62 kişide (%41.1) rapor edilmiştir. COVID-19 aşılamasından bu yana geçen ortalama gün sayısı 89.6 ± 40.07 ve 11 kişide (%7.3) aşılama sonrası COVID-19 bildirildi. Antikor titre seviyeleri 108 kişide (%71.5) >250 U/mL ve 18 kişide ise (%11.9) ≤100 U/mL ve altında saptandı. Aşılama sonrası algı puanı ile karşılaştırıldığınd
目的:了解某三级保健心脏中心医护人员在2019冠状病毒病(COVID-19)疫苗接种前后认知和做法的变化及抗体滴度。材料和方法:本描述性研究包括在巴基斯坦卡拉奇一家三级保健心脏中心工作的医护人员。在接种疫苗前、接种疫苗后和知道抗体滴度后，使用预先定义的结构化问卷来评估卫生保健员的安全感、实践和感知。结果:151例HCWs中，男性占70.2%(106例)，年龄≤35岁占65.6%(99例)，总体平均年龄34.92±7.64岁。近一半(74人，49%)为医生，10人(6.6%)为非临床工作人员，8人为护理人员。感染前接种新冠肺炎疫苗的平均时间为89.6±40.07天。抗体滴度>250 U/mL的108例(71.5%)，≤100 U/mL的18例(11.8%)。与接种疫苗后的感知评分相比，血清学后的感知评分显著增加，平均为61.04±25.23 vs 53.86±28.96 (p=0.008)。平均练习分数呈明显下降趋势，接种前平均值为69.93±27.12，接种后平均值为59.47±30.61 (p250 U/mL / 18 ki(%11.9)≤100 U/mL / altında saptandir)。Aşılama sonrasyalgypuanyile karşılaştırıldığında algyskorunda seroloji sonasyortalama 61.04±25.23 ile 53.86±28.96 arasında anlamlybir artış gözlendi (p=0.008)。Aşılama öncesi ortalama 69.93±27.12,aşılama sonrasyi ortalama 59.47±30.61 (p<0.001) ve seroloji sonrasyi 55.1±27.1 olmak zere (p<0.001) olan ortalama uygulama puanlarında önemli bir d eğilimi görülmüştür(土耳其语)[来自作者]版权属于土耳其免疫学杂志Galenos Yayinevi Tic。有限公司未经版权所有者的明确书面许可，STI及其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有人。)
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