Dr. Sharon Straus is the Division Director of Geriatric Medicine at the University of Toronto and practices geriatric and general internal medicine at St. Michael's Hospital. She is the Director of the Knowledge Translation Program at the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. Her research interests include knowledge translation, quality of care, mentorship, and education, often with an evidence-based medicine approach. She has co-authored several books about the practice of evidence-based medicine in various clinical settings.
{"title":"Geriatrics: An Interview with Dr. Sharon Straus","authors":"Judith Seary","doi":"10.5015/UTMJ.V88I1.1297","DOIUrl":"https://doi.org/10.5015/UTMJ.V88I1.1297","url":null,"abstract":"Dr. Sharon Straus is the Division Director of Geriatric Medicine at the University of Toronto and practices geriatric and general internal medicine at St. Michael's Hospital. She is the Director of the Knowledge Translation Program at the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. Her research interests include knowledge translation, quality of care, mentorship, and education, often with an evidence-based medicine approach. She has co-authored several books about the practice of evidence-based medicine in various clinical settings.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74024436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Debate about the moral status of assisted suicide may inform debate about the act’s legal status. Therefore, the purpose of this paper is raise questions about the moral status of assisted suicide by comparing the views of Richard Doerflinger with those of Tom Beauchamp and James Childress.
{"title":"Assisted Suicide: To the Heart of the Matter","authors":"D. Pincus","doi":"10.5015/UTMJ.V88I1.1299","DOIUrl":"https://doi.org/10.5015/UTMJ.V88I1.1299","url":null,"abstract":"Debate about the moral status of assisted suicide may inform debate about the act’s legal status. Therefore, the purpose of this paper is raise questions about the moral status of assisted suicide by comparing the views of Richard Doerflinger with those of Tom Beauchamp and James Childress.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72742091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Tak W. Mak is Director of the Campbell Family Institute for Breast Cancer Research, Director of the Advanced Medical Discovery Institute, and Senior Scientist in the Division of Stem Cell and Developmental Biology. In 1984 he gained international notoriety for cloning the T-cell receptor, and he remains one of Canada’s most highly-cited scientists. His laboratory continues to study the mechanisms of the immune response and tumorigenesis, often with the use of genetically engineered mouse strains.
Tak W. Mak博士是Campbell Family Institute for Breast Cancer Research的主任，Advanced Medical Discovery Institute的主任，以及干细胞和发育生物学部门的高级科学家。1984年，他因克隆t细胞受体而在国际上声名狼藉，他仍然是加拿大被引用次数最多的科学家之一。他的实验室继续研究免疫反应和肿瘤发生的机制，经常使用基因工程小鼠品系。
{"title":"An Interview with Dr. Tak W. Mak","authors":"R. Vanner","doi":"10.5015/utmj.v87i3.1265","DOIUrl":"https://doi.org/10.5015/utmj.v87i3.1265","url":null,"abstract":"Dr. Tak W. Mak is Director of the Campbell Family Institute for Breast Cancer Research, Director of the Advanced Medical Discovery Institute, and Senior Scientist in the Division of Stem Cell and Developmental Biology. In 1984 he gained international notoriety for cloning the T-cell receptor, and he remains one of Canada’s most highly-cited scientists. His laboratory continues to study the mechanisms of the immune response and tumorigenesis, often with the use of genetically engineered mouse strains.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76403741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Distributed Medical Education the Solution","authors":"Eric Siu","doi":"10.5015/UTMJ.V87I3.1249","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1249","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82287277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Macroscopic to Microscopic: A Brief History of the Origins and Treatment of Cancer in the Western World","authors":"M. Olszewski","doi":"10.5015/UTMJ.V87I3.1252","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1252","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75725721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-06-14DOI: 10.3138/9781442661813-052
S. Croft
{"title":"Tale of a T-shirt","authors":"S. Croft","doi":"10.3138/9781442661813-052","DOIUrl":"https://doi.org/10.3138/9781442661813-052","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80631859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell Phones and Cancer: A Short Communication.","authors":"T. Soeyonggo, Shelly Wang","doi":"10.5015/UTMJ.V87I3.1242","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1242","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85104596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Robert N. Gryfe is a colorectal surgical oncologist at Mount Sinai and Princess Margaret Hospitals and researcher at Mount Sinai’s Samuel Lunenfeld Research Institute. Dr. Gryfe's clinical practice specializes in the management of patients with colon and rectal cancer and hereditary cancer syndromes. His research laboratory investigates the genetic determinants of colorectal cancer risk, prognosis and response to chemotherapy.
Robert N. Gryfe博士是Mount Sinai和Princess Margaret Hospitals的结直肠外科肿瘤学家，Mount Sinai ' s Samuel Lunenfeld Research Institute的研究员。Gryfe博士的临床实践专长于结肠癌、直肠癌和遗传性癌症综合征患者的管理。他的研究实验室研究结直肠癌风险、预后和化疗反应的遗传决定因素。
{"title":"An Interview with Dr. Robert N. Gryfe, Surgical Oncologist","authors":"C. Woodford","doi":"10.5015/UTMJ.V87I3.1264","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1264","url":null,"abstract":"Dr. Robert N. Gryfe is a colorectal surgical oncologist at Mount Sinai and Princess Margaret Hospitals and researcher at Mount Sinai’s Samuel Lunenfeld Research Institute. Dr. Gryfe's clinical practice specializes in the management of patients with colon and rectal cancer and hereditary cancer syndromes. His research laboratory investigates the genetic determinants of colorectal cancer risk, prognosis and response to chemotherapy.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82292550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glioblastoma, the most common and aggressive adult brain malignancy, is characterized by the presence of morphologically diverse neural cell types that differ in their ability to form and maintain tumours. The marked resistance of this cancer to conventional treatments has sparked attempts to identify therapeutically targetable cellular populations. Defined pools of tumour initiating cells have already been identified in other malignancies, i.e., leukemia. Like normal stem cells, these “cancer stem cells†(CSCs) have extensive self renewal capacity and multipotency; however, the origin of the CSC remains elusive. Recently, a small percentage of quiescent, undifferentiated, multipotent cells termed neural stem cells (NSCs) were found in the hippocampus, subâ€ventricular zone (SVZ), and olfactory bulb of the adult human brain. Since their discovery, it has been hypothesized that NSCs may act as a depot of tissueâ€specific stem cells in the brain that may be transformed into CSCs. The purpose of this essay is to critically review the literature to demonstrate that oncogenic mutations in NSCs allow them to become CSCs in glioblastomas, in light of the advantages and flaws of existing experimental models. Insights into the mechanism of CSC formation in the brain may allow for the optimization of current therapeutic approaches, as pathways in NSC-->CSC formation will provide opportunities to specifically target this notoriously treatmentâ€resistant malignancy.
{"title":"Does Glioblastoma arise from Oncogenic Transformation of Neural Stem Cells into Cancer Stem Cells","authors":"S. Jeimy","doi":"10.5015/UTMJ.V87I3.1247","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1247","url":null,"abstract":"Glioblastoma, the most common and aggressive adult brain malignancy, is characterized by the presence of morphologically diverse neural cell types that differ in their ability to form and maintain tumours. The marked resistance of this cancer to conventional treatments has sparked attempts to identify therapeutically targetable cellular populations. Defined pools of tumour initiating cells have already been identified in other malignancies, i.e., leukemia. Like normal stem cells, these “cancer stem cells†(CSCs) have extensive self renewal capacity and multipotency; however, the origin of the CSC remains elusive. Recently, a small percentage of quiescent, undifferentiated, multipotent cells termed neural stem cells (NSCs) were found in the hippocampus, subâ€ventricular zone (SVZ), and olfactory bulb of the adult human brain. Since their discovery, it has been hypothesized that NSCs may act as a depot of tissueâ€specific stem cells in the brain that may be transformed into CSCs. The purpose of this essay is to critically review the literature to demonstrate that oncogenic mutations in NSCs allow them to become CSCs in glioblastomas, in light of the advantages and flaws of existing experimental models. Insights into the mechanism of CSC formation in the brain may allow for the optimization of current therapeutic approaches, as pathways in NSC-->CSC formation will provide opportunities to specifically target this notoriously treatmentâ€resistant malignancy.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79251088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Calcification occasionally occurs in Hodgkin’s lymphoma after therapy due to tissue necrosis. Rarely, calcification may be detected prior to treatment. This likely represents a dystrophic process when bulky tumours outgrow their blood supply. Due to this rare presentation, pre treatment calcified Hodgkin’s lymphoma is often mistaken for germ cell tumours on imaging. It is thus important to include Hodgkin’s lymphoma in the differential of this presentation. We present such a case of pre-treatment calcification of Hodgkin’s lymphoma in a young male and discuss the incidence, pathophysiology and imaging findings.
{"title":"Calcification of Untreated Mediastinal Hodgkin's Lymphoma: A Case Report","authors":"C. Rivest, M. Ianni, E. Haider","doi":"10.5015/UTMJ.V87I3.1238","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1238","url":null,"abstract":"Calcification occasionally occurs in Hodgkin’s lymphoma after therapy due to tissue necrosis. Rarely, calcification may be detected prior to treatment. This likely represents a dystrophic process when bulky tumours outgrow their blood supply. Due to this rare presentation, pre treatment calcified Hodgkin’s lymphoma is often mistaken for germ cell tumours on imaging. It is thus important to include Hodgkin’s lymphoma in the differential of this presentation. We present such a case of pre-treatment calcification of Hodgkin’s lymphoma in a young male and discuss the incidence, pathophysiology and imaging findings.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78000665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：