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Successful management of a postpartum mother with severe COVID-19 associated ARDS complicated by life-threatening respiratory events 成功管理1例产后母亲合并严重COVID-19相关急性呼吸窘迫综合征并发危及生命的呼吸事件
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9277
Kavisha P. Dissanayake, P. T. R. Makuloluwa
Reported mortality of severe COVID-19 pneumonia-associated ARDS is high. This mortality rate increases further in obstetric patients who develop COVID-19 ARDS. We report a case of a postpartum mother who developed life-threatening events while being on respiratory support for severe COVID-19 pneumonia-associated ARDS and made a complete recovery due to the timely diagnosis and efficient interventions.
据报道,严重COVID-19肺炎相关ARDS的死亡率很高。在发生COVID-19 ARDS的产科患者中,这一死亡率进一步增加。我们报告一例产后母亲因COVID-19肺炎相关严重急性呼吸窘迫综合征(ARDS)接受呼吸支持时发生危及生命事件,并因及时诊断和有效干预而完全康复。
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引用次数: 0
The Effect of Single-Dose Dexmedetomidine on Cough Response During Tracheal Extubation 单剂量右美托咪定对气管拔管时咳嗽反应的影响
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9148
Bhavish Reddy, Leena H. Parate, Suresh Govindswamy
Introduction: Optimal strategy for smooth, cough less extubation is still not well established. We aimed to study the effect of single dose of dexmedetomidine (0.5ug/kg) given prior to extubation on cough response during extubation.Methods: 220 patients undergoing laparoscopic cholecystectomy under general anaesthesia were included in the study. Group D (n=110) received IV dexmedetomidine 0.5ug/kg diluted in 100 ml saline and Group S (n=110) received 100ml saline 15 minutes before extubation. Primary outcome was incidence and severity of cough at the time of extubation. Secondary outcome was haemodynamic parameters and sedation. The severity of cough was graded on a four-point scale. Statistical analysis was performed using chi square test and independent t test.Results: The incidence of coughing was significantly lower in Group D than Group S (49.1% vs.70.9%, p = 0.002). Lower grades of cough was observed more in Group D than Group S (17.2% vs. 30.9% p = 0.018). The mean heart rate and blood pressure were lower in Group D. (p <0.001) Sedation score was similar in both groups. (p=0.07)Conclusion: Use of single bolus dose of dexmedetomidine prior to extubation reduces the incidence and severity of cough grade. In addition, it also attenuated haemodynamic response to tracheal extubation without affecting recovery.
顺畅,少咳嗽拔管的最佳策略仍然没有很好地建立。我们的目的是研究拔管前给予单剂量右美托咪定(0.5ug/kg)对拔管时咳嗽反应的影响。方法:选取全麻下行腹腔镜胆囊切除术的220例患者作为研究对象。D组(n=110)静脉滴注右美托咪定0.5ug/kg,稀释于100ml生理盐水中;S组(n=110)拔管前15分钟静脉滴注生理盐水100ml。主要结局是拔管时咳嗽的发生率和严重程度。次要结果是血流动力学参数和镇静。咳嗽的严重程度按四分制进行分级。统计学分析采用卡方检验和独立t检验。结果:D组咳嗽发生率明显低于S组(49.1% vs.70.9%, p = 0.002)。D组咳嗽程度较低者多于S组(17.2% vs. 30.9% p = 0.018)。d组平均心率和血压较低(p <0.001),镇静评分两组相似。(p=0.07)结论:拔管前单次给药右美托咪定可降低咳嗽等级的发生率和严重程度。此外,它还能在不影响康复的情况下减弱对气管拔管的血流动力学反应。
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引用次数: 0
Serotonin syndrome: A case report 血清素综合征1例报告
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9108
Sasika Wijayasinghe, Roshana Mallawaarachchi, Ruwani Dharmabandu
Serotonin syndrome or serotonin toxicity is defined as an iatrogenic drug-induced toxidrome associated with increased intrasynaptic serotonin concentration in the central nervous system. Most cases are provoked by therapeutic doses of a combination of two or more serotonergic agents. The incidence of serotonin syndrome is on the rise, because of increased use of serotonergic medications in current clinical practice. However, the actual incidence of perioperative serotonin syndrome and its morbidity are likely unknown. The diagnosis is difficult in the perioperative period, as clinical features may mimic other conditions commonly seen in the perioperative period or may be masked by the use of anaesthetic medications. Therefore, anaesthetists must be proactive in preventing, identifying and managing serotonin syndrome in the perioperative period.
5 -羟色胺综合征或5 -羟色胺毒性被定义为一种医源性药物引起的与中枢神经系统突触内5 -羟色胺浓度升高相关的毒副反应。大多数病例是由两种或两种以上血清素能药物的组合治疗剂量引起的。血清素综合征的发病率正在上升,因为在目前的临床实践中,血清素能药物的使用越来越多。然而,围手术期血清素综合征的实际发病率及其发病率可能尚不清楚。在围手术期诊断是困难的,因为临床特征可能与围手术期常见的其他情况相似,或者可能被麻醉药物的使用所掩盖。因此,麻醉师必须在围手术期积极预防、识别和处理血清素综合征。
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引用次数: 0
Study on Ward-Based Practice of Vasopressor Administration for Patients with Sepsis, in National Hospital of Sri Lanka (NHSL) 斯里兰卡国立医院(NHSL)脓毒症患者以病房为单位给药血管加压素的研究
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9144
H. S. Vitharana, Ramya Amarasena
Background: Vasopressors are administrated peripherally in hemodynamically unstable patients with sepsis in the initial period. International guidelines are available for peripheral administration of vasopressors, including Surviving Sepsis guidelines 2021.Objective: Assess the ward-based practice regarding peripheral administration of vasopressors in patients with sepsis, in NHSL.Methods: A prospective cross-sectional study, during a period of six weeks in 2022, setting of Medical and surgical wards in NHSL, in a group of 52 patients.Results: Noradrenaline was the vasopressor used for all patients with septic shock. 93% of patients had peripheral noradrenaline infusions for a medium duration of 77.7 hours. Peripheral cannula for noradrenaline was sited in the forearm at 46% and in the dorsum of the hand at 34%. Only 7% had a central line for vasopressors. Other infusions along with noradrenaline in the same cannula were given in 75%. Approximately 90% were monitored hourly during the infusion of vasopressors. ICU referral was done only in 5.7% of patients. Adverse reactions were noted in 38% of patients, all minor complications.Conclusion: Peripheral administration of vasopressors was prolonged compared to standard. Adverse reactions were identified, but all were minor complications.
背景:血液动力学不稳定的脓毒症患者在初始阶段给予血管加压药。血管加压药外周给药的国际指南,包括《2021年生存败血症指南》。目的:评估NHSL脓毒症患者外周血管加压药物的病房实践。方法:在2022年为期6周的前瞻性横断面研究中,在NHSL内科和外科病房设置,一组52例患者。结果:所有脓毒性休克患者均使用去甲肾上腺素。93%的患者外周输注去甲肾上腺素,输注时间为77.7小时。去甲肾上腺素外周插管位于前臂(46%)和手背(34%)。只有7%的患者有血管加压药物中心静脉导管。75%的患者在同一插管中同时输注去甲肾上腺素。大约90%的患者在输注血管加压剂期间每小时监测一次。只有5.7%的患者转诊到ICU。38%的患者出现不良反应,均为轻微并发症。结论:外周给药时间较标准延长。发现了不良反应,但都是轻微的并发症。
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引用次数: 0
Randomized Double-Blind Trial Comparing Efficacy of Intravenous Nalbuphine vs Intrathecal Nalbuphine for Prevention of Intrathecal Morphine Induced Pruritus in Orthopaedic Surgeries 静脉注射纳布啡与鞘内注射纳布啡预防骨科手术鞘内吗啡性瘙痒的随机双盲试验比较
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9031
Pranjali Kurhekar, J. Shesha dhiviya Krishna
Intrathecal morphine provides excellent postoperative pain relief but results in pruritus in 30-60% of patients. Nalbuphine, an opioid agonist-antagonist prevents intrathecal morphine-induced itch when given by intravenous route. In this study, we compared efficacy of intrathecal and intravenous nalbuphine for the prevention of intrathecal morphine-induced pruritus. 90 patients were randomly divided into two groups. IT group received 100 mcg of morphine with 400 mcg of nalbuphine intrathecally. IV group received 100 mcg of morphine intrathecally and 400 mcg of nalbuphine intravenously. Incidence of itching, respiratory depression, hypotension, nausea, vomiting, sedation and analgesia were compared between the groups every 4th hourly for 24 hours. Data were analyzed with Chi-square test and Mann-Whitney test. Incidence of itching in 24 hours period was 11.6% (5 patients) in IV group and 4.8% (2 patients) in IT group which was comparable. (P= 0.250) Two patients in IV group had intractable itching requiring naloxone. Incidence of itching at all time intervals was comparable between the groups. Analgesia was prolonged in IV group (P=0.03) Incidence of nausea, vomiting, sedation and respiratory depression was comparable. We conclude that intrathecal nalbuphine and intravenous nalbuphine were equally effective in preventing intrathecal morphine induced pruritus. The duration of analgesia was more when nalbuphine was given by IV route as compared to IT route.
鞘内注射吗啡能很好地缓解术后疼痛,但30-60%的患者会出现瘙痒。纳布啡,一种阿片激动剂-拮抗剂,通过静脉给药可预防鞘内吗啡引起的瘙痒。在这项研究中,我们比较了鞘内注射和静脉注射纳布啡预防鞘内吗啡引起的瘙痒的疗效。90例患者随机分为两组。IT组给予吗啡100 mcg +纳布啡400 mcg的鞘内注射。静脉注射组给予鞘内吗啡100 mcg,静脉注射纳布啡400 mcg。比较各组瘙痒、呼吸抑制、低血压、恶心、呕吐、镇静、镇痛的发生率,每4 h进行一次,持续24 h。资料分析采用卡方检验和Mann-Whitney检验。静脉注射组24 h内瘙痒发生率为11.6%(5例),静脉注射组为4.8%(2例),两组比较具有可比性。(P= 0.250)静脉注射组有2例难治性瘙痒需要纳洛酮治疗。各组间瘙痒发生率在所有时间间隔均具有可比性。静脉注射组镇痛时间延长(P=0.03),恶心、呕吐、镇静、呼吸抑制发生率无明显差异。我们得出结论,鞘内注射纳布啡和静脉注射纳布啡在预防鞘内吗啡引起的瘙痒方面同样有效。静脉给药比IT给药镇痛时间更长。
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引用次数: 0
Myoclonus in the Post-Operative Period: A Case Report 术后肌阵挛1例报告
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9153
B. Chandana, Prapti Rath, Akshita Niranjan, Sharmila Narayana, C. A. Tejesh
Involuntary movements/myoclonus are brief, short-lived jerky movements and a complication in the post-operative period are seen following central neuraxial blockade causing distress to the patient but is usually self-limiting. We wish to bring cognizance among fellow anesthesiologists regarding this possible, extremely rare complication and also review the available work for its cause and management.Post-spinal myoclonus was witnessed in a young adult patient in their twenties who underwent closed reduction and internal fixation for a right femur shaft fracture under combined spinal-epidural anaesthesia. The patient developed involuntary jerky movements of the right foot 8 hours after the subarachnoid block gradually reduced in the next 24 hours. After ruling out other possible causes of myoclonus, the case was followed up and discharged on postoperative day 5. Post spinal myoclonus though a rare complication can be distressing to the patient and the doctor. It is a self-limiting complication with no residual effects.
不自主运动/肌阵挛是短暂的,短暂的突然运动,术后并发症见于中枢神经轴阻滞后,引起患者痛苦,但通常是自我限制的。我们希望引起同行麻醉师对这种可能的,极其罕见的并发症的认识,并回顾其原因和管理的现有工作。脊髓后肌挛发生于一位二十多岁的年轻成年患者,他在脊髓-硬膜外联合麻醉下接受了右侧股骨骨干骨折的闭合复位和内固定。在接下来的24小时内蛛网膜下腔阻滞逐渐减少,8小时后患者出现右脚不自主的抽搐运动。排除其他可能引起肌阵挛的原因后,对患者进行随访,于术后第5天出院。脊髓后肌阵挛虽然是一种罕见的并发症,但对病人和医生来说都是痛苦的。这是一种自限性并发症,没有后遗症。
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引用次数: 0
Prediction model for the need of postoperative organ support in an adult population undergoing elective major general surgery - Utilizing the American College of Surgeons - National quality improvement project (ACS-NSQIP) surgical risk calculator 成人择期大普外科术后器官支持需求预测模型——利用美国外科医师学会-国家质量改进项目(ACS-NSQIP)手术风险计算器
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9243
Kavya Galle Kankanamge Botejue, Aloka Pathirana, Shamini Prathapan
An accepted model for predicting the need for postoperative organ support and intensive care, in patients undergoing elective surgery, is lacking worldwide. A reliable tool that could predict the need for postoperative organ support would facilitate the efficient utilisation of ICU beds while ensuring patient safety. The American College of Surgeons - National Quality Improvement Project (ACS-NSQIP) surgical risk calculator is validated for the prediction of the risk of serious complications in the postoperative period. We aimed to validate this calculator to predict the need for post-operative organ support. We obtained perioperative data from 126 patients who underwent elective major general surgery. We calculated the percentage risk of serious complications for each patient using the ACS-NSQIP calculator and correlated it with the level of postoperative organ support needed. The mean predicted percentage risk of serious complications, for the group that did not require any organ support was 10.5% and the group requiring 1 or more organ support was 18.1%. The standard error was 0.49 (p= 0.001). A receiver-operating characteristic (ROC) curve gave an area under the curve of 0.71. We chose a cutoff for the percentage risk of serious complications for needing postoperative organ support and 10.8% was chosen as a fair value as it had a sensitivity of 71.4% and a specificity of 66%. The percentage risk of serious complications calculated by the ACS-NSQIP surgical risk calculator has a strong positive correlation with the need for postoperative organ support. Multi-center data is needed to determine definite cut-offs.
一个公认的模型预测需要术后器官支持和重症监护,在接受选择性手术的患者,是缺乏世界范围内。一种能够预测术后器官支持需求的可靠工具将促进ICU床位的有效利用,同时确保患者安全。美国外科医师学会-国家质量改进项目(ACS-NSQIP)手术风险计算器用于预测术后严重并发症的风险。我们的目的是验证这个计算器来预测术后器官支持的需求。我们获得了126例接受择期大普外科手术患者的围手术期数据。我们使用ACS-NSQIP计算器计算每位患者发生严重并发症的风险百分比,并将其与术后所需器官支持水平相关联。不需要任何器官支持的组发生严重并发症的平均预测百分比风险为10.5%,需要一种或更多器官支持的组为18.1%。标准误差为0.49 (p= 0.001)。受试者工作特征(ROC)曲线下面积为0.71。我们为需要术后器官支持的严重并发症的百分比风险选择了一个临界值,10.8%被选为一个公平值,因为它的敏感性为71.4%,特异性为66%。ACS-NSQIP手术风险计算器计算出的严重并发症风险百分比与术后器官支持需求呈正相关。需要多中心数据来确定明确的截止点。
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引用次数: 0
C-MAC VL as Saviour Following Failed Intubation Attempts in an Infant with Huge Hydrocephalous C-MAC VL作为巨大脑积水婴儿插管失败后的救星
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9081
Farah Nasreen, Atif Khalid, Sobia Manaal Siddiqui
Airway management in infants can become more challenging in the presence of congenital anomalies such as hydrocephalus. In this case, we present the extreme airway challenges faced during the intubation of a 7-month-old child with massive hydrocephalus presenting for ventriculoperitoneal (VP) shunt surgery. The C-MAC video laryngoscope (VL) turned out to be the ultimate saviour after the failure of direct laryngoscopy and Airtraq. Paediatric airway management can sometimes be a nightmare for the anaesthesiologist in such scenarios. Early use of rescue devices such as the C-MAC VL can help tide over the crisis.
在存在先天性异常(如脑积水)的情况下,婴儿气道管理可能变得更具挑战性。在这种情况下,我们提出了极端的气道挑战,在插管期间面临的一个7个月大的儿童大量脑积水提出脑室-腹膜(VP)分流手术。在直接喉镜和Airtraq失败后,C-MAC视频喉镜(VL)成为最终的救星。在这种情况下,儿科气道管理有时是麻醉师的噩梦。尽早使用像C-MAC VL这样的救援设备可以帮助渡过危机。
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引用次数: 0
Anaphylaxis: Unveiling the silent killer 过敏反应:揭开沉默杀手的面纱
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9288
Vasanthi Pinto, Ashani Ratnayake
No abstract available
没有摘要
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引用次数: 0
A quality improvement project to establish accuracy in completing Early Warning Score chart and appropriate clinical response depending on the score in acute care wards at Asiri Surgical Hospital 在Asiri外科医院的急性护理病房中,根据评分确定完成早期预警评分表的准确性和适当的临床反应的质量改进项目
Q4 ANESTHESIOLOGY Pub Date : 2023-10-04 DOI: 10.4038/slja.v31i2.9132
Nimali Lochanie, Kalsara Haresh Abeyasekara, Gayani Senanayaka
Failure or delay in recognition of acutely deteriorating patients in acute care ward setting leads to preventable morbidity, cardiac arrest, and death. Assessment and responding to Early Warning Score (EWS) adapted from National Early Warning Score 2 is implemented at Asiri Surgical Hospital to capture these patients early and escalate their care appropriately. Though a colour-coded EWS chart and a hospital policy are available, gaps in accurate recording, monitoring, and triggering were reported. Thus, a quality improvement project was conducted with the aim of establishing more than 80% accuracy in completing the EWS chart and appropriate clinical response to EWS score in acute care wards at Asiri Surgical Hospital by August 2022.A multidisciplinary team performed a series of Plan-Do-Study-Act cycles focusing on correct documentation and calculation of EWS score and appropriate monitoring and escalation of care. Key drivers for hindering the pathway were identified and addressed. Over the course of the project, correct recording improved from 81.25% to 99.4%, accurate calculation of total EWS score had improved from 79% to 88%, patients who received recommended monitoring as triggered by EWS score improved from 78.8% to 84.6% and escalation of care when EWS score is 5 or more improved from 70.9% to 91.7%.A step improvement in the clinical response to a deteriorating patient in the acute care ward setting at Asiri Surgical Hospital was attained by the successful quality improvement project involving the frontline care providers.
急性监护病房中急性恶化患者的识别失败或延迟导致可预防的发病率、心脏骤停和死亡。Asiri外科医院实施了根据国家预警评分2改编的早期预警评分(EWS)评估和应对措施,以便及早发现这些患者并适当升级其护理。虽然有彩色编码的EWS图表和医院政策,但据报告,在准确记录、监测和触发方面存在差距。因此,开展了一项质量改进项目,目标是到2022年8月,在Asiri外科医院的急症病房中,完成EWS图表的准确率达到80%以上,并对EWS评分做出适当的临床反应。一个多学科小组执行了一系列计划-实施-研究-行动循环,重点是正确记录和计算EWS评分以及适当的监测和护理升级。确定并解决了阻碍这一途径的关键驱动因素。在整个项目过程中,正确记录从81.25%提高到99.4%,准确计算总EWS评分从79%提高到88%,由EWS评分触发的患者接受推荐监测从78.8%提高到84.6%,EWS评分为5分及以上时的护理升级从70.9%提高到91.7%。Asiri外科医院急诊病房对病情恶化病人的临床反应,由于成功开展了涉及一线医护人员的质量改进项目而得到了进一步改善。
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引用次数: 0
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Sri Lankan Journal of Anaesthesiology
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