首页 > 最新文献

University of Toronto Medical Journal最新文献

英文 中文
Linguistic and cultural barriers to health care among Chinese patients at the Toronto Western Hospital 多伦多西部医院华人患者的语言和文化障碍
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-05-19 DOI: 10.5015/UTMJ.V87I3.1173
E. Lam, E. Heathcote
Objective: Patient satisfaction surveys are primarily conducted in English and thus exclude respondents who cannot read or are not proficient in the English language. This study used a language and culture-specific questionnaire to explore potential barriers to health care among Chinese patients and to determine their satisfaction with health care services received at their visit to the Toronto Western Hospital (TWH), University Health Network. Methods: A cross-sectional survey design was used. Patients were recruited from the General Internal Medicine inpatient ward and Tuberculosis, Liver and Angiography ambulatory care clinics at TWH. A questionnaire was administered by an interviewer to patients who self-identified as Chinese. The interviewer administered the questionnaire in English, Cantonese and Mandarin. The questionnaire explored three main topics which included language barriers, cultural barriers and patient satisfaction. Results: A total of 138 patients were approached to participate in the study over a six week period. There was a 97.1% response rate. Of the 134 patients who participated in the study, 52% reported having difficulty speaking English but only 24% utilized the hospital’s interpretation and translation service. Barriers to health care identified by patients included: limited discussion of use of Chinese medical therapies with physicians, difficulty understanding explanations provided by physicians and nurses, and difficulty finding a hospital staff member who could talk with them about their illness in their preferred language. Conclusion: Language and culture-specific questionnaires can reveal barriers to health care in patients with limited English proficiency. These barriers need to be addressed to ensure delivery of quality health care in a culturally responsive manner.
目的:患者满意度调查主要以英语进行,因此排除了不能阅读或不精通英语的受访者。本研究采用语言和文化调查问卷,探讨中国患者在多伦多西部医院(TWH)接受医疗服务时的潜在障碍,并确定他们对医疗服务的满意度。方法:采用横断面调查设计。患者从TWH的普通内科住院病房和结核病、肝脏和血管造影门诊招募。一名采访者对自认为是中国人的患者进行问卷调查。采访者用英语、广东话和普通话进行问卷调查。问卷主要探讨了三个主题,包括语言障碍、文化障碍和患者满意度。结果:在为期六周的研究期间,共接触了138名患者参与研究。应答率为97.1%。在参与这项研究的134名患者中,52%的人报告说英语有困难,但只有24%的人利用了医院的口译和翻译服务。患者确定的保健障碍包括:与医生讨论使用中医疗法的问题有限,难以理解医生和护士提供的解释,难以找到能够用他们喜欢的语言与他们谈论疾病的医院工作人员。结论:语言和文化特异性问卷可以揭示英语水平有限的患者在医疗保健方面的障碍。必须消除这些障碍,以确保以符合文化的方式提供高质量的保健服务。
{"title":"Linguistic and cultural barriers to health care among Chinese patients at the Toronto Western Hospital","authors":"E. Lam, E. Heathcote","doi":"10.5015/UTMJ.V87I3.1173","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1173","url":null,"abstract":"Objective: Patient satisfaction surveys are primarily conducted in English and thus exclude respondents who cannot read or are not proficient in the English language. This study used a language and culture-specific questionnaire to explore potential barriers to health care among Chinese patients and to determine their satisfaction with health care services received at their visit to the Toronto Western Hospital (TWH), University Health Network. \u0000Methods: A cross-sectional survey design was used. Patients were recruited from the General Internal Medicine inpatient ward and Tuberculosis, Liver and Angiography ambulatory care clinics at TWH. A questionnaire was administered by an interviewer to patients who self-identified as Chinese. The interviewer administered the questionnaire in English, Cantonese and Mandarin. The questionnaire explored three main topics which included language barriers, cultural barriers and patient satisfaction. \u0000Results: A total of 138 patients were approached to participate in the study over a six week period. There was a 97.1% response rate. Of the 134 patients who participated in the study, 52% reported having difficulty speaking English but only 24% utilized the hospital’s interpretation and translation service. \u0000Barriers to health care identified by patients included: limited discussion of use of Chinese medical therapies with physicians, difficulty understanding explanations provided by physicians and nurses, and difficulty finding a hospital staff member who could talk with them about their illness in their preferred language. \u0000Conclusion: Language and culture-specific questionnaires can reveal barriers to health care in patients with limited English proficiency. These barriers need to be addressed to ensure delivery of quality health care in a culturally responsive manner.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"18 1","pages":"174-176"},"PeriodicalIF":0.7,"publicationDate":"2010-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73124015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Historical changes in perspective of the etiology, pathophysiology and treatment of obstructive sleep apnea 阻塞性睡眠呼吸暂停的病因、病理生理及治疗的历史变迁
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-05-19 DOI: 10.5015/UTMJ.V87I3.1175
J. Gabriel
NOTE: This is a History of Medicine submission and does not have an abstract. As such the Introduction section has been pasted here as an "abstract". Obstructive sleep apnea (OSA) is a condition characterized by repeated occlusion of the upper airway (UA) during sleep. From OSA’s initial clinical description less than 50 years ago to present day, progression in respiratory sleep medicine has vastly expanded the scope of our knowledge of OSA. What was once regarded as a rare affliction that simply led to daytime hypersomnelence1 is now recognized as a common and serious condition capable wreaking havoc in the cardiovascular system, independently promoting heart failure, stroke, hypertension and likely atherosclerosis.At the beginning of a new decade, the field of OSA research finds itself at yet another frontier as a radically new etiological perspective emerges. This new paradigm of the cause of OSA promises the possibility of novel OSA treatments and prophylaxes. This article will follow the progression of OSA research, from the condition's initial discovery, on to the current widely-accepted view of OSA and finally to the future of respiratory sleep medicine.
注:这是一篇医学史投稿,没有摘要。因此,介绍部分被粘贴在这里作为“摘要”。阻塞性睡眠呼吸暂停(OSA)是一种以睡眠中反复阻塞上呼吸道(UA)为特征的疾病。从不到50年前OSA最初的临床描述到今天,呼吸睡眠医学的进步极大地扩展了我们对OSA的认识范围。这种曾经被认为只是导致白天嗜睡的罕见疾病,现在被认为是一种常见而严重的疾病,能够对心血管系统造成严重破坏,独立地引发心力衰竭、中风、高血压和可能的动脉粥样硬化。在新的十年开始之际,OSA研究领域发现自己处于另一个前沿,因为一种全新的病因学观点出现了。这种关于阻塞性睡眠呼吸暂停病因的新范式为新的阻塞性睡眠呼吸暂停治疗和预防提供了可能。本文将跟随OSA研究的进展,从最初的发现,到目前广泛接受的OSA观点,最后到呼吸睡眠医学的未来。
{"title":"Historical changes in perspective of the etiology, pathophysiology and treatment of obstructive sleep apnea","authors":"J. Gabriel","doi":"10.5015/UTMJ.V87I3.1175","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1175","url":null,"abstract":"NOTE: This is a History of Medicine submission and does not have an abstract. As such the Introduction section has been pasted here as an \"abstract\". \u0000 \u0000 \u0000Obstructive sleep apnea (OSA) is a condition characterized by repeated occlusion of the upper airway (UA) during sleep. From OSA’s initial clinical description less than 50 years ago to present day, progression in respiratory sleep medicine has vastly expanded the scope of our knowledge of OSA. What was once regarded as a rare affliction that simply led to daytime hypersomnelence1 is now recognized as a common and serious condition capable wreaking havoc in the cardiovascular system, independently promoting heart failure, stroke, hypertension and likely atherosclerosis.At the beginning of a new decade, the field of OSA research finds itself at yet another frontier as a radically new etiological perspective emerges. This new paradigm of the cause of OSA promises the possibility of novel OSA treatments and prophylaxes. This article will follow the progression of OSA research, from the condition's initial discovery, on to the current widely-accepted view of OSA and finally to the future of respiratory sleep medicine.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"42 1","pages":"177-180"},"PeriodicalIF":0.7,"publicationDate":"2010-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85817766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing the Growing Burden of Rheumatic Heart Disease in Low-Income Countries: A Primary Healthcare Approach in Ethiopia 管理低收入国家风湿性心脏病日益增长的负担:埃塞俄比亚的初级卫生保健方法
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-05-19 DOI: 10.5015/UTMJ.V87I3.1176
Kadia Petricca
Rheumatic fever and rheumatic heart disease continue to be the most common form of cardiovascular disease in low-income countries. Poor diagnostic and treatment capacity and limited patient understanding of disease etiology have kept both disease recognition and patient adherence to treatment low. In rural and remote areas, this is worsened as a result of poorer access to health facilities for diagnosis, treatment and monitoring. As recommended by the World Health Organization, to treat the chronic effects of rheumatic heart disease, patients must adhere to strict monthly treatment regimes of secondary prophylaxis with penicillin. However, adherence to treatment remains difficult for poor populations who struggle to meet the travel, economic and opportunity costs associated with seeking care. To address these challenges, lessons from Ethiopia suggest that a community-based primary healthcare approach that offers follow-up treatment and care through satellite health centres with health officers can be a sustainable and effective strategy for rheumatic fever and rheumatic heart disease management.
在低收入国家,风湿热和风湿性心脏病仍然是最常见的心血管疾病。诊断和治疗能力差,患者对疾病病因的了解有限,使得疾病的认知度和患者对治疗的依从性都很低。在农村和偏远地区,由于难以获得保健设施进行诊断、治疗和监测,这种情况更加严重。根据世界卫生组织的建议,为了治疗风湿性心脏病的慢性影响,患者必须坚持严格的每月青霉素二级预防治疗方案。然而,对于贫困人口来说,坚持治疗仍然很困难,他们难以支付与求医有关的旅行、经济和机会成本。为了应对这些挑战,埃塞俄比亚的经验表明,通过配备卫生官员的卫星卫生中心提供后续治疗和护理的以社区为基础的初级卫生保健办法可能是风湿热和风湿性心脏病管理的可持续和有效战略。
{"title":"Managing the Growing Burden of Rheumatic Heart Disease in Low-Income Countries: A Primary Healthcare Approach in Ethiopia","authors":"Kadia Petricca","doi":"10.5015/UTMJ.V87I3.1176","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I3.1176","url":null,"abstract":"Rheumatic fever and rheumatic heart disease continue to be the most common form of cardiovascular disease in low-income countries. Poor diagnostic and treatment capacity and limited patient understanding of disease etiology have kept both disease recognition and patient adherence to treatment low. In rural and remote areas, this is worsened as a result of poorer access to health facilities for diagnosis, treatment and monitoring. As recommended by the World Health Organization, to treat the chronic effects of rheumatic heart disease, patients must adhere to strict monthly treatment regimes of secondary prophylaxis with penicillin. However, adherence to treatment remains difficult for poor populations who struggle to meet the travel, economic and opportunity costs associated with seeking care. To address these challenges, lessons from Ethiopia suggest that a community-based primary healthcare approach that offers follow-up treatment and care through satellite health centres with health officers can be a sustainable and effective strategy for rheumatic fever and rheumatic heart disease management.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"R-26 1","pages":"170-173"},"PeriodicalIF":0.7,"publicationDate":"2010-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84745171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Guilt and Time: My Enemies 内疚和时间:我的敌人
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-04-02 DOI: 10.5015/UTMJ.V87I2.1258
Jay M. Baruch
{"title":"Guilt and Time: My Enemies","authors":"Jay M. Baruch","doi":"10.5015/UTMJ.V87I2.1258","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1258","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"1 1","pages":"106-108"},"PeriodicalIF":0.7,"publicationDate":"2010-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74420815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
For David: After Words 给大卫的:After Words
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-03-30 DOI: 10.5015/UTMJ.V87I2.1257
S. Cox
{"title":"For David: After Words","authors":"S. Cox","doi":"10.5015/UTMJ.V87I2.1257","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1257","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74079291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motivational Interviewing: Preparing People for Change 动机性访谈:让人们为改变做好准备
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-03-30 DOI: 10.5015/utmj.v87i2.1178
S. Dabbo, Nader Dabbo
{"title":"Motivational Interviewing: Preparing People for Change","authors":"S. Dabbo, Nader Dabbo","doi":"10.5015/utmj.v87i2.1178","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1178","url":null,"abstract":"","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"225 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77285925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2214
Interventional Neuroradiology: An Interview with Dr. Karel terBrugge 介入神经放射学:采访Dr. Karel terBrugge
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-03-30 DOI: 10.5015/utmj.v87i2.1254
C. Woodford
Dr. Karel terBrugge, MD, FRCPC, is a Professor at the University of Toronto and Chief of Neuroradiology at the Toronto Western Hospital. As an internationally recognized interventional neuroradiologist, he specializes in treatment of brain aneurysms, arterio-venous malformations, and acute stroke.
Dr. Karel terBrugge,医学博士,FRCPC,多伦多大学教授,多伦多西部医院神经放射学主任。作为一名国际公认的介入神经放射学家,他擅长治疗脑动脉瘤、动静脉畸形和急性中风。
{"title":"Interventional Neuroradiology: An Interview with Dr. Karel terBrugge","authors":"C. Woodford","doi":"10.5015/utmj.v87i2.1254","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1254","url":null,"abstract":"Dr. Karel terBrugge, MD, FRCPC, is a Professor at the University of Toronto and Chief of Neuroradiology at the Toronto Western Hospital. As an internationally recognized interventional neuroradiologist, he specializes in treatment of brain aneurysms, arterio-venous malformations, and acute stroke.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"96 1","pages":"75-78"},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79183501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroradiology: An Interview with Dr. David J. Mikulis 神经放射学:专访David J. Mikulis博士
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-03-30 DOI: 10.5015/utmj.v87i2.1255
R. Vanner
Dr. David J. Mikulis is a staff neuroradiologist at Toronto Western Hospital and Senior Scientist at the Toronto Western Research Institute, part of the University Health Network. He met with the UTMJ to discuss his career as a clinician-scientist and his lab's novel method of generating maps of cerebrovascular reactivity.
David J. Mikulis博士是多伦多西部医院的神经放射科医生,也是多伦多西部研究所的高级科学家,该研究所是大学健康网络的一部分。他会见了UTMJ,讨论了他作为临床科学家的职业生涯,以及他的实验室生成脑血管反应性图的新方法。
{"title":"Neuroradiology: An Interview with Dr. David J. Mikulis","authors":"R. Vanner","doi":"10.5015/utmj.v87i2.1255","DOIUrl":"https://doi.org/10.5015/utmj.v87i2.1255","url":null,"abstract":"Dr. David J. Mikulis is a staff neuroradiologist at Toronto Western Hospital and Senior Scientist at the Toronto Western Research Institute, part of the University Health Network. He met with the UTMJ to discuss his career as a clinician-scientist and his lab's novel method of generating maps of cerebrovascular reactivity.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"47 1","pages":"79-82"},"PeriodicalIF":0.7,"publicationDate":"2010-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72863101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curing the Heart Under the Wire 治疗钢丝下的心脏
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-03-22 DOI: 10.5015/UTMJ.V87I2.1171
T. Soeyonggo
A significant proportion of patients who sufferfrom heart disease have both these predisposing factors andother comorbidities, making their management more difficult.While medical treatment of heart conditions has helped toextend the durability of the native heart, many patients willeventually reach a point where invasive surgical manoeuvreshave to be considered.Fortunately, there is an emerging field in cardiovascular med -icine that can provide a new alternative for these patients: per-cutaneous cardiac therapies. These procedures are minimallyinvasive and are often associated with fewer peri-proceduralcomplications than a coronary-artery bypass graft (CABG), lead -ing to fewer subsequent morbidities.
很大一部分患有心脏病的患者同时具有这些易感因素和其他合并症,这使得他们的治疗更加困难。虽然心脏疾病的医学治疗有助于延长原生心脏的耐久性,但许多患者最终将达到必须考虑侵入性手术的地步。幸运的是,心血管医学中有一个新兴领域可以为这些患者提供新的选择:经皮心脏治疗。与冠状动脉旁路移植术(CABG)相比,这些手术是微创的,通常伴有较少的术周并发症,导致较少的后续发病率。
{"title":"Curing the Heart Under the Wire","authors":"T. Soeyonggo","doi":"10.5015/UTMJ.V87I2.1171","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1171","url":null,"abstract":"A significant proportion of patients who sufferfrom heart disease have both these predisposing factors andother comorbidities, making their management more difficult.While medical treatment of heart conditions has helped toextend the durability of the native heart, many patients willeventually reach a point where invasive surgical manoeuvreshave to be considered.Fortunately, there is an emerging field in cardiovascular med -icine that can provide a new alternative for these patients: per-cutaneous cardiac therapies. These procedures are minimallyinvasive and are often associated with fewer peri-proceduralcomplications than a coronary-artery bypass graft (CABG), lead -ing to fewer subsequent morbidities.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"14 1","pages":"70-73"},"PeriodicalIF":0.7,"publicationDate":"2010-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75513860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Imaging of Atherosclerosis 动脉粥样硬化的分子影像学
IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2010-02-14 DOI: 10.5015/UTMJ.V87I2.1172
Danny L. Costantini
Molecular imaging is a rapidly evolving field that aims to develop novel technologies and methods to image specific biological processes in the living organism at the cellular and molecular level. This review discusses several novel imaging strategies that exploit the unique biological properties of atherosclerosis to detect key aspects of the disease. Among the approaches, targeting macrophage activity, protease activity, apoptosis and angiogenesis for in vivo molecular imaging of atherosclerosis have demonstrated the greatest potential for translation into the clinical setting.
分子成像是一个快速发展的领域,旨在开发新的技术和方法,在细胞和分子水平上对生物体中的特定生物过程进行成像。本文综述了几种利用动脉粥样硬化独特生物学特性来检测疾病关键方面的新型成像策略。在这些方法中,针对巨噬细胞活性、蛋白酶活性、细胞凋亡和血管生成进行动脉粥样硬化的体内分子成像已经显示出最大的转化为临床环境的潜力。
{"title":"Molecular Imaging of Atherosclerosis","authors":"Danny L. Costantini","doi":"10.5015/UTMJ.V87I2.1172","DOIUrl":"https://doi.org/10.5015/UTMJ.V87I2.1172","url":null,"abstract":"Molecular imaging is a rapidly evolving field that aims to develop novel technologies and methods to image specific biological processes in the living organism at the cellular and molecular level. This review discusses several novel imaging strategies that exploit the unique biological properties of atherosclerosis to detect key aspects of the disease. Among the approaches, targeting macrophage activity, protease activity, apoptosis and angiogenesis for in vivo molecular imaging of atherosclerosis have demonstrated the greatest potential for translation into the clinical setting.","PeriodicalId":41298,"journal":{"name":"University of Toronto Medical Journal","volume":"58 1","pages":"87-90"},"PeriodicalIF":0.7,"publicationDate":"2010-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77253479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
University of Toronto Medical Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1