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Inequality in the use of microvascular versus pedicled flaps in oral cancer reconstruction across India: Can we bridge the gap? 印度口腔癌症重建中微血管与带蒂皮瓣使用的不平等:我们能弥合这一差距吗?
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_80_22
A. Vaidya
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引用次数: 0
Percutaneous dilatational tracheostomy: an observational study at tertiary level teaching hospital 三级教学医院经皮扩张气管造口术的观察研究
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_62_22
R. Shah, Bipin Koirala, Lalit Rajbansi, Batsalya Arjyal
Introduction: Tracheostomy is the most commonly performed procedure worldwide. It is mainly done in critically ill patients requiring long-term ventilation, facial trauma, laryngeal fractures, laryngeal malignancy, etc., Converting from endotracheal intubation to tracheostomy has many benefits in terms of maintaining laryngeal function, feeding, and safety, it is more comfortable than endotracheal intubation. Tracheostomized patients require less analgesics and sedatives. It also helps in easier and early weaning from the mechanical ventilator, possibility of speech, and initiation of oral intake of medication. Percutaneous dilatational tracheostomy (PDT) is a safe and feasible procedure performed at bedside with minimal invasive technique in the intensive care unit (ICU). This all contributes to shorter ICU stay and hospital stay which becomes more cost-effective. Methods: This is a prospective observational study that was conducted in the 22-bedded neurointensive care and medical ICU of Birat Medical College and Teaching Hospital. The data were collected from August 01, 2021, to February 28, 2022. All patients needing tracheostomy for prolonged intubation, protection of airway, and to maintain tracheobronchial toileting was taking under study. Results: Our study was a prospective observational regarding PDT. A total of 71 patients were included in the study. Out of which, 39 (54.9%) were male and 32 (45.1%) were female with the ratio of (1.2:1). The age of the patients ranged from 18 to 82 years with the mean age of 53.25 years. The most common indication of PDT was prolonged intubation and that accounted for 29 (40.8%) of the patients which was followed by airway protection in 27 (38%) patients and to maintain pulmonary hygiene was seen in 15 (21.1%) patients. Conclusion: Tracheostomy is among the most frequently performed procedures in critically ill patients. PDT is a safe and feasible procedure performed at bedside with minimal invasive techniques in ICU.
简介:气管切开术是世界上最常用的手术。主要用于需要长期通气、面部外伤、喉骨折、喉恶性肿瘤等危重患者,由气管插管转气管造口在维持喉功能、喂养、安全等方面有诸多好处,比气管插管更舒适。气管造口术患者需要较少的镇痛剂和镇静剂。它也有助于更容易和更早地脱离机械呼吸机,说话的可能性,以及口服药物的开始。经皮扩张性气管切开术(PDT)是一种安全可行的手术,可以在重症监护病房(ICU)床边使用微创技术进行。这一切都有助于缩短ICU住院时间和住院时间,从而变得更具成本效益。方法:本研究是一项前瞻性观察性研究,在Birat医学院和教学医院的22个床位的神经重症监护和内科ICU进行。数据收集时间为2021年8月1日至2022年2月28日。所有因长时间插管、保护气道、维持气管支气管排便而需要气管造口术的患者均纳入研究。结果:我们的研究是关于PDT的前瞻性观察。研究共纳入了71例患者。其中男性39人(54.9%),女性32人(45.1%),比例为(1.2:1)。患者年龄18 ~ 82岁,平均年龄53.25岁。PDT最常见的适应症为延长插管29例(40.8%),其次为气道保护27例(38%),保持肺部卫生15例(21.1%)。结论:气管切开术是危重病人最常用的手术之一。PDT是一种安全可行的手术,可以在ICU的床边使用微创技术进行。
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引用次数: 0
Expression of human epidermal growth factor receptor 2/Neu in oral leukoplakia 人表皮生长因子受体2/Neu在口腔白斑中的表达
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_41_22
A. Jha, Vansh Verma, K. Patiri, N. Arora
Background: Molecular alterations in premalignant lesions of the oral cavity are not well known. Many reports have found increased human epidermal growth factor receptor 2 (HER-2) expression in oral cancer. Overexpression of HER-2 in premalignant lesions may denote its positive contribution in the malignant transformation of these lesions. Materials and Methods: Twenty-three samples of leukoplakia were stained by routine H and E to assess any dysplasia; five samples of normal mucosa were used as control. Immunohistochemical staining for HER-2 was done. ASCO/CAP 2018 guidelines were used for reporting the results. The percentage of lesions expressing cytoplasmic or membranous expression was calculated. Results: One sample of leukoplakia with severe dysplasia expressed focal membranous staining. Cytoplasmic staining was observed in 3/9 (33.33%) dysplastic leukoplakia. Only one nondysplastic leukoplakia expressed cytoplasmic HER-2 staining. Conclusions: Membranous expression in severe dysplasia and higher expression in oral cancer are in concordance with the multistep theory of carcinogenesis.
背景:口腔癌前病变的分子改变尚不清楚。许多报道发现,人表皮生长因子受体2(HER-2)在口腔癌症中表达增加。HER-2在癌前病变中的过度表达可能表明其在这些病变的恶性转化中的积极作用。材料和方法:对23例白斑标本进行常规H和E染色,以评估是否存在发育不良;取5例正常黏膜作为对照。对HER-2进行免疫组织化学染色。ASCO/CAP 2018指南用于报告结果。计算表达细胞质或膜质表达的病变的百分比。结果:1例伴有严重发育不良的白斑标本表达局灶膜染色。在3/9(33.33%)的发育异常白斑中观察到细胞质染色。只有一个非变性白斑表达细胞质HER-2染色。结论:膜在严重发育不良中的表达和在口腔癌症中的高表达符合多步骤致癌理论。
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引用次数: 0
Comparative evaluation of sclerostin levels in gingival crevicular fluid of periodontal health and disease before and after nonsurgical periodontal therapy 非手术牙周治疗前后牙周健康和疾病患者龈沟液中硬化素水平的比较评价
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_48_22
Ankita Mathur, D. Gopalakrishnan, S. Shetty, Vini Mehta, Shreya Bagwe
Aim: The purpose of this study was to measure the concentration of sclerostin in the gingival crevicular fluid (GCF) before and after 1, 3, and 6 weeks of nonsurgical periodontal therapy (NSPT) in subjects with and without chronic periodontitis. Materials and Methods: An interventional study was conducted among 35 subjects of age groups 30–50 years. Subjects were divided into three groups: Group I (10 healthy individuals), Group II (10 gingivitis), and Group III (15 chronic periodontitis only). Clinical parameters assessed were gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL). The GCF samples were collected from all the groups at baseline and in Group III at baseline and 1, 3, and 6 weeks after NSPT using micropipettes. Results: Table 1 shows age and gender details. Although the mean sclerostin concentration in GCF (ng/ml) was highest in Group III at baseline (5.41 ± 0.68) and lowest in Group 1 (4.98 ± 0.46), there was no statistically significant difference (P < 0.05) when intergroup comparison was done [Tables 2 and 3]. PPD and CAL measured for Group III were 6.93 + 1.2 and 7.67 + 1.2, respectively. PI (2.52 + 0.25) and GI (2.52 + 0.17) were measured highest in Group III [Table 4]. Conclusion: There was a substantial decrease in the concentration of sclerostin in the GCF of chronic periodontitis patients after 1, 3, and 6 weeks after NSPT. This proves sclerostin to be a responsive measure of inflammation in periodontal destruction.
目的:本研究的目的是测量患有和不患有慢性牙周炎的受试者在接受非手术牙周治疗(NSPT)前后1、3和6周龈沟液(GCF)中硬化素的浓度。材料与方法:对年龄在30 ~ 50岁的35例受试者进行介入性研究。受试者分为三组:第一组(10名健康人),第二组(10名牙龈炎患者),第三组(15名慢性牙周炎患者)。评估的临床参数包括牙龈指数(GI)、菌斑指数(PI)、探测袋深度(PPD)和临床附着水平(CAL)。所有组在基线和第三组在基线和NSPT后1、3和6周使用微移液管收集GCF样本。结果:表1显示了年龄和性别细节。虽然III组GCF中平均硬化蛋白浓度(ng/ml)在基线时最高(5.41±0.68),1组最低(4.98±0.46),但组间比较差异无统计学意义(P < 0.05)[表2、3]。第三组PPD和CAL分别为6.93 + 1.2和7.67 + 1.2。III组PI(2.52 + 0.25)和GI(2.52 + 0.17)最高[表4]。结论:慢性牙周炎患者在NSPT后1、3、6周GCF中硬化素浓度明显降低。这证明了硬化蛋白是牙周破坏炎症的反应性措施。
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引用次数: 0
Diagnostic role of galectin-3 immunohistochemistry in thyroid lesions 半乳糖凝集素-3免疫组织化学在甲状腺病变诊断中的作用
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_37_22
K. Sarin, R. Bhagat, R. S. Punia, Arjun Das, U. Handa
Background: Galectin-3 (Gal-3) is a good diagnostic marker for thyroid cancer. Evaluation of diagnostic accuracy of this marker complements the morphological assessment of a particular thyroid lesion. The aim of this study was to evaluate the immunohistochemical expression and diagnostic role of Gal-3 in various surgically resected thyroid lesions. Materials and Methods: Surgically resected thyroid specimens from 50 patients with hematoxylin and eosin (H and E)- and Gal-3-stained sections were studied. Results: The age of the patients ranged from 14 to 64 years. Of the 50 patients, 12 (24%) were male and 38 (76%) were females. Various histopathological diagnoses included were inflammatory lesions 8 (16%), hyperplastic lesions 15 (30%), and benign 2 (4%) and malignant 25 (50%) lesions. On quantitative analysis of Gal-3 immunostaining, 16/16 (100%) of the papillary thyroid carcinoma (PTC) cases showed a positive expression. In the rest of the malignant cases, 5 (20%) of follicular thyroid carcinoma, 3 (12%) of medullary thyroid carcinoma, and 1 (4%) of anaplastic thyroid carcinoma showed a negative expression. The PTC cases showed a statistically significant difference from the rest of the benign lesions (P = 0.000). In PTC cases, the sensitivity of Gal-3 came out to be 100%, specificity was 64%, positive predictive value was 75.3%, negative predictive value was 100%, and accuracy was 82%. Conclusion: The data thus obtained indicate that Gal-3 is a valuable marker for differentiating classical PTC and its common variants (follicular variant and microcarcinoma in our study) from the other benign and malignant lesions. Gal-3 as a diagnostic marker for thyroid cancer can lead to improved outcomes for individuals diagnosed with equivocal or suspicious lesions.
背景:半乳糖凝集素-3 (Galectin-3, Gal-3)是甲状腺癌的良好诊断标志物。该标志物的诊断准确性评估补充了特定甲状腺病变的形态学评估。本研究的目的是评估Gal-3在各种手术切除的甲状腺病变中的免疫组织化学表达和诊断作用。材料和方法:对50例手术切除的甲状腺标本进行苏木精和伊红(H和E)-和gal -3染色切片的研究。结果:患者年龄14 ~ 64岁。50例患者中,男性12例(24%),女性38例(76%)。各种组织病理学诊断包括炎性病变8例(16%),增生性病变15例(30%),良性病变2例(4%),恶性病变25例(50%)。定量分析Gal-3免疫染色,16/16(100%)的甲状腺乳头状癌(PTC)呈阳性表达。其余甲状腺滤泡癌5例(20%)、甲状腺髓样癌3例(12%)、间变性癌1例(4%)呈阴性表达。PTC病例与其他良性病变相比差异有统计学意义(P = 0.000)。在PTC病例中,Gal-3的敏感性为100%,特异性为64%,阳性预测值为75.3%,阴性预测值为100%,准确率为82%。结论:Gal-3是鉴别典型PTC及其常见变体(本研究中为滤泡型变体和微癌)与其他良恶性病变的重要标志物。Gal-3作为甲状腺癌的诊断标志物可以改善诊断为模棱两可或可疑病变的个体的预后。
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引用次数: 0
Contralateral neck dissection in oral cavity cancers crossing midline: A look in the mirror 跨中线口腔癌的对侧颈清扫术:照照镜子
IF 0.1 Q4 Medicine Pub Date : 2022-07-01 DOI: 10.4103/jhnps.jhnps_35_22
Sachin V Wani, Nishith R. Modi, M. Srinitya, R. Bhatt, Shishir Shah, A. Shah, Nikita Choksi
Introduction: Oral cavity cancer is the most common cancer in our country. In patients with oral cavity squamous cell carcinoma (OCSCC) elective neck dissection results in higher rates of overall survival and disease-free survival. Nodal metastasis in OCSCC is related to poor prognosis. Elective ipsilateral node dissection is recommended in all patients. Contralateral nodal metastasis is associated with poorer prognosis. The purpose of our study is to identify the predictors and factors associated with bilateral or contralateral nodal metastasis in oral cavity cancers reaching or crossing the midline. Materials and Methods: All patients of oral cavity cancer where the primary cancer was reaching or crossing the midline, operated during 3 years in a single institute were taken up for the study. All patients underwent surgery of primary cancer and bilateral neck dissection. Patients with truly lateral disease not approaching midline, history of any previous oncologic treatment, and recurrent cancers, and patients with two or more primaries were excluded from the study. Results: Out of 93 patients, 43% of the buccal mucosa – gingivobuccal sulcus region and 57% of the tongue – floor of mouth region. Out of 46 patients having nodal metastasis (50%), 26.8% of patients had bilateral nodal metastasis, but none had isolated contralateral nodal metastasis. On univariate and bivariate analysis, we found tumor grade, stage, site of ENE, and presence of multiple ipsilateral positive nodes were significant factors predicting contralateral nodal metastasis. Conclusion: Surgical management of the contralateral neck in oral cavity cancer is a complex issue. The simplistic approach of doing contralateral neck dissection in all oral cavity cancers when disease crosses midline is not sufficient. The presence of contralateral neck node metastasis in the absence of positive ipsilateral neck is very rare (0% in our study). There are other important clinic radiological factors such as DOI >10 mm, involvement of skin and bone, and presence of extranodal extension and location of primary tumor which also need to be considered in decision-making algorithm.
简介:口腔癌症是我国最常见的癌症。在口腔鳞状细胞癌(OCSCC)患者中,选择性颈清扫可提高总生存率和无病生存率。OCSCC的淋巴结转移与预后不良有关。建议所有患者进行选择性同侧淋巴结清扫。对侧淋巴结转移与预后较差有关。我们研究的目的是确定到达或穿过中线的口腔癌双侧或对侧淋巴结转移的预测因素和相关因素。材料与方法:将原发癌症达到或越过中线的癌症口腔患者在一个研究所内手术3年进行研究。所有患者均接受了原发性癌症手术和双侧颈清扫术。未接近中线的真正横向疾病患者、既往任何肿瘤治疗史、复发性癌症患者以及两种或两种以上原发性疾病的患者被排除在研究之外。结果:在93例患者中,43%的患者位于颊粘膜-牙龈颊沟区,57%的患者位于舌底区。在46例有淋巴结转移的患者中(50%),26.8%的患者有双侧淋巴结转移,但没有一例有孤立的对侧淋巴结转移。在单变量和双变量分析中,我们发现肿瘤分级、分期、ENE部位和多个同侧阳性淋巴结的存在是预测对侧淋巴结转移的重要因素。结论:癌症对侧颈部的手术治疗是一个复杂的问题。当疾病越过中线时,对所有口腔癌进行对侧颈清扫的简单方法是不够的。在同侧颈部没有阳性的情况下,对侧颈部淋巴结转移是非常罕见的(在我们的研究中为0%)。决策算法中还需要考虑其他重要的临床放射学因素,如DOI>10mm、皮肤和骨骼的受累、结外延伸的存在和原发肿瘤的位置。
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引用次数: 0
Preservation of eye in carcinoma of the nose and paranasal sinuses – A critical review 鼻和鼻窦癌中眼睛的保存-一个重要的回顾
IF 0.1 Q4 Medicine Pub Date : 2022-01-01 DOI: 10.4103/jhnps.jhnps_21_22
S. Bahadur, Amit Kumar Sharma, J. Malik, S. Monga
Background: Tumor invasion into the orbit by carcinoma is well known and its negative impact on the survival and quality of life has been discussed in the literature. Methods: This article is a narrative review on the preservation of eye in the management of cancers of the nose and paranasal region. Conclusions: The clinical features and modern imaging can help in preoperative planning, aided by the intraoperative assessment in decision-making to preserve the eye or not. Unlike in the past, when even orbital periosteum involvement was considered for orbital sacrifice, more conservative approach has been advocated in recent years in view of anatomic, radiological, and histological studies. Limited involvement of the periorbita or even the small part of intraorbital fat may still be considered for the preservation of the eye in selected patients with frozen section control and without affecting the oncologic outcome.
背景:肿瘤侵犯眼眶是众所周知的,其对生存和生活质量的负面影响已在文献中进行了讨论。方法:这篇文章是一篇叙述性的综述,在鼻子和鼻旁区域癌症的治疗中保存眼睛。结论:临床特征和现代影像学有助于术前计划,并在术中评估是否保留眼睛的决策中提供帮助。与过去不同的是,即使是眼眶骨膜受累也被考虑用于眼眶牺牲,近年来,从解剖学、放射学和组织学研究的角度来看,提倡更保守的方法。在冷冻切片对照的选定患者中,在不影响肿瘤学结果的情况下,仍可以考虑对眶周甚至眶内脂肪的小部分进行有限的受累,以保护眼睛。
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引用次数: 0
Facial nerve anatomy revisited – A surgeon's perspective 面神经解剖学重访——外科医生的观点
IF 0.1 Q4 Medicine Pub Date : 2022-01-01 DOI: 10.4103/jhnps.jhnps_30_22
Riju Ramachandran, A. Pillai
Facial nerve (FN) anatomy is an enigma and its knowledge helps in safe and adequate parotidectomy without compromising the nerve. A review of the literature was done by searching the databases in PubMed, Embase, Scopus, and Google Scholar using the keywords “Parotid,” “FNT,” “Anatomy,” “Surgery,” and “Parotidectomy” and retrieving about 433 manuscripts fulfilling our requirements. FNT anatomy has been described in detail dividing the extracranial FNT under “Exit,” “Trunk,” “Pes Anserinus,” “Divisions,” “Branches,” “Communications,” “Relationships,” and “Termination.” Normal anatomy and variations including classification of the variation have been done. Knowledge of FNT anatomy helps in performing a safe parotidectomy. It is possible to preempt the course of the nerve and dissect the gland in a precise and rapid fashion, especially in surgery for a recurrence.
面神经解剖是一个谜,它的知识有助于在不损害神经的情况下安全、充分地进行腮腺切除术。检索PubMed、Embase、Scopus和b谷歌Scholar数据库,检索关键词为“腮腺”、“FNT”、“Anatomy”、“Surgery”和“Parotidectomy”,检索到符合要求的文献约433篇。FNT解剖已详细描述颅外FNT分为“出口”、“主干”、“鹅足”、“分支”、“交流”、“关系”和“终止”。正常解剖和变异,包括变异的分类已经完成。了解FNT解剖有助于进行安全的腮腺切除术。这是可能的,以一种精确和快速的方式预先控制神经的进程和解剖腺体,特别是在手术复发。
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引用次数: 0
Infrahyoid flap: Myocutaneous pedicled flap for reconstrcution of tongue carcinomas 舌骨下皮瓣:带蒂肌皮瓣重建舌癌
IF 0.1 Q4 Medicine Pub Date : 2022-01-01 DOI: 10.4103/jhnps.jhnps_3_22
H. Saluja, Seemit Shah, Shivani Sachdeva, A. Dadhich
The infrahyoid flap (IHF) is a myocutaneous pedicled flap which is mostly supplied by the superior thyroid vessels through the infrahyoid muscles perforators. The flap is thin and it could be transferred as a pedicle of superior thyroid artery along with the vein for the reconstruction of medium-sized defects of head and neck surgeries. The added advantage of this flap is that it is pliable and provides a skin island which is approximately seven by four centimeters from the central part of the anterior neck. The best substitute for reconstruction of oral defects is IHF. It can be carried out for the moderate defects of mouth along with that of pharynx carcinomas. The flap can be either unilateral or bilateral superior thyroid pedicle flaps but the main limitations are restricted arc of rotation and small flap volume. The IHF is contraindicated in cases with prior irradiation as well as cases of neck metastasis. The flap is most trusted and can be easily yielded during dissections of the head and neck; oncologically, it is safe and it carries least morbidity of the donor site.
舌骨下皮瓣(IHF)是一种肌皮瓣,主要由甲状腺上血管通过舌骨下肌穿支提供。该皮瓣薄,可作为甲状腺上动脉和静脉的蒂,用于头颈部手术中中等大小缺损的重建。这种皮瓣的另一个优点是它是柔韧的,并且提供了距离前颈部中心部分大约7乘4厘米的皮肤岛。口腔缺损重建的最佳替代品是IHF。它可以用于口腔的中度缺陷和咽癌。该皮瓣可以是单侧或双侧甲状腺上蒂皮瓣,但主要局限性是旋转弧受限和皮瓣体积小。IHF在既往放疗和颈部转移的病例中是禁忌的。皮瓣是最值得信赖的,可以很容易地在头部和颈部解剖过程中产生;在肿瘤学上,它是安全的,并且它携带的供区发病率最低。
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引用次数: 0
Papillary carcinoma thyroid – Histological subtypes and clinical significance 甲状腺乳头状癌组织学亚型及其临床意义
IF 0.1 Q4 Medicine Pub Date : 2022-01-01 DOI: 10.4103/jhnps.jhnps_32_22
H. Ravindran
Papillary carcinoma thyroid is a very common malignancy of the thyroid having a very good overall prognosis. Among the subtypes of this tumor certain histological subtypes identified are more aggressive than the ones with classic histology. The purpose of this review is to stratify the prognosis concerning papillary thyroid carcinoma patients with different histopathological patterns, their features of identification, and molecular differences. This is a narrative review of various published articles including meta-analysis results. This does not contain any studies with human participants by the author. A general outline of each subtype with histologic descriptions, relevant differential diagnosis, immunohistochemical as well as ancillary studies is discussed in this article. The rarity of the aggressive subtypes of papillary carcinoma and poor understanding of tumor biology can lead to inadequate treatment, and hence, the correct diagnosis is very important, and equally important is the awareness of these entities among the treating physicians.
甲状腺乳头状癌是一种非常常见的甲状腺恶性肿瘤,具有非常好的整体预后。在这种肿瘤的亚型中,确定的某些组织学亚型比具有经典组织学的亚型更具侵袭性。这篇综述的目的是对不同组织病理学模式的甲状腺乳头状癌患者的预后、识别特征和分子差异进行分层。这是对包括荟萃分析结果在内的各种已发表文章的叙述性综述。这不包含作者对人类参与者的任何研究。本文讨论了每种亚型的一般概况,包括组织学描述、相关鉴别诊断、免疫组织化学以及辅助研究。乳头状癌侵袭性亚型的罕见性和对肿瘤生物学的不了解可能导致治疗不足,因此,正确的诊断非常重要,同样重要的是治疗医生对这些实体的认识。
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引用次数: 0
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Journal of Head & Neck Physicians and Surgeons
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