Background: Glomus apparatus maintains flow in capillaries in response to changes in temperature. Glomus tumors are rare perivascular hamartomas arising from glomus bodies at fingertips. They are associated with classic triad of symptoms including paroxysmal pain, cold hypersensitivity, and pinpoint tenderness. Due to its rarity and peculiar presentation, they are often misdiagnosed and inappropriately treated. Surgical excision is the treatment of choice either by transungual or lateral periosteal approach. Materials and Methods: We conducted a retrospective analysis of the cases of glomus tumors that were operated in the past 5 years in our institute. Patient demographic details, clinical features, imaging parameters, operative details, photographs and complications if any during follow up were analysed. QuickDASH was the primary statistical parameter, and change in QuickDASH score was analyzed with paired t-test. Results: The average age at diagnosis was 29.77 years. The male-to-female ratio was 1:5. The mean duration of symptoms is 10.08 months. The mean preoperative QuickDASH score was 25.27 (range: 11.25–34). The mean follow-up was 26.7 months (range: 6–48 months). At 6-month follow-up, the mean score was 1.52 (range: 0–13.64). The difference in mean scores was 23.7708 with significant P < 0.001. Conclusion: Glomus tumors are rare but debilitating lesions. They are often misdiagnosed and intervened inappropriately before arriving at an actual diagnosis. With complete excision by magnification-assisted surgery, quality of life generally improves, and recurrence is prevented.
{"title":"Glomus tumors of the digit: A retrospective analysis of clinical and functional outcomes","authors":"Pavan Kolisetty, Imran Ahmad, Sheikh Ali, Indrajith Sudhy","doi":"10.4103/tjps.tjps_46_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_46_23","url":null,"abstract":"Background: Glomus apparatus maintains flow in capillaries in response to changes in temperature. Glomus tumors are rare perivascular hamartomas arising from glomus bodies at fingertips. They are associated with classic triad of symptoms including paroxysmal pain, cold hypersensitivity, and pinpoint tenderness. Due to its rarity and peculiar presentation, they are often misdiagnosed and inappropriately treated. Surgical excision is the treatment of choice either by transungual or lateral periosteal approach. Materials and Methods: We conducted a retrospective analysis of the cases of glomus tumors that were operated in the past 5 years in our institute. Patient demographic details, clinical features, imaging parameters, operative details, photographs and complications if any during follow up were analysed. QuickDASH was the primary statistical parameter, and change in QuickDASH score was analyzed with paired t-test. Results: The average age at diagnosis was 29.77 years. The male-to-female ratio was 1:5. The mean duration of symptoms is 10.08 months. The mean preoperative QuickDASH score was 25.27 (range: 11.25–34). The mean follow-up was 26.7 months (range: 6–48 months). At 6-month follow-up, the mean score was 1.52 (range: 0–13.64). The difference in mean scores was 23.7708 with significant P < 0.001. Conclusion: Glomus tumors are rare but debilitating lesions. They are often misdiagnosed and intervened inappropriately before arriving at an actual diagnosis. With complete excision by magnification-assisted surgery, quality of life generally improves, and recurrence is prevented.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139537705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pirfenidone and tendon healing: Comment","authors":"H. Daungsupawong, V. Wiwanitkit","doi":"10.4103/tjps.tjps_61_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_61_23","url":null,"abstract":"","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Recurrence and scar formation are the key leftover problems in the treatment of verrucous epidermal nevus (VEN). The objective of this study was to assess the long-term efficacy of bleomycin with triamcinolone acetonide in reducing the recurrence of VEN and scar formation after treatment. Methods: Bleomycin and triamcinolone were injected percutaneously into the lesion, and the drug was evenly distributed in the lesion. Several treatment courses were carried out according to the size and hyperplasia of the lesion. Necessary laser treatment was performed. Patients were followed up for 2–5 years. Results: The results showed that 83% of the patients were cured. The recurrence rate was 17%. The recurrence was localized and accounted for 3%–6% of the original lesion area. Scar formation accounted for 3.4%. Other complications did not occur. The patients or his/her guardian were satisfied with the treatment effect. Conclusion: Bleomycin with triamcin acetonide can significantly improve the cure rate of VEN and reduce the recurrence rate and scar formation. This method is a good option for VEN treatment.
目的：复发和疤痕形成是疣状表皮痣（VEN）治疗过程中的主要遗留问题。本研究旨在评估博莱霉素联合曲安奈德对减少疣状表皮痣复发和治疗后疤痕形成的长期疗效。研究方法将博莱霉素和曲安奈德经皮注入病灶，使药物均匀分布在病灶中。根据病灶的大小和增生情况进行多个疗程的治疗。必要时进行激光治疗。对患者进行 2-5 年的随访。结果显示结果显示，83%的患者治愈。复发率为 17%。复发是局部的，占原病变面积的 3%-6%。疤痕形成占 3.4%。没有出现其他并发症。患者或其监护人对治疗效果表示满意。结论博莱霉素联合曲安奈德能显著提高 VEN 的治愈率，降低复发率和疤痕形成。这种方法是治疗 VEN 的良好选择。
{"title":"Bleomycin and triamcinolone for the treatment of verrucous epidermal nevus: Long-term follow-up","authors":"Q. Luo","doi":"10.4103/tjps.tjps_29_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_29_23","url":null,"abstract":"Objective: Recurrence and scar formation are the key leftover problems in the treatment of verrucous epidermal nevus (VEN). The objective of this study was to assess the long-term efficacy of bleomycin with triamcinolone acetonide in reducing the recurrence of VEN and scar formation after treatment. Methods: Bleomycin and triamcinolone were injected percutaneously into the lesion, and the drug was evenly distributed in the lesion. Several treatment courses were carried out according to the size and hyperplasia of the lesion. Necessary laser treatment was performed. Patients were followed up for 2–5 years. Results: The results showed that 83% of the patients were cured. The recurrence rate was 17%. The recurrence was localized and accounted for 3%–6% of the original lesion area. Scar formation accounted for 3.4%. Other complications did not occur. The patients or his/her guardian were satisfied with the treatment effect. Conclusion: Bleomycin with triamcin acetonide can significantly improve the cure rate of VEN and reduce the recurrence rate and scar formation. This method is a good option for VEN treatment.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Ozgur, M. Çalış, Murat Kara, M. K. Kulak Kayikci
Background: Pharyngeal flap (PF) is a commonly used surgical technique in the treatment of velopharyngeal insufficiency (VPI), but it still faces limitations that have not been overcome. The present study aims to objectively analyze the results of PF combined with velar muscle repair, which aims to transform the static structure of PF into a dynamic one, addressing one of its limitations. Patients and Methods: Patients were divided into two groups based on the surgical technique: Group 1: the traditional PF group and Group 2: PF with radical intravelar veloplasty (PF-RIVVP) group. Acoustic evaluation of the velopharyngeal unit (VFU) and nasality level was conducted using a nasometry device during the preoperative period and at 1-year postoperative follow-up. Direct anatomical evaluation of the VFU was performed using a flexible fiberoptic endoscope. Student's t-test and Chi-square test were used for statistical analysis. Results: The mean preoperative nasalance score was 56.5 ± 11.0 in Group 2 and 59.9 ± 10.3 in Group 1. The postoperative mean nasalance score was 29.2 ± 3.1 in Group 2 and 35.3 ± 3.1 in Group 1. Although no statistically significant difference was observed in the mean preoperative nasalance scores, a statistically significant difference was found in the postoperative scores (P < 0.001). Furthermore, nasopharyngoscopic evaluation revealed a superior velopharyngeal movement in Group 2. Conclusion: Through the objective evaluation techniques, the present study demonstrates that PF combined with velar muscle repair provides an enhanced velopharyngeal function in the treatment of VPI compared to the traditional technique.
{"title":"Comparative analysis of speech outcomes in the treatment of velopharyngeal insufficiency: Traditional superior-based pharyngeal flap and pharyngeal flap combined with radical intravelar veloplasty","authors":"F. Ozgur, M. Çalış, Murat Kara, M. K. Kulak Kayikci","doi":"10.4103/tjps.tjps_34_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_34_23","url":null,"abstract":"Background: Pharyngeal flap (PF) is a commonly used surgical technique in the treatment of velopharyngeal insufficiency (VPI), but it still faces limitations that have not been overcome. The present study aims to objectively analyze the results of PF combined with velar muscle repair, which aims to transform the static structure of PF into a dynamic one, addressing one of its limitations. Patients and Methods: Patients were divided into two groups based on the surgical technique: Group 1: the traditional PF group and Group 2: PF with radical intravelar veloplasty (PF-RIVVP) group. Acoustic evaluation of the velopharyngeal unit (VFU) and nasality level was conducted using a nasometry device during the preoperative period and at 1-year postoperative follow-up. Direct anatomical evaluation of the VFU was performed using a flexible fiberoptic endoscope. Student's t-test and Chi-square test were used for statistical analysis. Results: The mean preoperative nasalance score was 56.5 ± 11.0 in Group 2 and 59.9 ± 10.3 in Group 1. The postoperative mean nasalance score was 29.2 ± 3.1 in Group 2 and 35.3 ± 3.1 in Group 1. Although no statistically significant difference was observed in the mean preoperative nasalance scores, a statistically significant difference was found in the postoperative scores (P < 0.001). Furthermore, nasopharyngoscopic evaluation revealed a superior velopharyngeal movement in Group 2. Conclusion: Through the objective evaluation techniques, the present study demonstrates that PF combined with velar muscle repair provides an enhanced velopharyngeal function in the treatment of VPI compared to the traditional technique.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epithelioid angiomatous nodule (EAN) is a rare benign vascular lesion that was first reported in 2004. This article presents the case of a 29-year-old male with multiple focal EANs on his penis, a highly uncommon location for this condition. The patient had been experiencing painful nodules for 6 months, initially misdiagnosed as hemangioma and later as epithelioid hemangioendothelioma. Physical examination revealed bluish, well-circumscribed lesions on the corona and glans penis. Microscopic evaluation of an incisional biopsy confirmed the diagnosis of a penile EAN. EAN falls within the spectrum of epithelioid vascular tumors, but it is considered a newly described acquired vascular proliferation. It typically presents as small, fast-growing nodules on the extremities and trunk, though it can also occur on the face and mucosal surfaces. While most cases are solitary, conglomerated multiple nodules may also be seen. The condition predominantly affects adults between 15 and 45 years old. Differential diagnoses for EAN include epithelioid hemangioma, epithelioid angiosarcoma, and bacillary angiomatosis. EAN is clinically benign but can significantly impact the patient's quality of life, especially when located on sensitive areas like the penis. Simple local excision is a curative method, though reconstructive procedures may be necessary in some cases. Due to the limited number of cases reported in the literature, the pathogenesis and possible causes of EAN remain unclear. Further research and increased study of this condition are needed to gain a better understanding of its nature and potential etiology. Accurate diagnosis is crucial to distinguish EAN from other malignant vascular pathologies and prevent unnecessary interventions.
{"title":"Multifocal penile epithelioid angiomatous nodule: A rare tumor of penis","authors":"Emre Ozer, U. Bingöl, Murat Sav","doi":"10.4103/tjps.tjps_44_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_44_23","url":null,"abstract":"Epithelioid angiomatous nodule (EAN) is a rare benign vascular lesion that was first reported in 2004. This article presents the case of a 29-year-old male with multiple focal EANs on his penis, a highly uncommon location for this condition. The patient had been experiencing painful nodules for 6 months, initially misdiagnosed as hemangioma and later as epithelioid hemangioendothelioma. Physical examination revealed bluish, well-circumscribed lesions on the corona and glans penis. Microscopic evaluation of an incisional biopsy confirmed the diagnosis of a penile EAN. EAN falls within the spectrum of epithelioid vascular tumors, but it is considered a newly described acquired vascular proliferation. It typically presents as small, fast-growing nodules on the extremities and trunk, though it can also occur on the face and mucosal surfaces. While most cases are solitary, conglomerated multiple nodules may also be seen. The condition predominantly affects adults between 15 and 45 years old. Differential diagnoses for EAN include epithelioid hemangioma, epithelioid angiosarcoma, and bacillary angiomatosis. EAN is clinically benign but can significantly impact the patient's quality of life, especially when located on sensitive areas like the penis. Simple local excision is a curative method, though reconstructive procedures may be necessary in some cases. Due to the limited number of cases reported in the literature, the pathogenesis and possible causes of EAN remain unclear. Further research and increased study of this condition are needed to gain a better understanding of its nature and potential etiology. Accurate diagnosis is crucial to distinguish EAN from other malignant vascular pathologies and prevent unnecessary interventions.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article presents a case of skin necrosis following computed tomography-guided radiofrequency ablation (RFA) treatment in an 18-year-old female patient with osteoid osteoma. Although RFA is generally considered safe and effective for managing bone tumors, serious complications are rare but require careful attention. The patient developed a necrotic wound on her right forearm 2 days after the RFA procedure, necessitating wound care, antibiotic treatment, and reconstruction surgery. Skin necrosis is a severe complication associated with RFA, and prompt and appropriate management is crucial for favorable patient outcomes. The awareness of potential complications and adherence to proper procedural techniques are essential when using RFA for bone tumor management.
{"title":"A complication after radiofrequency ablation: Skin necrosis","authors":"Melih Sifil, Nuh Evin, Can Koç, E. Güneren","doi":"10.4103/tjps.tjps_50_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_50_23","url":null,"abstract":"This article presents a case of skin necrosis following computed tomography-guided radiofrequency ablation (RFA) treatment in an 18-year-old female patient with osteoid osteoma. Although RFA is generally considered safe and effective for managing bone tumors, serious complications are rare but require careful attention. The patient developed a necrotic wound on her right forearm 2 days after the RFA procedure, necessitating wound care, antibiotic treatment, and reconstruction surgery. Skin necrosis is a severe complication associated with RFA, and prompt and appropriate management is crucial for favorable patient outcomes. The awareness of potential complications and adherence to proper procedural techniques are essential when using RFA for bone tumor management.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Burn contractures are a common complication in the pediatric population, leading to significant functional limitations and decreased quality of life. This study aimed to investigate the impact of surgical access time on burn contracture outcomes in pediatric patients, particularly wound quality and hand function. Materials and Methods: This retrospective study included 27 pediatric patients with upper-extremity burn contractures between November 2022 and August 2023. Patients with underlying medical conditions or medications were excluded from this study. A variety of surgical procedures were performed, and complications, follow-up times, access times, and postoperative evaluations were assessed. Contracture locations were divided into four groups: axilla (Group I), elbow (Group II), wrist (Group III), and fingers (Group IV). Access time was defined as the time from symptom onset to first surgical intervention. Results: Among the 27 patients with pediatric burn contractures, Group II had significantly longer access times than the other groups (P < 0.05). This delayed access was associated with lower Patient and Observer Scar Assessment Scale (POSAS) and Michigan Hand Outcome Questionnaire (MHQ) scores in Group II (P < 0.05), indicating worse wound quality and hand function in Group II. Correlation analysis in Group II revealed a significant negative correlation between access time and POSAS (−0.8, P = 0.036) and MHQ scores (r = −0.43, P = 0.039). The changes in Groups I, III, and IV are statistically significant in terms of range of motion (P < 0.05). Conclusion: This study suggests that access time is an important factor for pediatric burn contractures. Early surgical intervention has been associated with improved wound quality and hand function.
{"title":"Investigating the effects of surgical access time on scar quality and function in pediatric upper-extremity burn contractures in a rural area","authors":"B. Tatar","doi":"10.4103/tjps.tjps_60_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_60_23","url":null,"abstract":"Background: Burn contractures are a common complication in the pediatric population, leading to significant functional limitations and decreased quality of life. This study aimed to investigate the impact of surgical access time on burn contracture outcomes in pediatric patients, particularly wound quality and hand function. Materials and Methods: This retrospective study included 27 pediatric patients with upper-extremity burn contractures between November 2022 and August 2023. Patients with underlying medical conditions or medications were excluded from this study. A variety of surgical procedures were performed, and complications, follow-up times, access times, and postoperative evaluations were assessed. Contracture locations were divided into four groups: axilla (Group I), elbow (Group II), wrist (Group III), and fingers (Group IV). Access time was defined as the time from symptom onset to first surgical intervention. Results: Among the 27 patients with pediatric burn contractures, Group II had significantly longer access times than the other groups (P < 0.05). This delayed access was associated with lower Patient and Observer Scar Assessment Scale (POSAS) and Michigan Hand Outcome Questionnaire (MHQ) scores in Group II (P < 0.05), indicating worse wound quality and hand function in Group II. Correlation analysis in Group II revealed a significant negative correlation between access time and POSAS (−0.8, P = 0.036) and MHQ scores (r = −0.43, P = 0.039). The changes in Groups I, III, and IV are statistically significant in terms of range of motion (P < 0.05). Conclusion: This study suggests that access time is an important factor for pediatric burn contractures. Early surgical intervention has been associated with improved wound quality and hand function.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Agrawal, Armaan Khosa, Vidhi Mehta, Vinita Puri
Bosma arhinia microphthalmia (BAM) is a very rare illness, with fewer than 100 cases documented worldwide. Criteria for diagnosis of BAM syndrome include congenital absence of nose (arhinia) or hypoplasia, hypogonadotropic hypogonadism, and eye defects (microphthalmia) in males. Our patient was a male child of 4 years of age who was brought by parents with left nasal arhinia for reconstruction. We devised three-layered nasal reconstruction for the child. Flip-over flap from the other half of the nose was used for the nasal lining, conchal cartilage grafts for the nasal framework, and pedicled forehead flap for skin cover.
{"title":"Nasal reconstruction in a rare case of unilateral arhinia in bosma arhinia microphthalmia syndrome","authors":"K. Agrawal, Armaan Khosa, Vidhi Mehta, Vinita Puri","doi":"10.4103/tjps.tjps_53_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_53_23","url":null,"abstract":"Bosma arhinia microphthalmia (BAM) is a very rare illness, with fewer than 100 cases documented worldwide. Criteria for diagnosis of BAM syndrome include congenital absence of nose (arhinia) or hypoplasia, hypogonadotropic hypogonadism, and eye defects (microphthalmia) in males. Our patient was a male child of 4 years of age who was brought by parents with left nasal arhinia for reconstruction. We devised three-layered nasal reconstruction for the child. Flip-over flap from the other half of the nose was used for the nasal lining, conchal cartilage grafts for the nasal framework, and pedicled forehead flap for skin cover.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Autologous fat graft survival depends on many variables such as vascularization and inflammation. Fat grafts are also frequently used in breast reconstructions. Objective: The objective is to investigate the effect of tamoxifen (TAM), which is frequently used in hormonal therapy after breast cancer, on fat graft survival and to determine the possible benefits of local and systemic deferoxamine (DFO) applications with TAM. Materials and Methods: Thirty-two female Wistar Albino rats were randomly divided into four groups. Fat graft from the inguinal region was transferred to the left subscapular area, suprafascial plan on the back of the rats. No application was made to the control group after fat grafting. Group 2 received TAM by oral gavage, Group 3 received TAM + local (L) DFO application to the fat graft area, and Group 4 received TAM + intraperitoneal (IP) DFO application. The grafted adipose tissue was excised 2 months after surgery. Macroscopic and histopathologic analysis was performed. Results: In the 2nd postoperative month, the weight and volume of fat grafts were significantly higher in the TAM + L DFO and TAM + IP DFO groups compared to the control group, whereas there was no statistically significant difference in the TAM-only group. Furthermore, vascularization and vascular endothelial growth factor (VEGF) expression were significantly increased in the TAM + L DFO and TAM + IP DFO groups compared to the control and TAM groups. Conclusions: Local DFO application to the fat graft recipient site and systemic DFO application increased fat graft survival in TAM-treated rats. VEGF expression was shown to increase with DFO and fat graft survival was also increased accordingly. The use of DFO is promising in improving fat graft survival in breast reconstruction patients using TAM.
导言：自体脂肪移植物的存活取决于许多变量，如血管化和炎症。脂肪移植物也经常用于乳房再造。研究目的目的是研究乳腺癌术后激素治疗中常用的他莫昔芬（TAM）对脂肪移植物存活率的影响，并确定局部和全身应用去氧胺（DFO）与他莫昔芬的可能益处。材料与方法32 只雌性 Wistar 白化大鼠被随机分为四组。将腹股沟区的脂肪移植到大鼠背部左侧肩胛下区筋膜上平面。脂肪移植后，对照组不施用任何药物。第 2 组大鼠口服 TAM，第 3 组大鼠在脂肪移植区局部注射 TAM 和 DFO，第 4 组大鼠注射 TAM 和腹腔注射 DFO。手术 2 个月后切除移植的脂肪组织。进行宏观和组织病理学分析。结果：术后第 2 个月，TAM + L DFO 组和 TAM + IP DFO 组的脂肪重量和体积明显高于对照组，而纯 TAM 组的差异无统计学意义。此外，与对照组和 TAM 组相比，TAM + L DFO 组和 TAM + IP DFO 组的血管化和血管内皮生长因子（VEGF）表达明显增加。结论在脂肪移植受体部位局部应用 DFO 和全身应用 DFO 可提高 TAM 处理大鼠的脂肪移植存活率。DFO 可增加血管内皮生长因子的表达，脂肪移植的存活率也相应提高。使用 DFO 有助于提高使用 TAM 的乳房再造患者的脂肪移植物存活率。
{"title":"The effect of deferoxamine on fat graft survival in tamoxifen use: An experimental study","authors":"Burak Yaşar, Ramazan Ünlü","doi":"10.4103/tjps.tjps_64_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_64_23","url":null,"abstract":"Introduction: Autologous fat graft survival depends on many variables such as vascularization and inflammation. Fat grafts are also frequently used in breast reconstructions. Objective: The objective is to investigate the effect of tamoxifen (TAM), which is frequently used in hormonal therapy after breast cancer, on fat graft survival and to determine the possible benefits of local and systemic deferoxamine (DFO) applications with TAM. Materials and Methods: Thirty-two female Wistar Albino rats were randomly divided into four groups. Fat graft from the inguinal region was transferred to the left subscapular area, suprafascial plan on the back of the rats. No application was made to the control group after fat grafting. Group 2 received TAM by oral gavage, Group 3 received TAM + local (L) DFO application to the fat graft area, and Group 4 received TAM + intraperitoneal (IP) DFO application. The grafted adipose tissue was excised 2 months after surgery. Macroscopic and histopathologic analysis was performed. Results: In the 2nd postoperative month, the weight and volume of fat grafts were significantly higher in the TAM + L DFO and TAM + IP DFO groups compared to the control group, whereas there was no statistically significant difference in the TAM-only group. Furthermore, vascularization and vascular endothelial growth factor (VEGF) expression were significantly increased in the TAM + L DFO and TAM + IP DFO groups compared to the control and TAM groups. Conclusions: Local DFO application to the fat graft recipient site and systemic DFO application increased fat graft survival in TAM-treated rats. VEGF expression was shown to increase with DFO and fat graft survival was also increased accordingly. The use of DFO is promising in improving fat graft survival in breast reconstruction patients using TAM.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Propylthiouracil (PTU)-induced vasculitis is a rare antineutrophilic cytoplasmic antibody-associated vasculitis involving small vessels. The patients are often present with constitutional symptoms such as skin rash, fever, sore throat, and joint pain, and rarely with systemic symptoms such as muscle pain, weakness, weight loss, conjunctival, and mucosal irritation. Early diagnosis with the help of clinical findings, laboratory and serological markers, discontinuation of PTU, and immunosuppressive treatments are beneficial. In this study, a case of necrotizing vasculitis after PTU is presented, and the literature is reviewed.
{"title":"Propylthiouracil-induced necrotizing vasculitis","authors":"Nuh Evin, Fatih Demir","doi":"10.4103/tjps.tjps_45_23","DOIUrl":"https://doi.org/10.4103/tjps.tjps_45_23","url":null,"abstract":"Propylthiouracil (PTU)-induced vasculitis is a rare antineutrophilic cytoplasmic antibody-associated vasculitis involving small vessels. The patients are often present with constitutional symptoms such as skin rash, fever, sore throat, and joint pain, and rarely with systemic symptoms such as muscle pain, weakness, weight loss, conjunctival, and mucosal irritation. Early diagnosis with the help of clinical findings, laboratory and serological markers, discontinuation of PTU, and immunosuppressive treatments are beneficial. In this study, a case of necrotizing vasculitis after PTU is presented, and the literature is reviewed.","PeriodicalId":42065,"journal":{"name":"Turkish Journal of Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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